• In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. (nih.gov)
  • The class of mTOR inhibitors, including sirolimus (rapamycin), temsirolimus, and everolimus, are increasingly being used as anticancer agents and have been associated with the development of oral aphthous-like ulcers, referred to as mTOR inhibitor-associated stomatitis, or mIAS. (medscape.com)
  • Resistance to antimicrobial agents is an emerging problem worldwide. (cdc.gov)
  • Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. (cdc.gov)
  • In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). (cdc.gov)
  • Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries. (cdc.gov)
  • Resistance containment also requires improvements in infectious disease control, access to and quality assurance of antimicrobial agents, as well as diagnostic facilities. (cdc.gov)
  • Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
  • The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. (nih.gov)
  • Several studies report that GLP-1R agonists had anti-inflammatory effects in multiple disorders including T2D. (justia.com)
  • In converse, some diseases appear to primarily involve the T cells and do not appear to affect antibody production. (medscape.com)
  • This is the first study to identify an FDA approved pharmacologic agent that inhibits lung IL-33 release, providing an alternative to biologic therapies that target IL-33-mediated diseases. (justia.com)
  • Plant diseases, caused by a wide range of phytopathogenic fungi, could be managed using of Trichoderma sp, as a biocontrol agent. (ijbiotech.com)
  • [ 1 ] This article reviews basic salivary anatomy and physiology, several important diseases affecting the glands, salivary constituents as measures of health, trends in diagnosis, and the management of xerostomia and drooling. (medscape.com)
  • This chapter provides a summary of the major disorders affecting the lower GI system and the medications that are used most frequently to treat them. (ashp.org)
  • Each gram of Triamcinolone Acetonide Cream USP, 0.025 % contains 0.25 mg triamcinolone acetonide USP in a cream base consisting of purified water, emulsifying wax, mineral oil, propylene glycol, sorbitol solution, cetyl palmitate, sorbic acid, and potassium sorbate. (nih.gov)
  • A new solution could be the esterification of wood with sorbitol and citric acid (SCA) since these are inexpensive and readily available feedstock chemicals and have shown protective properties against fungal wood degradation in earlier studies and prevented macrobiological degradation, as shown in this study. (nibio.no)
  • The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. (nih.gov)
  • Prodrugs may be used to reduce side effects of the active medication or to permit administration via an alternate route. (ashp.org)
  • Data from patients with moderate to severe hepatic impairment show that hepatic dysfunction does not affect lamivudine pharmacokinetics significantly. (who.int)
  • Symptoms in affected patients indicate the crucial involvement of MHC proteins in the immune recognition of self and nonself. (medscape.com)
  • consider opioid rotation to reverse opioid neurotoxicity  Consider psychotropic drugs for patients developing "sun downing" effect (confusion in the evening). (chestervetclinic.com)
  • Here we tested if acidified drinking water has beneficial effects in Cln2R207X mice, a nonsense mutant model of late infantile CLN2 disease. (bvsalud.org)
  • This suggests that gut bacteria might contribute to the beneficial effects of acidified drinking water. (bvsalud.org)
  • Discuss the therapeutic effects, drug properties, dosages, and routes of administration for each class of medications listed above, and list their most common side effects and drug interactions. (ashp.org)
  • When used as a food additive, a humectant has the effect of keeping moisture in the food. (wikipedia.org)
  • They commonly occur as food spoilage agents and opportunistic pathogens and are widely used as versatile cell factories. (nature.com)
  • The objective of this study was to improve the antagonistic effect of the biocontrol agent T. harzianum by overexpressing the Chit42 gene, derived from T. atroviride under the control of a constitutive promoter. (ijbiotech.com)
  • This study evaluated the effects of aPDT, SDT and SPDT mediated by curcumin on the metabolism, adhesion capacity, biofilm formation ability and structural alteration in the Staphylococcus aureus biofilm. (preprints.org)
  • The genus Trichoderma , a soil borne group of fungi, acts as important biocontrol agents against phytopathogenic fungi. (ijbiotech.com)
  • HA286 trade name] is indicated in combination with another antiretroviral agent for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children weighing over 25 kg. (who.int)
