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  • molecule
  • We developed bispecific antibody variants targeting CD47 and CD20 to combine these two functions into a single molecule that recapitulated the potent synergistic effect of combination therapy with no toxic effects on normal cells. (aacrjournals.org)
  • ScFv
  • We used ScFv (single chain variable fragment) from mouse CD47 antibody to generate CD47-CAR-T cells for targeting different cancer cell lines. (mdpi.com)
  • Moreover, we humanized mouse CD47 ScFv and showed that it effectively bound CD47 antigen. (mdpi.com)
  • The ready-to-use lentiviral particles of Lenti-CD47 CAR (scFv-28εRIγ, B6H12.2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. (creative-biolabs.com)
  • peptides
  • The CD47-binding peptides and the mutated peptides (Anaspec, Fremont, CA, USA) of TSP1 (Fig. 3A) were used at a concentration of 1 μM (26) in basal M131 media. (nih.gov)
  • signals
  • The IND approval signals that Innovent's discovery and development on CD47 has advanced IBI188 as a leading player for this target to enter into clinical development stage. (medindia.net)
  • clinical
  • Innovent will be among one of a few companies pursuing the development of an anti-CD47 antibody in the early clinical stage. (medindia.net)
  • specifically
  • To overcome these limitations and address selective tumor targeting, we developed SIRPabodies to improve the therapeutic benefits of CD47-SIRPα blockade specifically toward tumor. (aacrjournals.org)
  • Products
  • CD antigen cancer market is expected to witness introduction of several products which will help the pharmaceutical companies to generate significant revenues. (marketreport.jp)
  • cancer
  • Thus, CD47-CAR-T cells can be used as a novel cellular therapeutic agent for treating different types of cancer. (mdpi.com)
  • Several molecules have been discovered out of which CD antigens have been found to play an important role in cancer progression and proliferation. (marketreport.jp)
  • high
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
  • growth
  • In addition, CD47-CAR-T cells significantly blocked BxPC3 pancreatic xenograft tumor growth after intratumoral injection into NSG mice. (mdpi.com)