Anticancer luteolin. Medical search. Frequent questions

In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. (frontiersin.org)
Beyond apigenin and luteolin, celery contains other plant compounds that have powerful antioxidant properties. (medicalnewstoday.com)
Luteolin being a prime example of this compound class has shown an ability to act as an antioxidant. (nstchemicals.com)
In order to be a successful antioxidant, Luteolin has to be able to counteract several reactive molecules like reactive oxygen and nitrogen species. (nstchemicals.com)
Punicalagin is an anti-hepatitis B virus ( HBV ) agent and has antioxidant, anti-inflammatory, and anticancer effects. (medchemexpress.com)
This study reviews its antioxidant, anti-inflammatory, antimicrobial and anticancer activities. (earthtokathy.com)
Luteolin is a powerful antioxidant that helps protect mitochondria from damage and the effects of aging. (simplesanutrition.com)
3.Luteolin has antioxidant, anti-inflammatory, anti-allergic, anticancer, and immune-modulating properties to suppress hyperactive immune systems. (sxgreenfine.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

That means that these substances (called apigenin and luteolin) keep the tiny free radicals that attack healthy cells from being successful. (healthline.com)
Sixteen compounds were identified and quantified, in which three were chlorogenic acid derivatives and eleven apigenin and luteolin derivatives. (rsc.org)
A growing body of evidence indicates that flavonoids are an integral component of any cancer-preventive strategy.3 Two of these flavonoids, apigenin and luteolin , found in celery are distinguished for their ability to protect against various types of cancer.4 In one study reported in the International Journal of Cancer , scientists compared the intake of five flavonoids in women with and without ovarian cancer. (foodtrients.com)
Both apigenin and luteolin provide a powerful defense against breast cancer. (foodtrients.com)

Many cell studies have shown that luteolin induces apoptosis (cell death) in cancer cells. (longevitylifehacks.me)
Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines. (cedarville.edu)
1). Further, increased expression of the pro-apoptotic proteins Bax and caspase 8 and the inhibition of the antiapoptotic protein Bcl-2 were instituted in the synergistic doses (chrysin + cisplatin and luteolin + cisplatin), hence promoting apoptosis. (bvsalud.org)
In the present study, we investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG , and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and neck and lung cancer cell lines . (cancertreatmentsresearch.com)
Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)

Luteolin is a natural compound known for its anticancer effects on various human cancers by regulating signal transduction cascades. (ewha.ac.kr)

Luteolin is a flavonoid found in herbs and vegetables. (longevitylifehacks.me)

LUT possess anticancer prospective despiteCopyright: 2021 by the authors. (jnkinhibitor.com)
It also seems to possess anticancer properties and may improve cognitive performance. (simplesanutrition.com)

The focus of this review is on illuminating the anticancer attributes found in a variety of nutraceuticals, such as polyphenols, flavonoids, carotenoids, and other bioactive compounds. (ijpbp.com)
Anticancer effect of antimalarial artemisinin compounds. (ijpbp.com)
The anti-cancer activities of two compounds luteolin and daidzin from leaves of Perilla ocymoides L and Glucine max L resulting from those models turn out to be agreement with experimental data. (juniperpublishers.com)

Luteolin acts as an antiviral agent against one of the causes of encephalitis (Flaviviridae virus). (longevitylifehacks.me)
Cell studies also show that luteolin has antiviral activity against the flu virus (H1N1). (longevitylifehacks.me)

Luteolin has been quite extensively studied for its neuroprotective properties. (nstchemicals.com)

Background: Although luteolin has been confirmed as potent anticancer agent, its potential application as therapeutic is limited by its water solubility. (ac.rs)
TY - JOUR AU - Matić, Ivana Z. AU - Mraković, Ana AU - Rakočević, Zlatko AU - Stoiljković, Milovan AU - Pavlović, Vladimir B. AU - Momić, Tatjana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11544 AB - Background: Although luteolin has been confirmed as potent anticancer agent, its potential application as therapeutic is limited by its water solubility. (ac.rs)
4.Luteolin is a potent hypoglycemic agent and improves sensitivity. (sxgreenfine.com)

