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  • cytotoxic T-lymphocyte-associated antig
  • Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). (drugbank.ca)
  • Known as a recombinant fusion protein, the drug consists of the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc portion of human immunoglobulin G 1 (IgG 1 . (drugbank.ca)
  • activation
  • Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (abcam.com)
  • Receptor
  • Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. (nih.gov)
  • Despite increased efficiency of uptake, interaction between iC3b-opsonized apoptotic cells and iDCs down-regulated the expression of major histocompatibility complex class II, CD86, CC chemokine receptor (CCR)2, CCR5, and beta2-integrins (P (nih.gov)
  • CD14
  • 90% CD14−CD1a+, as well as low DR, CD83, and CD86 (see below). (nih.gov)
  • dendritic
  • Immature dendritic cells (iDCs) do not mature after uptake of apoptotic cells and may play a role in the induction of peripheral tolerance to self antigens derived from apoptotic material. (nih.gov)
  • stimulation
  • CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. (novusbio.com)
  • Human
  • Detects human B7‑2/CD86 in direct ELISAs and Western blots. (novusbio.com)
  • Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human CD86. (abcam.cn)
  • Mouse
  • Detects mouse B7-2/CD86 in direct ELISAs and Western blots. (novusbio.com)
  • A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD86(66-80aa YEHYLGTEKLDSVNA), different from the related rat sequence by two amino acids. (bosterbio.com)