Progenitor cell antigenCD45Epithelial membranCD11bAntibodyReceptorMSCsActinGp105-120Bone marrowHematopoietic cellsSignal TransductionCluster of differentiatMoleculesMonoclonal antibodiesTransmembrane glycoproteinCD38ProgenitorsCorresponding to amino acidsVascularMyeloidImmunohistochemicalCellsProtein encodedCD117TumorsHumanExpressionAdhesion moleculeClinicalLymphocytesCapillaryCellVariantCloneNegative
Progenitor cell antigen2
- CD-34 is a myeloid progenitor cell antigen. (medscape.com)
- This cell surface antigen, formerly known as hemopoietic progenitor cell antigen 1 ( HPCA1 ), is called also gp105-120 . (copewithcytokines.org)
CD455
- In contrast, the α-SMA(+) human TFPI(+) CD34(+) cells recruited in Tg recipients were from a CD45(-) lineage. (nih.gov)
- 2 ] in 1994 and is defined by the expression of a variety of cell surface antigens, including the stem cell marker CD34, the pan-leukocyte marker CD45, and monocyte markers CD14 and CD11. (ersjournals.com)
- A feature of fibrocytes is that they tend to lose the expression of haematopoietic markers, such as CD45 and CD34, within a short time frame once incorporated into the disease tissue. (ersjournals.com)
- A significant proportion (two thirds) of CD45+ cells in the normal corneal stroma expressed CD34+ while no CD45- cells (ie keratocytes) co-expressed CD34. (arvojournals.org)
- Immunophenotyping of hWMSCs by flow cytometry To confirm the derived MSCs, specific cell-surface antigens including CD45, CD44, CD34 and CD105 (Sigma, Germany) were probed using monoclonal antibodies and compared with cells treated with control isotype antibodies. (bioskinrevive.com)
Epithelial membran3
- Immunohistochemical studies performed in 42 cases showed only focal smooth muscle actin (10 cases) and CD34 (4 cases) positivity, whereas CD68, S-100 protein, desmin, pan-keratin, and epithelial membrane antigen were negative. (lww.com)
- Immunohistochemical examination revealed positive expression of cluster of differentiation 34(CD34), vimentin and CD99, and negative expression of epithelial membrane antigen, S100 and glial fibrillary acidic protein. (spandidos-publications.com)
- No expression of epithelial membrane antigen (EMA) or progesterone receptor was observed. (surgicalneurologyint.com)
CD11b1
- In contrast, the remaining population of CD45+ CD34- cells in the corneal stroma expressed CD11b, MHC Class II+ but not CD11c, and were found mostly in anterior and peripheral part of stroma. (arvojournals.org)
Antibody2
- The 581 monoclonal antibody specifically binds to CD34, a sialomucin-like type I transmembrane glycoprotein. (bdbiosciences.com)
- The 581 antibody blocks reactivity of another anti-CD34 monoclonal antibody, 8G12. (bdbiosciences.com)
Receptor3
- Compared with syngeneic controls, endogenous CD34(+) cells were mobilized in significant numbers after allogeneic transplantation, the majority showing sustained expression of tissue factor and protease-activated receptor-1 (PAR-1). (nih.gov)
- [ 2 ] They are often CD34 immunoreactive and express tyrosine kinase c-kit (CD117) receptor activity, in contrast to leiomyosarcomas. (medscape.com)
- CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. (thermofisher.com)
MSCs1
- This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. (hindawi.com)
Actin1
- These cells stained for CD31, CD34, and actin. (thedoctorsdoctor.com)
Gp105-1201
- CD34, also known as gp105-120, is a type I monomeric sialomucin-like glycophosphoprotein with an approximate molecular weight of 105-120 kD. (biolegend.com)
Bone marrow2
- The CD117 antigen is expressed on very few normal bone marrow cells. (beckman.com)
- Selectively expressed on the majority of hematopoietic stem/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue, CD34 is a commonly used marker to identify human hematopoietic stem/progenitor cells. (biolegend.com)
Hematopoietic cells1
- The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
Signal Transduction1
- The cytoplasmic region of the CD34 antigen is a target for phosphorylation by activated protein kinase C suggesting CD34 may play a role in signal transduction. (bdbiosciences.com)
Cluster of differentiat1
- CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. (wikipedia.org)
Molecules1
- Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Monoclonal antibodies1
- Immunohistochemistry was performed on deparaffinized sections by using monoclonal antibodies directed against CD34 and latent nuclear antigen (LANA-1) ( 12 ). (cdc.gov)
Transmembrane glycoprotein1
- CD34 is a 67 kDa transmembrane glycoprotein. (copewithcytokines.org)
CD382
- Later studies have reported that low rhodamine retention identifies LT-HSCs within the Lin−CD34+CD38− population. (wikipedia.org)
- To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
Progenitors1
- The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
Corresponding to amino acids2
- Human recombinant protein fragment corresponding to amino acids 312-385 of human CD34(NP_001020280) produced in E.coli. (origene.com)