Celery contains a flavonoid called luteolin. (medicalnewstoday.com)
Luteolin is a commonly found natural chemical that can be found in several plant species like carrots, peppers, celery, cucumbers and many more. (nstchemicals.com)

Recently, we have isolated two flavonoids luteolin and daidzin from leaves of Perilla ocymoides L and Glucine max L in Viet Nam [ 1 ], with cytotoxic activity relatively strong in Hela cell line. (juniperpublishers.com)

As we discussed, the antioxidative potential of Luteolin could be a great factor for it to be a tool as an anticancer prevention tool and therapeutic agent. (nstchemicals.com)
He was awarded a Farrow Fellowship grant to study the therapeutic potential of anticancer agents. (cedarville.edu)
Hence, elastic liposomes might be a promising strategy for improved transdermal delivery of luteolin, too as enhancing its therapeutic efficacy in controlling breast cancer. (jnkinhibitor.com)

AE has notable anticancer effects and inhibits cell viability while stimulating the arrest of G2/M of the cell cycle. (herbshealthhappiness.com)

Cell studies show that luteolin is antimicrobial. (longevitylifehacks.me)

There is growing interest in using natural substances from plants to potentially enhance anticancer activity. (academicjournals.org)
Although previous research suggests that flavonoids like Luteolin have poor bioavailability, current research has found that, indeed, Luteolin can bind with proteins and carbohydrates increasing uptake, therefore, increasing antioxidative activity in our bodies. (nstchemicals.com)
Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. (medchemexpress.com)
Luteolin-4'-O-glucoside shows anticancer activity. (medchemexpress.com)
Evaluation of the Anticancer Activity of Bioactive Fraction G Extracted from Pavetta crassipes in Malignant Brain Tumor Cell Lines (Rachel M. Wilcox, Eric Huseman, Stacy Lin, et al. (cedarville.edu)
Chrysin and luteolin have demonstrated effective anticancer activity. (bvsalud.org)
Furthermore, the in vitro anticancer activity of OLEL1 was compared against a control utilizing MCF-7 cell lines. (jnkinhibitor.com)
Furthermore, OLEL1 was evaluated for anticancer activity and showed maximized inhibition as compared with DS. (jnkinhibitor.com)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

We compared viability of JAR and JEG-3 cells in response to luteolin alone or in combination with other chemotherapeutic drugs (etoposide, cisplatin, and paclitaxel) and found that luteolin has synergistic effects with the conventional chemotherapeutic drugs as an anticancer agent. (ewha.ac.kr)

Additionally, some research shows that luteolin may help to stop the proliferation of certain cancer cells. (longevitylifehacks.me)
Additionally, luteolin increased sleep time and non-REM sleep. (longevitylifehacks.me)
Additionally, AuNPL were shown as more cytoprotective towards HaCaT cells then luteolin due to the more successful elimination of H2O2 induced intracellular ROS. (ac.rs)
Luteolin can additionally reverse epithelial mesenchymal transition (EMT) through a mechanism that involves cytoskeleton shrinkage, induction of the epithelial biomarker E-cadherin expression, and by down-regulation of the mesenchymal biomarkers N-cad herin, snail, and vimentin. (stiftung-plantafood.de)
Additionally, research indicates that Luteolin may be capable of shrinking tumors - although further research into human subjects is essential. (rewiredmagazine.com)

In 2015, researchers from Jordan and Egypt isolated four of these, all of which were flavonoids including luteolin, chrysoeriol, isoorientin and isovitexin. (cancerdefeated.com)

