• Individuals without K antigens(K 0 ) who have formed an antibody to a K antigen, must be transfused with blood from donors who are also K 0 to prevent hemolysis. (wikidoc.org)
  • Autoimmune hemolytic anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red blood cells. (wikidoc.org)
  • CD55, an mCRP, plays an important role in inhibiting antibody-mediated CDC. (bvsalud.org)
  • Our results indicate that miR-132-3p regulates colon cancer cell sensitivity to antibody-mediated CDC by directly targeting CD55. (bvsalud.org)
  • CD55/CD59-neutralizing antibody treatment or mutation of the LINC00973 promoter activates the complement and CD8+ T cells, inhibiting tumor growth. (bvsalud.org)
  • Importantly, combined anti-CD55/CD59 and anti-programmed death 1 (anti-PD-1) antibody treatments elicit a synergistic tumor-inhibiting effect. (bvsalud.org)
  • A, B and H antigens mainly elicit IgM antibody reactions, although anti-H is very rare, see the Hh antigen system (Bombay phenotype, ISBT #18). (wikidoc.org)
  • The classical pathway is activated by an antibody binding to a target antigen, forming a complex. (aacc.org)
  • This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Mouse anti Human CD55 antibody, clone Bu14 recognizes human CD55, also known as Decay Accelerating Factor (DAF). (bio-rad-antibodies.com)
  • 7. Expression of the DAF (CD55) and CD59 antigens during normal hematopoietic cell differentiation. (nih.gov)
  • These pig lines include transgenic strains expressing various human complement regulatory proteins [i.e., decay accelerating factor (CD55), terminal complement inhibitor (CD59), and monocyte chemoattractant protein (CD56)] to minimize the deleterious effects of the complement cascade. (nih.gov)
  • Here, we demonstrate that epidermal growth factor receptor (EGFR)/Wnt signaling induces ß-catenin-mediated long noncoding RNA (lncRNA) LINC00973 expression to sponge CD55-targeting miR-216b and CD59-targeting miR-150. (bvsalud.org)
  • The consequently upregulated CD55/CD59 expression suppresses the complement system and cytokine secretion required for CD8+ T cell activation. (bvsalud.org)
  • In addition, CD55/CD59 levels are inversely correlated with infiltration of M1 macrophages and CD8+ T cells in human lung cancer specimens and predict patient outcome. (bvsalud.org)
  • These findings underscore the critical role of EGFR/Wnt/ß-catenin-upregulated CD55/CD59 expression in inhibiting the complement and CD8+ T cell activation for tumor immune evasion and immune checkpoint blockade resistance and identify a potential combination therapy to overcome these effects. (bvsalud.org)
  • Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). (neobiotechnologies.com)
  • The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). (rupress.org)
  • CD97 is an activation-induced antigen on leukocytes with a seven-span transmembrane (7-TM) region homologous to the secretin receptor superfamily. (rupress.org)
  • Sublining FLS expressing human leukocyte antigen-DRA (HLA-DRA) produce C-X-C motif chemokine 12 (CXCL12) and receptor activator of nuclear factor-κB ligand (RANKL) and seems to constitute a pro-inflammatory subset that is associated with inflammation and tertiary lymphoid structures. (intechopen.com)
  • Using EL4 cell-derived transfectants with differential expression levels of exogenous human CC chemokine receptor 4 or human CD20 as target cells, ADCC of fucose variants of chimeric IgG1 antibodies specific for these antigens were measured. (aacrjournals.org)
  • The quantitative analysis revealed that fucose depletion could reduce the antigen amount on target cells required for constant degrees of ADCC induction by 10-fold for CC chemokine receptor 4 and 3-fold for CD20. (aacrjournals.org)
  • Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)
  • Recent clinical success with immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and adoptive immune cellular therapies has generated excitement and new hopes for patients and investigators. (frontiersin.org)
  • A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. (rush.edu)
  • Moreover, complement activation was blocked by exogenous recombinant CD55 protein in both skin sections and keratinocytes exposed to pathogenic antibodies from patients with bullous pemphigoid. (oncotarget.com)
  • A mAb selected on its capacity to block the adhesion between CD97 transfectants and red cells was found to be directed to the NH2-terminal short consensus repeat (SCR) of decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. (rupress.org)
  • [1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
  • The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
  • Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • CD55 protein levels were negatively correlated with miR-132-3p expression in colon cancer tissues. (bvsalud.org)
  • CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF). (bvsalud.org)
  • CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120. (uams.edu)
  • CD55 is a glycosylphosphatylinositol (GPI) anchored type I surface protein which prevents complement mediated lysis of autologous cells. (bio-rad-antibodies.com)
  • The KEL gene encodes a type II transmembrane glycoprotein [5] that is the highly polymorphic Kell blood group antigen. (wikidoc.org)
  • SVDV infection of HeLa cells was also inhibited by an anti-CD55 MAb, suggesting that this virus, like some CVB, may interact with CD55 (decay accelerating factor) in addition to CAR. (nih.gov)
  • The FLS in the synovial lining layer are identified by surface complement decay-accelerating factor (CD55) along with lubricin and metallopeptidase expression. (intechopen.com)
  • This pathway is regulated by properdin, factor H, and decay-accelerating factor (CD55). (msdmanuals.com)
  • CD55 functions to limit the formation and accelerate the decay of C3/C5-convertases from the classic and alternative pathway. (bio-rad-antibodies.com)
  • Preclinical animal studies have identified tumor-specific antigens and the direct killing of tumor cells using T cells specific for these antigens ( 2 , 3 ). (frontiersin.org)
  • The specificity of the interaction of CD97 with CD55 was established by the observation that erythrocytes that lack CD55, obtained from patients with paroxysmal nocturnal hemoglobinuria (PNH) or the CD55, phenotype Inab, failed to adhere to CD97 transfectants. (rupress.org)
  • Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. (edu.au)
  • CD97 antibodies and lack of CD97 or CD55 in mice reduced synovial inflammation and joint damage in collagen- and K/BxN serum transfer-induced arthritis. (wikipedia.org)
  • In this report, we investigated the relationship between enhanced ADCC and antigen density on target cells using IgG1 antibodies with reduced fucose. (aacrjournals.org)
  • Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikidoc.org)
  • Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
  • Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies. (explorationpub.com)
  • Glycoprotein (DAF or CD55 , regulates complement fractions C3 and C5, attached to the membrane by GPI). (wikidoc.org)
  • Mice lacking CD97 or its ligand CD55 have twice as many granulocytes as wild-type mice possibly due to enhanced granulopoiesis. (wikipedia.org)
  • Finally, the interaction between CD97 and its ligand CD55 regulates T-cell activation and increases proliferation and cytokine production. (wikipedia.org)
  • The expression of CD97 on macrophage and the abundant presence of its ligand CD55 on fibroblast-like synovial cells suggest that the CD97-CD55 interaction is involved in the recruitment and/or retention of macrophages into the synovial tissue in rheumatoid arthritis. (wikipedia.org)
  • Binding of chilly agglutinins to the target antigen initiates the classical pathway of the match system.9 C1 complexes with antigen-bound chilly agglutinins lead to cleavage of C2 and C4. (nos-nop.org)
  • A functional analysis of recombinant soluble CD46 in vivo and a comparison with recombinant soluble forms of CD55 and CD35 in vitro. (edu.au)
  • These strategies include eliminating tumor bulk to provoke the release of tumor antigens, using adjuvants to enhance antigen-presenting cell function, and employ agents that enhance immune cell effector activity. (frontiersin.org)
  • Some of these findings were recapitulated in humans and used to develop cancer immunotherapies based on provoking tumor-antigen-specific T-cell responses ( 4 , 5 ). (frontiersin.org)
  • The immune system is an important line of defense for tumor formation of malignancies that express unique antigens. (biomedcentral.com)
  • Antigens, CD15" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • In addition, CD15 antigen is a stage-specific embryonic antigen. (childrensmercy.org)
  • This graph shows the total number of publications written about "Antigens, CD15" by people in this website by year, and whether "Antigens, CD15" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Antigens, CD15" by people in Profiles. (childrensmercy.org)
  • 16. Flow cytometric analysis of the Hermes homing-associated antigen on human lymphocyte subsets. (nih.gov)
  • In pre-active lesion, increased expression of CD55 in endothelial cells and robust CD97 expression on infiltrating leukocytes suggest a possible role of both molecules in immune cell migration through the blood-brain barrier. (wikipedia.org)
