• A study comparing different prophylactic strategies concluded that dexamethasone with or without ondansetron (Zofran), ideally administered intraoperatively, should be used as initial agents. (aafp.org)
  • You refer to a recent study that recommends 4 mg of dexamethasone and 4 mg of ondansetron for prevention of postoperative nausea and vomiting, and recommend that she receive these antiemetics intraoperatively. (aafp.org)
  • Both groups received TIVA + epidural anesthesia, 4 mg of dexamethasone after induction, and 4 mg of ondansetron at the end of surgery. (apsf.org)
  • Cisplatin-based highly emetogenic chemotherapy (HEC) regimens, which are key treatments for some of malignant tumors, were conventionally administered after an antiemetic premedication with dexamethasone plus a 5-hydroxytryptamine 3 receptor antagonist (5-HT 3 RA) such as ondansetron or granisetron. (medscape.com)
  • Randomized controlled studies have shown that the addition of aprepitant to dexamethasone and a 5-HT 3 RA can achieve better CINV control when compared with the doublet antiemetic therapy. (medscape.com)
  • Pregnant women ≥18 years of age with NVP starting antiemetic therapy with promethazine, prochlorperazine, metoclopramide, or ondansetron at ≤ 16 weeks gestational age were eligible. (biomedcentral.com)
  • Given concerns for the additive sedative and extrapyramidal effects of many anti-emetics when coadministered with opioids, the routine use of prophylactic antiemetics likely causes far more adverse effects relative to episodes of vomiting prevented.2-4 The existing research is limited in terms of the antiemetics used (mostly metoclopramide), however more recent studies have evaluated ondansetron as well. (aaem.org)
  • At study commencement, participants will be given baseline prescriptions for antiemetics (metoclopramide 10mg, ondansetron 8mg) and pancreatic enzyme replacement therapy (PERT) (Creon, 25,000IU) to ensure proactive nutrition impact symptom management is feasible. (who.int)
  • Ondansetron and granisetron can be taken orally or as injections. (epnet.com)
  • Introduction: The aim of the study was to compare the antiemetic effects of intravenous ondansetron 80 mcg/kg and granisetron 40 mcg/kg in a double blind placebo controlled manner for prevention of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
  • Group A (n=30) received 40mcg/kg granisetron intravenously, group B (n=30) received 80mcg/kg ondansetron intravenously and group C (n=30) received 5 ml of normal saline by the same route 2 minutes before induction of general anaesthesia. (ispub.com)
  • Results: The incidence of nausea and vomiting over a period of 24 hour were found in 20% of patients who had received granisetron, 45% of patients who had received ondansetron and 77.5% of patients who had received placebo. (ispub.com)
  • Conclusion: It was concluded that granisetron is more effective than ondansetron and placebo in controlling postoperative nausea & vomiting after laparoscopic gynecological surgery. (ispub.com)
  • The newer antiemetics used for the prevention and treatment of PONV are 5HT 3 receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron) are devoid of these side effects. (ispub.com)
  • The use of these 5-HT 3 receptor antagonists have been shown to improve patients' satisfaction, decrease recovery and discharge times and reduced an unanticipated hospital admission especially when they are used prophylactically 25 26 .This prospective, randomized, double blind placebo controlled study was undertaken to compare the efficacy of granisetron and ondansetron in prevention PONV in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
  • These patients received 40 μg/kg granisetron in group A, Ondansetron (80 μg/kg) in group B and 0.9% saline in group C two minutes prior to induction of anesthesia. (ispub.com)
  • These agents include dolasetron, ondansetron, and granisetron. (medscape.com)
  • In this paper, we will report the results of randomized phase III study to evaluate the efficacy of palonosetron versus granisetron in the standard triplet antiemetic therapy for cisplatin-based HEC. (medscape.com)
