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  • Specificity
  • Although extensively cultured CTLs retain antigen specificity for the tumor ( 10 ), they present striking alterations in function and gene and protein expressions ( 8 ), e.g. they are in an irreversible cell cycle arrest, resistant to apoptosis, with short telomeres and unable to respond to antigenic cues or IL-2 stimulation. (mcponline.org)
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  • Previous studies of primary immune responses to viral infection in mice have shown that antigen-specific T-helper 1 (Th1) CD4 responses can be readily detected in the early stages of the infection, but rapidly decline as antigen is cleared. (bloodjournal.org)