  • Notably, a significant increase in the expression of TNF-α and IFN-γ, administration of which downregulated CD55 levels in HaCaT cells, was observed in the sera of patients with bullous pemphigoid (n = 38) compared to that in healthy controls (n = 19). (oncotarget.com)
  • We further investigated IgG1 binding to natural killer (NK) cells and NK cell activation during ADCC induction to elucidate the mechanism by which low-fucose IgG1 induces ADCC upon target cells with low antigen expression. (aacrjournals.org)
  • IgG1 binding to NK cells was increased by ligating IgG1 with clustered antigen, especially for low-fucose IgG1. (aacrjournals.org)
  • Our data showed that fucose removal from IgG1 could reduce the antigen amount required for ADCC induction via efficient recruitment and activation of NK cells. (aacrjournals.org)
  • The Kell antigen system (also known as Kell-Cellano system ) is a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikidoc.org)
  • However, the mechanisms regulating CD55 expression in tumour cells remain unclear. (bvsalud.org)
  • The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. (ox.ac.uk)
  • Progressive megaloblastic anemia ensues, often accompanied by elevated expression of the i antigen on the red cells. (ashpublications.org)
  • for synovial cells in the surface region, CD55? (conferencedequebec.org)
  • [3] Most of them categorize the differences in 345 known antigens of our red blood cells (RBC) and are genetically determined by 48 known genes. (genomsys.com)
  • Figure B . Alexa Fluor 647 conjugated Mouse anti Human CD14 ( MCA1568A647 ) and FITC conjugated Mouse anti Human CD55 ( MCA2659F ). (bio-rad-antibodies.com)
  • Kell antigens are important in transfusion medicine , autoimmune hemolytic anemia and hemolytic disease of the newborn (anti-Kell) . (wikidoc.org)
  • McLeod phenotype (or McLeod syndrome) is an X-linked anomaly of the Kell blood group system in which Kell antigens are poorly detected by laboratory tests. (wikidoc.org)
  • The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • in 1996 reported that exosomes have the ability of antigen presentation, activating T cell immune response [ 23 ]. (hindawi.com)
  • Other transgenic pig strains express different glycosyltransferases which compete with alpha-1,3- galactosyltransferase, the enzyme that generates the gal epitope, to decrease the gal antigen expression. (nih.gov)
  • CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex. (bvsalud.org)
  • Interestingly, CD55 depletion in HaCaT human keratinocytes enhanced autoantibody-mediated complement activation. (oncotarget.com)
  • Low-fucose IgG1s showed potent ADCC at low antigen densities at which their corresponding high-fucose counterparts could not induce measurable ADCC. (aacrjournals.org)
  • In brain tissue, CD97 is undetectable in normal white matter, and expression of CD55 is fairly restricted to the endothelium. (wikipedia.org)
  • Differential quantitative expression of T-200 common leukocyte antigen during normal hemopoiesis. (nih.gov)
  • 19. Expression of leukemia-associated antigen, JL1, in bone marrow and thymus. (nih.gov)
  • miR-132-3p overexpression or inhibition transcriptionally regulated CD55 expression by specifically targeting its mRNA 3'-untranslated regions. (bvsalud.org)
  • Moreover, miR-132-3p expression was significantly reduced, whereas CD55 expression was increased, in colon cancer tissues compared to levels in adjacent normal tissues. (bvsalud.org)
  • Individuals lacking Duffy antigens altogether are immune to malaria caused by Plasmodium vivax and Plasmodium knowlesi . (wikidoc.org)
  • N-glycosylation of CD97 within the EGF domains is crucial for CD55 binding. (wikipedia.org)
  • We found that CD55 levels were significantly lower in the lesions of patients with bullous pemphigoid (n = 8) compared to those in skin samples from healthy controls (n = 6). (oncotarget.com)
  • Thus, CD55 deficiency is a crucial factor in bullous pemphigoid pathogenesis, suggesting that increasing CD55 levels may exert a therapeutic effect. (oncotarget.com)
  • The gene causing it was CD55. (nih.gov)
  • Here, we investigated the involvement of CD55 in bullous pemphigoid, as little is known regarding its role in this disease. (oncotarget.com)
  • Bullous pemphigoid is the most common autoimmune subepidermal blistering disease and is characterized by the production of autoantibodies that directly target the bullous pemphigoid antigen 180 (BP180 or COL17A1) within the dermoepidermal junction (DEJ) [ 1 , 2 ]. (oncotarget.com)