- Recombinant fusion protein containing a sequence corresponding to amino acids 32-290 of human CD34 (NP_001020280.1). (prosci-inc.com)
Vascular4
- The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early haematopoietic and vascular-associated progenitor cells. (wikipedia.org)
- Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
- CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
- The gross appearance of the tumor was suggestive of a highly vascular lesion, and so intraoperatively, a decision was made to attempt an en-bloc resection. (surgicalneurologyint.com)
Myeloid1
- Aberrant expression of myeloid antigens was found in 94 (26%) cases of B-ALL. (bvsalud.org)
Immunohistochemical1
- High-power magnification with CD-34 antigen immunohistochemical stain showing membrane positivity of the tumor cells. (medscape.com)
Cells15
- Adoptively transferred Tg CD34(+) (but not CD34(-)) cells inhibited IH in WT recipients, indicating the phenotype of α-TFPI-Tg mice was due to these cells. (nih.gov)
- WT CD34(+) cells incubated with a PAR-1 antagonist or taken from PAR-1-deficient mice inhibited IH as Tg cells did. (nih.gov)
- Specific inhibition of thrombin generation or PAR-1 signaling on α-SMA(+) CD34(+) cells inhibits IH and promotes regenerative repair despite ongoing immune-mediated damage. (nih.gov)
- CD34 was first described on hematopoietic stem cells independently by Civin et al. (wikipedia.org)
- CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. (wikipedia.org)
- CD34 is expressed in roughly 20% of murine haematopoietic stem cells, and can be stimulated and reversed. (wikipedia.org)
- The majority of CD117+ marrow cells co-express CD34. (beckman.com)
- To count the number of cells that are positive for the CD34 protein (CD34+), a sample of the cord blood is mixed with a fluorescent dye that adheres to the CD34 antigen. (cryo-cell.com)
- A flow cytometer uses a laser to pick up on the dye and count the number of CD34-positive cells. (cryo-cell.com)
- PGCB says the median private cord blood collection of 60 mL equates to 1.8 million cells with the CD34 antigen. (cryo-cell.com)
- Human KG-1a cells (blue) and mouse EL4 T cells (red) stained with 148Nd-anti-CD34 (581). (biolegend.com)
- In addition, they act as antigen presenting cells and promote angiogenesis [ 8 ]. (ersjournals.com)
- CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
- The larger population are CD34+ and resemble haemopoietic stem cells while the smaller population are CD34-CD11b+ MHC Class II+ macrophages. (arvojournals.org)
- CD34 is expressed selectively on human hematopoietic progenitor cells . (copewithcytokines.org)
Protein encoded1
- CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. (wikipedia.org)
CD1171
- The CD117 antigen is the 145 kDa protooncogene c-kit. (beckman.com)
Tumors1
- A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the stomach. (wikipedia.org)
Human2
- Human HSCs express the CD34 marker. (wikipedia.org)
- The human CD34 gene, which maps to chromosome 1q32, spans 26 kb and has 8 exons . (copewithcytokines.org)
Expression3
- For primary CML samples, retention of CD34-expression was also seen after culture. (haematologica.org)
- CD34 expression was found in 73 (20%) cases of B-ALL. (bvsalud.org)
- CD34 expression was found in only 19 cases of T-ALL. (bvsalud.org)
Adhesion molecule1
- CD34 may also play a role as an adhesion molecule since it binds to CD62E and CD62L. (bdbiosciences.com)
Clinical3
- We present the case of a 9-year-old girl with an acquired variant of a plaque-like CD34-positive dermal fibroma without clinical epidermal change. (nih.gov)
- Our case expands the clinical spectrum to include an acquired variant of a plaque-like CD34-positive dermal fibroma without clinical epidermal change. (nih.gov)
- Examination of more cases is needed to determine whether all clinical variants are truly subtypes of the same neoplasm or represent distinct CD34-positive spindle cell proliferations. (nih.gov)
Lymphocytes1
- CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands. (biolegend.com)
Capillary1
- Reticulin and CD34 staining outlined the dense reticular capillary network of the tumor, but the typical dense pericellular network found in schwannoma was not present. (surgicalneurologyint.com)
Cell5
- Plaque-like CD34-positive dermal fibromas, also known as medallion-like dermal dendrocyte hamartomas (MDDHs), are a recently recognized group of congenital and acquired spindle cell neoplasms that may appear histologically similar to dermatofibrosarcoma protuberans. (nih.gov)
- Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
- Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
- Leukocyte Typing V:White Cell Differentiation Antigen. (biolegend.com)
- The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
Variant1
- myofibroblastoma breast neoplasms aspiration biopsy CD 34 antigens immunohistochemistry Acta Cytologica Fine Needle Aspiration Cytology Presentation of a Cellular Variant. (karger.com)
Clone1
- Clone 581 binds to the class III CD34 epitope. (bdbiosciences.com)
Negative1
- Mouse keratocytes are negative for CD34. (arvojournals.org)