Anticholinergic autonomic agents. Medical search. Frequent questions

Both BZ and its Iraqi look-alike, Agent 15, are competitive inhibitors of the effects of acetylcholine at the postsynaptic muscarinic receptors in the peripheral and central nervous systems. (medscape.com)
Antimuscarinic agents (also known as muscarinic antagonists), including atropine and hyoscine, block acetylcholine at the muscarinic acetylcholine receptors. (wikipedia.org)
Antinicotinic agents (also known as ganglionic blockers, neuromuscular blockers), including tubocurarine and hexamethonium, block acetylcholine action at nicotinic acetylcholine receptors. (wikipedia.org)
Flavoxate (flay vox' ate) is a synthetic quaternary ammonium anticholinergic which inhibits the muscarinic actions of acetylcholine on autonomic nerve endings, decreasing the smooth muscle tone of bladder and gastrointestinal tract. (nih.gov)
Para sympatholytic agents, also known as anticholinergics or muscarinic receptor antagonists, are a diverse group of drugs that exert their pharmacological effects by blocking the actions of acetylcholine at muscarinic receptors [ 1 ]. (scitechnol.com)
Para sympatholytic agents exert their effects by competing with acetylcholine for binding to muscarinic receptors [ 7 ]. (scitechnol.com)
Once bound, these agents prevent the activation of downstream signaling pathways, effectively blocking the actions of acetylcholine. (scitechnol.com)
BTX-A inhibits acetylcholine release at the neuromuscular junction and in cholinergic autonomic neurons. (comparethetreatment.com)

Cardiovascular Drugs / Antilipemic Agents / HMG-CoA Reductase Inhibitors (i.e. (tevausa.com)
Approximately 300 years later, the US Army explored several classes of drugs, as well as noise, microwaves, and photostimulation, and found none to be as promising incapacitating agents as the anticholinergics. (medscape.com)
The unpredictable behavior incurred by psychedelic agents (ie, lysergic acid diethylamide [LSD], phencyclidine [PCP]) led to an early halt in the testing of that particular class of drugs. (medscape.com)
According to their site of actions, cholinergic blocking drugs can be classified into two general types - antimuscarinic and antinicotinic agents. (wikipedia.org)
For example, antispasmodic or anticholinergic drugs can help prevent urinary incontinence . (diabetesprohelp.com)
Review Anticholinergic drugs versus other medications for overactive bladder syndrome in adults. (nih.gov)

Incapacitating agent" is a military term used to denote an agent that temporarily and nonlethally impairs the performance of an enemy by targeting the central nervous system (CNS). (medscape.com)
In the peripheral nervous system, this inhibition is observed in the smooth muscle, autonomic ganglia, and exocrine glands. (medscape.com)
The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
Diabetic autonomic neuropathy affects the autonomic nervous system, the nerves that control body functions. (diabeteshealthmatters.com)
Autonomic neuropathy is a symptom complex associated with the dysfunction of the autonomic nervous system that is responsible for the control of everyday body functions including blood pressure , heart rate, sweating , bowel and bladder function. (symptoma.mt)
These agents have found wide application in various medical fields due to their ability to modulate the parasympathetic nervous system [ 2 ]. (scitechnol.com)
These agents have broader effects on various tissues and systems regulated by the parasympathetic nervous system. (scitechnol.com)
Para sympatholytic agents have the ability to cross the blood-brain barrier, leading to various central nervous system effects. (scitechnol.com)
Usually, the autonomic nervous system regulates blood pressure (BP) and increases blood vessel constriction upon standing to keep BP constant. (msadownunder.org.au)
In MSA, disturbances in the autonomic nervous system leads to neurogenic orthostatic hypotension (nOH), defined as a drop in systolic BP ≥ 14 mmHg or in diastolic BP ≥ 6 mmHg. (msadownunder.org.au)

Medications can also help manage the troublesome symptoms of autonomic neuropathy. (diabetesprohelp.com)
The symptoms of autonomic neuropathy are different depending on the area of the body that has been affected. (diabetesprohelp.com)
Motor examination is also important because a somatic peripheral neuropathy is frequently associated with an autonomic neuropathy. (symptoma.mt)
Training Effects The presence of cardiac autonomic neuropathy (CAN) impairs exercise tolerance and lowers maximal heart rate 4. (symptoma.mt)

[ 1 ] Other sources of anticholinergic toxicity include clinical medicines such as atropine, antihistamines, and tricyclic antidepressants. (medscape.com)
[2] Other conditions that can produce similar symptoms such as neuroleptic malignant syndrome , malignant hyperthermia , anticholinergic toxicity , heat stroke , and meningitis should be ruled out. (wikipedia.org)

autonomic ganglia, which likely increases peripheral vasoconstriction sympathetic nerve fiber transmission. (medscape.com)
Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects. (hhs.gov)

Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a poor quality of life Oxybutynin, also marketed as Ditropan XL, is an anticholinergic medication used for the relief of overactive bladder symptoms that has been optimized for high levels of safety and efficacy since initial FDA approval in 1975. (pharmaoffer.com)
Sometimes, other autonomic symptoms may prevent prior to POTS. (symptoma.mt)
Use as an antipsychotic agent for schizophrenia, psychoses, mania and hypomania, organic brain damage (depending on symptoms). (pillintrip.com)
Appreciate that any patient with foodborne illness may ing suspicious symptoms, disease clusters, and etiologic agents, represent the sentinel case of a more widespread outbreak. (cdc.gov)

