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  • artificial antigen prese
  • To quickly generate large numbers of functional tumor-specific T cells from na├»ve T cell precursors, we developed a T cell Enrichment+Expansion strategy using paramagnetic, nanoscale artificial Antigen Presenting Cells (nano-aAPC), which are capable of enriching rare tumor-specific T cells in a magnetic column and activating them. (springer.com)
  • The researchers harnessed artificial antigen-presenting cells (aAPCs), themselves developed in the same lab, which can be used to give guidance to T cells on how to attack various pathogens. (medgadget.com)
  • glycolipid
  • The major advantages of CAR T cells over other cell based therapies are (1) killing of tumor targets in a MHC independent manner and thereby overcoming certain tumor escape mechanisms such as MHC-I down regulation and faulty antigen processing, (2) engineering of multiple anti-tumor immuno-modulators, and (3) targeting wide array of antigens (protein, carbohydrate, and glycolipid). (frontiersin.org)
  • In this interview, Mitch Kronenberg discusses his laboratory's efforts to understand the mechanism through which NKT cells are activated by glycolipid antigens. (jove.com)
  • patients
  • Dudley ME, Rosenberg Sa: Adoptive-cell-transfer therapy for the treatment of patients with cancer. (springer.com)
  • The immunotherapy is now being tested in patients with glioma. (dana.org)
  • Adoptive transfer of CMV-specific T-cell lines has demonstrated promising results in patients after hematopoietic stem cell transplantation. (semanticscholar.org)
  • Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome. (nih.gov)
  • Results from a trial targeting PAP by means of an antigen-presenting cell vaccine approach have suggested clinical benefit in terms of overall survival [ 14 ], and a confirmatory phase III randomized trial to test this approach in patients with advanced, metastatic prostate cancer has been recently completed with results confirming the earlier suggestion that patients receiving vaccine survive longer than patients not receiving vaccine [ 15 ]. (pubmedcentralcanada.ca)
  • This may enhance the prospects of HPV16-specific adoptive CTL immunotherapy in CxCa patients. (jimmunol.org)
  • Therapy
  • Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy. (semanticscholar.org)
  • Also called adoptive cell therapy, adoptive cell transfer, and T-cell transfer therapy. (cancer.gov)
  • Adoptive T cell therapy (ACT) for the treatment of established cancers is actively being pursued in clinical trials. (washington.edu)
  • So far, examples of HPV16-specific CTLs mainly represent poorly characterized, mostly bulk cultures with limited value for adoptive CTL therapy ( 6 , 7 , 8 , 14 ). (jimmunol.org)
  • Vaccine
  • The identification of PAP-specific CD8+ T cell epitopes should provide a means of monitoring the immunological efficacy of vaccines targeting PAP, and these epitopes might themselves be developed as vaccine antigens. (pubmedcentralcanada.ca)
  • potentially
  • Immunotherapies" represent a new and potentially more effective approach. (dana.org)
  • Among these, tryptophan catabolism plays a central role in creating an immunosuppressive environment, leading to tolerance to potentially immunogenic tumor antigens. (jove.com)
  • In addition, while there has been significant interest in PSA as an antigen in anti-tumor vaccines, targeting PAP has a potential advantage by permitting the measurement of serum PSA as a biomarker for clinical response without potentially confounding this analysis by also targeting it immunologically. (pubmedcentralcanada.ca)
  • transplantation
  • Clearly, this more diverse view of the genome has significant implications for allogeneic hematopoietic stem cell transplantation, not least in the generation of transplant antigens but also in terms of individual susceptibility to transplant-related toxicities. (bloodjournal.org)
  • multiple
  • Using this approach, TCR sequences, epitope sequences and respective MHC-restriction elements were identified for multiple antigens in a single round procedure. (aacrjournals.org)