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  • CD1d
  • Surprisingly, however, the mouse contains no group 1 CD1 genes but has two group 2 CD1d genes, whereas the rat contains only one CD1d, and other rodents and mammals may contain 8-12 group 1 CD1 genes. (jimmunol.org)
  • Together, these findings indicate that CD1d-dependent activation of NKT cells aggravates atherosclerosis and that lack of CD1d, the restriction element for presentation of lipid antigens to NKT cells, leads to reduced lesions in a mouse model of human atherosclerosis. (nih.gov)
  • CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. (wikipedia.org)
  • CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. (wikipedia.org)
  • CD1d (group 2 CD1) is expressed in a wider variety of cells. (wikipedia.org)
  • Natural Killer T (NKT) cells are activated by CD1d-presented antigens, and rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. (wikipedia.org)
  • CD1b
  • This apparent bias to CD1b restriction might derive from the unique capacity of CD1b to recycle in the late endosomal or lysosomal compartments ( 21 , 22 ) and from the organization of its antigen-binding pockets ( 23 ). (rupress.org)
  • CD1b tetramer staining of T cells requires glucose monomycolate (GMM) antigens, is specific for TCR structure, and is blocked by a recombinant clonotypic TCR comprised of TRAV17 and TRBV4-1, proving that CD1b-glycolipid complexes bind the TCR. (rupress.org)
  • Polyclonal T cells from patients sorted with tetramers are activated by GMM antigens presented by CD1b. (rupress.org)
  • CD1b tetramers detect a natural CD1b-restricted T cell repertoire ex vivo with unexpected features, opening a new investigative path to study the human CD1 system. (rupress.org)
  • immune
  • Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. (biomedsearch.com)
  • As a skin resident member of the DC family of APCs, Langerhans cells (LCs) initiate both innate and adaptive immune responses to skin-relevant antigens, thereby acting as immunological sentinels. (jci.org)
  • CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. (nih.gov)
  • Systemic tolerance can be elicited by introducing antigen into an immune-privileged site, such as the eye, or directly into the blood. (nih.gov)
  • Antigen-presenting cells are vital for effective adaptive immune response, as the functioning of both cytotoxic and helper T cells is dependent on APCs. (wikipedia.org)
  • Antigen presentation allows for specificity of adaptive immunity and can contribute to immune responses against both intracellular and extracellular pathogens. (wikipedia.org)
  • Antibody
  • There are currently no images for CD1.1 antigen Antibody (NBP1-28362). (novusbio.com)
  • and (c) anti-CD1 monoclonal antibody treatment of wild-type mice prevented ACAID development. (nih.gov)
  • mycobacterial
  • Most notably, all of them were derived from mycobacterial species, possibly reflecting a special role for CD1-restricted T cells in protection against tuberculosis. (rupress.org)
  • mediate
  • Significantly, CD1-reactive NKT cells were not required for intravenously induced systemic tolerance, thereby establishing that different mechanisms mediate development of tolerance to antigens inoculated by these routes. (nih.gov)
  • Immunity
  • CD1 is a ligand for T cell subpopulation, is present in intestinal epithelium adjacent to GALT, possibly involved in epithelial immunity. (thefreedictionary.com)
  • Tissue
  • The download t cell activation by cd1 and that rest and pool want contacted in the town result of the testosterone relies associated to the fatty that nutritional annihilation might be the discovery of post-surgical s warmth( AMD), which increases the early temephos of the tissue and is the most systemic normal-weight of interesting tract in the Unable cell. (houseoflaurence.com)
  • CD21
  • The MZ B cells within this region typically express high levels of IgM, CD21, CD1, CD9 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. (wikipedia.org)
  • isoforms
  • Following assembly with β2-microglobulin in the endoplasmic reticulum, all CD1 isoforms are transported to the cell surface but are subsequently delivered to distinct endosomal and/or lysosomal compartments. (jci.org)
  • lymphocyte
  • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. (wikipedia.org)
  • Krensky AM, Weiss A, Crabtree G, Davis M, Parham P: Mechanisms of disease: T lymphocyte - antigen interactions in transplant rejection. (wikipedia.org)
  • ligands
  • Only few bacterial CD1 ligands have been identified to date. (rupress.org)
  • The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. (genecards.org)
  • human
  • Interleukin 1 induces CD1 antigen expression on human gingival epithelial cells. (semanticscholar.org)
  • Previous studies have demonstrated that crude preparations containing murine interleukin-1 (IL-1) or a human epithelial cell-derived IL-1 inhibitor (ILS) modulate CD1 expression by LC in organ culture. (semanticscholar.org)
  • However, existing experimental models for study of group 1 CD1 function rely on activation assays that destroy the responding cells or focus on a limited number of in vitro-derived human T cell clones, which may not accurately reflect the in vivo phenotype. (rupress.org)
  • cell receptor
  • T cells must be activated by interacting with a professional APC presenting an antigen which their T cell receptor recognizes before they can divide and perform their function. (wikipedia.org)
  • CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. (wikipedia.org)