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  • Protein
  • CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. (novusbio.com)
  • Because of the crucial role of dendritic cells in adaptive immunity and their potent activity in animal tumor models, numerous pilot studies have evaluated immunotherapy with dendritic cells loaded with antigen in the form of peptide, protein, DNA, mRNA, tumor lysates, tumor fusions, and viral vectors ( 1 ). (aacrjournals.org)
  • antibodies
  • Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. (freepatentsonline.com)
  • tumor
  • Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because it is widely expressed in gastrointestinal, lung, breast, and other malignancies. (aacrjournals.org)
  • immunotherapy
  • Finally, we discuss the potential interest of these AAPCs, both as fundamental tools to decipher CD4 + T cell responses and as reagents to generate clinical grade antigen-specific CD4 + T cells for immunotherapy. (frontiersin.org)
  • model
  • In this paper, we present a theoretical model that simulates the accumulation of CD2 and CD58 in the contact area of a Jurkat T lymphoblast and a CD58-containing substrate. (ox.ac.uk)
  • specific
  • Adoptive cell therapy (ACT) is an emerging approach that necessitates defining robust and efficient methods for the in vitro expansion of antigen-specific T cells then infused into patients. (frontiersin.org)
  • They constitute a reliable and easily usable platform to stimulate and amplify antigen-specific CD4 + T cells. (frontiersin.org)