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  • FUT9
  • FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis. (wikipedia.org)
  • typically
  • CD15 is also present in about 50% of adenocarcinoma cells and can be used to distinguish such conditions from mesothelioma, which is typically negative. (wikipedia.org)
  • At immunophenotyping, cHL is typically CD15 + , CD30 +* , possibly EBER + , and CD20 -/+ (Olympus BX41 microscope, Olympus CAMEDIA C-7070 camera, magnification ×400, colours balanced after acquisition with Adobe Photoshop). (hindawi.com)
  • Antibodies
  • Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
  • Although antibodies show preferential avidity for specific epitopes, they may partially or weakly bind to sites on nonspecific proteins (also called reactive sites) that are similar to the cognate binding sites on the target antigen. (wikipedia.org)
  • cells
  • These cells express the surface antigen CD15/SSEA-1 and have elevated levels of genes associated with the G2-M phases of the cell cycle. (ca.gov)
  • Here, we show that CD15(+) cells progress more rapidly through the cell cycle than CD15(-) cells and contain an increased proportion of cells in G2-M, suggesting that they might be vulnerable to inhibitors of this phase. (ca.gov)
  • Tissue, cells or virus corresponding to Human CD15. (abcam.com)
  • The CD15 antigen is expressed on immature bone marrow cells and leukemic cells of the myelo-monocytic lineage and sometimes on lymphocytic leukemia cells. (abcam.com)
  • CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. (wikipedia.org)
  • Reed-Sternberg cells display a characteristic pattern of CD15 positivity, with membranous staining combined with staining of the Golgi apparatus. (wikipedia.org)
  • Intriguingly, the B cells within the HL cell lines expressed immunoglobulin light chain, the memory B-cell antigen CD27, and the stem cell marker aldehyde dehydrogenase (ALDH) [ 13 ]. (hindawi.com)
  • DCs are antigen-presenting cells that play an essential role in bridging innate and adaptive immunity. (rupress.org)
  • citation needed] Follicular dendritic cells are localized in germinal centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B cells. (wikipedia.org)
  • Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. (exbio.cz)
  • Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. (wikipedia.org)
  • Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. (wikipedia.org)
  • tissues
  • Immature DCs are situated underneath epithelia throughout peripheral tissues, where they are ideally located to acquire antigens of invading pathogens. (rupress.org)
  • For formalin-fixed paraffin-embedded tissues, antigen-retrieval is often necessary, and involves pre-treating the sections with heat or protease. (wikipedia.org)
  • cell
  • This allows mature DCs to leave the periphery and migrate to the lymph nodes, and endows them with the capacity to present antigen in the context of MHC molecules in order to initiate T cell responses within the lymph nodes ( 3 ). (rupress.org)
  • An antigen recognition domain from native T-cell receptor (TCR) alpha and beta single chains have been described, as have simple ectodomains (e.g. (wikipedia.org)
  • detection
  • A great amount of non-specific binding causes high background staining which will mask the detection of the target antigen. (wikipedia.org)