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  • gp120
  • We have previously demonstrated that the presence of specific gp120/V3 peptides during antigen presentation can modify the activation of normal T-cells leading to altered immune function. (biomedcentral.com)
  • Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cell membrane. (wikipedia.org)
  • Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research. (wikipedia.org)
  • viral
  • Interestingly, we found that the percentage of CD39(-) cells within baseline CD4(+) T-cell responses to HIV-Gag was negatively correlated with HIV viral load pre-ART and positively correlated with CD4(+) T-cell recovery over 96 weeks of ART. (sigmaaldrich.com)
  • Acute viral infections typically induce a CD4 + T cell response that is almost exclusively composed of Tfh and Th1 cells, in approximately equal proportion. (frontiersin.org)
  • murine
  • We have transfected the mouse CD4 gene into a beef insulin (BI)-specific murine T helper hybridoma that lacks CD4 surface expression. (rupress.org)
  • Murine clonal CD4 and CD8 T cells were stimulated with cognate peptide antigen and antigen presenting cells (APCs) in the absence or presence of human MSCs, different aspects of T cell activation were monitored and analyzed using flow cytometery, real time RT-PCR and cytokine measurement. (biomedcentral.com)
  • Human MSCs (hMSCs) can alter multiple aspects of murine T cell activation induced by stimulation with specific antigen, including: reduced proliferation, inhibited or stimulated cell surface marker expression (CD25, CD69, CD44 and CD62L), inhibited mRNA expression of transcription factors (T-bet and GATA-3) and decreased cytokine expression (interferon-gamma, interleukin-10). (biomedcentral.com)
  • In murine models, MHC class II-restricted CD4 T cells ( 1 ), MHC class I-restricted CD8 T cells ( 2 , 3 ), IFN-γ ( 4 ), and TNF-α ( 5 ) are essential for protection. (jimmunol.org)
  • protein-tyrosi
  • In this study, we reveal that the human CD8 antigen is also associated with the T-cell-specific protein-tyrosine kinase (p56lck). (pnas.org)
  • Two-dimensional nonequilibrium pH-gradient gel electrophoresis and sodium dodecyl sulfate/polyacrylamide gel electrophoresis demonstrated the similarity of p56lck to the protein-tyrosine kinase associated with the CD4 antigen. (pnas.org)
  • clonal
  • Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven. (nih.gov)
  • The findings support a model of psoriatic arthritis inflammation involving extensive and selective Ag, likely autoantigen, driven intra-articular CD4, and CD8 T cell clonal expansions. (nih.gov)
  • thymocytes
  • We demonstrate here that conventional SP CD4thymocytes bearing autoreactive TCRs drive a homeostatic process that fine-tunes medullary plasticity in adult mice by governing the expansion and patterning of the medulla. (kuleuven.be)
  • Our results show that Ag-dependent interactions between autoreactive CD4thymocytes and mTECs fine-tune homeostasis of the medulla by completing the signaling axes implicated in mTEC expansion and medullary organization. (kuleuven.be)
  • CD1 antigens are expressed on cortical thymocytes, but not on mature T cells. (wikipedia.org)
  • residues
  • Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex. (pnas.org)
  • peripheral
  • We exposed primary human peripheral blood monocytes to V3 lipopeptides using a liposome delivery system followed by a superantigen-mediated antigen presentation system. (biomedcentral.com)
  • human
  • Human Ag-specific CD4(+) Txa0cells can be detected by their dual expression of CD134 (OX40) and CD25 after a 44 hours stimulation with cognate Ag. (sigmaaldrich.com)
  • The presence of antibody to one of these constituent antigens in human or animal sera is presumptive evidence of past or present contact with specific microorganisms, and this finds application in clinical diagnosis and epidemiological surveys. (thefreedictionary.com)
  • Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings. (rti.org)
  • clonotypes
  • In contrast, strong TCR signaling leading to TCR downregulation and induction of LAG3 expression in high TCR avidity clonotypes restrained CD4 + T cell commitment and further differentiation. (frontiersin.org)
  • specificity
  • Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma. (rupress.org)
  • These experiments suggest that CD4 may be important in determining the antigen fine specificity and, therefore, may also play a role in altering the T cell repertoire. (rupress.org)
  • Surface
  • We have shown previously that antigen presentation can be deregulated by the presence of V3 epitopes on the surface of macrophages. (biomedcentral.com)
  • Treg
  • Control and Treg‐depleted EF 4.1 mice were immunized, and the extent of the Vα2‐bearing, antigen‐specific TCR repertoire was characterized by high‐throughput sequencing and spectratyping analysis. (embopress.org)
  • distinct
  • Since whole microorganisms are complex structures, vaccines may contain 10 or more distinct antigens, of which generally not more than one or two engender a protective antibody. (thefreedictionary.com)
  • antibody
  • Antigen-antibody reactions serve as host defenses against microorganisms and other foreign bodies, or are used in laboratory tests for detecting the presence of either antigen or antibody. (thefreedictionary.com)
  • With a few exceptions, such as the autoantigens and the isoantigens of the blood groups, antigens produce antibody only in species other than the ones from which they are derived. (thefreedictionary.com)
  • interactions
  • Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds[citation needed]. (wikipedia.org)
  • humans
  • Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system. (wikipedia.org)
  • decline
  • RESULTS: Sibling pairs sharing one or two haplotypes were significantly concordant in CD4 decline and AIDS status within 5 years of seroconversion. (rti.org)