Antigen cd1a cells. Medical search. Frequent questions

The tetramers used in the assay are made up of four major histocompatibility complex (MHC) molecules, which are found on the surface of most cells in the body. (wikipedia.org)
MHC molecules present peptides to T-cells as a way to communicate the presence of viruses, bacteria, cancerous mutations, or other antigens in a cell. (wikipedia.org)
CTLs are also called CD8+ T-cells, because they have CD8 co-receptors that bind to MHC class I molecules. (wikipedia.org)
Most cells in the body express MHC class I molecules, which are responsible for processing intracellular antigens and presenting at the cell's surface. (wikipedia.org)
If the peptides being presented by MHC class I molecules are foreign-for example, derived from viral proteins instead of the cell's own proteins-the CTL with a receptor that matches the peptide will destroy the cell. (wikipedia.org)
MHC tetramer molecules developed in a lab can mimic the antigen presenting complex on cells and bind to T-cells that recognize the antigen. (wikipedia.org)
They bind to class II MHC molecules, which are only expressed in professional antigen-presenting cells like dendritic cells or macrophages. (wikipedia.org)
Class II MHC molecules present extracellular antigens, allowing helper T-cells to detect bacteria, fungi, and parasites. (wikipedia.org)
Class II MHC tetramer use is becoming more common, but the tetramers are more difficult to create than class I tetramers and the bond between helper T-cells and MHC molecules is even weaker. (wikipedia.org)
CD1a is a member of the lipid antigen presenting molecules family. (beckman.com)
2007. Leukocyte and Stromal Cell Molecules:The CD Markers. (biolegend.com)
I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
To establish whether these cells were differentiated into iDCs, we analysed the expression of cell surface molecules on these cells and the capacity to capture antigens using flow cytometry. (eur.nl)
Upon maturation, these MMF-iDCs upregulated CD83 and costimulatory molecules and HLA-DR on their surface, indicating that these cells respond to LPS, albeit less than control iDCs. (eur.nl)
Molecules and cells , 44 (5), 310-317. (korea.ac.kr)
Yoo, HJ, Kim, NY & Kim, JH 2021, ' Current understanding of the roles of cd1a-restricted t cells in the immune system ', Molecules and cells , vol. 44, no. 5, pp. 310-317. (korea.ac.kr)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
In B-lymphocytes, endocytosis of MHC I and MHC II molecules is important for the cross-priming and presentation of labile antigens, respectively. (silverchair.com)
Humans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different. (ufl.edu)
An international team of scientists has developed a method for simultaneously detecting thousands of lipid molecules that are displayed to T cells in the human immune system. (rossjohnlab.com)
The team developed a new and sensitive method to detect more than 2,000 lipids bound to CD1 antigen presenting molecules, which display antigens to the human immune system. (rossjohnlab.com)
Four lipid presenting molecules, CD1a, CD1b, CD1c and CD1d, including a three dimensional CD1-lipid complex, fall toward the surface of a blue and watery environment surrounding a T cell. (rossjohnlab.com)
These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. (sysmex-flowcytometry.com)
The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
Our data revealed that at early times (30 min), both Antigen Presenting Cells (APCs) showed induction of important costimulatory molecules (CD80, CD86). (springeropen.com)
CD1 molecules are cell-surface glycoproteins with strong structural similarities to major histocompatibility complex (MHC) class I molecules, and studies in humans and mice have demonstrated that CD1 proteins perform the unique role of presenting lipid antigens to T lymphocytes. (elsevierpure.com)

As other group 1 CD1 antigens, CD1a is found on professional antigen-presenting cells (APC) such as dendritic cells, particularly on Langerhans cells and their direct circulating precursors. (beckman.com)
Several types of professional antigen-presenting cells inhabit the healthy skin. (cnrs.fr)

