Antigen in ovarian tumors antigen of tumor. Medical search. Frequent questions

Increased concentrations were found in 21 of 27 patients with epithelial ovarian cancer and two of three patients with ovarian teratoma. (ox.ac.uk)
The combination of two tumour markers, CA125 and HE4, in the risk of ovarian malignancy assay (ROMA) has been shown to be successful in classifying patients into those who have a high or low risk of epithelial ovarian cancer. (nih.gov)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (merckmanuals.com)
A study by Potenza et al indicated that in patients with epithelial ovarian cancer, combined analysis of CA 125 and human epididymis protein 4 (HE4) is an effective indicator of success in chemotherapy. (medscape.com)

Although new tumour markers models are promising, they do not contribute significantly to the diagnosis of ovarian cancer. (nih.gov)
However, owing to the lack of sensitivity and specificity, elevations in single or sequential CA 125 levels alone are not recommended for ovarian cancer screening or in the initial diagnosis of ovarian cancer. (medscape.com)

Ultrasound, especially subjective assessment by ultrasound, remains superior in discriminating malignant from benign ovarian masses. (nih.gov)
Although the discovery of an ovarian cyst causes considerable anxiety in women owing to fears of malignancy, the vast majority of these lesions are benign. (medscape.com)
A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
Of these tumors, 75% are benign and are found in women aged 30-50 years. (medscape.com)
The radiological impressions included benign stromal tumor, benign epithelial tumor, and borderline epithelial tumor. (iiarjournals.org)
Among these cases, 36.5% were associated with PJS and tumors in these patients were usually benign, multifocal, bilateral, calcified, and very small or even microscopic in size. (biomedcentral.com)
However, pelvic examination reveals that up to 88% of ovarian cysts are benign. (medscape.com)

Bilateral oophorectomy and, often, hysterectomy are performed in many postmenopausal women with ovarian cysts, because of the increased incidence of neoplasms in this population. (medscape.com)
Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
GISTs (Gastrointestinal stromal tumors) are most common mesenchymal neoplasms of gastrointestinal tract. (scirp.org)

As poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP-1) is overexpressed in various cancer types, and is localized to the nucleus, PARP-1 can be safely targeted with Auger emitters to induce DNA damage in tumors. (osti.gov)
Here, we investigated a radioiodinated PARP inhibitor, [ 125 I]KX1, and show drug target specific DNA damage and subsequent killing of BRCA1 and non-BRCA mutant ovarian cancer cells at sub-pharmacological concentrations several orders of magnitude lower than traditional PARP inhibitors. (osti.gov)
Furthermore, we demonstrated that viable tumor tissue from ovarian cancer patients can be used to screen tumor radiosensitivity ex-vivo, enabling the direct assessment of therapeutic efficacy. (osti.gov)
Finally, we showed tumors can be imaged by single-photon computed tomography (SPECT) with PARP theranostic, [ 123 I]KX1, in a human ovarian cancer xenograft mouse model. (osti.gov)
Serum CA-125, a glycoprotein antigen, has been measured in serum of patients with ovarian cancer, cervical cancer, or nonseminomatous germ-cell tumor of testis. (ox.ac.uk)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Ovarian cancer is often fatal because it is usually advanced when diagnosed. (merckmanuals.com)
Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (merckmanuals.com)
In the United States, ovarian cancer is the second most common gynecologic cancer (affecting approximately 1/70 women). (merckmanuals.com)
Cancer Stat Facts: Ovarian Cancer. (merckmanuals.com)
Ovarian cancer affects mainly perimenopausal and postmenopausal women. (merckmanuals.com)
Objective To evaluate the clinicopathological features and survival outcomes of mucinous ovarian cancer (MOC) patients in an Asian population. (thieme-connect.de)
Results Nine-hundred patients with primary ovarian cancer were reviewed, out of which 94 patients (10.4%) had MOC. (thieme-connect.de)
Conclusion MOC is a challenging and rare subtype of ovarian cancer requiring special attention and recognition. (thieme-connect.de)
1 ] Mucinous ovarian cancer (MOC) is a rare subtype of malignant ovarian cancer. (thieme-connect.de)
In all postmenopausal women with a pelvic mass, the cancer antigen 125 (CA-125) level, though an imprecise indicator, should be ordered and pelvic ultrasonography performed. (medscape.com)
Newer markers for ovarian cancer are on the horizon. (medscape.com)
In women desiring future fertility who have stage IA low-risk ovarian cancer, conservative surgical therapy is appropriate, provided that close follow-up can be maintained. (medscape.com)
Cancer antigen 125 (CA 125) is the only tumor marker recommended for clinical use in the diagnosis and management of ovarian cancer . (medscape.com)
Role of the 18:1 lysophosphatidic acid-ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1)-integrin axis in generating late-stage ovarian cancer. (nih.gov)
Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. (nih.gov)
TCR 2 aims to develop T-cell therapies for cancer based on its TRuC™ (TCR Fusion Construct) T cells, designed to harness the natural T-cell receptor complex to recognize and kill cancer cells using the full power of T-cell signaling pathways independent of human leukocyte antigen (HLA). (genengnews.com)
According to its filing, TCR 2 intends to use its IPO proceeds in part toward funding the development of its lead solid tumor candidate TC-210-designed to target mesothelin-positive solid tumors-through the completion of its planned Phase I/II trial in patients with mesothelin-positive non-small cell lung cancer, ovarian cancer, malignant pleural mesothelioma, and cholangiocarcinoma. (genengnews.com)
Development of TC-220, a mono TRuC-T cell, for the treatment of patients with MUC16-positive ovarian cancer through a Phase I/II clinical trial. (genengnews.com)
The company notes that MUC16 is highly expressed in other solid tumors, including pancreatic, gastric, and colorectal cancer. (genengnews.com)
Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
Ultrasound and MRI are not able to differentiate a GIST from ovarian cancer. (scirp.org)
Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. (mdpi.com)
The aim of this study was to evaluate serum levels of caspase-3, caspase-8, and caspase-9 in women with ovarian cancer. (mdpi.com)
Serum levels of cancer antigen 125 was increased in two patients with MACF. (iiarjournals.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
Today we speak with Dr. Robert Coleman about several new agents that have shown promise in early-stage clinical trials for ovarian cancer. (cancernetwork.com)
Ovarian cancer has been historically difficult to treat, in part because the cancer is often only diagnosed at a late stage in the disease. (cancernetwork.com)
Ovarian cancer often has few symptoms that are unique to the disease, and there are currently no reliable screening tests for the general population. (cancernetwork.com)
Ovarian cancer is also diverse, and sequencing studies continue to show that the cancer is genomically complex. (cancernetwork.com)
Ovarian cancer is most often treated with surgery and/or chemotherapy. (cancernetwork.com)
Dr. Coleman treats women with ovarian cancer and is active in clinical trial research to develop new therapies for women with ovarian cancer. (cancernetwork.com)
Dr. Coleman, I mentioned some of the reasons why ovarian cancer is difficult to treat, but could you discuss this in more detail? (cancernetwork.com)
Are there any promising genetic targets for any ovarian cancer patients or any subpopulations that have been defined? (cancernetwork.com)
Dr. Coleman: One of the things that came out of the Atlas Genome Project was that, as I mentioned, many diseases that are wrapped up into the term ovarian cancer-even among the high-grade serous ovarian cancer, which is the most common type. (cancernetwork.com)
The introduction of genes that code for tumor-specific receptors into T lymphocytes, which are cells of the immune system that mediate tumor elimination, was a novel approach to cancer therapy. (acgtfoundation.org)
The physical structure of these solid tumors presents a formidable challenge to drug delivery vehicles that need to penetrate and reach all cancer cells in order to be optimally effective. (acgtfoundation.org)
Ovarian cancer is the leading cause of gynecologic cancer death, and though most patients respond to initial chemotherapy, the majority will eventually relapse and die of chemotherapy resistant disease. (acgtfoundation.org)
