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  • melanoma antigens
  • The availability of antitumor cytotoxic T lymphocytes which can be generated from either peripheral blood lymphocytes after stimulation in vitro or tumor infiltrating lymphocytes (TIL) has made it possible to identify a number of melanoma antigens presented by major histocompatibility complex class I molecules. (rupress.org)
  • antitumor
  • However, while vaccines have proven to be effective in combating pathogenic microorganisms, based on the immune recognition of these foreign antigens, vaccines aimed at inducing effective antitumor activity are still unsatisfactory. (asm.org)
  • Tumors use various evasion strategies to inhibit the development of antitumor immunity and avoid subsequent immune response-mediated elimination ( 1 - 3 ). (aacrjournals.org)
  • Additionally, reovirus oncotherapy synergistically enhances the efficacy of tumor-specific immunotherapies and, most importantly, promotes the establishment of protective antitumor immunity. (aacrjournals.org)
  • These findings should advance our current knowledge in devising antitumor immunotherapeutic remedies to complement virotherapy-mediated tumor destruction and restrict cancer remission in clinical settings. (aacrjournals.org)
  • immunologic
  • However, recent reports show that synchronized blockade or overriding of tumor immune evasion strategies with appropriate immunomodulatory intervention may overcome immunologic tolerance and promote tumor regression ( 1 , 17 , 18 ). (aacrjournals.org)
  • In the present study, we investigated if immunologic events initiated on reovirus exposure could overcome the immunosuppressive activities associated with the tumor microenvironment. (aacrjournals.org)
  • blockade
  • Collectively, our findings support the use of Tim-3-Tim-3L blockade together with PD-1-PD-L1 blockade to reverse tumor-induced T cell exhaustion/dysfunction in patients with advanced melanoma. (nih.gov)
  • antibody
  • Consistent with this train of thought, the targets of approved antibody therapies are predominantly extracellular antigens ( 1 ). (frontiersin.org)
  • elicit
  • Induction of T cell tolerance suggests tumor antigen-T cell interactions occurring during tumorigenesis may elicit T cell tolerance and hence confound some immunotherapeutic approaches. (wiley.com)
  • molecule
  • Traditionally, immune checkpoint molecule is not included in the tumor antigens. (hstalks.com)
  • In the presence of the relevant antigen-positive cell line, each respective DART molecule was able to promote T-cell proliferation and cytokine release in a HER2 or EphA2-dependent manner. (aacrjournals.org)
  • The present and previous studies indicated that TIL586 recognized an antigen expressed on most melanoma and normal melanocytes in the context of the HLA-A31 molecule. (rupress.org)
  • molecules
  • By contrast, small molecules have been used to target those intracellular antigens with a functionality that is suitable for drug screening. (frontiersin.org)
  • Co-culturing of a CD137/NF-κB reporter cell line with tumor lines expressing HER2 or EphA2 revealed tumor antigen-dependent CD137 pathway activation by HER2 x CD137 and EphA2 x CD137 DART molecules, respectively. (aacrjournals.org)
  • cell
  • However, their target repertoire is limited as there are relatively few tumor-specific or tumor-associated cell surface or soluble antigens. (frontiersin.org)
  • A large glycoprotein of molecular weight ~210 kD, CA 19-9 is a cell surface antigen located on MUC-1 whose carbohydrate determinant is defined as a sialylated Lewis (a) blood group antigen. (bio-rad.com)
  • Metastasizing tumors from serum-supplemented and serum-free cell lines from a C57BL mouse lung tumor. (pubmedcentralcanada.ca)
  • In vitro demonstration of humoral and cell-bound immunity against common specific transplantation atigen(s) of adenovirus 12-induced mouse and hamster tumors. (pubmedcentralcanada.ca)
  • These monoclonal antibodies can be used for Immunoassay, are reactive on Western Blot to both cell culture and human fluid derived antigens, and are IHC positive for breast tumor in frozen and paraffin sections. (bio-rad.com)
  • B ) The tumor specificity of the T cell line was determined by cytotoxicity using a standard JAM assay. (nih.gov)
  • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. (nih.gov)
  • We also observed that PD-1 regulates NY-ESO-1-specific CD8(+) T cell expansion upon chronic antigen stimulation. (nih.gov)
  • The identification of new tumor-associated antigens (TAA) is critical for the development of effective immunotherapeutic strategies, particularly in diseases like B-cell acute lymphoblastic leukemia (B-ALL), where few target epitopes are known. (aacrjournals.org)
  • stimulation
  • Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. (rcsb.org)
  • Clinical
  • Unique TAAs are now being frequently found in several human tumors, although their use in clinical trials is difficult for the time required to characterize unique TAAs at a single patient level ( 8 , 9 , 13 ). (aacrjournals.org)
  • The clinical potential of these antigens is hampered by their limited expression in ALL patients or by their restricted presentation by nonprevalent HLA alleles. (aacrjournals.org)
  • antibodies
  • Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg? (frontiersin.org)
  • This review will summarize multiple approaches to targeting intracellular antigens with therapeutic antibodies, in particular describing the production and characterization of TCRm antibodies, the factors influencing their target identification, their advantages and disadvantages in the context of TCR therapies, and the potential to advance TCRm-based therapies into the clinic. (frontiersin.org)
  • More recently, there are three broad approaches whereby antibodies have been used to target intracellular antigens. (frontiersin.org)
  • A few tumor antigen (TA)-specific monoclonal antibodies (mAb) have been approved by the Food and Drug Administration for the treatment of several major malignant diseases and are commercially available. (aacrjournals.org)
  • Tumor antigen-specific monoclonal antibodies (mAb) have been successfully implemented into standard treatment regimens for patients with a variety of malignant diseases. (aacrjournals.org)
  • No antibodies against prostate-specific antigen were detected. (aacrjournals.org)
  • mice
  • Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. (pubmedcentralcanada.ca)
  • B ) Mouse Spas-1 expression in normal versus tumor prostate: the level of Spas-1 expression was determined in a panel of normal prostates and primary TRAMP tumors from 21- and 27-week-old mice. (nih.gov)
  • expression
  • Spas-1 expression was increased in advanced primary TRAMP tumors. (nih.gov)
  • Spas-1 expression is not restricted to the prostate but is increased in older TRAMP tumors. (nih.gov)
  • We report here the cloning of a cDNA that directs the expression of the shared melanoma antigen recognized by this TIL. (rupress.org)
  • Tolerance
  • Significant improvements may result from the selection of the appropriate tumor-specific target antigen (to overcome the peripheral immune tolerance) and/or the development of immunization strategies effective at inducing a protective immune response. (asm.org)