Antifungal agent ketoconazole. Medical search. Frequent questions

Of the azole group of antifungal agents, ketoconazole appears to be antifungal agent of choice, although isolated reports of successful treatment with itraconazole exist. (medscape.com)
Itraconazole is a triazole antifungal agent known to be a potent inhibitor of the cytochrome P-450-dependent synthesis of ergosterol in vitro. (medscape.com)
However, ketoconazole has largely been replaced as a first-line systemic antifungal medication by other azole antifungal agents, such as itraconazole, because of ketoconazole's greater toxicity, poorer absorption, and more limited spectrum of activity. (wikipedia.org)
The oral drugs currently available in Australia for the treatment of cutaneous fungal infections include griseofulvin, ketoconazole, fluconazole, itraconazole and terbinafine. (infectiontalk.net)
Ketoconazole cream is an antifungal medication in the same family of drugs as fluconazole (Diflucan), itraconazole (Sporanox), and miconazole (Micatin, Monistat). (lyotomachida.net)

Antifungal agents such as fluconazole (Diflucan) are sometimes prescribed to treat fungal infections, of which Candida is one kind. (mpkb.org)
Antifungal therapy for C. auris infections is currently limited due to widespread resistance to fluconazole and amphotericin B and increasing resistance to the front-line drug echinocandin. (bvsalud.org)

Ketoconazole shampoo in conjunction with an oral 5α-reductase inhibitor such as finasteride or dutasteride has been used off label to treat androgenic alopecia. (wikipedia.org)
Limited clinical studies suggest ketoconazole shampoo used either alone or in combination with other treatments may be useful in reducing hair loss in some cases. (wikipedia.org)
Washing your scalp with an anti-dandruff shampoo that contains antifungal agents, such as ketoconazole, ciclopirox, or tea tree oil, may be helpful. (healthline.com)
Nizoral Anti-Dandruff Shampoo with 1% Ketoconazole is a clinically-proven dandruff treatment shampoo that can help relieve itchy and flaky scalps. (socialmoms.com)
Ketoconazole shampoo, for example, is stronger and irritating but is often more effective at killing fungus than zinc pyrithione. (exposedskincare.com)
KETOCIP Shampoo a liquid for topical application, containing the broad-spectrum synthetic antifungal agent Ketoconazole in a concentration of 1% as an aqueous suspension. (shopclues.com)
Ketoconazole cream, sometimes referred to as "K-cream," is a topical cream or shampoo that may reduce sun flare or light-driven immunopathology. (mpkb.org)
For some of the most severely sun sensitive, ketoconazole cream or shampoo seems to work better for preventing or reducing sun flare symptoms, but for others, zinc oxide (not an anti-fungal) seems to work better. (mpkb.org)
maintenance antifungal regimens (oral ketoconazole once weekly or ketoconazole 2% shampoo 2 or 3 times weekly) may be used as prevention. (contemporarypediatrics.com)
Prominent & Leading Manufacturer from Ahmedabad, we offer terbinafine 250 mg tablets, ketonix shampoo (ketoconazole shampoo), ketoconazole cetrimide (soap), coal tar & salicylic acid shampoo, isotretinoin 20 mg capsules and hydroquinone tretinoin mometasone furoate cream. (schwitzbiotech.net)
Ketonix Shampoo is a Ketoconazole Shampoo with Zinc Pyrithione (ZTPO) for Remove Dandruff, Itchy scalp, Seborrheic, Dermatitis. (schwitzbiotech.net)
Tarlic Shampoo Controls Symptoms Of Psoriasis,Dandruff And Other Fungal Infection Its Contents Like Coaltar And Salicylic Acid Are Anti Septic ,Anti Bacterial And Antifungal Agents.Coaltar Known As Its Antiseptic Qualities. (schwitzbiotech.net)
Tell your doctor if you have the following symptoms while using the ketoconazole 2% shampoo: hair discoloration, abnormal hair texture, removal of the curl from permanently waved hair, hair loss, itching, burning sensation of the skin, or blistering, peeling, or redness of the skin. (lyotomachida.net)
Prescription ketoconazole shampoo is usually applied one time to treat the infection. (lyotomachida.net)
If you are using over-the-counter ketoconazole shampoo to treat dandruff, your symptoms should improve during the first 2 to 4 weeks of your treatment. (lyotomachida.net)
Ketoconazole topical is available as a cream, gel, and as a shampoo. (lyotomachida.net)

Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. (wikipedia.org)
The oral antifungal ketoconazole (Nizoral) should not be used to treat skin and nail fungal infections, the FDA cautioned on Thursday. (lyotomachida.net)

Imidazole antifungal agents appear to be the agents of choice. (medscape.com)
Reportedly, imidazole antifungal agents are variably effective in the treatment of eumycetoma when they are used alone or in conjunction with surgical therapy. (medscape.com)
Ketoconazole is a synthetic imidazole antifungal agent. (medscape.com)
It is an imidazole broad-spectrum antifungal agent. (medscape.com)
It is an imidazole compound and like other antifungals of this group, has a wide spectrum of use. (lyotomachida.net)

Thus patients coadministered with inhibitors of CYP3A4 such as macrolide antibiotics (e.g., erythromycin), azole antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritanovir) while receiving Buprenex should be carefully monitored and dosage adjustment made if warranted. (druglib.com)

The novel classes of antifungal agents, the lipid formulation of amphotericins, and the echinocandins have demonstrated unique antifungal activity against the resistant Candida biofilms, providing a breakthrough in the treatment of life-threatening invasive systemic mycoses. (cdc.gov)
Compare and contrast the mechanisms of action of various classes of antifungal agents. (ashp.org)

Preliminary biochemical and biophysical assays and antifungal susceptibility testing with a variety of classical antifolates were also performed, highlighting the enzyme-inhibition rates and the inhibition of yeast growth. (bvsalud.org)
ABSTRACT This study was carried out from October 2003 to March 2007 to investigate susceptibility patterns to antifungals of Candida strains isolated from 410 immunocompromised patients in Shiraz, Islamic Republic of Iran. (who.int)
Susceptibility of the isolates to antifungal agents was determined using the reference broth microdilution method. (who.int)
The objective of this study was to determine the in vitro antifungal susceptibility pattern of Candida albicans in HIV and AIDS patients to eight antifungal agents in the Nylon Health District of Douala in Cameroon. (bvsalud.org)
The disk diffusion method was used for antifungal susceptibility testing using eight antifungal agents. (bvsalud.org)

Clotrimazole is a broad-spectrum antifungal agent that inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells. (medscape.com)

It is a broad-spectrum agent known to be a potent inhibitor of the cytochrome P-450 3A4 enzyme system in vitro. (medscape.com)
It is a synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation, which prevents conversion of lanosterol to ergosterol, thereby disrupting cellular membranes. (medscape.com)
Ketoconazole is an orally administered broad-spectrum antifungal agent that acts through the inhibition of the steroid synthetic pathways. (mssm.edu)
3. Which antifungal drug is most effective with a broad spectrum? (remixeducation.in)

Alternatives include other azole antifungals but also the allylamine terbinafine and the hydroxypyridone antifungal agent ciclopirox olamine. (unboundmedicine.com)
If you are allergic to any of the ingredients listed (Ingredients: Ketoconazole, Terbinafine, DMSO, Hydrocortisone, Biotin) please stop the compound, reach out to us and contact your doctor. (struthealth.com)

Clinical experience with a new amikacin antibiotic, miconazole nitrate, with a fixed combination with ketoconazole as a topical antifungal agent has shown that there is no evidence of miconazole resistant mutants. (computerwise.com)

First made in 1977, ketoconazole was the first orally-active azole antifungal medication. (wikipedia.org)
Ketoconazole is used orally in dosages of 200 to 400 mg per day in the treatment of superficial and deep fungal infections. (wikipedia.org)
Ketoconazole is a new, orally effective, antifungal agent. (lyotomachida.net)

