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  • allowed CD8 T ce
  • Recent technical advances including the use of MHC class I tetramers complexed with defined viral peptide epitopes and measurement of the production of cytokines in response to stimulation with synthetic peptides have allowed CD8 T cell responses to be quantitated with great accuracy. (rupress.org)
  • exogenous
  • As evidenced by the brain being the preferred site of immunopathology, despite much lower b-gal levels, and the enhancement of retinal PC pathology with the addition of exogenous DC, our results show that MHC class-I antigen presentation is significantly limited in the retina compared to the brain. (arvojournals.org)
  • mice
  • Transduced hHSC expressing an HLA-A*0201-restricted melanoma-specific T-cell receptor were introduced into humanized mice, resulting in the generation of a sizeable melanoma-specific naïve CD8 + T-cell population. (pnas.org)
  • In this study, using islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8 + T cell-mediated T1D development via the gut microbiota. (rupress.org)
  • Herein, we investigated the impact of sialylation mediated by trans-sialidase, a specific and unique Trypanosoma transglycosylase for sialic acid, on CD8(+) T cell response of mice infected with T. cruzi. (unifesp.br)
  • To investigate the impact of immune evasion on CD8 T cell priming, we infected mice with wild-type (wt) MCMV or a mutant lacking its MHC I immune evasion genes, Δm4+m6+m152 MCMV. (jimmunol.org)
  • At 2 years postinfection, differences in CD8 T cell immunodominance emerged between individual mice, but on average there were only slight differences between wt and mutant virus infections. (jimmunol.org)
  • Ozone exposure impairs antigen-specific immunity but activates IL-7-induced proliferation of CD4(-)CD8(-) thymocytes in balb/c mice. (cdc.gov)
  • IFABP-tOva mice, expressing the model-antigen Ovalbumin (Ova) in IECs, were used as recipients to set up chimeras using either CD11c-cre.Irf8fl/fl bone marrow, which cannot generate IRF8-DCs, or cre-negative Irf8fl/fl control bone marrow. (dtu.dk)
  • It has been shown that IL-21R knock-out mice express higher levels of IgE and lower levels of IgG1 than normal mice after antigen exposure. (wikipedia.org)
  • extracellular
  • The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. (wikipedia.org)
  • The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule. (wikipedia.org)
  • intracellular
  • These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis. (sciencemag.org)
  • molecule
  • Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts. (rupress.org)
  • The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikipedia.org)
  • If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (wikipedia.org)
  • In order for the TCR to bind to the class I MHC molecule, the former must be accompanied by a glycoprotein called CD8, which binds to the constant portion of the class I MHC molecule. (wikipedia.org)
  • The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. (wikipedia.org)
  • Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. (wikipedia.org)
  • The structure of the CD8 molecule was determined by Leahy, D.J., Axel, R., and Hendrickson, W.A. by X-ray Diffraction at a 2.6A resolution. (wikipedia.org)
  • proliferation
  • It was also found that O3 exposure dramatically enhanced the proliferation of CD4-CD8- thymocytes stimulated by recombinant mouse interleukin-7 (rmIL-7), which is usually observed during the mammal aging process. (cdc.gov)
  • peptide
  • Taken together, these results demonstrate, for the first time, that T. cruzi subverts sialylation to attenuate CD8(+) T cell interactions with peptide-major histocompatibility complex class I complexes. (unifesp.br)
  • immune system
  • As the immune system must accommodate this diversity within a relatively limited total population size there must be compromise between the repertoire of different antigens the immune system can effectively recognize and the number of precursors with any given specificity. (rupress.org)
  • The immune system must recognize millions of potential antigens. (wikipedia.org)
  • clonal
  • Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven. (nih.gov)
  • The findings support a model of psoriatic arthritis inflammation involving extensive and selective Ag, likely autoantigen, driven intra-articular CD4, and CD8 T cell clonal expansions. (nih.gov)
  • activation
  • These results demonstrate the potential of pH-responsive polymeric micelles for use in vaccine applications that rely on CD8(+) T cell activation. (sigmaaldrich.com)
  • selectively
  • In contrast, an anti-CD8 antibody selectively inhibited the B27- but not the DR2-directed killing by these clones. (rupress.org)
  • protein
  • In this study, we reveal that the human CD8 antigen is also associated with the T-cell-specific protein-tyrosine kinase (p56lck). (pnas.org)
  • Two-dimensional nonequilibrium pH-gradient gel electrophoresis and sodium dodecyl sulfate/polyacrylamide gel electrophoresis demonstrated the similarity of p56lck to the protein-tyrosine kinase associated with the CD4 antigen. (pnas.org)
  • The functions of CD8 in the TCR complex are thought to be signaling through the association of CD8 with the protein tyrosine kinase p56lck and adhesion to MHC class I through the alpha 3 domain. (rupress.org)
  • It is also required for induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination. (wikipedia.org)
  • Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene. (wikipedia.org)
  • HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene. (wikipedia.org)
  • Human
  • Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. (sigmaaldrich.com)
  • Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. (wikipedia.org)
  • There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. (wikipedia.org)
  • antibody
  • The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens of interest. (biocompare.com)
  • clones
  • Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. (rupress.org)
  • The results indicate that these clones display dual recognition for HLA-B27.1 and for HLA-DR2 and suggest that HLA-B27.1 may share at least one epitope that is closely related to some stimulatory Dw determinants present on the HLA-DR2 antigens. (rupress.org)
  • The inferred amino acid sequence of a single CD8 oligoclonal expansion revealed that they usually are composed of one or a few structurally related clones at the amino acid sequence level with beta-chains that encode identical or highly homologous CDR3 motifs. (nih.gov)
  • p56lck
  • Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex. (pnas.org)
  • ovalbumin
  • Conjugation of ovalbumin to the micelles significantly enhanced antigen cross-presentation in vitro relative to free ovalbumin, an unconjugated physical mixture of ovalbumin and polymer, and a non-pH-responsive micelle-ovalbumin control. (sigmaaldrich.com)
  • cytotoxicity
  • Selective involvement of CD8 in their class I--directed cytotoxicity. (rupress.org)
  • Current subunit vaccines are incapable of inducing Ag-specific CD8 + T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. (jimmunol.org)