  • These highlights do not include all the information needed to use ONDANSETRON HYDROCHLORIDE TABLETS, and ONDANSETRON ORALLY DISINTEGRATING TABLETS safely and effectively. (nih.gov)
  • The objective was to separately compare effectiveness of 1.25 mg of intravenous (IV) droperidol and 8 mg of IV ondansetron with 0.9% saline placebo for adult emergency department (ED) patients with nausea. (nih.gov)
  • Should Antiemetics be Given Prophylactically with Intravenous Opioids While Treating Acute Pain in the Emergency Department? (aaem.org)
  • You should not start or change the dosage of Ondansetron or any medications without first talking to your doctor. (seagullindia.com)
  • The medications with the highest potential for actionability were analgesics, the antiemetic ondansetron, and antidepressants. (cdc.gov)
  • The first oral dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. (rxwiki.com)
  • The dose of ondansetron was can i get lotensin over the counter 2 mg for children who weighed between 17 lb 10 oz and 33 lb (15 kg) and 8 mg for those who weighed more than 66 lb. (seagullindia.com)
  • A new, simple, rapid, sensitive and specific isocratic RP-LC-UV method was developed and validated for the determination of ondansetron in pharmaceutical dosage forms of orally disintegrating tablets, oral solution and injection. (springer.com)
  • The method was successfully applied for analysis of ondansetron in the presence of excipients in commercially available pharmaceutical dosage forms. (springer.com)
  • The objective of this study was to evaluate the role of serotonin receptor subunit HTR3A and HTR3B genotype with NVP severity and antiemetic efficacy. (biomedcentral.com)
  • Ondansetron prevents nausea and vomiting by blocking the body's production of serotonin. (rxwiki.com)
  • Ondansetron belongs to a group of drugs called serotonin 5-HT3 antagonists, which block serotonin, a natural chemical in the body, from causing nausea and vomiting. (rxwiki.com)
  • If concomitant use of ondansetron with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome. (nih.gov)
  • Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. (hdkino.org)
  • The objective of this study was to evaluate the association between response to antiemetics in the treatment of NVP and genetic polymorphisms in the serotonin receptor subunit genes HTR3A and HTR3B . (biomedcentral.com)
  • Several dopamine antagonist antiemetics commonly used in pregnancy also act as weak serotonin receptor antagonists. (biomedcentral.com)
  • Many antiemetics are substrates for serotonin receptors and transporters-which are known to have clinically relevant genetic polymorphisms. (biomedcentral.com)
  • Exclusion criteria included a history of allergy to drug(s), pregnancy & lactation, menstruation, vomiting or retching within 24 h before the operation, administration of antiemetic or psychoactive medication within 24 h before surgery, active alcohol or drug abuse. (ispub.com)
  • Severity of NVP was captured (using Pregnancy Unique Quantification of Emesis (PUQE) and Quality of Life (QOL) tools) upon enrollment and after one week of antiemetic therapy. (biomedcentral.com)
  • Additionally, the 5-HT 3 receptor antagonist ondansetron is an often used antiemetic in pregnancy. (biomedcentral.com)
  • To reduce nausea and vomiting, the primary team initially ordered intramuscular (IM) trimethobenzamide, later substituted ondansetron, and then reached out to the MFM consultant for advice on antiemetic use in pregnancy. (ahrq.gov)
  • Ondansetron is commonly used to treat HG, but studies are urgently needed to determine whether it is safer and more effective than using first-line antiemetics. (nature.com)
  • Commonly used older, traditional antiemetics for PONV were known to cause adverse effects such as dry mouth, dysphoria, sedation, hypotension, tachycardia, extra-pyramidal reactions, dystonic effects and restlessness leading to patient dissatisfaction 22 . (ispub.com)
  • This study suggests that adding atypical antipsychotic medication like olanzapine, which targets multiple PONV receptors, to commonly used intraoperative antiemetic regimens can substantially reduce PONV and alleviate the associated challenges for both patients and healthcare systems. (apsf.org)