The protocol will test whether the T cells that are designed to withstand the toxic effects of the tumor are able to mediate tumor regression in patients with advanced ovarian cancer that has failed to regress after chemotherapy. (acgtfoundation.org)
Immunotherapy using gene-transduced tumor cells has emerged as a potentially plausible approach for the control of advanced stage ovarian cancer. (acgtfoundation.org)
We have recently demonstrated that vaccination with irradiated murine allogeneic ovarian cancer cells secreting heat shock protein 70 (Hsp70) were capable of generating potent tumor antigen-specific immune responses and strong anti-tumor effects against ovarian cancers (Chang et al. (acgtfoundation.org)
The secretion of Hsp70 from the ovarian cancer cells will allow the Hsp70-associated antigenic peptide to be concentrated and targeted to dendritic cells (DCs) with subsequent DC activation. (acgtfoundation.org)
Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, today presents the screening and identification of novel immunogenic tumor-specific antigens (TSAs) derived from non-coding regions of the human genome at the American Association for Cancer Research Virtual Annual Meeting (AACR) 2021. (medigene.com)
Under a collaboration agreement with IRICoR and the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, Canada, Medigene gained access to 47 potential TSAs presented by one of five common HLA types that were identified as novel peptides eluted from the HLA molecules of tumor cells. (medigene.com)
These peptides were found to be shared among specimens of several patients with solid tumors of different origin, such as ovarian, breast, and lung cancer, but were not detected in healthy tissues, giving them the character of TSAs for TCRs. (medigene.com)
We are very proud to demonstrate that our high-throughput functional T cell screening approach proves to be a key tool in development of TCR-based cancer immunotherapies that can target a new class of TSAs based on peptides derived from non-coding genetic regions expressed by tumor cells. (medigene.com)
This immunotherapy approach attempts to overcome the patient's tolerance towards cancer cells and tumor-induced immunosuppression by activating and modifying the patient's T cells outside the body (ex vivo). (medigene.com)
The designation was granted based on the encouraging initial data particularly in patients with testicular cancer which is the most common type of germ cell tumors. (pipelinereview.com)
Together with the recently granted PRIME designation for BNT211 in testicular cancer it also reinforces our strategy to combine two of our key technology platforms in hard-to-treat tumor indications," said Prof. Özlem Türeci, M.D., Chief Medical Officer and Co-Founder at BioNTech . (pipelinereview.com)
Tumor indications included testicular cancer (n=13), ovarian cancer (n=4), endometrial cancer, fallopian tube cancer, sarcoma, gastric cancer (one patient each) and one patient with a tumor of unknown primary origin. (pipelinereview.com)
Despite their specificities, the general idea is to detect certain cancer markers in various body fluids (blood, urine, saliva, etc.), for example, molecules released by cancer cells (cytokines, inflammatory proteins, leptin, etc.) or distinctive features of the DNA in tumor cells. (medscape.com)
In addition, patients with cancer of unknown primary origin are defined as patients with histologically proven metastatic malignant tumors in which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
Cancer surveillance traditionally is conducted based on tumor anatomic location, histologic features, size, involvement of lymph nodes and distant metastasis (i.e., anatomic stage) at diagnosis. (cdc.gov)
Gleason score and prostate specific antigen) others such as gene expression profiling for breast cancer are used to predict response to therapy and guide treatment decisions. (cdc.gov)
For example, the 2015 annual report showed breast cancer incidence by molecular subtypes using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. (cdc.gov)
With rapidly evolving clinical applications in sequencing of the human genome as well as the genomes of tumors, the traditional anatomic descriptions of cancer types will be supplemented by molecular classification based on tumor genetic aberrations. (cdc.gov)
Other tumor-related genome markers are rapidly maturing providing prognostic indicators for survival and response to therapy (e.g. gene expression profiling in prostate cancer ). (cdc.gov)
Examples include inherited mutations in BRCA1/2 in breast and ovarian cancer, and mutations in mismatch repair genes (Lynch syndrome) in colorectal and endometrial cancer. (cdc.gov)
The NCI's Surveillance, Epidemiology, and End Results (SEER) cancer surveillance program is currently supporting an important pilot in which BRCA mutation panels have been linked to breast and ovarian cancer cases in California and Georgia. (cdc.gov)
This linkage represents the first population-based set of information on testing of women with breast and ovarian cancer. (cdc.gov)
At the time of the previous IARC evaluation of atrazine (Vol. 73, 1999), the most relevant epidemiologic studies consisted of two cohort studies of manufacturing workers, three population-based case-control studies of lymphatic and hematopoietic malignancies in agricultural areas of the U.S., and a population-based case-control study of ovarian cancer in a rice-growing area of Italy. (who.int)
ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
and ovarian cancer) or non-oncolog- (mean 14 per patient) were performed. (who.int)
In the past 5 years, there has been an explosion of breast cancer research on circulating tumor DNA (ctDNA), fueled by the idea that ctDNA may provide a liquid biopsy alternative to tissue biopsies. (medscape.com)
In a recent study, researchers compared radiographic imaging of tumors with an assay of ctDNA, cancer antigen 15-3 ( CA 15-3 ), and circulating tumor cells in 30 women with MBC who were receiving systemic therapy. (medscape.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
Up to 80% of women with ovarian carcinoma of epithelial origin have elevated serum CA 125 levels, with the frequency of elevation correlating with the clinically detected stage. (medscape.com)
Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library. (nih.gov)
We have access to several high grade serous carcinoma cell lines, that express several known tumor antigens, such as CA-125 and mesothelin. (acgtfoundation.org)

