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  • binds
  • 1. A method for depleting a B-cell comprising contacting a population of cells comprising a non-cancerous B-cell with an antibody or antigen binding fragment thereof that specifically binds to CD37, wherein said antibody or fragment thereof is capable of inducing apoptosis in vitro in the absence of a cross-linking agent. (patentsencyclopedia.com)
  • 2. A method for treating a patient having an autoimmune or inflammatory disease comprising administering to said patient a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to CD37, wherein said antibody or fragment thereof is capable of inducing apoptosis in vitro in the absence of a cross-linking agent. (patentsencyclopedia.com)
  • molecules
  • Phosphorylation of tyrosine residues within an immune receptor tyrosine-based activation motif (ITAM) sequence in the C-terminal tail of the CD79 molecules results in recruitment of an additional PTK, Syk, resulting in generation of further phosphotyrosine sites. (blogspot.com)
  • peptide
  • that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR. (wikipedia.org)
  • CDR3 is the main CDR responsible for recognizing processed antigen , although CDR1 of the alpha chain has also been shown to interact with the N-terminal part of the antigenic peptide, whereas CDR1 of the β-chain interacts with the C-terminal part of the peptide. (wikipedia.org)
  • Murine clonal CD4 and CD8 T cells were stimulated with cognate peptide antigen and antigen presenting cells (APCs) in the absence or presence of human MSCs, different aspects of T cell activation were monitored and analyzed using flow cytometery, real time RT-PCR and cytokine measurement. (biomedcentral.com)
  • surface
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. (elisa-kits.de)
  • Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. (elisa-kits.de)
  • Human MSCs (hMSCs) can alter multiple aspects of murine T cell activation induced by stimulation with specific antigen, including: reduced proliferation, inhibited or stimulated cell surface marker expression (CD25, CD69, CD44 and CD62L), inhibited mRNA expression of transcription factors (T-bet and GATA-3) and decreased cytokine expression (interferon-gamma, interleukin-10). (biomedcentral.com)
  • protein
  • Several techniques and reagents for heat-induced antigen retrieval, non-specific protein blocking, endogenous peroxidase blocking, and visualization-detection systems were tested during IHC protocol development. (peerj.com)
  • This gene encodes the Ig-beta protein of the B-cell antigen component. (elisa-kits.de)
  • macrophages
  • The majority of infiltrating cells were CD3-positive T cells, followed by CD79α-positive B cells and CD68-positive microglia/macrophages. (gla.ac.uk)
  • targets
  • In paraffin embedded tissues, mAbs and pAbs derived from human and swine antigens were very successful at binding equine tissue targets. (peerj.com)
  • strongly
  • and (iv) viral antigen is strongly associated with the presence of inflammation in naturally infected animals. (gla.ac.uk)
  • cell
  • Activation of CD79 alerts two tyrosine kinases, Lyn and Syk, which are capable of sending messages onward through the cell. (blogspot.com)
  • found
  • In particular, SBV antigen was found in 93.3% (14 out of 15 ruminants) and 32.8% (22 out of 67 ruminants) of animals with and without encephalitis, respectively. (gla.ac.uk)
  • therefore
  • There is also an additional area of hypervariability on the β-chain (HV4) that does not normally contact antigen and, therefore, is not considered a CDR. (wikipedia.org)
  • method
  • Additional investigative steps are required to determine if antigens can be retrieved and what retrieval method works best. (peerj.com)