This L161 monoclonal antibody detects CD1c, a glycoprotein that is noncovalently linked to beta-2 microglobulin on thymocytes and antigen presenting cells such as dendritic and Langerhans cells. (fishersci.com)
CD1c is involved in the presentation of lipid antigens such as microbial fatty acids to effector T cells during the adaptive immune response. (fishersci.com)
Like the other CD1 proteins (group 1: CD1a, CD1b, CD1c and group 2: CD1d, CD1e), CD1a is a transmembrane protein of 49 kDa, noncovalently associated with β2-microglobulin. (beckman.com)
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. (biolegend.com)
CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. (biolegend.com)
It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. (biolegend.com)
CD1c is involved in antigen-presentation of glycolipids. (biolegend.com)
CD1a, CD1b, and CD1c in immunity against mycobacteria. (hcdm.org)
CD1a, together with CD1b and CD1c, belongs to group 1 of CD1 glycoproteins. (sysmex-flowcytometry.com)
Our results indicated that multiple members of the guinea-pig CD1 family, including members that are homologous to the human CD1b and CD1c proteins, are expressed at the protein level in transfected cells and in specialized antigen-presenting cells such as monocyte-derived dendritic cells. (elsevierpure.com)
Interestingly, three different patterns of intracellular localization were observed for the various guinea-pig CD1 isoforms, a finding that is reminiscent of the distinct patterns of intracellular localization that have been previously demonstrated for human CD1a, CD1b and CD1c. (elsevierpure.com)

CD1a is a protein of 43 to 49 kDa and is expressed on dendritic cells and cortical thymocytes. (micro-shop.pl)

T cells autoreactive to the antigen -presenting molecule CD1a are common in human blood and skin , but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids . (bvsalud.org)
This molecule is also expressed on some circulating and marginal zone B cells, as well as in lymph nodes and germinal centers. (fishersci.com)
The BL6 antibody recognizes the C epitope of the CD1a molecule. (beckman.com)
It may also act in T cells as an immune regulatory molecule. (biolegend.com)

This proposal is further supported by the finding that development of thymic DCs and T cells is linked via a common precursor at an early stage of thymocyte development. (ashpublications.org)

Langerhans cells are differentiated cells of the dendritic cell system and are closely related to the monocyte-macrophage line. (medscape.com)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)

CD1A is a transmembrane glycoprotein that is structurally related to the major histocompatibility complex (MHC) proteins and forms heterodimers with beta-2-microglobulin. (nih.gov)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)

CD1A functions as an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (nih.gov)
The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. (arigobio.com)

The tetramers are labeled with a fluorophore, allowing tetramer-bound T-cells to be analyzed with flow cytometry. (wikipedia.org)
Quantification and sorting of T-cells by flow cytometry enables researchers to investigate immune response to viral infection and vaccine administration as well as functionality of antigen-specific T-cells. (wikipedia.org)
Tetramer stains allow for the visualization, quantification, and sorting of these cells by flow cytometry, which is extremely useful in immunology. (wikipedia.org)

MHC tetramers can bind to more than one receptor on the target T-cell, resulting in an increased total binding strength and lower dissociation rates. (wikipedia.org)
When the tetramers are mixed with a blood sample, they will bind to T-cells expressing the appropriate antigen specific receptor. (wikipedia.org)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
This wide range of receptors allows for efficient receptor mediated phagocytosis of many foreign antigens. (jscimedcentral.com)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

A tetramer assay (also known as a tetramer stain) is a procedure that uses tetrameric proteins to detect and quantify T cells that are specific for a given antigen within a blood sample. (wikipedia.org)
Moreover, clustering of MHC proteins at the cell surface resulted in shifts of the respective DRMs, revealing proximity-induced changes in the membrane environment. (silverchair.com)
While scientists have long known that T cells recognise antigens, until the 1990s, it was thought that these antigens were always peptides derived from proteins. (rossjohnlab.com)
In the current study, we raised monoclonal anibodies (mAbs) against guinea-pig CD1 proteins and generated transfected cell lines expressing individual members of the guinea-pig CD1 family. (elsevierpure.com)
In addition, CD1 proteins, especially guinea-pig CD1b3, were expressed on a large number of B cells in the guinea-pig, and CD1 expression appeared to be regulated by B-cell maturation or differentiation. (elsevierpure.com)

