• abstract = "Objective To determine the impact of empiric antibiotics on men with an elevated prostate-specific antigen (PSA) level. (elsevier.com)
  • The antigenome technology offers an integrated approach for antigen validation in order to select the most promising candidates for the development of subunit vaccines against the targeted bacterial diseases. (nih.gov)
  • Despite the fact that these vaccines have used one or another of a very small number of immunodominant antigens, a direct comparison of the relative efficacy of the antigens and delivery systems has been difficult, because the studies have used different parameters for assessment. (mendeley.com)
  • RESULTS: The relative efficacy of different vaccines is dependent on the delivery system, the antigen, and the animal model. (mendeley.com)
  • With emphasis on antigen expression, in this minireview we discuss some of the vaccine platforms that are currently being explored for the development of Leishmania vaccines. (asm.org)
  • To target and appropriately skew the anti- Leishmania response, vaccines require both pathogen-specific antigens and immune-stimulating molecules to be rendered effective. (asm.org)
  • BGs are a wonderful tool for preparing different kind of bacterial vaccines [ 1 ]. (hindawi.com)
  • Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. (google.com)
  • This invention relates to the microencapsulation of antigens for use as therapeutic or prophylactic vaccines. (google.com)
  • Subunit vaccines contain one or more pure or semi-pure antigens. (biomedcentral.com)
  • Vaccines can not be developed using this approach for microorganisms which can not easily be cultured and only allows for the identification of those antigens which can be obtained in sufficient quantities. (biomedcentral.com)
  • The present invention provides pharmaceutical compositions of such antigens and/or vaccines. (freepatentsonline.com)
  • In this study, we are adding a further step to the protocol, which is dealing with the cell wall surface antigens, where Salmonella typhimurium ATCC 14028 was used for such purposes. (hindawi.com)
  • The recombinant glycoprotein OAg-AcrA can be produced in large homogeneous batches in a standardized way, making it an ideal candidate for further validation as a universal antigen for diagnosis of "smooth" brucellosis in animals and humans. (conicet.gov.ar)
  • The unique criteria of such protocol are that no genetically modified or recombinant elements were used but only the bacterial cells and the described chemical compounds were used. (hindawi.com)
  • This suggests that recognition of LPS receptor play a major role to recognize bacterial entry and processing of ingested bacteria. (nii.ac.jp)
  • Lipopolysaccharide (LPS), a major component on the surface of Gram-negative bacteria, is composed of a lipid A-core and the O-antigen polysaccharide. (diva-portal.org)
  • IgE-reactivity to antigens from gram-positive and negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitisation are not fully understood. (blogspot.com)
  • We demonstrated the genotype-dependent removal of human norovirus particles with a microfiltration (MF) membrane in the presence of bacteria bearing histo-blood group antigens (HBGAs). (elsevier.com)
  • The O antigen is an important cell wall antigen of gram-negative bacteria, and the genes responsible for its biosynthesis are located in a gene cluster. (asm.org)
  • Lipopolysaccharide (LPS), an important component of the outer membrane of Gram-negative bacteria, usually consists of three distinct regions: lipid A, core oligosaccharide, and O-specific polysaccharide (O antigen). (asm.org)
  • Second group of TI antigens consists mainly of highly repetitive surface structures (epitopes) of encapsulated bacteria. (wikipedia.org)
  • Publications] Miyake, M., L. Zhao, L. T. Ezaki, K. Hirose, A. Q. Khan, Y. Kawamura, R. Shima, M. Kamijo, T. Masuzawa and Y. Yanagihara: 'Vi-deficient and nonfimbriated mutants of Salmonella typhi agglutinate human blood type antigens and are hyperinvasive. (nii.ac.jp)
  • While specific antibody for Salmonella is available on the market under the commercial names (of some kits) such as Febrile Antigen Kit (N.S. BIO-TEC), we used the described Kit to investigate the validity of the SLRP. (hindawi.com)
  • The antigen-antibody interaction (agglutination) results of both the SLRP and the animal experiments prove that we have correct STGs able to immunize the rats against viable Salmonella . (hindawi.com)
