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  • CD59
  • Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissues. (arvojournals.org)
  • METHODS: After euthanasia of female Wistar rats, followed by orbital exenteration, eyelids and orbital tissue including the lacrimal gland were separated from the globes and immediately snap-frozen in liquid nitrogen at -70 degrees C. Tissues then were sectioned at -20 degrees C and examined immunohistochemically for 5I2 antigen and rat CD59. (arvojournals.org)
  • Corneal endothelial cells showed intense labeling for rat CD59 but not for 5I2 antigen. (arvojournals.org)
  • The retina showed labeling at multiple levels, with that of rat CD59 being more intense than that of 5I2 antigen. (arvojournals.org)
  • CONCLUSIONS: 5I2 antigen and rat CD59 are expressed in high levels and distributed similarly in the rat eye and lacrimal gland to DAF, MCP, and MIRL in the human eye and lacrimal gland. (arvojournals.org)
  • Reactivity
  • A "two-hit" infection with HHV-6A appears to result in neurological deficits and pathologically, CNS inflammatory demyelination similar to human MS. Affected animals appear to develop immune reactivity to myelin antigens, indicating the possibility that mechanisms of mimicry may be involved in pathogenesis. (dana.org)
  • Longitudinal studies of reactivity to myelin antigens and to HHV6, and viral persistence/replication in relation to time-course of disease will be examined. (dana.org)
  • gene
  • CHO-Anti-Human CD46 MAb stable cell line is clonally-derived from a CHO cell line, which has been transfected with an Anti-human CD46 MAb gene to allow expression of the MAb. (creativebiomart.net)
  • protein
  • Western blot analyses showed that the cellular complement protein CD46, the receptor for HHV-6A, is associated with the purified and infectious virions.Also, the cellular proteins clathrin, ezrin and Tsg101 are associated with intact HHV-6A virions.Cellular proteins are associated with HHV-6A virions. (nih.gov)
  • viral
  • Possible cytotoxicity of lymphocytes from HHV6-infected animals towards antigen-sensitized targets and capacity for immune viral clearance or neutralization will be explored. (dana.org)
  • A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. (creativebiomart.net)
  • species
  • This proposal is based on the novel finding that common marmosets, a species of New World primates that is prone to develop an MS-like immune-mediated CNS illness after immunization with myelin antigens, can be infected with HHV6. (dana.org)
  • novel
  • FOR46 targets a novel immune modulatory receptor, CD46, which is highly expressed in multiple tumor types and is part of the tumor's immune defense shield. (businesswire.com)
  • tissues
  • CD46 is an attractive target for a number of cancers but has yet to be exploited due to its role in healthy tissues," said Jay Lichter, Ph.D., President and CEO of Fortis Therapeutics. (businesswire.com)
  • cell
  • Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF, Horvat B: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. (sysmex-flowcytometry.com)
  • high
  • Of interest is that medulloblastoma (a malignant brain tumor common in childhood) specimens express a high level of CD46. (qedbio.com)