Recently, several studies have shown that by producing T H 2 or T H 17 cytokines, CD1a-restricted T cells contribute to inflammatory skin disorders, including atopic dermatitis, psoriasis, allergic contact dermatitis, and wasp/bee venom allergy. (korea.ac.kr)
Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (msdmanuals.com)
Interestingly, cytokines from type-2 innate immune cells, such as M2 macrophages or D2 dendritic cells exhibit a protective effect on both types of diabetes. (biobran.org)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
C.Schwartz, K.O'Grady, E.C. Lavelle, Fallon, P.G . (2016) Interleukin 33: an innate alarm for adaptive T cell immunity. (tcd.ie)
I have pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. (cardiff.ac.uk)
2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity . (cardiff.ac.uk)
Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)

The granulomatous infiltrates seen in PLCH are composed of Langerhans cells, eosinophils, lymphocytes, macrophages, plasma cells, and fibroblasts, which form nodules centered on the terminal and respiratory bronchioles, causing destruction of the airway walls. (medscape.com)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages. (tcd.ie)
Pathology of the tissue biopsy demonstrated proliferation of macrophages or dendritic cells, and positive staining with CD1a confirmed a diagnosis of Langerhans' cell histiocytosis (See Figure 2) . (reviewofophthalmology.com)
Scattered T gamma-delta and B lymphocytes, macrophages and NK cells were observed among the cells of the dermal infiltrate of vulvar condylomata. (medicaljournals.se)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
We therefore investigated the consequences of exposing two major APCs, macrophages (Mfs) and conventional Dendritic Cells (cDCs) to NETs. (springeropen.com)
PMNs are rapidly recruited to tissues upon injury or infection, where they likely encounter other cells, for instance local and/or recruited dendritic cells and monocytes/macrophages. (springeropen.com)

In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite derived phospholipase. (tcd.ie)

Thus, MHC tetramers that are bioengineered to present a specific peptide can be used to find T-cells with receptors that match that peptide. (wikipedia.org)
Stains using soluble MHC monomers were also unsuccessful due to the low binding affinity of T-cell receptors and MHC-peptide monomers. (wikipedia.org)
Helper T-cells or CD4+ T-cells express CD4 co-receptors. (wikipedia.org)
There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind to both the CD1a surface and the antigen or to only CD1a itself, which activates the T cell, or they are unable to bind because of bulky motifs protruding from the antigen-binding groove, which might inhibit autoreactive T-cell activation. (korea.ac.kr)
In the last years higher attention focused on the role of immunoregulation both in the insulin production by β-cell of Langerhans-islets and in the insulin sensitivity (resistance) of insulin receptors. (biobran.org)
While CD4 T cells are by far the most abundant HIV-infected cell, DCs express a variety of HIV co-receptors and lectin receptors that modulate HIV uptake, antigen processing, and trans-infection to T cells, thus contributing to a wide variety of immunological outcomes. (jscimedcentral.com)
In addition, the ability of HIV to exploit DC surface receptors or intracellular routing mechanisms to avoid antigen-processing machinery also contributes to viral persistence and promotes trans or cis-infection of CD4 T cells. (jscimedcentral.com)
Immature DCs possess a wide variety of receptors, such as Fc receptors, lectins, and langerin, which allow them to efficiently bind and internalize antigen. (jscimedcentral.com)

Peptides loaded on MHC I are mainly derived from endogenous antigens. (silverchair.com)
We analyzed here, the transduction efficiency of a pDC cell line, GEN2.2, and of pDC derived from CD34+ progenitors, using lentiviral vectors (LV) pseudotyped with different envelope glycoproteins such as the vesicular stomatitis virus envelope (VSVG), the gibbon ape leukaemia virus envelope (GaLV) or the feline endogenous virus envelope (RD114). (biomedcentral.com)