Ketoconazole has activity against many kinds of fungi that may cause human disease, such as Candida, Histoplasma, Coccidioides, and Blastomyces (although it is not active against Aspergillus), chromomycosis and paracoccidioidomycosis. (wikipedia.org)
Candida species, including the novel opportunistic pathogen Candida dubliniensis , are now emerging as major agents of nosocomial infections. (cdc.gov)
Biofilm-associated Candida show uniform resistance to a wide spectrum of the currently available conventional antifungal agents, which implies that antimicrobial drugs that specifically target biofilm-associated infections are needed. (cdc.gov)
Although C. albicans is the predominant etiologic agent of candidiasis, other Candida species that tend to be less susceptible to the commonly used antifungal drugs such as C. krusei , C. glabrata , C. lusitaniae , and the newest Candida species, C. dubliniensis, have emerged as substantial opportunistic pathogens ( 10 ) . (cdc.gov)
If Candida albicans is present, topical antifungal medications can be used when the condition is symptomatic (eg, glossopyrosis). (medscape.com)
infungihavebeenusedinthedevelop- clinicalsamples(blood,urine,oesopha- these recommended end-points for mentofcurrentlyavailableantifungal geal,oropharyngeal,vagina,biopsyand azolesarethelowestdrugconcentra- agents[1].Resistanceamong Candida broncho-alveolarlavage)wereexam- tionwithaprominentdecreaseintur- spp.toantifungaldrugsisanincreas- inedforfungalinfectionusingroutine bidity(inhibitoryconcentrationthat ingprobleminimmunocompromised methods.The Candida speciesisolated gives50%growthreduction),whilefor patients[2]. (who.int)

Ketoconazole possesses the strongest in vitro activity against Malassezia, and represents the treatment of choice for topical therapy of pityriasis versicolor. (unboundmedicine.com)
The yeasts were identified by MALDI-TOF mass spectrometry (MS). For all isolates, we performed phospholipases and proteinases assays, in vitro adherence to buccal epithelial cells (BEC), minimum inhibitory concentration of antifungal drugs and determined the cytokine profile by Cytometric Bead Array flow citometry assay. (biomedcentral.com)
Finally, many studies have demonstrated the promising antifungal action of MFS in vitro, but there is little or no data on antifungal activity in vertebrate animal models and clinical trials, so have a need to develop more research for the repositioning of MFS as an antifungal therapy. (bvsalud.org)

Moreover, the increased incidence of antifungal-resistant isolates and the emergence of intrinsically resistant species raise concerns about seeking alternatives for efficient antifungal therapy. (bvsalud.org)

It's a well-known ingredient in anti-dandruff shampoos and creams and has been lauded for its antifungal and antibacterial properties. (exposedskincare.com)

Topically administered ketoconazole is usually prescribed for fungal infections of the skin and mucous membranes, such as athlete's foot, ringworm, candidiasis (yeast infection or thrush), jock itch, and tinea versicolor. (wikipedia.org)
EDURANT is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-naïve patients 12 years of age and older and weighing at least 35 kg with HIV-1 RNA less than or equal to 100,000 copies/mL ( 1.1 ). (guidelinecentral.com)
Ketoconazole topical is also used to treat a fungal infection called pityriasis, which causes scaly discolored patches on the skin of the neck, chest, arms, or legs. (lyotomachida.net)

Specifically, ketoconazole has been shown to inhibit cholesterol side-chain cleavage enzyme, which converts cholesterol to pregnenolone, 17α-hydroxylase and 17,20-lyase, which convert pregnenolone into androgens, and 11β-hydroxylase, which converts 11-deoxycortisol to cortisol. (wikipedia.org)
Like the other antifungals, ketoconazole cream may inhibit bacteria die-off, especially in the skin areas where it has the highest concentration. (mpkb.org)

Seborrhoeic dermatitis is best treated with topical medication, including topical corticosteroids and antifungal agents like ketoconazole or sertaconazole. (unboundmedicine.com)
This medication belongs to a class of drugs known as antifungals. (schwitzbiotech.net)
You should not breastfeed while using this medication since it contains topical ketoconazole. (struthealth.com)

Medicated shampoos with ingredients like zinc pyrithione, ketoconazole, or selenium sulfide target underlying causes of dandruff. (blacksoaphaven.com)
Antifungal shampoos containing ingredients like ketoconazole or selenium sulfide can help control the overgrowth of Malassezia. (blacksoaphaven.com)
Ketoconazole and selenium sulphide shampoos can be used as body washes left on the skin for up to 15 minutes. (skinhealthinfo.org.uk)

Oral ketoconazole has various contraindications, such as concomitant use with certain other drugs due to known drug interactions. (wikipedia.org)
Although reportedly successful, the agents listed above (with the exception of treatment of oral candidiasis) are used off label and their application should be limited to selected cases with close monitoring. (medscape.com)
These agents are used to treat oral candidiasis in association with hairy tongue. (medscape.com)
Summary Cutaneous fungal infections are usually treated topically, but nail and hair infections, widespread dermatophytosis and chronic non-responsive yeast infections are best treated with oral antifungal drugs. (infectiontalk.net)
however, these agents may not penetrate deep enough into the follicles to act on the organism, and oral agents may be required. (contemporarypediatrics.com)
If oral antifungals are given for more than 6 weeks, liver enzyme levels must be monitored. (contemporarypediatrics.com)
2. Which antifungal drug is available as a troche, for treatment of oral candidiasis? (remixeducation.in)