  • The available moisture determines microbial activity, physical properties, sensory properties and the rate of chemical changes, that if not controlled, are the cause of reduced shelf life. (wikipedia.org)
  • Diabetes mellitus affects 200 million people worldwide and the incidence appears to be increasing throughout the world, at least in part due to the increasing incidence of obesity and sedentary lifestyle. (institut-vision.org)
  • Therefore, the visual sensing of MtMET-AP1 was successfully performed by DDAN-MT, and MtMET-AP1 inhibitors were discovered as potential antituberculosis agents. (bvsalud.org)
  • Overexpression of single chitinase can improve the mycoparasitic potential of the biocontrol agent ( 13-15 ). (ijbiotech.com)
  • The improved Trichoderma sp could reduce the development of S. sclerotiorum , the causal agent of stem rot disease in canola plants. (ijbiotech.com)
  • Trichoderma strains are ubiquitous biocontrol agents because of their high reproductive capacity, strong aggressiveness against pathogens, ability to survive under difficult conditions, efficiency in promoting plant growth and defense mechanisms ( 2 ). (ijbiotech.com)
  • With a very high molar proportion of fatty acid to saccharide when compared to the other studies, the authors suggested that increasing the proportion of fatty acid could negatively affect the lipase conformation due to an acidification of the reaction medium. (researchgate.net)
  • The choice of the optimal cleansing agent for removable dental prostheses is of high significance. (opendentistryjournal.com)
  • Dermatophytoses representing a major global health problem and dermatophyte species with reduced susceptibility to antifungals are increasingly reported. (bvsalud.org)
  • Sorbitol - Sorbitol is usually added to toothpaste as a sweetener and a preservative. (topdogtips.com)
  • The sweetener Sorbitol is naturally derived from corn. (yourhealthstore.net.au)
  • Studies on the mechanism of action were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), sorbitol and ergosterol assay, nucleotide leakage measurement, and UPLC-based test and enzyme-linked immunosorbent assay. (hindawi.com)
  • The membrane damaging effects of PB were attributed to binding with ergosterol to increase membrane permeability and interfering ergosterol biosynthesis involved with the reduction of SE and CYP51 activities. (hindawi.com)
  • The antifungal activity of 2-chloro- N -phenylacetamide was evaluated in vitro by the determination of the minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), inhibition of biofilm formation and its rupture, sorbitol and ergosterol assays, and association between this molecule and common antifungal drugs, amphotericin B and fluconazole. (scielo.br)
  • 2-chloro- N- phenylacetamide did not promote antifungal activity through binding to cellular membrane ergosterol nor it damages the fungal cell wall. (scielo.br)
  • A atividade antifúngica da substância foi avaliada in vitro através da determinação da concentração inibitória mínima (CIM), concentração fungicida mínima (CFM), ruptura e inibição da formação de biofilme, ensaios de sorbitol e ergosterol, e associação entre esta molécula e antifúngicos comuns, anfotericina B e fluconazol. (scielo.br)
  • Even this minimal functionality can be difficult to achieve, however, e.g., when delivery of a hydrophobic active agent requires interaction with aqueous physiological environments, such as gastric fluids and intestinal fluids. (justia.com)
  • A number of approaches to formulating active agents having low aqueous solubility are known. (justia.com)
  • In aqueous solution, micelles can incorporate hydrophobic therapeutic agents in the hydrocarbon core of the micelle, or entangled at various positions within the micelle walls. (justia.com)
  • Resistance to antimicrobial agents is an emerging problem worldwide. (cdc.gov)
  • Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries. (cdc.gov)
  • Resistance containment also requires improvements in infectious disease control, access to and quality assurance of antimicrobial agents, as well as diagnostic facilities. (cdc.gov)
  • SYNTHESIS OF 4-HYDROXY-3-METHOXYBENZALDEHYDE (VANILLIN) DERIVATIVES AND PHARMACOPHORE MODELLING FOR ANTIMICROBIAL AGENTS Staphylococcus aureus (S.aureus) Nur Sabrina Binti Mohd. (dokumen.tips)
  • Superficial mycoses have affected about 20-25% of the worldwide population with incidence, in particular those involving dermatophyte infection, having increased in the recent decades [ 1 , 2 ]. (hindawi.com)
  • These findings impart a useful insight into the development of an effective and safe antifungal agent for the treatment of superficial fungal infections caused by dermatophytes. (bvsalud.org)