CD1a antibodies are useful in the definition of the thymic stage of T cells. (beckman.com)

Generally, if a person's immune system has encountered a pathogen, the individual will possess T cells with specificity toward some peptide on that pathogen. (wikipedia.org)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
New insights into IL-10 dependent and IL-10 independent regulatory B cell immune suppression. (tcd.ie)
Recently my team has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. (cardiff.ac.uk)
Their efforts yielded the first integrated CD1 lipidomic map, which could help guide the investigation and discovery of lipid blockers and antigens for T cells and support the view that lipids normally influence immune responses. (rossjohnlab.com)
Recent progress in the clinical approach to these patients has emphasized important roles for high-resolution computed tomographic (CT) scanning and immune reactive tissue markers including cluster differentiation (CD) 1a antigen in the diagnosis of this disorder. (elsevierpure.com)
This clinical cancer strategy incorporates advancements in cancer treatment based on a multi-approach to the disease that includes targeting apoptosis, immune cell activation, angiogenesis, restoration of cellular respiration, inhibition of inflammatory mediators, not mentioning some secondary factors such as intoxication, disturbed microbiome, and nervous disorders. (biobran.org)
SLA plays a key role in the immune response against grafts or transplants, but also in the control of antigen presentation and the development of the immune response. (bioxcell.com)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
However, the functional consequences of NETs interacting with other immune cells, either resident or recruited during early inflammation, have not been assessed. (springeropen.com)
Polymorfonuclear leukocytes (PMNs) or neutrophils, one of the first effector cells of the innate immune system against infection are the most abundant circulating leukocytes and were discovered by Paul Ehrlich. (springeropen.com)
Dendritic cells (DC) are central purveyors of both innate and adaptive immune responses. (jscimedcentral.com)
A failure of DCs to mature, as witnessed during HIV uptake, however, leads to attenuation of antigen-specific immune responses and may significantly contribute to induction of T cell regulatory responses. (jscimedcentral.com)
Dendritic cells (DC) are both widely dispersed in the body and are potent activators of effector immune response, which stresses their important role in HIV infection [1,2]. (jscimedcentral.com)
They are also key players in spread of infection via trans-CD4 T cell infection (or in cis), and stimulation of adaptive immune responses in attempt to eliminate virus. (jscimedcentral.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)

2016). The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism. (tcd.ie)

Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. (korea.ac.kr)

Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)

CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A′ pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. (korea.ac.kr)

Objectives: As dendritic cells (DCs) present in these skin lesions play a key role in the activation of Th lymphocytes, we investigated the effects of MMF on monocyte-derived DC differentiation. (eur.nl)
For this purpose we measured cytokine production by these LPS-stimulated cells (MMF-DCs) using enzyme-linked immunosorbent assays as well as their ability to activate naive Th lymphocytes. (eur.nl)
The production of IL-4 and IL-10 by naive Th lymphocytes cocultured with MMF-DCs did not differ from that by T cells cocultured with control DCs. (eur.nl)
Pulmonary Langerhans cell histiocytosis is a disease in which monoclonal CD1a-positive Langerhans cells (a type of histiocyte) infiltrate the bronchioles and alveolar interstitium, accompanied by lymphocytes, plasma cells, neutrophils, and eosinophils. (msdmanuals.com)
MHC I presents peptides to cytotoxic T-lymphocytes, whereas MHC II displays peptides or larger antigen fragments to T-lymphocytes with helper or regulator function ( Jensen, 2007 ). (silverchair.com)
T lymphocytes with a mean CD4/CD8 ratio of 0.25 and a mean density of 267 +/- 59 cells/mm2 of epithelial section were the main cellular infiltrate in vulvar papillomavirus infection. (medicaljournals.se)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

Imiquimod induced an IFN signature and led to reduced infiltration of inflammatory cells. (cnrs.fr)
Conceivable, this "late" induction of cell death in these two APCs might start limiting an ongoing inflammatory process to control it. (springeropen.com)