Many patients with simple ovarian cysts found through ultrasonographic examination do not require treatment. (medscape.com)
Persistent simple ovarian cysts larger than 10 cm (especially if symptomatic) and complex ovarian cysts should be considered for surgical removal. (medscape.com)
A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)

These data support the utility of PARP-1 targeted radiopharmaceutical therapy as a theranostic option for PARP-1 overexpressing ovarian cancers. (osti.gov)
Epithelial ovarian cancers (EOC) are the second-most common gynecologic malignancy. (thieme-connect.de)
It accounts for 3 to 10% of all epithelial ovarian cancers. (thieme-connect.de)
MOC is mostly diagnosed in patients at a younger age than patients with other types of epithelial ovarian cancers and the only clinical risk factor associated is tobacco smoking. (thieme-connect.de)
No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)

However, tumor recurrence may occur in the setting of normal CA 125 levels, and serum measurements do not replace imaging and physical examination of the patient. (medscape.com)
The slides of original ovarian tumors in patients with recurrence were reviewed by pathologists in our hospital. (biomedcentral.com)

Some complications of ovarian cysts may result in adnexal tenderness or cervical motion tenderness. (medscape.com)

Histologically, these tumors are characterized by mixed solid and cystic components. (wikipedia.org)
Magnetic resonance imaging revealed solid or mixed solid and cystic ovarian masses with diameters of 7.3-14.9 cm. (iiarjournals.org)
Sometimes, discerning the cystic nature of an ovarian cyst may be possible, and it may be tender to palpation. (medscape.com)
The malignant potential of small cystic ovarian tumors in women over 50 years of age. (medscape.com)

The candidate combines an autologous chimeric antigen receptor (CAR) T cell therapy targeting the oncofetal antigen Claudin-6 (CLDN6) with a CLDN6-encoding CAR-T cell amplifying RNA vaccine (CARVac). (pipelinereview.com)