The authors of an article published in 2009 suggested that luteolin may have anticancer properties - it may help prevent the spread of cancer cells and induce cell death. (medicalnewstoday.com)
They proposed that luteolin may make cancer cells more susceptible to attack by chemicals in treatments. (medicalnewstoday.com)
Mint contains luteolin, which is also believed to fight breast cancer. (50connect.co.uk)
It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. (mdpi.com)
In conclusion, this review sheds light on the emerging insights into nutraceuticals' anticancer properties and their potential as valuable components of integrative cancer therapy. (ijpbp.com)
and it is the most widely-used term - however please note that the National Cancer Institute considers that the term "anticancer herb" is not accurate enough. (herbshealthhappiness.com)
In a study published in the journal BMC Gastroenterology , researchers observed that luteolin suppresses the secretion of IGF II, thus halting the progression of colon cancer. (foodtrients.com)
Externally luteolin can be used for skin allergic/inflammatory disorders and for skin cancer prevention. (sxgreenfine.com)
In this study, a stable carboxylated luteolin (CL)-functionalized superparamagnetic iron oxide nanoparticle (SPION) as a potential drug carrier for in vitro analysis of L929 (mouse fibroblast), U87 (glioblastoma (brain cancer)), MCF-7 (breast cancer), HeLa (cervix cancer), and A549 (human lung cancer) cell lines has been synthesized. (istanbul.edu.tr)

Chemically, the drug is usually a natural flavone (tetrahydroxy flavone) with 4 hydroxyl functional groups positioned at 3, four, 5, and 6 of simple moiety and conjugate acid of 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) ( IEM-1460 iGluR Figure 1A) [5,6]. (jnkinhibitor.com)

Already known from folk medicine, extracts containing luteolin have been used to treat epilepsy. (nstchemicals.com)
L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

Other studies suggest more positive effects of luteolin like improving cardiomyocyte function, regulates nitric oxide production and prevents damage from its free radicals, improves cardiac functions in case of heart failure and more. (nstchemicals.com)

In a mouse study of Alzheimer's, luteolin protects against amyloid β memory dysfunction and also increases levels of endogenous antioxidants including Mn-SOD, Cu/Zn-SOD, and glutathione. (longevitylifehacks.me)
To date, the global marine pharmaceutical pipeline consists of seven approved pharmaceuticals in clinical use, four of which are anticancer drugs, and about 26 natural products in Phase I to Phase III clinical trials, 23 as anticancer agents, two for schizophrenia and Alzheimer's, and one for chronic pain ( http://marinepharmacology.midwestern.edu/clinPipeline.htm ). (frontiersin.org)
Luteolin has also been looked at as a possible treatment for Autism spectrum disorder, Alzheimer's disease, Parkinson's disease, multiple sclerosis, diabetes-associated cognitive decline, brain injury from trauma and many more. (nstchemicals.com)

A very significant amount of scientific research has been done in the investigation of anticancer properties of various plants - however much work still needs to be done. (herbshealthhappiness.com)
With the above said, on to our list of over 60 herbs and plants for which anticancer properties have been reported / claimed . (herbshealthhappiness.com)

Previously we mentioned that antioxidants like Luteolin can prevent blood blockage from overoxidized healthy fats. (nstchemicals.com)

However, the effects of luteolin on human placental choriocarcinoma are not known. (ewha.ac.kr)
Next, we established effects of luteolin in the presence of pharmacological inhibitors of PI3K/AKT, ERK1/2 MAPK, and mTOR on proliferation of JAR and JEG-3 cells. (ewha.ac.kr)

Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)

It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers. (stiftung-plantafood.de)

Expression levels of both SREBP1 and SREBP2 mRNAs were significantly reduced, but only SREBP1 protein was influenced by luteolin. (ewha.ac.kr)

ram studies have used varying doses, anticancer effect. (cancertreatmentsresearch.com)

The anticancer activities of test substances resulting from those models are in good agreement with those from literature. (juniperpublishers.com)

5. Luteolin powder is a promising agent for use in ophthalmology,for prevention and treatment of cataract and of vascular eye disorders. (ceresherb.com)

