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  • antibody
  • It is the bound IgE antibody that confers a selective response of these cells to environmental substances, for example, pollen proteins or helminth antigens. (wikipedia.org)
  • However, peripheral blood Bregs were mostly CD24 and CD27 positive after cultivation with anti-CD40 antibody and CpG bacterial DNA. (wikipedia.org)
  • cluster
  • The only difference in the coding sequence, between cluster-4 and CD24 antigens is the substitution of a single base pair leading to a substitution of Val by Ala near the putative glycosylphosphatidylinositol (GPI) anchorage sites of the mature protein. (ox.ac.uk)
  • Here we demonstrate that the nucleotide substitution which distinguishes the cluster-4 and CD24 antigen genes is due to an allelic polymorphism on chromosome band 6q21. (ox.ac.uk)
  • In addition, we identified by Southern blotting and PCR of DNA from somatic human x hamster hybrid cell lines homologues of cluster-4/CD24 on the Y chromosome and chromosome 15. (ox.ac.uk)
  • However, it is noteworthy that homozygosity for cluster-4 was found in only one case whereas heterozygosity and homozygosity for CD24 both contribute up to 50% of the samples examined. (ox.ac.uk)
  • Cell lines derived from human small cell carcinoma of the lung express high levels of a surface polypeptide termed the cluster-w4 antigen, which was previously identified as a potential target for toxin-based immunotherapy of lung cancer. (semanticscholar.org)
  • Northern blot hybridization indicated the presence of several transcript sizes for the cluster-w4 antigen that were greatly overexpressed in small cell carcinoma cell lines, compared with normal hemopoietic cells and CD24-positive cell lines. (semanticscholar.org)
  • ab31622 binds to the non-glycosylated GPI anchor of the protein core of the cluster w4/CD24. (abcam.com)
  • genes
  • In this study, we show that CD24+ cells isolated from human NPC cell lines express stem cell genes (Sox2, Oct4, Nanog, Bmi-1, and Rex-1), and show activation of the Wnt/β-catenin signaling pathway.CD24+ cells further show increased invasion ability in vitro, which correlates with enhanced expression of matrix metalloproteinase 2 and 9.In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC. (nih.gov)
  • As indicated in Figure 2A, CD24+ cells consistently expressed higher levels of the five stem cell genes than parental or CD24− cells. (nih.gov)
  • By comparison of P CK/AS and P AS/ASAC , the DAVID genes functional classification was found to be changed from "immune response" to "response to steroid hormone stimulus", and the GO term "antigen processing and presentation of peptide antigen" disappeared in P AS/ASAC . (biomedcentral.com)
  • dendritic cells
  • CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. (ac.be)
  • chromosome
  • CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. (wikipedia.org)
  • Human
  • CONCLUSION: HSS has a potential cytotoxic effect on human ovarian cancer cells, which was mediated by multiple signal molecules including bcl-2, caspase-3, beta-catenin, and CD24. (biomedsearch.com)
  • Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. (nih.gov)
  • Cox multifactor analysis showed that CD24 (P = 0.02) was an independent prognosis factor for human glioma. (nih.gov)
  • novel
  • In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC. (nih.gov)
  • cell
  • Bispecific antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for therapeutic use. (mdpi.com)
  • CD48 was the first B-cell-specific cellular differentiation antigen identified in transformed B lymphoblasts. (wikipedia.org)
  • CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM-1 contribute to the formation of an immunological synapse between a T cell and an antigen presenting cell. (wikipedia.org)