Initial assessment of tumor-associated antigen CA-125 in patients with ovarian, cervical, and testicular tumors. (ox.ac.uk)
Dygerminomas are Malignant germ cell tumor of ovary and particularly prominent in patients diagnosed with gonadal dysgenesis. (wikipedia.org)
Most patients with ovarian cysts are asymptomatic, with the cysts being discovered incidentally during ultrasonography or routine pelvic examination. (medscape.com)
In the fourth quarter of 2022, the Phase 2 study sponsored by the Children's Oncology Group evaluating nirogacestat in pediatric patients with desmoid tumors met its accrual goal. (biospace.com)
Patients continue to be enrolled in a Phase 2 trial evaluating nirogacestat in ovarian granulosa cell tumors. (biospace.com)
The Phase 1 trial evaluating BGB-3245, a selective RAF dimer inhibitor, as a monotherapy in adult patients with RAF mutant solid tumors is advancing into cohort expansion studies. (biospace.com)
The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. (aacrjournals.org)
patients often present with ovarian torsion. (medscape.com)
Considering that only few patients with gastrointestinal stromal tumors have been reported in the obstetrical and gynecological literature, the awareness of such an entity by the obstetricians-gynecologists is necessary in order to facilitate coordinated approach with the general surgeons and oncologists for the optimal care of the patients. (scirp.org)
Patients with ovarian serous cystadenoma ( Cystadenoma serosum ) and papillary serous cystadenocarcinoma ( Cystadenocarcinoma papillare serosum IIIC ) were included in the study, as well as healthy women who constituted the control group. (mdpi.com)
The aim of our study was to investigate the treatment outcomes and prognosis of patients with ovarian SCTAT. (biomedcentral.com)
For patients with recurrent SCTAT, complete recurrent tumor resection (RTR) was the main treatment of choice. (biomedcentral.com)
Our technologies allowed new peptide-HLA combinations to be rapidly defined that have the potential to broaden TCR diversity for patients with different HLA types whose tumors present these novel peptides. (medigene.com)
MAINZ, Germany I September 9, 2022 I BioNTech SE (Nasdaq: BNTX, "BioNTech" or "the Company") today presented positive follow-up data from its ongoing first-in-human Phase 1/2 trial evaluating the safety and efficacy of the Company's novel CAR-T cell therapy candidate, BNT211, in patients with relapsed or refractory advanced solid tumors. (pipelinereview.com)
A subpopulation of these can be potentially curable, including patients with lymphomas, germ cell tumors, or neuroendocrine tumors. (medscape.com)
Changes in levels of circulating tumor DNA very closely followed treatment responses in these patients, and tracking levels of ctDNA may provide us with an early indicator of treatment resistance," said Dawson. (medscape.com)

Methods Data of MOC were evaluated for demographics, tumor stage, clinical characteristics, tumor markers, treatment modalities, and outcomes from electronic Hospital Information System. (thieme-connect.de)

In this respect, not only known proteins but also non-coding genetic regions of cells are studied as sources of peptides that can be presented by HLA molecules at the surface of tumor cells and be recognized by T cell receptors (TCRs). (medigene.com)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)

We look forward to reporting topline data from our Phase 2b ReNeu trial this year, which could support an NDA submission in the first half of 2024, and to advancing our emerging portfolio of BCMA combinations in multiple myeloma and biomarker-defined metastatic solid tumor programs. (biospace.com)

Background: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors that may mimic ovarian tumor on presurgical testing. (scirp.org)
Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
Histologically the tumor showed the mass to be a malignant epitheioid gastrointestinal stromal tumor with mitoses in 8 - 9 of 10 high-power fields ( Figure 1 ). (scirp.org)
SCTAT accounted for 1.4% of ovarian sex cord stromal tumors, with an average onset age of 22.6 years. (biomedcentral.com)
Sex cord tumor with annular tubules (SCTAT) is a rare and distinctive ovarian sex cord-stromal tumor (SCST), accounting for approximately 2.3% of SCSTs [ 1 ]. (biomedcentral.com)

Pathologists and clinicians should be aware of this rare entity to prevent misdiagnosis of MACF as fibrosarcoma or adult granulosa cell tumor and resultant overtreatment. (iiarjournals.org)
The predominant component of this tumor has intermediate morphologic features between granulosa cell tumors and Sertoli cell tumors and focal differentiation into either of these tumor types may occur [ 2 ]. (biomedcentral.com)

By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)

The definitive diagnosis of all ovarian cysts is made based on histologic analysis. (medscape.com)
Laboratory tests, although not diagnostic for ovarian cysts, may aid in the differential diagnosis of cysts and in the diagnosis of cyst-related complications. (medscape.com)
Oral contraceptive pills (OCPs) protect against the development of functional ovarian cysts. (medscape.com)
[ 1 ] although malignant ovarian cysts commonly do not cause symptoms until they reach an advanced stage. (medscape.com)

However, a few factors have been identified which may contribute to increased risk of OGCTs including endometriosis, polycystic ovarian syndrome, and genetic risk factors. (wikipedia.org)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)

