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  • Pathogen
  • These two complexes provide two different pathways of antigen presentation that stimulates different population of T cells to eliminate the invading pathogen concerned. (ukessays.com)
  • This can potentially reduce the cost while allowing control over generating large numbers of functional pathogen-specific T cells for therapy. (wikipedia.org)
  • anti-tumor
  • Additionally, several studies point to improved anti-tumor efficacy when the T cells are activated immediately prior to or directly after adoptive transfer. (frontiersin.org)
  • This enhances the anti-tumor immune response to tumor antigens released following viral lysis and provides a patient-specific vaccine. (wikipedia.org)
  • lymph
  • Optimal skin-DC targeting in combination with adequate adjuvant delivery facilitates DC maturation and migration to draining lymph nodes and enhances antigen cross-presentation and T cell priming. (frontiersin.org)
  • Airway DCs can capture inhaled Ag, migrate to regional paratracheal lymph nodes (pLNs), and present Ag to naive CD4 + and CD8 + T cells ( 10 ). (jimmunol.org)
  • Nanoparticles are able to be transported through the porous extracellular matrix much easier and reach the lymph nodes where the T cells reside. (wikipedia.org)
  • Bone marrow, lymph node and spleen enlargement from leukemic cell infiltration usually is present. (wikipedia.org)
  • tissues
  • Dendritic cells, one major class of professional APC, reside in tissues exposed to the external environment and represent the first line of defense against invading pathogenic organisms. (qiagen.com)
  • Since DCs are localized, amongst other locations, in peripheral tissues such as the skin, new vaccines are aiming at targeting antigens to DCs in situ . (frontiersin.org)
  • Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. (sciencemag.org)
  • Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan. (wikipedia.org)
  • microbe
  • Each macrophage contains packets of chemicals and enzymes, which digest the ingested antigen or microbe. (hon.ch)
  • Cancer
  • Artificial antigen presenting cells (aAPCs) are a new technology and approach to cancer immunotherapy. (wikipedia.org)
  • Immunotherapy aims to utilize the body's own defense mechanism-the immune system-to recognize mutated cancer cells and to kill them the way the immune system would recognize and kill a virus. (wikipedia.org)
  • These T cells can be then re-infused or adoptively transferred into the patient for effective cancer therapy. (wikipedia.org)
  • Mesothelioma: (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. (wikipedia.org)
  • Cancer cells can also metastasize (spread) from their original site to other parts of the body. (wikipedia.org)
  • Those that bind to tumor antigens treat cancer. (wikipedia.org)
  • The only US-approved cell-based therapy is Dendreon's Provenge, for the treatment of prostate cancer. (wikipedia.org)
  • In cancer treatment they aid cancer antigen targeting. (wikipedia.org)
  • peptides
  • Tc cells detect foreign peptides bound to an MHC so if a cell has been invaded by a virus or parasite, the Tc cells are alerted and respond by destroying the abnormal cell thus preventing the spread of viruses throughout the body (DeFranco et al, 2007). (ukessays.com)
  • Infection
  • Of these APC, only B cells support complete, lytic HHV-8 infection. (frontiersin.org)
  • In this review, we discuss the effects of HHV-8 infection on professional APC and their relationship to the development of KS and B cell lymphomas. (frontiersin.org)
  • regulation
  • QIAGEN provides a broad range of assay technologies for dendritic and antigen presenting cell research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • Several studies over the past decade using mouse model of colitis and human IBD samples have established the central role for antigen presenting cells and CD4 + T cells in induction and regulation of intestinal inflammation. (biospace.com)
  • lymphoid
  • Microfold cells (or M cells) are found in the gut-associated lymphoid tissue (GALT) of the Peyer's patches in the small intestine, and in the mucosa-associated lymphoid tissue (MALT) of other parts of the gastrointestinal tract. (wikipedia.org)
  • precursor
  • IL-5 controls the development of eosinophils in the bone marrow, as they differentiate from myeloid precursor cells. (wikipedia.org)