Anticancer effects effects anticancer drugs or radiation. Medical search. Frequent questions

Cancer is treated with surgery, chemotherapy, or radiation - or sometimes a combination of these treatments. (kidshealth.org)
Chemotherapy (say: kee-mo-THER-uh-pee) is the use of anti-cancer medicines (drugs) to treat cancer. (kidshealth.org)
In addition, chemotherapy, surgery, or radiation are often combined to increase the effectivity of the treatment. (aiche.org)
Many cancer patients need to abort chemotherapy due to complications arising from its side effects, and this is a primary contributor to mortality. (aiche.org)
Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
Chemotherapy uses anti-cancer drugs given either intravenously or orally depending on the drug, to kill cancer cells that may be in your bloodstream. (dartmouth.edu)
Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (uchicagomedicine.org)
Studies have shown that paying several individual fees for testing, radiation, surgery, and chemotherapy cost more than the bundled payment method . (issels.com)
These products may not be prescription drugs, but they do have a powerful ability to interact with chemotherapy, radiation treatments, and anti-cancer medicines. (issels.com)
Glioblastoma, the most aggressive form of brain cancer is commonly treated with surgery, radiation, and chemotherapy. (businesswire.com)
These new genomic targeted drugs have greater specificity and reduce toxic effects for patients compared to conventional chemotherapy. (businesswire.com)
If diagnosed with leukemia, chemotherapy, radiation therapy or bone marrow transplants are all possible alternative for treatments of leukemia. (ostatic.com)
Chemotherapy is the treatment(s) of cancer with drugs that can attempt to destroy cancerous cells. (ostatic.com)
In the 1970 St. Jude announced that Leukemia could now be called a curable disease using chemotherapy and radiation. (ostatic.com)
A commonly used form of drug therapy is chemotherapy, which uses agents that inhibit the rapid growth of cancer cells or destroy them. (bosch.com)
Surgery, chemotherapy, and radiation therapy are still the main treatment methods, but each method has its limitations and risks. (frontiersin.org)
Reducing hypoxia may have sensitizing effects on radiotherapy, chemotherapy, phototherapy, acoustic therapy and so on. (frontiersin.org)
In these countries, mushrooms have been used safely for a long time, either alone or combined with radiation or chemotherapy. (cigna.com)
Chemotherapy forms the mainstay of cancer treatment particularly for patients who do not respond to local excision or radiation treatment. (nih.gov)
Tumour removal may be curative when small in size, but mostly, surgery is combined with other treatment modalities such as radiation and/or chemotherapy. (fagoniacreticaforcancer.com)
At times, when the tumour is extensive, chemotherapy or radiation is given prior to the surgery to shrink the lesion. (fagoniacreticaforcancer.com)
Chemotherapy is the systemic use of drugs for the treatment of cancer. (fagoniacreticaforcancer.com)
At times, the patient may develop serious side-effects, requiring a change in the chemotherapy plan or even stopping the drug. (fagoniacreticaforcancer.com)
To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required. (connersclinic.com)
Drug resistance is a main obstacle for curative cancer chemotherapy. (hindawi.com)
Ears and hearing can be damaged by chemotherapy, high-dose radiation, and some antibiotics. (alexslemonade.org)
My daughter Sarah had an ependymoma treated with radiation when she was 4 and chemotherapy when it returned at age 6. (alexslemonade.org)
The doctors think that some of the chemotherapy side effects-including the hearing loss-were a result of the chemotherapy compounding damage already done by the radiation. (alexslemonade.org)
Trastuzumab enhances the effect of chemotherapy drugs. (msdmanuals.com)
from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
Radiation chemotherapy (IARC, 2012b ). (who.int)
Because a high percentage of these cancer patients are diagnosed in advanced stages, the treatment is increasingly invasive, including surgery, radiation therapy, or chemotherapy applied in isolation or in association with other treatment, depending on the tumor's site, histological degree, clinical stage, and the patient's physical condition 1 . (bvsalud.org)

Due to its ability to induce cell cycle arrest, ionizing radiation is used on abnormal growths in the human body such as cancer cells, in radiation therapy. (wikipedia.org)
In medicine, medical diagnostic methods such as CT scans and radiation therapy expose the individual to ionizing radiation. (wikipedia.org)
Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (uclahealth.org)
