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  • simian immun
  • More recently, African green monkeys have been of significant interest because of the high levels of simian immunodeficiency virus type 1 ( SIV-1 ) that frequently occur in their blood, which may be distantly related to the human immunodeficiency virus ( HIV ) that causes AIDS. (fsu.edu)
  • Additionally, CTLs demonstrate a negative correlation with disease progression due to HIV infection ( 3 , 19 , 30 , 35 ), and in a simian immunodeficiency virus (SIV) macaque model, the control of SIV replication correlated directly with the presence of CD8 + T lymphocytes ( 16 , 38 ). (asm.org)
  • HBsAg
  • Suppression of HBsAg production by combination therapy with nucleotide analogues and interferon in children with genotype C Hepatitis B virus infection. (bioportfolio.com)
  • immunity
  • Varicella-zoster virus (VZV) vaccines induce immunity against childhood chickenpox and against shingles in older adults. (hindawi.com)
  • Taken together, this novel vaccine platform is well suited to deliver antigens and immunostimulatory cytokines to DCs and to initiate and maintain protective immunity. (asm.org)
  • immune
  • Varicella-zoster virus (VZV) vaccines provide immune protection against diseases that affect both the young and the elderly. (hindawi.com)
  • EBV-PK phosphorylation of IRF3 inhibits its function and may thus decrease the innate immune response to the virus ( 54 ). (asm.org)
  • Although direct cytopathic effects have a major role in human immunodeficiency virus type 1 (HIV-1) infection, immune defects that disrupt normal immune function also contribute to HIV-1 pathogenesis. (asm.org)
  • However, the virus can be detected in secondary lymphoid organs for several months, indicating failure of host immune response to clear the virus ( 2 ). (asm.org)
  • The immune response to PRRSV infection is characterized by a delayed appearance of neutralizing antibodies ( 31 ), a short cell-mediated immune response ( 34 , 59 ), and slow development of a virus-specific gamma interferon (IFN-γ) response ( 35 ). (asm.org)
  • plasmid
  • These results suggest that the 19-kDa Elb protein is essential for virus-mediated cell transformation, in agreement with results of others, but not for plasmid-mediated cell transformation. (uu.nl)
  • superinfection
  • Positive results usually indicate 1 of the following conditions: 1) simultaneous acute or chronic coinfection with hepatitis B virus (HBV) and HDV, 2) acute HDV infection in patients with known chronic HBV infection (ie, HDV superinfection), or 3) resolved HDV infection. (mayomedicallaboratories.com)
  • Caredda F, Rossi E, D'Arminio Monforte A, Zampini L, Re T, Meroni B, Moroni M (1985) Hepatitis B virus coinfection and superinfection with delta agent: indistinguishable disease with different outcome. (springer.com)
  • Colombo M, Cambieri R, Rumi MG, Ronchi G, Del Ninno E, De Franchis R (1983) Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis.Gastroenterology 85: 235-239. (springer.com)
  • protein
  • The Epstein-Barr virus (EBV) BGLF4 gene product, EBV-PK, is homologous to the cytomegalovirus (CMV) UL97 kinase and belongs to a conserved family of herpesviral protein kinases. (asm.org)
  • The purified whole-virus proteins derived from A/swine/Shanghai/1/2014 (H1N1) (SH1) were chosen to immunize BALB/c mice to prepare the monoclonal antibody (MAb) against hemagglutinin (HA) protein of a. (bioportfolio.com)
  • polyomavirus
  • Chimeras constructed by substituting the J-domain of DnaJ with the J-domain from any of several polyomavirus T antigens can replace wild-type DnaJ in vivo ( 23 ). (pnas.org)
  • Most, but not all, DnaJ homologs contain a domain that binds two Zn 2+ atoms, a feature shared with polyomavirus small t antigens ( 26 ). (pnas.org)
  • vaccines
  • Recent preclinical studies have shown potent immunogenicity and antitumor effects for alphavirus vaccines encoding self-antigens ( 15 - 17 ). (aacrjournals.org)
  • mutant
  • Maturation inhibitors facilitate virus assembly and release of HIV-1 capsid P224 mutant. (amedeo.com)
  • Rous
  • I first came across an endogenous factor which functionally complemented env -defective Rous sarcoma virus (RSV) during my doctoral studies in 1966. (royalsocietypublishing.org)
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • primate
  • Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses. (amedeo.com)
  • clinical
  • A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen. (hindawi.com)
  • detection
  • To establish a sensitive and rapid quantitative detection method for equine arteritis virus (EAV), an antigen-capture enzyme-linked immunosorbent assay (AC-ELISA) was developed by using two EAV nucleoprotein monoclonal antibodies (mAbs), 2B9 and 2B3, prepared in this study. (springer.com)
  • However, as a quantitative antigen detection method, the sensitivity of the AC-ELISA was approximately 300 times than the western blotting assay. (springer.com)
  • These results show that the AC-ELISA established in this study is a good alternative for antigen detection of EAV, being a simple, convenient and quantitative detection method for EAV antigens. (springer.com)
  • Balasuriya UB, Leutenegger CM, Topol JB, McCollum WH, Timoney PJ, MacLachlan NJ (2002) Detection of equine arteritis virus by real-time TaqMan reverse transcription-PCR assay. (springer.com)
  • Gilbert SA, Timoney PJ, McCollum WH, Deregt D (1997) Detection of equine arteritis virus in the semen of carrier stallions by using a sensitive nested PCR assay. (springer.com)
  • We utilized three separate methodologies for the detection of CTLs in a cohort of HIV-infected individuals who were also human leukocyte antigen A2 (HLA-A2) positive. (asm.org)
  • respiratory
  • Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of family Arteriviridae which, along with the Coronaviridae , are classified in the order Nidovirales ( 9 ). (asm.org)
  • transformation
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • chronic
  • Hepatitis delta virus (HDV) causes chronic and, occasionally, fulminant hepatitis in humans ( 16 ). (pubmedcentralcanada.ca)
  • Of the six main genotypes of the hepatitis C virus (HCV), genotypes 2 and 3 account for approximately 30% of chronic infections worldwide. (bioportfolio.com)
  • promoter
  • Moreover, when tested in a porcine myelomonocytic cell line, NSP1β inhibited Sendai virus-mediated activation of porcine IFN-β promoter activity. (asm.org)
  • respectively
  • For MVA, deletion of the non-essential genes E3L and F13L, respectively [ 23 , 24 ] resulted in viruses of altered plaque properties or narrowed host range, allowing the selection of recombinants after re-introduction of these genes and rescue of the wild-type phenotype. (biomedcentral.com)
  • Efficacy
  • The aim of the study is to analyze treatments available for patients infected with genotype (G) 3 hepatitis C virus (HCV) in Poland at the beginning of the interferon (IFN)-free era and evaluate the efficacy and safety of different therapeutic options administered in a real-world setting. (bioportfolio.com)