Pulmonary Langerhans cell histiocytosis X (PLCH) is histologically characterized by parenchymal infiltration of the lungs by activated Langerhans cells. (medscape.com)
The accumulation of Langerhans cells in the lungs is hypothesized to occur in response to exposure to cigarette smoke. (medscape.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
CD1a [O10] staining has been shown to be useful in the differentiation of Langerhans cells from interdigitating cells. (micro-shop.pl)
Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
Microscopic review of the tissue specimen revealed proliferation of histiocytes (left) with positive CD1a staining, a marker for Langerhans' cells (right). (reviewofophthalmology.com)
The results indicated that in vulvar papillomavirus infection the intraepithelial Langerhans' cells showed abnormal morphology and a significantly lower density than controls. (medicaljournals.se)
CD1a positive Langerhans' cells were also observed in dermis of condylomata, suggesting an abnormal epithelial traffic of dendritic cells. (medicaljournals.se)
CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied. (ox.ac.uk)
Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence. (ox.ac.uk)
Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
In the present study, immunohistochemical and immunoelectron microscopic techniques were used to differentiate Langerhans cells (LC) from interdigitating cells (IDC) in the lymph nodes (LN) of dermatopathic lymphadenopathy. (fujita-hu.ac.jp)
This finding may mean that LC In the LN are fully developed cells and do not divide In the LN. Langerhans cells may migrate from the skin lesions to the paracortical areas in the LN, which then may become enlarged. (fujita-hu.ac.jp)
Dive into the research topics of 'Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
Background/purpose Langerhans cells (LCs) are antigen-presenting cells. (tmu.edu.tw)
Epidermal Langerhans cells (CD207/langerin(+)), dermal langerin(neg), and dermal langerin(+) dendritic cells (DC) have been described, the latter subset so far only in mouse skin. (cnrs.fr)

Applications Tested: This L161 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (fishersci.com)
T6 (ref 6T-CD1.7) was used as a CD1a reference monoclonal antibody during HLDA 6. (beckman.com)
The majority of the dendritic cells that existed in the LN of dermatopathic lymphadenopathy were positive for OKT-6 (CD 1a) antibody. (fujita-hu.ac.jp)
Most of the LC In the lymph nodes we examined were negative for the anti-proliferating nuclear antigen (PCNA) antibody. (fujita-hu.ac.jp)
human CD14(+) dermal DC can promote antibody production by B cells. (cnrs.fr)
The 74-11-10 monoclonal antibody reacts with the swine leucocyte antigen (SLA) class I. This corresponds to the major histocompatibility complex (MHC) class I. Class I antigens are expressed on the surface of all nucleated cells with the exception of neurons and trophoblasts. (bioxcell.com)
Nevertheless, despite the addition of the anti-IL-10 antibody in the PBMC culture from persistently infected piglets, the response of the IFN-gamma producing cells was not restored. (bioxcell.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. (bvsalud.org)
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. (ox.ac.uk)
In addition to responding to GAS, subsets of expanded GAS-reactive T cell clones/lines were found to be autoreactive, which included the recognition of the self-lipid antigen lysophosphatidylcholine. (ox.ac.uk)
Together, these findings link GAS infection to the CD1a pathway and show that GAS infection promotes the proliferation and activation of CD1a-autoreactive T cells, with relevance to post-streptococcal disease, including the pathogenesis and treatment of psoriasis. (ox.ac.uk)

1-3 These nonoverlapping functions have been proposed to result from the actions of 2 major DC populations which have been characterized as myeloid and lymphoid DCs, respectively, on the basis of their anatomical localization and cell-surface phenotypes and, ultimately, of their distinct developmental origin. (ashpublications.org)

Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. (hcdm.org)

Tetramer stains can also be paired with functional assays like ELIspot, which detects the number of cytokine secreting cells in a sample. (wikipedia.org)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

Exogenous antigens can also serve as the peptide source in a process called cross-presentation. (silverchair.com)

[ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)
As a consequence, the vaccine is immunologically processed by antigen-presenting cells of the skin or the muscle. (cnrs.fr)

