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  • CD98HC
  • Pre-expansion/differentiation of CD98-null T cells in vitro prior to adoptive transfer restored population effector functions and diabetogenicity, confirming that the mechanism by which CD98hc deletion protected from T1D was a block of clonal expansion. (jimmunol.org)
  • LAT1
  • We recently have identified the vertebrate proteins which mediate Na+-independent exchange of large neutral amino acids corresponding to transport system L. This transporter consists of a novel amino acid permease-related protein (LAT1 or AmAT-L-lc) which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen. (tcdb.org)
  • We show that h4F2hc also associates with other mammalian light chains, e.g. y+LAT1 from mouse and human which are approximately 48% identical with LAT1 and thus belong to the same family of glycoprotein-associated amino acid transporters. (tcdb.org)
  • Reverse transcription-polymerase chain reaction (RT-PCR) for large neutral amino acid transporter-1 (LAT1) was performed on total RNA from rabbit cornea, SIRC cells, and human cornea. (arvojournals.org)
  • CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis. (springer.com)
  • Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth. (springer.com)
  • human
  • Human endometrial CD98 is essential for blastocyst adhesion. (springer.com)
  • Reverse transcriptase-polymerase chain reaction indicates that mRNA of hEMT and of the human organic cation transporter 1 (hOCT1) are present in Caco-2 cells. (antibody-antibodies.com)
  • 1997
  • 1997 ). Depending on the number of N-glycan chains, the CD69 polypeptide forms subunits of the size 28 kDa or 32 kDa. (springer.com)
  • CD69
  • CD69 was first described as the activation antigen expressed on natural killer (NK) cells and T lymphocytes upon in vitro stimulation with interleukin (IL)-2 (Lanier et al. (springer.com)
  • interactions
  • The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. (ximbio.com)
  • cell
  • The mRNAs of these five genes were analyzed by the real-time reverse transcription polymerase chain reaction in matched sets of tumor and non-tumor tissues obtained at operation from 82 Japanese patients with clear cell RCC. (biomedcentral.com)
  • Deletion of CD98 H chain in B cells leads to complete failure of B cell proliferation, plasma cell formation, and Ab secretion. (jimmunol.org)
  • In this study, we examined the role of T cell CD98 in cell-mediated immunity and autoimmune disease pathogenesis by specifically deleting it in murine T cells. (jimmunol.org)
  • Deletion of T cell CD98 prevented experimental autoimmune diabetes associated with dramatically reduced T cell clonal expansion. (jimmunol.org)
  • induction
  • This characteristic renders DCs an attractive therapeutic target for the induction of tolerance against auto-antigens or allergens. (jimmunol.org)
  • Targeting Ags to resting DCs using a DC-specific Ab has been suggested as a potential therapeutic strategy for the induction of tolerance against auto-antigens ( 9 , 10 ). (jimmunol.org)
  • cells
  • In sharp contrast to B cells, CD98-null T cells showed only modestly impaired Ag-driven proliferation and nearly normal homeostatic proliferation. (jimmunol.org)
  • When we expanded CD98-null T cells in vitro, they adoptively transferred diabetes, establishing that impaired clonal expansion was responsible for protection from disease. (jimmunol.org)
  • present
  • If one N-glycan chain is present either on the typical or on the atypical N-glycosylation site, the unit size will be 28 kDa. (springer.com)
  • At rest, DCs continuously endocytose and present self-antigens ( 3 - 5 ). (jimmunol.org)