AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AntigensHLA AntigensAntigens, BacterialAntigens, NeoplasmAntigens, SurfaceAntigens, ViralAntigens, ProtozoanAntigens, Polyomavirus TransformingAntigens, FungalAntigens, CDHLA-DR AntigensAntigens, HelminthH-2 AntigensCarcinoembryonic AntigenAntigens, Viral, TumorHistocompatibility Antigens Class IIAntibodies, MonoclonalReceptors, Antigen, T-CellHistocompatibility AntigensHLA-A AntigensEpitopesProliferating Cell Nuclear AntigenHLA-B AntigensHistocompatibility Antigens Class IHLA-A2 AntigenReceptors, Antigen, B-CellO AntigensProstate-Specific AntigenT-LymphocytesMolecular Sequence DataAntigens, CD15Antigens, CD8Antigens, Tumor-Associated, CarbohydrateHLA-D AntigensEnzyme-Linked Immunosorbent AssayCross ReactionsImmunoglobulin GHepatitis B Surface AntigensHLA-DQ AntigensAntigens, CD3Blood Group AntigensAmino Acid SequenceAntibody SpecificityMice, Inbred BALB CLymphocyte ActivationCell LineAntigens, CD4Hepatitis B AntigensAntigens, CD45Receptors, AntigenFluorescent Antibody TechniqueAntigen-Antibody ReactionsAntibody FormationAntigens, CD1Immune SeraAntibodies, BacterialImmunizationB-LymphocytesAntigens, DifferentiationBase SequenceImmunoenzyme TechniquesMART-1 AntigenHistocompatibility TestingHIV AntigensHLA-C AntigensT-Lymphocytes, CytotoxicAntigens, CD80Cells, CulturedMice, Inbred C57BLEpstein-Barr Virus Nuclear AntigensHLA-B27 AntigenAntibodiesAntigens, CD19Flow CytometryAutoantigensAntigens, HeterophileHepatitis B Core AntigensSpleenAntigens, CD40HLA-DR3 AntigenAntigen-Presenting CellsImmunoglobulin MHLA-DR4 AntigenImmunodiffusionHLA-B7 AntigenAntigen-Antibody ComplexInterferon-gammaMolecular WeightImmunohistochemistryH-Y AntigenAntibodies, ViralAntigens, Thy-1Forssman AntigenRabbitsMajor Histocompatibility ComplexCD8-Positive T-LymphocytesDendritic CellsCD4-Positive T-LymphocytesLymphocytesHLA-A1 Antigen
EpitopesSurface antigenTumor antigensPeptidesImmuneDRB1AlleleEffectorMelanomaInfluenzaHumanReceptorUveitisProteinPolymorphismExposureAntigenicCytotoxicAntibodiesPredominantlyPrevalenceMoleculesInfectionCellsBacterialCharacterizationFunctionalCancerViralPatientsAssociationDevelopmentCellCommonSubjectsClassAddition
Epitopes16
  • 1. Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides. (nih.gov)
  • 3. Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides. (nih.gov)
  • 5. Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles. (nih.gov)
  • 6. Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. (nih.gov)
  • 9. HLA-A2.1/K(b) transgenic murine dendritic cells transduced with an adenovirus encoding human gp100 process the same A2.1-restricted peptide epitopes as human antigen-presenting cells and elicit A2.1-restricted peptide-specific CTL. (nih.gov)
  • 11. Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100. (nih.gov)
  • 13. Detection of naturally processed and HLA-A1-presented melanoma T-cell epitopes defined by CD8(+) T-cells' release of granulocyte-macrophage colony-stimulating factor but not by cytolysis. (nih.gov)
  • 14. Novel HLA-Cw8-restricted T cell epitopes derived from tyrosinase-related protein-2 and gp100 melanoma antigens. (nih.gov)
  • 16. Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro. (nih.gov)
  • 2001. A rapid method to identify cytotoxic T-lymphocyte peptide epitopes from HLA-A2(+) donors. (stjohns.edu)
  • The selection of peptides for ex vivo CD8+ T cell detection is critical because within a complex antigen exists a multitude of potential epitopes that can be presented by HLA class I molecules. (frontiersin.org)
  • Due to the abundance of experimentally defined HLA-A * 02:01-restricted pp65 epitopes, and because in silico epitope predictions are most advanced for HLA-A * 02:01, we elected to focus on subjects expressing this allele. (frontiersin.org)
  • Collectively, these data suggest that accurate CD8+ T cell immune monitoring may necessitate reliance on agnostic mega peptide pools, or brute force mapping, rather than electing individual peptides as representative epitopes for tetramer and other multimer labeling of surface antigen receptors. (frontiersin.org)
  • Instead, the CD8+ T cell epitopes need to be added as 8-11 amino acid long peptides that they can bind directly to cell surface expressed HLA class I molecules. (frontiersin.org)
  • HIV vaccine to induce cytotoxic T cells recognizing conserved HIV-1/2-epitopes derived from the most frequent HLA types of the human population. (geneticimmunity.ru)
  • Alloimmunization against human platelet antigen (HPA) or human leucocyte antigen (HLA) epitopes is also common 4 4 Santoro C, Rago A, Biondo F, Conti L, Pulcinelli F, Laurenti L, et al. (scielo.br)
Surface antigen1
  • A specific HLA-A surface antigen subtype. (nih.gov)
Tumor antigens2
Peptides4
  • 2. Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues. (nih.gov)
  • After the first cycle of six vaccinations, up to four antigen peptides, which were re-selected according to the titers of peptide-specific IgG at the sixth vaccination, were administered every two weeks. (medscape.com)
