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  • antibody
  • The following antibody was used in this experiment: CD38 Monoclonal Antibody (HIT2) from Thermo Fisher Scientific, catalog # MA1-19316, RRID AB_1072231. (thermofisher.com)
  • This can be sidelined by either pretreatment of the erythrocytes with dithiothreitol (DTT) or by using an anti-CD38 antibody neutralizing agent, e.g. (wikipedia.org)
  • In the phase III CASTOR trial reported in The New England Journal of Medicine , Antonio Palumbo, MD , of the University of Turin, and colleagues found that adding the anti-CD38 antibody daratumumab (Darzalex) to bortezomib (Velcade) and dexamethasone markedly improved progression-free. (ascopost.com)
  • In most, but not all, animal models of adaptive immune responses to viral infection, optimal clearance of virus depends on synergistic interactions between antigen-specific populations of helper CD4 + T cells, antibody-producing B cells, and cytotoxic CD8 + T cells. (bloodjournal.org)
  • This antibody recognises the murine CD38 cell surface antigen, a 42-46kD glycoprotein expressed by B lymphocytes, a proportion of peripheral T lymphocytes and by peritoneal macrophages. (abcam.cn)
  • Isatuximab is a chimeric immunoglobulin G1-κ (IgG1-κ) monoclonal antibody (mAb) that binds selectively to a unique epitope on the cell surface antigen CD38 and targets tumor cells via different mechanisms, including Fc-dependent immune-effector mechanisms and immunomodulatory effects. (bloodjournal.org)
  • Genes related to B-T cell interactions, including antigen presentation, B cell differentiation and antibody production, were profoundly downregulated. (biomedcentral.com)
  • cyclic ADP-ribose hydro
  • Publications] Ichiro Kato: 'Regulatory role of CD38(ADP-ribosyl cycalse/cyclic ADP-ribose hydrolase)in insulin secretion by glucose in pancreatic β-cells. (nii.ac.jp)
  • CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a transmembrane glycoprotein found on the surface of some immune cells including plasma cells, activated or immature T and B cells, monocytes, and natural killer cells. (creative-biogene.com)
  • CD38 ( cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells ( white blood cells ), including CD4 + , CD8 + , B lymphocytes and natural killer cells . (wikipedia.org)
  • FITC
  • CD38 (FITC) immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers. (abcam.cn)
  • expression
  • Furthermore, it also increased CD38 expression at the mRNA level by activating the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway. (springer.com)
  • Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. (umassmed.edu)
  • Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. (miltenyibiotec.com)
  • It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis. (miltenyibiotec.com)
  • Expression of CD38 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia. (miltenyibiotec.com)
  • inhibitor
  • LPS-induced CD38 release was blocked by the metalloproteinase-9 inhibitor indicating that MMP-9 solubilizes CD38. (springer.com)
  • Treatment of old mice with a specific CD38 inhibitor, 78c, prevents age-related NAD+ decline. (wikipedia.org)
  • prostate cancer
  • The ProtecT trial showing similar 10-year survival with active monitoring, surgery, or radiotherapy for prostate-specific antigen (PSA)-detected localized prostate cancer but a greater risk of disease progression/metastasis with monitoring was recently reported by Hamdy and colleagues and is. (ascopost.com)
  • mice
  • Previous studies of primary immune responses to viral infection in mice have shown that antigen-specific T-helper 1 (Th1) CD4 responses can be readily detected in the early stages of the infection, but rapidly decline as antigen is cleared. (bloodjournal.org)
  • Perform
  • Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (abcam.com)