A study consisting of 71 individual cases of ovarian yolk sac tumor provides evidence to the proliferation of the tumor. (wikipedia.org)
We recently experienced some cases of ovarian MACF, which initiated a comprehensive review of previously published cases ( 6 , 7 , 9 - 12 ) and the 10-year experience at our Institution. (iiarjournals.org)

In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
Tumour-specific expression of MHC-I and MHC-II has been associated with improved patient survival in most clinical studies. (portlandpress.com)
The engineered T cells eradicate large tumors in pre-clinical experiments. (acgtfoundation.org)
Based on the encouraging preclinical data, we propose to generate a clinical grade tumor cell-based vaccine engineered to secrete high levels of Hsp70. (acgtfoundation.org)
[ 5 ] The researchers characterized genomic architecture and inferred the clonal evolution using eight tumor biopsies and nine plasma samples collected over 1193 days of clinical follow-up using exome and targeted amplicon sequencing. (medscape.com)

In February 2023, the U.S. Food and Drug Administration (FDA) accepted SpringWorks' New Drug Application (NDA) for nirogacestat, an investigational oral, small molecule gamma secretase inhibitor, in development as a monotherapy for the treatment of adults with desmoid tumors. (biospace.com)

OGCTs can further give rise to ovarian torsion, hemorrhage, and even isosexual precocious puberty in young children. (wikipedia.org)

We aim to elucidate factors in the solid tumor microenvironment that can inhibit CAR T cells and develop decoys/traps or signaling switch receptors to rescue/enhance their activity. (unil.ch)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)

The company has cited preclinical studies in which TC-210 has shown better anti-tumor activity and persistence of TRuC-T cells compared to CAR-T cells while also exhibiting lower levels of cytokine release. (genengnews.com)
The results demonstrated encouraging signs of anti-tumor activity and the safety profile remained manageable for the two tested dose levels. (pipelinereview.com)

The T cell receptor-modified T cells (TCR-T cells) are then able to detect and efficiently kill tumor cells. (medigene.com)

Teratoma are most common germ cell tumor of ovary. (wikipedia.org)

The product candidate recently received Priority Medicines (PRIME) designation by the European Medicines Agency (EMA) for the third- or later-line treatment of testicular germ cell tumors. (pipelinereview.com)

Recurrent tumors were mostly ipsilateral to the primary tumor and located in retroperitoneum. (biomedcentral.com)

MACF is a newly-recognized subtype of ovarian cellular fibromatous tumor. (iiarjournals.org)

Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad, which accounts for about 2.6% of all ovarian malignancies. (wikipedia.org)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)

The 2003 WHO Classification designated ovarian fibromatous tumor with markedly increased cellularity, increased mitotic activity (≥4 per 10 HPFs), and diffuse moderate-to-severe cytological atypia as fibrosarcoma ( 2 ). (iiarjournals.org)
Amongst the family of ovarian fibromatous tumors, CF is regarded as a distinct entity and allocated a great deal of attention in the revised 2014 WHO Classification, whereas MACF is only briefly mentioned ( 8 ). (iiarjournals.org)
In most cases, histopathologic analysis will permit classification of these tumors into those with a favorable prognosis, which are mostly approached with locoregional treatment or systemic platinum-based chemotherapy, or an unfavorable prognosis, which are treated with empirical combination regimens involiving platinum or taxane. (medscape.com)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)

Carcinoembryonic antigen (CEA) Sample and study design years of follow-up. (who.int)

Morphologically, GISTs vary from cellular spindle cell tumors (70% - 80%) to epithelioid (20% - 30%) or mixed. (scirp.org)
The histopathological diagnosis of ovarian fibromatous tumor is usually unequivocal due to their distinct spindle-cell morphology and fascicular growth pattern. (iiarjournals.org)

20192203). We are now using these tools to evaluate logic-based, next generation CAR designs for the treatment of syngeneic solid tumors in the context of a fully competent immune system. (unil.ch)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)
A key role of the immune system is detection of these antigens to permit subsequent targeting for eradication. (msdmanuals.com)

These tumors occasionally present a pelvic mass and lead to the misdiagnosis of gynecologic diseases. (scirp.org)

MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)

We delivered highly positive data from our Phase 3 DeFi trial of nirogacestat in desmoid tumors, which served as the basis for our New Drug Application that was recently accepted by the FDA and granted Priority Review. (biospace.com)

They are unlikely to have metastasized and therefore the standard tumor management is surgical resection, coupled with chemotherapy. (wikipedia.org)

With recent advancements in pathology, gene expression profiling, identification of subtypes and various modalities available for exploring the GI tract, it has become possible to find the precise origin of mucinous tumors. (thieme-connect.de)
Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)

Dr. Jain's study will test an alternative treatment using a special polymer compound to deliver genes to the tumor site. (acgtfoundation.org)

The stem mutations, mutations that are carried in the bulk of an individual's disease, are going to be best for telling you something about tumor burden. (medscape.com)

Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
Mitotically-active cellular fibroma (MACF) is a rare form of ovarian fibromatous tumor. (iiarjournals.org)
Our 10-year review of cellular fibromatous tumors of the ovary diagnosed at a single institution revealed four cases of cellular fibroma (CF) and three cases of MACF. (iiarjournals.org)
Cellular fibroma (CF) of the ovary is an uncommon fibromatous tumor characterized by increased cellularity compared to fibroma of the conventional type. (iiarjournals.org)
In 2006, Irving and colleagues ( 4 ) first defined this kind of ovarian tumor as mitotically active cellular fibroma (MACF). (iiarjournals.org)

Our main research interest is the development of tumor-directed TCR- and CAR T cells that are programmed to logically respond to microenvironmental cues or/and small molecule administration for maximized function, fitness and safety. (unil.ch)
We have optimized retroviral, lentiviral and CRISPR-Cas9 based tools and methodologies, as well as T cell expansion conditions, allowing efficient evaluation of next-generation T cells in the context of both syngeneic and xenograft tumor models. (unil.ch)
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. (unil.ch)
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells. (unil.ch)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. (aacrjournals.org)
CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. (wikidoc.org)
Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
The discovery of MHC-II on tumour cells has been less characterized. (portlandpress.com)
However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
Dr. Sadelain demonstrated that human peripheral blood T cells could be effectively redirected to recognize the CO19 antigen and eradicate established, systemic human B cell tumors borne by immunodeficient mice, This was the first publication showing that genetically modified human T cells can induce durable remissions in an in vivo setting. (acgtfoundation.org)
Having examined the nature of the signals required by the T cells for their own survival and sustained functionality, Dr. Sadelain designed improved antigen receptors that provide both activating and co-stimulatory signals to the tumor-targeted T cell. (acgtfoundation.org)
TCR-T technology arms a patient's own T cells with tumor-specific T cell receptors. (medigene.com)
Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)
Tumor-specific antigens (TSAs) are unique to tumor cells. (msdmanuals.com)
References Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
[ 4 ] CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points. (medscape.com)
ctDNA was successfully detected in 97% women in whom somatic genomic alterations were identified, and CA 15-3 and circulating tumor cells were detected in 78% and 87%, respectively. (medscape.com)
ctDNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. (medscape.com)

Anatomy21

Organisms12

Diseases65

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

Health Care7

Epithelial ovarian cancer5

Diagnosis of ovarian cancer2

Benign8

Neoplasms4

Cancer78

Carcinoma4

Simple ovarian cysts3

Cancers5

Recurrence2

Complications of ovarian cysts1

Cystic4

Chimeric antigen receptor1

Patients16

Markers1

Surface of tumor cells2

Metastatic1

Stromal6

Granulosa2

Serous1

Cysts4

Polycystic ovarian1

Metastasis4

Cases of ovarian2

Clinical5

20231

Torsion1

Microenvironment2

Anti-tumor activity2

Receptor1

Germ-cell1

Testicular1

Primary tumor1

Subtype1

Embryonic2

Classification3

Mechanisms3

Carcinoembryonic1

Spindle cell2

Immune5

Pelvic mass1

Proteins1

Nirogacestat1

Surgical1

Mucinous2

Genes1

Mutations1

Cellular5

Cells21