  • Further study is needed to develop PB as a natural antifungal candidate for clinical use. (hindawi.com)
  • This research aimed to evaluate the antifungal potential of 2-chloro- N -phenylacetamide against fluconazole-resistant clinical strains of C. albicans and C. parapsilosis . (scielo.br)
  • The antifungal activity of henna leaves extracts (HLE) toward 30 clinical dermatophytes isolates, including Trichophyton mentagrophytes, Microsporum canis, and T. rubrum, was determined. (bvsalud.org)
  • A biologics license application must contains specific information on the manufacturing processes, chemistry, pharmacology, clinical pharmacology and the medical affects of the biologic product, sufficient for the FDA to determine that the establishment and the product meet applicable requirements to ensure the continued safety, purity, and potency of the product, including but not limited to GMPs. (nih.gov)
  • This study was aimed at exploring the antifungal mechanism of PB against Trichophyton rubrum ( T. rubrum ). (hindawi.com)
  • Its combination with other antifungals should be avoided and its mechanism of action remains to be established. (scielo.br)
  • Trichophyton rubrum is the main etiological agent, accounting for about 70% of dermatophytosis [ 6 ]. (hindawi.com)
  • The entire plant constituents were determined by GC-MS. Moreover, the antimycotic activity against Ascosphaera apis, Microsporum canis, Trichophyton rubrum, and Trichophyton mentagrophytes was assessed utilizing the poison food technique method. (bvsalud.org)
  • Table 1 shows the relative glucocorticoid and mineralocorticoid potencies of different, commonly used systemic glucocorticoids and their approximate plasma and biologic effect half-lives. (medscape.com)
  • [ 1 ] This article reviews basic salivary anatomy and physiology, several important diseases affecting the glands, salivary constituents as measures of health, trends in diagnosis, and the management of xerostomia and drooling. (medscape.com)
  • One well-known approach uses surfactant micelles to solubilize and transport the therapeutic agent. (justia.com)
  • Although micellar formulations can solubilize a variety of hydrophobic therapeutic agents, the loading capacity of conventional micelle formulations is limited by the solubility of the therapeutic agent in the micelle surfactant. (justia.com)
  • acetoxy-17-(3-pyridyl) androsta-5, 16-diene), in combination with at least one additional therapeutic agent such as an anti¬ cancer agent or a steroid. (gc.ca)
  • hydroxylase/C17, 20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid. (gc.ca)
  • The substance exhibited significant antifungal activity by inhibiting both planktonic cells and biofilm of fluconazole-resistant strains. (scielo.br)
  • Isoflavaspidic acid PB (PB), a phloroglucinol derivative extracted from aerial parts of Dryopteris fragrans (L.) Schott, had antifungal activity against several dermatophytes. (hindawi.com)
  • Despite progress in antidermatophytic therapy, prolonged duration of treatment, resistance problems, and a narrow spectrum of activity severely limit the effectiveness of available antifungals [ 8 , 9 ]. (hindawi.com)
  • Antifungal activity of 2-chloro- N -phenylacetamide: a new molecule with fungicidal and antibiofilm activity against fluconazole-resistant Candida spp. (scielo.br)
  • The available moisture determines microbial activity, physical properties, sensory properties and the rate of chemical changes, that if not controlled, are the cause of reduced shelf life. (wikipedia.org)
  • Acetone and ethanol extracts exhibited the highest antifungal activity toward the tested dermatophyte species with minimum inhibitory concentration (MIC) ranges 12.5-37.5 and 25-62.5 µg/mL, respectively. (bvsalud.org)
  • In conclusion, acetone and ethanolic extracts of henna leaves with their major constituent fraxetin exhibited effective antifungal activity toward dermatophyte species and may be developed as an alternative for dermatophytosis treatment. (bvsalud.org)
  • Factors that influence the spectrum of adverse effects observed in hypercortisolemic individuals include duration of treatment, potency of the steroid, dose and route of administration, and the site and rate of metabolism and clearance. (medscape.com)
  • In addition to the glucocorticoid effects that cortisol has because of binding to the glucocorticoid receptor (GR), cortisol can also bind to and activate the mineralocorticoid receptor (MR). When cortisol binds to the kidney, MR is physiologically inhibited by conversion of cortisol to its inactive metabolite cortisone by the enzyme 11beta-hydroxy-steroid dehydrogenase (11beta-OHSD2), which co-localizes with the MR. (medscape.com)