Although many experts believe that most terrorists would opt for a lethal form of chemical attack (eg, nerve agent), use of incapacitating agents cannot be discounted. (medscape.com)
Capsaicin cream is an over-the-counter topical agent that has been shown to relieve nerve pain. (diabetesprohelp.com)
used as an anticholinergic for relaxation of smooth muscles in various organs, to increase heart rate by blocking the vagus nerve, and as a local application to the eye to dilate the pupil and to paralyze ciliary muscle for accommodation. (wildliferesearch.com)

Flavoxate is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome. (nih.gov)

Nicotinic receptors are ligand-gated ion channels that present in both parasympathetic and sympathetic ganglions, while the antagonistic effect of antinicotinic agents depend on which system predominates in a particular site. (wikipedia.org)

These agents are useful in cases of difficult bladder emptying. (medscape.com)
Competitive muscarinic receptor antagonist for overactive bladder, but differs from other anticholinergic types because of selectivity for urinary bladder over salivary glands. (medscape.com)

Furthermore, autonomic dysfunction contributes to delayed gastric emptying, putting patients at risk for aspiration of gastric contents. (symptoma.mt)

Moes D (2023) Exploring the Different Subtypes of Para Sympatholytic Agents and their Modes of Action. (scitechnol.com)

These somatic consequences could partly be due to metabolic, immuno-inflammatory, autonomic and hypothalamic-pituitary-adrenal (HPA)-axis dysregulations which have been suggested to be more often present among depressed patients. (biomedcentral.com)

Antimuscarinic and antinicotinic agents can increase heart rate, inhibit secretions, and gastrointestinal motility. (wikipedia.org)

Clinical autonomic research : official journal of the Clinical Autonomic Research Society. (lu.se)

Neurocardiogenic syncope is a self-limiting condition caused by an abnormal or exaggerated autonomic response to certain stimuli. (uspharmacist.com)

These agents can be used to treat orthostatic hypotension. (medscape.com)

This article discusses the roles of serotonin, the use of serotonergic agents, the diagnosis of serotonin syndrome, and its diagnostic differentials. (lww.com)

Slightly less consistent observations are for autonomic dysregulation among depressed patients. (biomedcentral.com)

These agents have broad effects due to their actions in nerves located vastly over the body. (wikipedia.org)

Drug induced - particularly the antidopaminergic antipsychotic agents. (thegasmanhandbook.co.uk)

When pharmacotherapy is warranted, selection of treatment agent(s) should be made based on the patient's medical history, cancer type, and disease severity. (cancernetwork.com)
In addition to their use in respiratory disorders like asthma and Chronic Obstructive Pulmonary Disease (COPD), these agents find utility in ophthalmology for mydriasis and cyclopedia during eye examinations or surgeries [ 8 ]. (scitechnol.com)

Anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention. (nih.gov)

Commonly used in conjunction with a drug that increases blood vessel constriction, such as midodrine, droxidopa or other agents. (msadownunder.org.au)

By antagonizing the parasympathetic system, para sympatholytic agents produce a range of physiological responses, including bronchodilation, decreased gastrointestinal motility, decreased secretions, and pupil dilation. (scitechnol.com)

This agent can be used to treat orthostatic tachycardia in POTS patients. (medscape.com)

These oral agents act peripherally to induce smooth muscle relaxation of the corpora cavernosa. (medscape.com)

Severe exposures may require several days of observation before the patient is clear of anticholinergic effects. (medscape.com)

Like other anticholinergic agents, flavoxate has not been linked to episodes of liver enzyme elevations or clinically apparent liver injury. (nih.gov)

While other pharmacological agents have been used to manage AD in individuals with SCI and their use has been reported in the literature (e.g. expert opinion, case report), they currently do not have sufficient evident to warrant recommendation. (scireproject.com)
Para sympatholytic agents can selectively target these subtypes to elicit specific pharmacological effects. (scitechnol.com)

Known for anticholinergic-antispasmodic effects. (medscape.com)
Long-term effects from poisoning by Agent 15 or other related glycolate anticholinergics are very unlikely. (medscape.com)
There are many adverse effects, interactions and contraindications for antinicotinic and antimuscarinic agents. (wikipedia.org)
One of the most common adverse effects of para sympatholytic agents is dry mouth or xerostomia. (scitechnol.com)
But higher doses may cause excessive sedation as well as serious anticholinergic side effects. (channuoivietnam.com)

References on the safety and potential hepatotoxicity of anticholinergics are given together after the Overview section on Anticholinergic Agents. (nih.gov)

Oral or nasal spray agents acting to prevent nocturnal urinary production. (medscape.com)

Dextromethorphan is an antitussive agent and, unlike the isomeric levorphanol, it has no analgesic or addictive properties. (medlibrary.org)

Seven years after the conclusion of the Gulf War, the British Foreign Ministry revealed, in February 1998, the existence of an Iraqi chemical warfare agent believed to be a glycolate anticholinergic, similar, if not identical, to BZ. (medscape.com)

The glycolate anticholinergics (eg, BZ, Agent 15) fit this description. (medscape.com)

Acetylcholine8

Drugs6

Nervous10

Neuropathy4

Toxicity2

Peripheral2

Symptoms4

Nerve3

Urinary incontinence1

Sympathetic1

Bladder2

Dysfunction1

20231

Somatic1

Inhibit1

Clinical1

Abnormal1

Orthostatic hypotension1

Diagnosis1

Observations1

Nerves1

Antipsychotic Agents1

Disease2

Narrow angle1

Increases1

Parasympathetic system1

Tachycardia1

Relaxation1

Severe1

Episodes1

Pharmacological2

Effects5

Overview1

Prevent1

Unlike1

Similar1

Description1