Topical ketoconazole is also used as a treatment for dandruff (seborrheic dermatitis of the scalp) and for seborrheic dermatitis on other areas of the body, perhaps acting in these conditions by suppressing levels of the fungus Malassezia furfur on the skin. (wikipedia.org)
The main active ingredient, ketoconazole 1%, binds to the hair's natural protein to kill dandruff, leaving your scalp flake-free and your hair manageable and shiny. (socialmoms.com)
Tea tree oil is naturally antibacterial and antifungal, making it ideal for combatting dandruff and other scalp issues. (socialmoms.com)
Tea tree oil is a highly effective natural remedy for dandruff due to its antifungal and antimicrobial properties. (blacksoaphaven.com)
It has natural antifungal properties that help combat the underlying causes of dandruff, such as yeast overgrowth on the scalp. (blacksoaphaven.com)

It was speculated that antifungal properties of ketoconazole reduce scalp microflora and consequently may reduce follicular inflammation that contributes to alopecia. (wikipedia.org)

Ketoconazole topical is used to treat fungal infections of the skin such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin). (lyotomachida.net)
How is ketoconazole used to treat jock itch? (lyotomachida.net)

A person should not take Stendra with nitrates or any strong CYP3A4 inhibitors, such as ketoconazole or ritonavir. (burlingtondentalcentre.com)

There was a statistically significant difference in the sensitivity pattern of antifungal agents with respect to the site of isolation of the organism (P0.05). (bvsalud.org)

Taken by mouth it is a less preferred option and only recommended for severe infections when other agents cannot be used. (wikipedia.org)
As a facultative pathogenic microorganism, Malassezia represents the causative agent both of superficial cutaneous infections and of blood stream infections. (unboundmedicine.com)
Fungal biofilm-associated infections are frequently refractory to conventional therapy because of resistance to antimicrobial agents. (cdc.gov)
Antifungal agents offer critically ill or immunocompromised patients multiple treatment options against invasive fungal infections. (clpmag.com)
It combines the benefits of chlorhexidine gluconate and ketoconazole, two powerful antiseptic and antifungal agents, to help treat and prevent skin infections in dogs and cats. (healthypets.com)
The addition of ketoconazole enhances ChloraSeb's effectiveness against fungal infections, such as yeast (Malassezia) overgrowth. (healthypets.com)
The usual approach to the management of cutaneous infections in immuno competent patients is to treat with topical agents. (infectiontalk.net)
4. Which antifungal agent is NOT indicated for use in fungal infections of the skin and nails? (remixeducation.in)

Most patients are treated with topical antifungal agents that are applied to the skin. (skinhealthinfo.org.uk)

The effects of Buprenex, particularly drowsiness, may be potentiated by other centrally acting agents such as alcohol or benzodiazepines. (druglib.com)

While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it potently inhibits the activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as testosterone and cortisol. (wikipedia.org)
Is ketoconazole cream 2% a steroid? (lyotomachida.net)
Many people will be prescribed ketoconazole cream and a steroid at the same time because they can be both be used to treat similar skin conditions. (lyotomachida.net)

However, because of their ability to act as a substrate or inhibitor of cytochrome P450 (CYP) metabolic enzymes, antifungal agents can also result in several clinical challenges, including interactions with coadministered drugs, concentration-dependent toxicity, and variations in drug absorption and?metabolism. (clpmag.com)
Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents. (clpmag.com)
We report a case of prostatic cancer in which ketoconazole resulted in rapid and sustained reduction in serum androgens as well as rapid induction of a clinical remission. (mssm.edu)

Zinc pyrithione is commonly recommended for conditions like fungal acne due to its antifungal properties. (exposedskincare.com)

The list below does not include all possible drug interactions with ketoconazole cream. (infectiontalk.net)

ChloraSeb contains chlorhexidine gluconate, a potent antiseptic agent that helps eliminate bacteria and other microorganisms on the skin's surface. (healthypets.com)
The combined action of chlorhexidine gluconate and ketoconazole makes ChloraSeb an excellent solution for treating a wide range of skin issues caused by bacteria and fungi. (healthypets.com)
This is different from other infectious agents such as bacteria. (ashp.org)

