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  • beta2
  • MCp concentrations were not altered in the tissues of mice deficient in the alphaE integrin (CD103), the beta2 integrin (CD18), or the recombination activating gene (RAG)-2 gene either alone or in combination with the interleukin (IL)-receptor common gamma chain. (nih.gov)
  • Antibodies
  • These data are consistent with expectations based on studies using blocking antibodies to inhibit CD11/CD18 complexes, and on observations of humans lacking CD11/CD18 complexes. (nih.gov)
  • neutrophils
  • Peripheral blood of CD18-/- mutants contained 11-fold more neutrophils than did blood of wild-type (WT) mice. (nih.gov)
  • During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18-/- mutants than in WT mice. (nih.gov)
  • The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18-/- mutants, but rather was greater than the WT values (240 +/- 30 and 220 +/- 30% WT, respectively). (nih.gov)
  • Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18-/- mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis. (nih.gov)
  • Emigrated neutrophils were quantitated morphometrically and expressed as mean ± SEM standardized volume fractions for WT (closed bars) or CD18−/− (open bars) mice. (nih.gov)
  • In contrast, there was no increase in emigrated neutrophils in the dermis of CD18−/− mutant mice after 6 h of croton oil dermatitis (Fig. 2). (nih.gov)
  • neutrophil
  • Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. (nih.gov)
  • To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants). (nih.gov)
  • During Streptococcus pneumoniae pneumonia, neutrophil emigration in CD18-/- mutants was not reduced. (nih.gov)
  • Dermal neutrophil emigration in WT and CD18−/− mice 6 h after topical application of 2% croton oil. (nih.gov)
  • skin
  • severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. (novusbio.com)
  • Target
  • CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. (novusbio.com)
  • complex
  • Integrin CD18, a component of the LFA-1 complex that also includes CD11a, is essential for Th2, but not Th1, cell homing, but the explanation for this phenomenon remains obscure. (jimmunol.org)