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  • CD45RB
  • Additionally we have shown agonism of the RB isoform of CD45 (CD45RB) abrogates lipopolysaccharide (LPS)-induced microglial activation. (nih.gov)
  • Data revealed cross-linking of CD45, particularly the CD45RB isoform, enhances microglial phagocytosis of Abeta(1-42) peptide and inhibits LPS-induced activation of p44/42 and p38 pathways. (nih.gov)
  • cells
  • Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features. (thefreedictionary.com)
  • This antigen is found on B cells, approximately 50% of bone marrow cells, all CD8+ve T cells, but splits CD4+ve T cells into two populations,CD4+ CD45RC (Th 1-like) and CD4+ CD45RC low (Th-2 like). (novusbio.com)
  • Memory CD4+ T cells are preferentially infected by HIV-1 compared to naïve cells.Conversely, the lower cortical actin density in naïve CD4+ T cells restricted viral antigen transfer and consequently HIV-1 infection.In conclusion, the cortical actin density differentially affects the susceptibility to HIV-1 infection in naïve and memory CD4+ T cells by modulating the efficiency of HIV antigen internalization. (nih.gov)
  • Here, we evaluate the role of the cortical actin in cell-to-cell transfer of virus antigens and infection of target CD4+ T cells. (nih.gov)
  • Thus, the higher cortical actin density of memory CD4+ T cells was associated to increased efficiency of HIV-antigen internalization and the establishment of a productive infection. (nih.gov)
  • Conversely, the lower cortical actin density in naïve CD4+ T cells restricted viral antigen transfer and consequently HIV-1 infection. (nih.gov)
  • both variants show intraepidermal, highly activated, proliferating T cells with variable loss of pan-T-cell antigens, contrasting with nonactivated dermal reactive T cells. (curehunter.com)
  • Microglial cells were co-treated with "aged" FITC-Abeta(1-42) and multiple CD45 isoform agonist antibodies. (nih.gov)
  • Co-treatment of microglial cells with agonist CD45 antibodies results in significant inhibition of LPS-induced microglial TNF-alpha and IL-6 release through p44/42 and/or p38 pathways. (nih.gov)
  • However, cross-linking of CD3 ( 5 ), CD2 ( 6 ), B cell surface Ig ( 7 ), CD44 ( 8 ), MHC class II ( 9 ), or CD45 ( 10 ) with specific mAbs or stimulation of cells with PMA results in a rapid enhancement of LFA-1-mediated cell adhesion to ICAM-1. (jimmunol.org)
  • actin
  • Because the cortical actin polymerization modulates the internalization of viral antigens during cell-to-cell contacts, we asked whether differences in cortical actin polymerization in distinct CD4+ T cell subtypes may determine different susceptibilities to infection by regulating the efficiency of viral antigen internalization. (nih.gov)
  • multiple
  • CD45 exists in multiple forms, such as the restricted variants and as allelic forms CD45.1/Ly5.1 and CD45.2/Ly5.2. (abcam.com)