  • After the second cycle of six vaccinations, up to four antigen peptides, which were also re-selected, were administered every four to eight weeks according to the immune responses after PPV. (medscape.com)
  • Such peptides are loaded onto HLA class I molecules, and transported to the cell surface to be displayed to CD8+ T cells ( 4 ). (frontiersin.org)
Immune5
  • CD8+ T cell immune monitoring aims at measuring the size and functions of antigen-specific CD8+ T cell populations, thereby providing insights into cell-mediated immunity operational in a test subject. (frontiersin.org)
  • T cell immune monitoring has a long and successful track record in murine models in which defined experimental conditions, small model antigens, and work with inbred mouse strains expressing few restriction elements (MHC molecules) simplified the task ( 1 ). (frontiersin.org)
  • Ipilimumab (Yervoy) is an immune checkpoint inhibitor of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and was approved in 2015 for the adjuvant treatment of stage III melanoma, including pathologic involvement of regional lymph nodes larger than 1 mm, followed by complete lymph node resection. (medscape.com)
  • axalimogene filolisbac [AXAL] or ADXS11-001) in which the modified LLO molecule is fused with the E7 oncoprotein of human papillomavirus type 16 (HPV-16) consistently stimulates strong innate and E7 antigen-specific adaptive immune responses, resulting in reduction of tumor burden in animal cancer models. (biomedcentral.com)
  • Shen R, Li P, Li B, Zhang B, Feng L, Cheng S. Identification of distinct immune subtypes in colorectal cancer based on the stromal compartment. (bdbiosciences.com)
DRB12
  • Effects of HLA-DRB1/DQB1 Genetic Variants on Neuroimaging in Healthy, Mild Cognitive Impairment, and Alzheimer's Disease Cohorts. (cdc.gov)
  • The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. (opinvisindi.is)
Allele2
  • Members of this subtype contain alpha chains that are encoded by the HLA-A *02 allele family. (nih.gov)
  • Association between the HLA-A2 allele and Alzheimer disease. (cdc.gov)
Effector1
  • 109). Lentinan Desk 1 Leukapheresis produce in advanced sarcoma individuals priming offers previously been proven to enrich to get a population of Compact disc8+ T cells with high affinity reputation of tumor antigen, effector function, and manifestation of co-stimulatory substances such as Compact disc28 [18,19]. (epf2013.org)
Melanoma2
  • 15. Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. (nih.gov)
  • 6, 7] A meta-analysis by Lee et al demonstrated that the prevalence of these mutations may also depend on melanoma histologic subtype. (medscape.com)
Influenza3
  • We selected 22 HLA-A2-positive healthy older adults who have relatively short or long telomere lengths to compare their antibody response against the influenza vaccine, and their CD8(+) T-cell response against an influenza antigen. (nih.gov)
  • Monocyte-derived antigen-presenting cells of both short and long telomere groups induced similar expansions of influenza M1-specific CD8(+) T cells. (nih.gov)
  • Infection with influenza A virus subtype H1N1 (swine flu) or even the vaccination for it. (factdr.com)
Human5
  • Class II human leukocyte antigen and other genetic factors may have contributed to the skewed distribution. (bvsalud.org)
  • In this study, we compare the actual CD8+ T cell recognition of a well-characterized model antigen, human cytomegalovirus (HCMV) pp65 protein, with its anticipated epitope coverage. (frontiersin.org)
  • The magnitude of scope is entirely different when the outbred human population is to be studied, largely due to the immense diversity in complexity restriction elements (human leukocyte antigens, HLA) and the of the antigenic systems, such as viruses. (frontiersin.org)
  • Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. (nature.com)
  • An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer. (bdbiosciences.com)
Receptor3
  • T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA-4 are used in combination with T cells engineered with chimeric antigen receptor (CAR) (CAR-T cells) against several malignancies in clinical trials. (bdbiosciences.com)
  • bombesin receptor subtype 3 [Source:H. (gsea-msigdb.org)
  • Estrogen receptor-positive breast cancer is subdivided into subtypes LuminalA and LuminalB, based on different expression patterns. (opinvisindi.is)
Uveitis2
  • Animals immunized with S antigen developed clinical anterior and posterior uveitis which was confirmed by histology. (nih.gov)
  • Remarkably the cyclosporine treatment completely prevented the S-antigen induced uveitis in animals. (nih.gov)
Protein8
  • The most promising approach was found to be the injection of a purified retinal protein, identified as S antigen, into Lewis rats, guinea pigs and monkeys. (nih.gov)