Its key constituents also include ginkgolide and bilobalide, catechin, tannin and luteolin. (amarteskincare.com)

The flavonoids diversity showed a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant apigenin content. (rsc.org)

1. Luteolin powder have potential value and exploition in food industry. (ceresherb.com)

A key target in this respect is natural killer (NK) cells in order to generate an anticancer-immune response. (academicjournals.org)

It has been proved that luteolin can lower oxidative stress, reduce inflammation and inhibit several enzymes in the brain that could lead to seizures. (nstchemicals.com)

Organic luteolin (LUT) is discovered in spinach, distinctive peppers, and lettuce. (jnkinhibitor.com)

Animal studies show that luteolin has a sleep-inducing effect - at least when given along with a sleep drug. (longevitylifehacks.me)
Novel luteolin capped gold nanoparticles (AuNPL) were synthesized and their anticancer effect towards human cervical adenocarcinoma HeLa cells was investigated in vitro. (ac.rs)

Phytochemicals are viewed as appropriate possibility for anticancer medication advancements due to their pleiotropic activities on track occasions with numerous habits. (researchsquare.com)

Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)

Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)

Flavonoids, such as luteolin, are produced by plants as a cellular defense against microorganisms or UV radiation. (longevitylifehacks.me)

In silico Modelling of 2D, 3D Molecular Descriptors for Prediction Of Anticancer Activities Of Luteolin And Daidzin From Plants Perilla ocymoides L and Glucine max L. Organic & Medicinal Chem IJ. (juniperpublishers.com)

Other studies point to luteolin reducing IL-6 (an inflammatory cytokine) production in response to bacterial infections. (longevitylifehacks.me)

In addition, these inhibitors were used to verify phosphorylation of AKT, GSK3beta, and ERK1/2 and to confirm mechanisms regulated by luteolin in JAR and JEG-3 cells. (ewha.ac.kr)

Luteolin has a wide range of biological activities like the ones that we discussed and even more. (nstchemicals.com)
Distribution and biological activities of the flavonoid luteolin. (earthtokathy.com)

In cell studies, luteolin i nhibits TNF-alpha and IL-6 released via suppressing NF-κB. (longevitylifehacks.me)

Luteolin and apigenin (another flavonoid) have shown to inhibit IL-31 and IL-33 in microglial cells. (longevitylifehacks.me)
In trials for SARS-CoV-1, luteolin blocks viral entry into host cells. (longevitylifehacks.me)
The results also suggested that the PI3K/AKT pathway was inhibited by luteolin treatment of JAR and JEG-3 cells in a dose- and time-dependent manner. (ewha.ac.kr)
We also determined levels of SREBP1 and SREBP2 expression to investigate regulatory functions of luteolin in lipid metabolism in JAR and JEG-3 cells. (ewha.ac.kr)

Note - " Anticancer Foods " have now been separated from this list and appear on their own page. (herbshealthhappiness.com)

Anatomy24

Organisms21

Diseases15

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes39

Disciplines and Occupations3

Technology, Industry, Agriculture4

Information Science1

Health Care3

Antioxidant10

Apigenin and luteolin4

Apoptosis5

Known for its anticancer1

Flavonoid found1

Possess anticancer2

Compounds3

Antiviral2

Neuroprotective1

Potent3

Celery2

Flavonoids luteolin1

Therapeutic3

Inhibits cell1

Antimicrobial1

Activity9

Synergistic1

Additionally5

Isovitexin1

Cancer9

Flavone1

Extracts2

Free radicals1

Alzheimer's3

Properties2

Antioxidants1

Effects2

Species1

Prostate1

Significantly1

Doses1

Substances1

Agent1

Constituents1

Derivatives1

Potential1

Natural1

Inflammation1

Peppers1

Effect2

Possibility1

Sheds light1

Human1

Defense1

Medicinal1

Inflammatory1

Mechanisms1

Biological2

Cell1

Cells4

Foods1