• Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (atcc.org)
  • Soluble TNFRSF7 (also called CD27) attenuates CD27 Ligand-induced proliferation of Human T-cells. (abcam.cn)
  • In the presence of 2.5 µg/mL of soluble TNFRSF7, 10µg/mL recombinant CD27 ligand, 2.5-10 µg/ml of ab89258 could attenuate proliferation of human T-cells by 50% (3H-thymidine Incorporation). (abcam.cn)
  • Interestingly, CD8+CD45RA+CD27- cells parallel effector CTLs, as they abundantly express Fas-ligand mRNA, contain perforin and granzyme B, and have high cytolytic activity without in vitro prestimulation. (nih.gov)
  • CTL effectors exert direct ex vivo cytolytic activity, whereas memory cells need restimulation with antigen to acquire cytotoxic function. (nih.gov)
  • Concomitantly, the quality of antigen-specific T cells improved as evidenced by increased interferon (IFN)-gamma production and a greater cytotoxic potential on a per cell basis. (nih.gov)
  • The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives. (antibodies-online.com)
  • CD27 is expressed by a subset of thymocytes and virtually all mature T cells and is upregulated upon T-cell stimulation. (thermofisher.com)
  • To assess whether CD27 stimulation contributes to the competence of antigen-specific T cells, we analyzed the acquisition of effector cell properties of NP366-374-specific T cells directly ex vivo. (nih.gov)
  • Importantly, on both transitional and activated memory/effector T cell subsets, the expression patterns of the 15/7 and 24 epitopes vs. a variety of T cell activation antigens are identical, and the expression of these epitopes relative to each other is linearly correlated, findings strongly supporting the coordinate activation of β1 and β2 integrins during T cell activation in vivo. (elsevier.com)
  • In vivo priming of antigen-specific CD8+ T cells results in their expansion and differentiation into effector T cells followed by contraction into a memory T cell population that can be maintained for life. (nih.gov)
  • It has been reported that triggering CD27 plays an important role in the maturation of CD4^+ and CD8^+ effector cells. (thermofisher.com)
  • Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. (thermofisher.com)
  • Several molecules have been discovered out of which CD antigens have been found to play an important role in cancer progression and proliferation. (marketreport.jp)
  • CD antigen cancer therapeutics have diverse design and target due to which they could be used for several malignancies. (marketreport.jp)
  • Some of the progress could be observed in case of monoclonal antibodies and same scenario could be observed for other CD antigen cancer therapeutics in coming years. (marketreport.jp)
  • Commercial success of marketed CD antigen cancer therapeutics shows that they would be generating significant revenues in coming years. (marketreport.jp)
  • CD antigen cancer market is expected to witness introduction of several products which will help the pharmaceutical companies to generate significant revenues. (marketreport.jp)
  • Numerous innovative CD antigen cancer therapeutics are at different stages of clinical trials which would increase their market shares. (marketreport.jp)
  • In this way, future of CD antigen cancer therapeutics looks optimistic due to their superior pharmacological profiles. (marketreport.jp)