Sulfates: These are harsh cleansing agents commonly found in shampoos. (blacksoaphaven.com)

Available antifungal agents have high toxicity and pharmacodynamic and pharmacokinetic limitations. (bvsalud.org)

Cerilliant's solution certified reference materials offer a full selection of internal standards for quantitation of the most common antifungal drugs in serum or plasma by mass spectrometry-based analytical methods. (clpmag.com)
Introduction to antifungal drugs. (clpmag.com)
By increasing levels of 25-D and therefore inhibiting immunopathology, long-term use of antifungal drugs may delay progress on the Marshall Protocol (MP). (mpkb.org)
This list does not contain all drugs that may interact with ketoconazole. (infectiontalk.net)
Before taking ketoconazole, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. (infectiontalk.net)

Based on these antiandrogen and antiglucocorticoid effects, ketoconazole has been used with some success as a second-line treatment for certain forms of advanced prostate cancer and for the suppression of glucocorticoid synthesis in the treatment of Cushing's syndrome. (wikipedia.org)

The authors concluded tics, antifungals, antivirals, antihistamines, that health care professionals need to give local anaesthetics, emollients, keratolytics, patients more information about their topi- antiparasitics and topical corticosteroids. (who.int)

Regular investigations into antifungal resistance in medical centres is highly recommended as this will result in more efficient management of invasive candidiasis in immunocompromised patients. (who.int)

Ketoconazole has additionally been used, in lower dosages, to treat hirsutism and, in combination with a GnRH analogue, male-limited precocious puberty. (wikipedia.org)
In some cases, a stronger antifungal agent like ketoconazole might be required to treat the affected area effectively. (exposedskincare.com)

Describe side effects commonly associated with each of the antifungal classes. (ashp.org)

The deuterium or carbon-13 substitutions of each internal standard conserve a minimum [M+3] separation from the unlabeled drug in the major ion fragments used in LC-MS/MS antifungal TDM applications and metabolism studies. (clpmag.com)
Snozek C. Antifungal drug monitoring: why, when, and how to measure serum concentrations. (clpmag.com)
1. Which antifungal drug is the most toxic drug and is administered intravenously? (remixeducation.in)
In this context, we review literature data addressing the potential action of miltefosine (MFS), an anti-Leishmania and anticancer agent, as a repositioning drug for antifungal treatment. (bvsalud.org)
Describe the drug interaction potential for each class of antifungals. (ashp.org)

Ketoconazole was patented in 1977 by Belgian pharmaceutical company Janssen, and came into medical use in 1981. (wikipedia.org)

Microscopic tissue reactions may be primarily suppurative or granulomatous depending on the specific causative agent. (msdmanuals.com)

While some patients have reported feeling better after taking antifungal agents, antifungals interfere with immune function. (mpkb.org)

Topical agents are listed in Table 1. (medscape.com)

Ketoconazole has been used to prevent the testosterone flare at the initiation of GnRH agonist therapy in men with prostate cancer. (wikipedia.org)
At high doses in humans ketoconazole can lower rapidly serum testosterone and maintain it in the castrate range with frequent administration. (mssm.edu)

Ketoconazole has fungistatic activity. (medscape.com)
Because Buprenex is metabolized by the liver, the activity of Buprenex may be increased and/or extended in those individuals with impaired hepatic function or those receiving other agents known to decrease hepatic clearance. (druglib.com)
continued antifungal activity seen even after the antifungal agent has been removed. (ashp.org)

Anatomy1

Organisms19

Diseases15

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes6

Health Care1

Itraconazole5

Fluconazole2

Shampoo16

Nizoral2

Imidazole5

Erythromycin1

Classes of antifungal agents2

Susceptibility5

Clotrimazole1

Broad-spectrum4

Terbinafine2

Miconazole1

Orally3

Candida6

Vitro3

Isolates1

Anti-dandruff1

Infection3

Inhibit2

Medication3

Selenium3

Oral7

Dandruff5

Scalp1

Jock itch2

Ritonavir1

Organism1

Infections8

Treated with topical1

Benzodiazepines1

Steroid3

Clinical3

Zinc1

Interactions1

Bacteria3

Shampoos1

Toxicity1

Drugs5

Synthesis1

Antihistamines1

Candidiasis1

Treat2

Commonly1

Drug5

Janssen1

Causative agent1

Immune1

Topical Agents1

Testosterone2

Activity3