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  • decrease
  • These include a slow onset of action, variable dose requirements reflecting, at least in part, common genetic polymorphisms that influence their metabolism, differences in dietary intake of vitamin K, and numerous drug-drug interactions that increase or decrease their anticoagulant effect. (ahajournals.org)
  • reviews
  • This chapter reviews commonly used anticoagulant regimens used for PCI with tailored guidance for the acute setting, in particular primary PCI for ST-elevation myocardial infarction (STEMI). (springer.com)