  • Ondansetron is a selective 5-HT3 receptor antagonist. (empr.com)
  • Your healthcare provider may prescribe a medicine called an antiemetic, such as trimethobenzamide, to help prevent nausea and vomiting. (rxlist.com)
  • Patients should be informed that ondansetron orally disintegrating tablets contain phenylalanine (a component of aspartame). (nih.gov)
  • [ 3 , 4 ] Current antiemesis guidelines from multiple organizations [American Society of Clinical Oncology (ASCO), Multinational Association of Supportive Care in Cancer/European Society for Medical Oncology (MASCC/ESMO), and National Comprehensive Cancer Network (NCCN)] recommend aprepitant-containing triplet regimens as the standard antiemetic prophylaxis for patients receiving HEC. (medscape.com)
  • Aprepitant, a neurokinin-1 (NK-1) receptor antagonist, and palonosetron, a second-generation 5-HT 3 RA, are two recently introduced antiemetic agents expected to improve control of CINV. (medscape.com)
  • [ 8 ] In patients receiving moderately emetogenic chemotherapy (MEC), better CINV control was obtained with palonosetron than with a first-generation 5-HT 3 RA, [ 9 ] which supports current guideline recommendations for palonosetron use as a part of antiemetic premedication for MEC. (medscape.com)
  • Ondansetron is an antiemetic agent that is used for the treatment of nausea and vomiting caused by anticancer therapies or surgeries. (biesterfeld.com)
  • Ondansetron is a prescription medication used to prevent nausea and vomiting caused by chemotherapy or surgery. (rxwiki.com)
  • Ondansetron is an anti-nausea medication used to prevent nausea and vomiting caused by cancer chemotherapy . (hdkino.org)
  • Inhaled saline solution and 4 mg oral ondansetron. (bmj.com)
  • Inhaled isopropyl alcohol and 4 mg oral ondansetron, included to counteract subjects guessing that the inhaled saline was the placebo. (bmj.com)
  • High-risk PONV patients often require multiple antiemetics, including propofol anesthesia, as per consensus guidelines. (apsf.org)
  • The study found a 60% reduction in PONV incidence in the olanzapine group during the first 24 hours (p=0.008), even though both groups received the recommended multimodal antiemetic regimen. (apsf.org)
  • Ondansetron and apomorphine (Apokyn) should not be taken at the same time as there is a risk of dangerously low blood pressure and loss of consciousness. (rxwiki.com)
  • ECG changes including QT interval prolongation has been seen in patients receiving ondansetron. (rxwiki.com)
  • Using ondansetron after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus). (rxwiki.com)
  • Ondansetron can cause headaches, tiredness, and constipation. (rxwiki.com)
  • Patients known to have hypersensitivity (e.g., anaphylaxis) to ondansetron or any components of the formulation. (nih.gov)
  • The majority of women with NVP can be managed with dietary and lifestyle changes, but more than one-third of patients experience clinically relevant symptoms that may require fluid and vitamin supplementation and/or antiemetic therapy such as, for example, combined doxylamine/pyridoxine, which is not teratogenic and may be effective in treating NVP. (nature.com)
  • while in group B, 18 patients (45%) and in group C, 31 patients (77.5%) received antiemetics. (ispub.com)
  • Consider antiemetics in patients with persistent vomiting. (medscape.com)
  • HTR3B and HTR3A gene variants may contribute to variability in response to antiemetic therapy for NVP. (biomedcentral.com)
  • Ondansetron can cause serious side effects. (rxwiki.com)
  • This is not a complete list of ondansetron side effects. (rxwiki.com)
  • This page from Great Ormond Street Hospital (GOSH) explains what ondansetron is, how it is given and some of the possible side effects. (seagullindia.com)
  • In addition to antiemetic effects, has advantage of augmenting hypoxic ventilatory response, acting as a respiratory stimulant at high altitude. (medscape.com)
  • Ondansetron is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional. (rxwiki.com)
  • If such symptoms occur, discontinue ondansetron and initiate supportive treatment. (nih.gov)