  • PMID- 5157721 TI - Effects of the muscarinic agonist McN-A-343 on responses to sympathetic nerve stimulation in the rabbit ear artery. (nih.gov)
  • Observations were made on the effects of 4-(m-chlorophenylcarbamoyloxy)-2 butynyltrimethylammonium chloride (McN-A-343) on responses of isolated segments of the central artery of the rabbit's ear to sympathetic nerve stimulation and noradrenaline.2. (nih.gov)
  • When McN-A-343 had an inhibitory effect on responses to sympathetic nerve stimulation, responses to noradrenaline were unaffected.5. (nih.gov)
  • Sympathetic stimulation has a direct effect on glandular cells, resulting in the formation of a more concentrated saliva that contains more mucous and extra enzymes, but also causes vasoconstriction of the blood vessels that supply the glands, reducing rate of secretion. (dimensionsofdentalhygiene.com)
  • A well-designed formulation must, at a minimum, be capable of presenting a therapeutically effective amount of the active agent to the desired absorption site, in an absorbable form. (justia.com)
  • For many therapeutic agents, such solubility is too low to offer formulations that can deliver therapeutically effective doses. (justia.com)
  • In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). (cdc.gov)
  • More specifically, the invention relates to novel pharmaceutical compositions for administration of active agents to patients, wherein the compositions provide for multi-stage drug release. (justia.com)
  • En outre, l'invention concerne des compositions comprenant un inhibiteur de 17.alpha. (gc.ca)
  • HA286 trade name] is indicated in combination with another antiretroviral agent for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children weighing over 25 kg. (who.int)
  • acétoxy-17-(3-pyridyl)androsta-5,16-diène), en association avec au moins un agent thérapeutique supplémentaire tel qu'un agent anticancéreux ou un stéroïde. (gc.ca)
  • Another conventional approach takes advantage of the increased solubility of hydrophobic therapeutic agents in lipids, particularly oils, i.e., triglycerides. (justia.com)
  • Many of these ecological approaches aim for long-term caries control by either disrupting cariogenic virulence factors without affecting bacterial viability, or include measures that can enhance the growth of health-associated, microbially diverse communities in the oral microbiome. (karger.com)
  • Traditional caries epidemiological measures do not adequately reflect the social impacts, economic costs, and health care system effects of the disease [Casamassimo et al. (karger.com)
  • It has been utilized as a resource of functional food, especially for the preparation of health drinks which contain Aloe Vera gel and which have no laxative effects. (niir.org)
  • Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD) affecting 2.5 million individuals worldwide,[3] is marked by the inflammation and ulceration of the colonic mucosa, or innermost lining, which may lead to bloody stools, severe diarrhea and frequent abdominal pain. (jnj.com)
  • C168639 PQ/CMC Application Type Terminology C80440 Humanitarian Device Exemption A premarket submission to FDA for a device intended to benefit patients by treating or diagnosing a condition affecting fewer than 4,000 individuals in the United States per year. (nih.gov)
  • The force and duration of your dog's teeth brushing also have an effect. (topdogtips.com)
  • Approximately 700,000 people in the United States[1] and 1.1 million people in the European Union (EU)[2] are affected by UC, a chronic inflammatory bowel disease marked by inflammation and ulceration of the colonic mucosa, or innermost lining, which may lead to bloody stools, severe diarrhea and frequent abdominal pain. (jnj.com)
  • The invention additionally relates to processes for preparing the suspensions and methods of using the suspensions to administer an active agent to a patient. (justia.com)
  • Cushing syndrome (CS) takes its name from Harvey Cushing, who, in 1912, was one of the first physicians to report a patient affected with excessive glucocorticoid. (medscape.com)
  • One or more additional active agents, which may be fully solubilized, partially solubilized, or suspended, may also be present. (justia.com)
  • In specific embodiments, the modulation of expression concerns downregulation of expression of multiple genes, including in at least some cases to non-detectable levels, such as determined by any standard means in the art (at the RNA and/or protein level, for example). (justia.com)
  • The comparative study on the effect of the locally made black soap and Dudu osun soap on dermatophytes isolated from barbing equipment using agar well diffusion method. (dataprojectng.com)