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  • lymph nodes
  • Optimal skin-DC targeting in combination with adequate adjuvant delivery facilitates DC maturation and migration to draining lymph nodes and enhances antigen cross-presentation and T cell priming. (frontiersin.org)
  • OVA-exposed eosinophils elicited activation (CD69 expression), proliferation (BrdU incorporation), and IL-4, but not IFN-γ, cytokine production by OVA-specific CD4 + T cells in paratracheal lymph nodes (LN). Exposure of eosinophils to lysosomotropic NH 4 Cl, which inhibits Ag processing, blocked each of these eosinophil-mediated activation responses of CD4 + T cells. (jimmunol.org)
  • Airway DCs can capture inhaled Ag, migrate to regional paratracheal lymph nodes (pLNs), and present Ag to naive CD4 + and CD8 + T cells ( 10 ). (jimmunol.org)
  • Here we used multiphoton intravital microscopy in lymph nodes and tumors to show that while NFAT nuclear import was fast (t(1/2 max)∼1 min), nuclear export was slow (t(1/2)∼20 min) in T cells. (nih.gov)
  • autoimmune
  • Manipulating effector or regulatory CD4 + T cells responses is a promising immunotherapy strategy for, respectively, chronical viral infections and cancer, or severe autoimmune diseases and transplantation. (frontiersin.org)
  • Due to their multiple functions in immunity and immune tolerance, targeting CD4 + T cells has important clinical applications to treat cancer and chronic viral diseases, or to induce tolerance in autoimmune diseases and allograft. (frontiersin.org)
  • Glatiramer acetate (GA) is approved for the treatment of relapsing-remitting multiple sclerosis (MS), and can suppress experimental autoimmune encephalomyelitis (EAE), a murine model of human MS. GA treatment is associated with the induction of anti-inflammatory TH2 responses and with the antigen specific expansion of regulatory T cells that counteract or inhibit pathogenic events in MS and EAE. (vuw.ac.nz)
  • peptide
  • This MHC-peptide complex is then transported to the cell surface for presentation. (ukessays.com)
  • Peptide specificity and MHC restriction of staphylococcal nuclease-specific T cell clones, J. Exp. (springer.com)
  • Similar results were obtained for HA-T CM . ( C) HA-CTL expressing NFAT-GFP (green) and H2B-mRFP (red) were co-cultured with B cells pulsed with 10 μM HA peptide or not (Ctrl). (nih.gov)
  • D) Percentage of HA-CTL (red symbols) and HA-T CM (black symbols) with visually scored nuclear NFAT upon exposure to B cells pulsed with a range of peptide doses. (nih.gov)
  • A ) Experimental setup: HA-T CM expressing NFAT-GFP (green) and H2B-mRFP (red) were transferred i.v. into mice with 7-day-old CT26 tumors implanted in the dorsal foot in order to maximize T CM recruitment to the draining popliteal LN. Two days later, target B cells pulsed with HA-peptide (blue) or not (white) were injected i.v., and MP-IVM was started immediately. (nih.gov)
  • Inhibition
  • K.L. Rock and B. Benacerraf, Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene controlled polymers, J. Exp. (springer.com)
  • humoral
  • The assay's combined simplicity, practicality, and efficiency tailor it for the analysis of antigen-specific cellular and humoral effector functions during the development of novel immunotherapies. (hindawi.com)
  • cytokines
  • Mouse CD1.1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be recognized by T cells, in particular NK1.1 + T cells, a subset of αβ T cells with semiinvariant TCRs that promptly releases potent cytokines such as IL-4 and IFN-γ upon stimulation. (jimmunol.org)
  • TCRs
  • Its recognition by a panel of 12 Vα14-positive and -negative CD1-specific αβ T cell hybridomas was blocked by two groups of mAbs that bound to adjacent clusters of epitopes, indicating that different αβ TCRs bind to the same region of CD1.1, presumably above the groove. (jimmunol.org)
  • regulation
  • QIAGEN provides a broad range of assay technologies for dendritic and antigen presenting cell research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • Several studies over the past decade using mouse model of colitis and human IBD samples have established the central role for antigen presenting cells and CD4 + T cells in induction and regulation of intestinal inflammation. (biospace.com)
  • Moreover, IL-10 is not active when Th1 cells are stimulated with glutaraldehyde-fixed APC, which also indicates that its action involves regulation of APC function. (jimmunol.org)
  • inflammation
  • With the increasing prevalence of asthma and related allergic disorders ( 9 ), attention has focused on cells that mediate or modulate ongoing Ag-dependent allergic airways inflammation in response to inhaled Ags. (jimmunol.org)
  • cytokine production
  • Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of APC. (jimmunol.org)
  • induction
  • This provides a potential mechanistic basis for the observation that a predominance of unstable APC interactions correlates with the induction of T cell tolerance. (nih.gov)
  • immunomodulatory
  • The models developed in this study were implemented in a web-based platform VaxinPAD to predict and design immunomodulatory peptides or A-cell epitopes. (springer.com)
  • mechanisms
  • There are many complex mechanisms employed by the immune system to destroy invading organisms, abnormal cells and contain infections in order to maintain health and life. (ukessays.com)
  • Antigen presenting cells (APC) are some of the cells that form part of these mechanisms. (ukessays.com)
  • An understanding of these mechanisms will provide very important information for the design of effective strategies for the treatment of a variety of diseases that are mediated by pathogenic T cells. (springer.com)
  • Dr. Vallières wants to unravel the mechanisms through which neutrophils exhibit their negative effects on MS by examining if they are interacting with another cell of the immune that is harmful in MS called T cells. (mssociety.ca)
  • induce
  • Eye-derived cells participate in generating blood-borne signals that induce ACAID. (springer.com)
  • Project hypothesizes that the activation of β-catenin pathway during naïve CD4 + T cell differentiation promote Treg and induce strong immune tolerance and suppress auto-immune pathologies. (biospace.com)
  • therapies
  • With the emerging fields of cancer vaccines and adoptive cell transfer therapies, there is an increasing demand for high-throughput in vitro cytotoxicity assays that efficiently analyze immune effector functions. (hindawi.com)
  • exhibit
  • Mouse ( 16 , 17 ) and human ( 18 ) CD1-specific cells exhibit a high frequency of autoreactivity to CD1-expressing cells, and are dependent on CD1 for selection ( 19 , 20 , 21 ). (jimmunol.org)
  • In addition, GA-modulated innate cells may also exhibit direct antigen non-specific suppression of autoreactive cells. (vuw.ac.nz)
  • Diversity
  • It has been shown that tremendous functional, morphological, and metabolic diversity exists among these cell populations. (rupress.org)