  • We have cloned and sequenced the DNA segment unique to the O-antigen gene cluster of Salmonella enterica group D3. (asm.org)
  • In Salmonella enterica , there are 46 types of O antigens ( 32 ), which differ in sugar composition and in linkages between sugars and between O units. (asm.org)
  • The data provide direct evidence that streptococcal T antigens function as virulence factors in vivo, but they also reveal that a pilus-like structure is not essential for the most common form of streptococcal skin disease. (asm.org)
  • The gene encoding the T6 antigen, which is an antigenic target of a major serological typing scheme, maps to the FCT regions of some isolates, where it forms part of the pilus structure ( 5 , 28 , 34 ). (asm.org)
  • The aim of this study was to examine the immune reactivity of a spontaneously colitic mouse strain, C3H/HejBir, to epithelial, food, and enteric bacterial Ags. (utmb.edu)
  • Only a small, highly selected number of enteric bacterial Ags were recognized. (utmb.edu)
  • These data are consistent with an abnormal immune reactivity to enteric bacterial flora in C3H/HeJBir mice, a reactivity that is highly selective considering the abundant bacterial Ags present in the colon lumen. (utmb.edu)
  • Specific T cells recognize complexes formed by individual glycolipids associated with dedicated antigen-presenting molecules belonging to the CD1 family. (rupress.org)
  • Thus, it`s shown the prospect of the use of TI-complexes as a new type of adjuvant carriers for antigens. (msk.ru)
  • Streptococcus pyogenes , a group A streptococcus (GAS), is the main bacterial etiology responsible for 15%-36% of acute pharyngitis in children ( Abachi, Lee & Rupasinghe, 2016 ). (peerj.com)
  • Standard properties recommended for apt bacterial antigens include higher specificity and sensitivity, reproducible scale-up for bulk quantities, minimal lot-to-lot variation and extended shelf-life. (factmr.com)
  • The sensitivity of the peptide cocktail as an antigen in a whole-blood gamma interferon assay was determined using naturally infected field reactor cattle, and the specificity was determined using blood from BCG-vaccinated and noninfected, nonvaccinated animals. (nih.gov)
  • Combined with magnetic-activated cell sorting (MACS), bacterial display technology makes it possible to isolate selective, high affinity peptide reagents in days to weeks. (spie.org)
  • Peptide affinity reagents for protective antigen (PA) of the biothreat Bacillus anthracis were previously discovered using bacterial display. (spie.org)
  • Such unnecessary antibiotic treatment can cause severe side effects like toxicity, allergic reactions, suppression of immune system, intestinal bacterial flora disruption or even, according to the latest studies, obesity. (termedia.pl)
  • Conclusions: The colitogenic Cdcs1 allele impairs innate immunity to bacterial products and in turn skews the adaptive immune response toward compensatory hyperresponsiveness and chronic intestinal inflammation. (utmb.edu)
  • The InMAD serum, which is free of whole bacterial cells, is used to immunize syngeneic BALB/c mice. (sigmaaldrich.com)
  • Immunohistochemistry for amyloid beta or Cpn antigens was performed on sections from brains of infected or mock-infected mice. (pcom.edu)
  • However, the sera from C3H/HeJBir mice had a reproducible banding pattern on Western blot to bacterial Ags, whereas sera from C3H/HeJ mice did not. (utmb.edu)
  • Comparison of sera reactivity to histopathologic severity showed an inverse relationship: one third of young C3H/HeJBir mice during the peak of colitis produced Abs to bacterial Ags, while later in life, when the colitis had resolved, 96% produced Abs. (utmb.edu)
  • Major incompatibility between donor ABO antigens and recipient plasma can result in acute humoral rejection of the transplanted organ. (labcorp.com)
  • north american herb and spice oreganol , as a broad spectrum anti-viral/anti-fungal/anti-bacterial can help too, and in fact the spices used in cooking are all about biofilm control! (tripod.com)
  • A preparation of 1mg/ml of monoclonal antibody (Ab) specific to C. trachomatis surface antigen (Ag) was conjugated to gold nanorods using standard commercial reagents, in order to produce a targeted contrast agent with a strong photoacoustic signal. (arvojournals.org)