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  • novel
  • With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding novel drug targets and evaluating antifungal resistance have become more important than ever. (springer.com)
  • Therefore, this screening reveals agent, CV-3988 that was previously unknown to be antifungal agent, which could be a novel therapies for superficial mucosal candidiasis. (frontiersin.org)
  • Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. (mdpi.com)
  • Calbistrins, novel antifungal agents produced by Penicillium restrictum. (wikipedia.org)
  • cell membrane
  • Aurones - have been shown to possess antifungal properties Benzoic acid - has antifungal properties, but must be combined with a keratolytic agent such as in Whitfield's ointment Ciclopirox - (ciclopirox olamine) - is a hydroxypyridone antifungal that interferes with active membrane transport, cell membrane integrity, and fungal respiratory processes. (wikipedia.org)
  • Miltefosine disrupts fungal cell membrane dynamics by interacting with ergosterol Apart from side-effects like liver damage or affecting estrogen levels, many antifungal medicines can cause allergic reactions in people. (wikipedia.org)
  • The chains act as anchors on the fungal cell membrane to help facilitate antifungal activity. (wikipedia.org)
  • Candidiasis
  • An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. (wikipedia.org)
  • ergosterol
  • Since ergosterol and cholesterol have sufficient structural differences, most antifungal agents targeted to ergosterol binding or biosynthesis does not cross-react with host cells. (hindawi.com)
  • Synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation, which prevents conversion of lanosterol to ergosterol, thereby disrupting cellular membranes. (medscape.com)
  • spectrum
  • Caspofungin, micafungin, and anidulafungin are semisynthetic echinocandin derivatives with clinical use due to their solubility, antifungal spectrum, and pharmacokinetic properties. (wikipedia.org)
  • therapeutic
  • Cutting-edge and highly practical, Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists, and molecular biologists the productive tools they need today in order to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections. (springer.com)
  • Polylysine-based nanoparticles have also been shown to passively accumulate in the injured sites of blood vessle after stroke due to incorporation into newly formed thrombus, which offers a new way to deliver therapeutic agents specifically to the sites of injury after vascular damage. (wikipedia.org)
  • Aspergillosis
  • The adoption of DNA sequence-based analysis of critical genes such as β-tubulin and calmodulin is likely to expand the number of case reports of this and other cryptic agents of aspergillosis. (wikipedia.org)
  • metabolites
  • Definition : Heteroorganic entities that are plant metabolites which have significant antifungal properties. (ebi.ac.uk)
  • Epicoccum nigrum produces a variety of biomedically and industrially useful metabolites, including important antifungal agents and pigments, including: flavipin, epicorazines A and B, epirodin, epicocconone, and a variety of carotenoid pigments. (wikipedia.org)
  • therapy
  • Antifungal therapy should be started immediately after necessary cultures have been obtained from all suspected sites of infection. (medscape.com)
  • In severe cases, treatment is quite complex and involves a combination of antifungal drug therapy and surgical excision. (wikipedia.org)
  • species
  • The antifungal effect of Sphagnum extract was tested by the disk-diffusion method on the spores of seventeen fungal species. (queensu.ca)
  • Fonsecaea pedrosoi is a fungal species in the family Herpotrichiellaceae, and the major causative agent of chromoblastomycosis. (wikipedia.org)
  • It is a biocontrol antifungal agent active against brown rot in stone fruit, caused the species Monilinia laxa and Monilinia fructigena. (wikipedia.org)
  • pigments
  • Geomyces pannorum has been identified as an agent of disfigurement of pigments used in the 15,000-year-old paintings on the walls of the Lascaux caves of France. (wikipedia.org)