  • In this report, we confined ourselves to a single protein of HCMV, pp65, which is "only" 561 amino acid long, and to subjects who shared a common HLA-A * 02:01 restriction element, but differed in the remaining HLA class I alleles. (frontiersin.org)
  • When the test antigen of interest is added as a protein to peripheral blood mononuclear cells (PBMC), the antigen presenting cells (APC) contained in the PBMC will acquire, process, and present the antigen ( 3 ). (frontiersin.org)
  • Protein antigens are not suited to recall in vivo -primed CD8+ T cells within PBMC because exogenously added proteins are not efficiently presented to CD8+ T cells in the context of class I molecules. (frontiersin.org)
  • In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1). (justia.com)
  • In particular embodiments, the genes that are knocked out or knocked down are Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and Programmed cell death protein 1 (PD-1). (justia.com)
  • A plasmid DNA immunogen expressing fifteen protein antigens and complex virus-like particles (VLP(+)) mimicking naturally occurring HIV » by Somogyi E., Xu J., Gudics A., Tóth J., Kovács AL. (geneticimmunity.ru)
  • In high-risk, oncogenic HPV subtypes, the E6 protein targets the p53 tumor suppressor protein, whereas E7 binds to the active form of the retinoblastoma protein, thereby disrupting normal cell cycle regulation and providing the means to cause cellular alterations that potentially lead to neoplasia [ 3 ]. (biomedcentral.com)
Polymorphism2
  • HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort. (cdc.gov)
  • Further complicating this task, there is HLA class I polygenism and polymorphism which predisposes CD8+ T cell responses towards individualized epitope recognition profiles. (frontiersin.org)
Exposure2
  • These observations are consistent with the idea that continuous or repetitive exposure to antigens slowly moulds memory T cell populations over time. (biomedcentral.com)
  • SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 + T cells. (cytekbio.com)
Antigenic1
  • They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS. (lookformedical.com)
Cytotoxic1
Antibodies2
Predominantly1
  • Distinction among these subtypes is based on histologic growth pattern (predominantly junctional in lentiginous types vs pagetoid in superficial spreading and predominantly dermal in nodular), anatomic site, and degree of sun damage. (medscape.com)
Prevalence1
  • Prevalence of allo-immunization anti-HLA and anti-integrin alphaIIbbeta3 in Glanzmann Thromboasthenia patients. (scielo.br)
Molecules1
  • Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). (lookformedical.com)
Infection1
  • Infection with high-risk, oncogenic HPV subtypes is directly attributable to all cases of cervical cancer, approximately 90% of anal cancers, approximately 40% of penile, vulvar, and vaginal cancers, and around 12% of head and neck cancers, mainly of the oropharynx [ 1 ]. (biomedcentral.com)
Cells2
  • Fulminant type 1 diabetes is a subtype of type 1 diabetes in which beta cells are destroyed within days or a few weeks. (bvsalud.org)
  • CD8+ T cells evolved to recognize antigens actively bio-synthetized within host cells, as opposed to antigens that APC acquire from their surroundings. (frontiersin.org)
Bacterial1
  • Utilized for decades as a model of host-disease immunology, Lm is well suited for use as an immunotherapeutic bacterial vector for the delivery of foreign antigen. (biomedcentral.com)
Characterization1
  • Established PDX models underwent further characterization for histology, WES, RNA-Seq, HLA typing and growth behavior. (opensourcebiology.eu)
Functional1
  • 1983. Pretreatment with minor histocompatibility complex antigens prevents the development of functional CTL helper cell activity. (stjohns.edu)
Cancer1
  • subtypes 16 and 18 alone are the causative agents of more than 70% of cervical cancer cases [ 2 ]. (biomedcentral.com)
Viral1
Patients2
  • All ICI-related T1D patients had susceptible HLA haplotypes. (bvsalud.org)
  • Still, it depends on the subtype, patients' age and overall fitness, and the presence or absence of comorbidities affecting organ function. (broadcastmed.com)
Association1
  • He and colleagues first described the association of HLA-A2 with juvenile idiopathic arthritis. (wikipedia.org)
Development1
  • Along with Alan Rosenberg, he described the syndrome of seronegativity, enthesitis and arthritis (SEA syndrome), its relationship to HLA-B27, and the development of ankylosing spondylitis. (wikipedia.org)
Cell1
  • We examined the function from the NY-ESO-1-particular T cell items by assaying particular lysis of T2 (HLA-A2+) focuses on pulsed with titrated concentrations of NY-ESO-1 peptide aswell as the NY-ESO-1+ tumor cell range Mel A375. (epf2013.org)
Common1
  • Fulminant type 1 diabetes is a common subtype in East Asian countries, including Japan, but rare in Western countries. (bvsalud.org)
Subjects3
Class1
  • Visual hallucinations and HLA class II antigens in cortical dementia. (cdc.gov)
Addition1