The cellular makeup of these monocytoid/histocytic cells is heterogeneous and ranges from cells of lymphoid, histiocytic, and dendritic origin. (medscape.com)
In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
8 As these latter DCs derive from an intrathymic lymphoid-restricted progenitor able to generate also T, B, and NK cells, but not myeloid cells, upon transfer in vivo, 5 , 9 , 10 they have hitherto been considered of lymphoid origin. (ashpublications.org)

The CD1a antigen is also present on a B cell subset. (beckman.com)
Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)

CD1-restricted T cell recognition of microbial lipoglycan antigens. (hcdm.org)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
Der bekannteste Marker für Langerhans-Zellen ist CD1a, ein Oberflächenmarker, der an der Antigenpräsentation beteiligt ist. (antikoerper-online.de)

This provides an essential priming or tolerizing signal to cytotoxic T-cells ( Rock and Shen, 2005 ). (silverchair.com)
Human skin and blood single-cell CITE-seq analyses of IL-22-producing T cells showed a type 17 signature with proliferative potential, whereas IFN-γ-producing T cells displayed cytotoxic T lymphocyte characteristics. (ox.ac.uk)

We found that efficient gene transfer into pDC can be achieved with VSVG-pseudotyped lentiviral vectors (LV) under the control of phoshoglycerate kinase (PGK) and elongation factor-1 (EF1α) promoters (28% to 90% of E-GFP + cells, respectively) in the absence of phenotypic and functional maturation. (biomedcentral.com)
HIV uptake by DCs is unique in that it does not preferentially drive DC maturation and stimulate T cell instruction, but rather favors viral spread [10]. (jscimedcentral.com)

After capturing CD1a- lipid complexes, we gently eluted ligands while preserving non- ligand -bound CD1a for testing lipids from tissues . (bvsalud.org)
They may also participate in other diseases, including pulmonary disorders and cancer, because CD1a-expressing dendritic cells are also located in non-skin tissues. (korea.ac.kr)
Methods The CD1a-positive LC numbers in the lining epithelia and subepithelial connective tissues were counted at 80 DC sites without inflammation, 33 DC sites with mild/moderate inflammation, and 9 DC sites with severe inflammation from 80 DC specimens. (tmu.edu.tw)
Most DCs in tissues and blood are present in an immature state, but upon antigen acquisition and activation they mature. (jscimedcentral.com)

DR+ epidermal macrophage induction, and noma in young women: An evaluation of the Langerhans cell depletion. (who.int)

Those condylomata with moderate to severe mononuclear infiltrate showed leucocyte function antigen 1 positive T cells forming small clusters in the lower epithelial half around the ICAM-1 positive keratinocytes. (medicaljournals.se)

In human skin langerin(neg) dermal DC can be further classified based on their reciprocal expression of CD1a and CD14. (cnrs.fr)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)

It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
Langerhans' cell histiocytosis (LCH), previously known as histiocytosis X, describes a rare spectrum of conditions with abnormal proliferation of histiocytes, occuring in various locations throughout the body. (reviewofophthalmology.com)

Vassallo, R & Limper, AH 2002, ' Pulmonary Langerhans' cell histiocytosis ', Seminars in Respiratory and Critical Care Medicine , vol. 23, no. 2, pp. 93-101. (elsevierpure.com)

Results: The presence of MMF during the differentiation of monocytes into iDCs resulted in cells that retained low levels of CD14 and hardly expressed CD1a. (eur.nl)

Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. (haematologica.org)
Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification. (sysmex-flowcytometry.com)
Unexpectedly, however, at later times (6 and 24 hours) NETs apparently triggered a cell death process in these APCs by a caspase- and Apoptosis induced factor (AIF)-dependent pathway, suggesting mitochondrial damage. (springeropen.com)

Anatomy29

Organisms10

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Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

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CD1c11

Thymocytes1

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Thymocyte1

Dendritic cell2

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S1002

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20021

CD141

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