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  • cells
  • Malfunctions during any step of antigen processing could lead to the development of self-reactive T cells or defective immune response to pathogens. (frontiersin.org)
  • Although much has been accomplished regarding how antigens are processed and presented to T cells, many questions still remain unanswered, preventing the design of therapeutics for direct intervention with antigen processing. (frontiersin.org)
  • potent
  • These recombinant subunit antigens require potent adjuvants or immune modulators to enhance their immunogenicity as well as their capacity to trigger CTLs responses required to fend off life-threatening infections caused by intracellular pathogens, such as HIV, malaria, and tuberculosis [ 6 ]. (hindawi.com)
  • cell responses
  • In turn, this enables the synchronous activation of both CD4 + and CD8 + T cell responses against the cognate antigen, thereby bridging the gap between the humoral and cellular branches of the adaptive immune response. (frontiersin.org)
  • chromosome
  • Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. (nih.gov)