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  • Gene
  • HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. (wikipedia.org)
  • Receptors
  • Although activation of natural killer (NK) cytotoxicity is generally inhibited by target major histocompatibility complex (MHC) class I expression, subtle features of NK allorecognition suggest that NK cells possess receptors that are activated by target MHC I. The mouse Ly-49D receptor has been shown to activate NK cytotoxicity, although recognition of MHC class I has not been demonstrated previously. (nih.gov)
  • These experiments show that the activating receptor Ly-49D specifically interacts with the MHC I antigen, H-2Dd, demonstrating the existence of alloactivating receptors on murine NK cells. (nih.gov)
  • Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor. (wikipedia.org)
  • Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. (wikipedia.org)
  • monoclonal antibody
  • As expected, anti- Ly-49D monoclonal antibody 12A8 specifically stimulated redirected lysis of the Fc receptor- bearing rat target YB2/0 by RNK.mLy-49D transfectants. (nih.gov)
  • vitro
  • To obtain insights into the mechanism of NK cell-mediated regulation, we conducted in vitro experiments, assaying antigen-induced proliferation of ZB-1 cells in the presence of irradiated spleen cells as APCs. (nih.gov)
  • Genes
  • Over the years, the Committee on Standardized Genetic Nomenclature for Mice has continued to assign new Ly and CD names to novel genes and Ags. (jimmunol.org)
  • The human homologues of a number of mouse Ags or genes, including members of the Ly-6 and Ly-49 families, have not yet been definitively identified. (jimmunol.org)
  • LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (wikipedia.org)
  • Cytokines
  • The disease enhancement was associated with augmentation of T cell proliferation and production of Th1 cytokines in response to MOG35-55.We further showed that NK cells inhibit T cell proliferation triggered by antigen or cytokine stimulation.Taken together, we conclude that NK cells are an important regulator for EAE in both induction and effector phases. (nih.gov)
  • Isotype
  • Lysis of all H-2d blasts by RNK.mLy-49D effectors was inhibited by anti-Ly-49D mAb 12A8, but not by isotype-matched control mAb 2C7 (panels A and B). (nih.gov)
  • Spleen
  • The experiment showed that antigen-induced ZB-1 cell proliferation is enhanced when spleen cells were derived from NK-deleted mice. (nih.gov)
  • We obtained similar results not only with spleen cells from wild-type B6 mice, but also from β2m−/− mice (Fig. 9, A and B). These indicate that irradiated, spleen NK cells would inhibit antigen-induced Th1 proliferation. (nih.gov)
  • induction
  • These mechanisms ensure induction of effective but appropriately limited responses against foreign antigens while preventing autoreactivity from inflicting escalating damage. (jci.org)
  • immunological
  • There are 2 broad categories of Tregs that function in different immunological settings depending upon the context of antigen exposure and the nature of the inflammatory response. (jci.org)
  • MOUSE
  • Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. (nih.gov)
  • To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK.mLy-49D). (nih.gov)