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  • Protein
  • Putative CD5 ligands include CD72, a pan-B cell antigen, and CD5L, a recently described protein expressed on activated splenocytes, B cells, and activated murine T cell clones (( 5 ), ( 6 )), suggesting that CD5 may be involved in regulating immune cell interactions. (rupress.org)
  • CD2 is a type 1 protein with two immunoglobulin superfamily (IgSF) domains. (hcdm.org)
  • CD2 and the nature of protein interactions mediating cell-cell recognition. (hcdm.org)
  • CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. (hcdm.org)
  • Rosette
  • Sheep red blood cells, which bind to CD2 via T11TS in E-rosette formation, and human autologous monocytes, which express the LFA-3 molecule, both induce proliferation of resting T cells in the presence of per se submitogenic concentrations of anti-T11(2) plus anti-T11(3) monoclonal antibodies (mAb). (ox.ac.uk)
  • receptors
  • These mutants lack detectable surface CD2 as determined by indirect immunofluorescence, immunoprecipitation analysis, and specific radiolabeled antibody binding assay, but nevertheless, expressed normal numbers of CD3-Ti receptors. (rupress.org)
  • activation
  • 3. King PD, Sadra A, Teng JM, Bell GM, Dupont B. CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail. (hcdm.org)
  • Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. (wikidoc.org)
  • majority
  • The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms . (wikidoc.org)