Loading...
  • Immunology
  • Radial immunodiffusion (RID) or Mancini method, Mancini immunodiffusion or single radial immunodiffusion assay, is an immunodiffusion technique used in immunology to determine the quantity or concentration of an antigen in a sample. (wikipedia.org)
  • epitope
  • An important area of focus is the impact on antibody binding of amino acid substitutions in the epitope-could mutation lead to escape? (frontiersin.org)
  • hypersensitivity
  • Presentation on theme: "Types II and III Immediate Hypersensitivity: Antibody-Mediated and Antigen-Antibody Complex-Mediated Folder Title: AgAbHypeNoTP Updated: November 02, 2012. (slideplayer.com)
  • 17 Antigen-generation and Persistence in Type III Immediate Hypersensitivity Persistent Infection Leprosy Malaria Viral hepatitis Dengue hemorrhagic fever Staphylococcal Endocarditis Streptococcal glomerulonephritis Mononucleosis Autoimmunity Rheumatoid arthritis Systemic Lupus Erythrematosis Persistent Exogenous Acquisition (Inhalation of Ag) Extrinsic Allergic Alveolitis (e.g. (slideplayer.com)
  • Such hypersensitivity progressing to disease states produces the immune complex diseases. (wikipedia.org)
  • interactions
  • We find that in some cases the impact of a substitution is local, while in others it causes a reorientation of the antibody with wide-ranging impact on residue-residue interactions: this explains, in part, why the change in chemical properties of a residue can be, on its own, a poor predictor of overall change in binding energy. (frontiersin.org)
  • The identification and characterization of broadly neutralizing antibodies (bnAbs) to highly mutable pathogens such as HIV ( 1 ) and influenza ( 2 , 3 ) has important consequences both for treatment and for vaccine development, but the structural understanding of antibody/antigen interactions is far from complete. (frontiersin.org)
  • Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server. (plu.mx)
  • Subsequent interactions between C5b and other terminal components C6, C7, C8, and C9 form the membrane attack complex or the C5b-9 complex which forms pores on the target cell membranes to lysing. (wikipedia.org)
  • Tumor
  • When injected into target tissue encourages recruitment of C1q and activates downstream events, eventually leading to the formation of the C5b-9 complex which damages tumor cells, killing them. (wikipedia.org)
  • Cytotoxicity
  • This process, called antibody-dependent cellular cytotoxicity, can cause inflammation of surrounding tissues and damage to healthy cells. (wikipedia.org)
  • equivalence
  • Expansion of the circle reaches an end point and stops when free antigen is depleted and when antigen and antibody reach equivalence. (wikipedia.org)
  • Therefore, a graph that compares the quantities or concentrations of antigen in the original samples with the areas or the squares of the diameters of the precipitin circles on linear scales will usually be a straight line when all circles have reached their end points (equivalence method). (wikipedia.org)
  • enzyme
  • 2) Purification of the monoclonal antibodies (Ab) against FP produced in BALb/c mice, and isoldrion of Fab segment (Ab-Fab) by partial digestion with papain enzyme. (nii.ac.jp)
  • amino
  • 5) The amino acid sequence determination of antibody started in 1990 at the Institut Pasteur in Paris according to G. Winter's procedure. (nii.ac.jp)
  • We completely determined the amino acid sequence of the heavy chain in Ab-Fab in 1991, and found two consensus cysteine residues in comparison with the other antibody sequences. (nii.ac.jp)
  • For vaccine development and disease surveillance, it is often vital to assess the impact of amino acid substitutions on antibody binding. (frontiersin.org)
  • inflammation
  • The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane. (wikipedia.org)