Lab principal investigator James C. Cusack, MD , is co-inventor of the patent "Use of NF-kappaB inhibition in combination therapy for cancer," (United States patent 6,831,057), which describes the therapeutic strategy noted above and is now licensed to two pharmaceutical companies for novel drug development. (massgeneral.org)
It's also used as an antiperspirant, a diuretic, and often recommended as an adjuvant drug during cancer and diabetes therapy [ 1 ]. (biomedcentral.com)
Radiation therapy uses radiation to kill cancer cells. (dartmouth.edu)
Many individuals with GI cancers will receive a recommendation to undergo radiation therapy either before or after surgery. (dartmouth.edu)
Radiation therapy (RT) is a mainstay in the treatment of both primary and recurrent gastrointestinal (GI) and pelvic malignancies. (medscape.com)
Radiation therapy is one of the most important options for cancer treatment. (emergency.co.jp)
Depending on the type and stage of cancer, initial treatment, preoperative radiation therapy, postoperative radiation therapy, and symptomatic treatment are provided. (emergency.co.jp)
It is more precise than regular x-ray therapy and can deliver higher doses of radiation to cancerous tissue, minimizing damage to surrounding normal tissue. (emergency.co.jp)
Compared to other radiation therapy modalities, heavy particle therapy tends to reduce complications. (emergency.co.jp)
It enhances the effect of radiation therapy and destroys cancer cells more effectively. (emergency.co.jp)
Radiation therapy is used to stimulate the immune system to attack cancer cells. (emergency.co.jp)
Ananda then invented the ABCD as a way to deliver safe and locally targeted cancer therapy though use of a drug-eluting device. (hillpost.in)
As mentioned, there is no drug-eluting device that is used for breast or other cancer therapy. (hillpost.in)
In contrast, ABCD represents a revolutionary advance for breast cancer patients as a meaningful adjunct or alternative to surgery, radiation and chemotherapies, using well-understood drug-eluting stent technologies re-purposed for oncology therapy and using anti-cancer weapons with demonstrated effectiveness. (hillpost.in)
A: That is exactly right - we are using drug-eluting technologies to deliver effective anti-cancer therapy by inserting the ABCD adjacent to the tumour site. (hillpost.in)
A: Exactly right - the drug-eluting device delivers the cancer therapy to the tumour site. (hillpost.in)
Chlorin e6-photodynamic therapy (Ce6-PDT), in addition to being the first-line treatment for malignancies, has been shown to lessen skin photoaging, while curcumin is well known for reducing the deleterious effects of ROS. (bvsalud.org)
Is it possible to improve the treatment of a cancer patient by selecting an appropriate individualized drug therapy? (bosch.com)
Despite great efforts in the development and clinical application of anti-cancer drugs, the individual response of a patient to a specific pharmacological cancer therapy can unfortunately vary strongly. (bosch.com)
As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)
Anticancer therapy that consisted of radiation to the stomach and daily capecitabine and weekly paclitaxel was begun 5 days after discharge. (cdc.gov)
After 6 weeks of anticancer therapy (7 weeks after tularemia), the patient's carcinoembryonic antigen decreased substantially. (cdc.gov)
Medicinal plants used by traditional medical practitioners (TMP) to treat cancers are considered safe when used alone or combined with conventional therapy to ensure their effectiveness and eliminate the toxic effects of orthodox medicines. (who.int)
Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)
who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
There is currently no cure for MM. However, advances in therapy, such as autologous stem cell transplantation, radiation, and surgical care in certain cases, have helped to lessen the occurrence and severity of adverse effects of this disease and to manage associated complications. (medscape.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
Hence, this study's aim was to perform a literature review addressing the main complications arising form radiation therapy while emphasizing the conduct of dental surgeons in the face of these changes. (bvsalud.org)
Approximately 60% of the patients receive radiation therapy to treat head and neck cancer and most receive the combined therapy so that the development of a series of changes is expected to affect the oral cavity 5 . (bvsalud.org)
As a consequence, non-neoplastic cells exposed to radiation are subjected to destruction, a fact that limits the dosage to be used in cancer therapy 6 . (bvsalud.org)
Female patients with evidence of either locally advanced (not amenable to radiation therapy or surgery in a curative intent), inoperable, and/or metastatic disease who have either progressed, recurred after standard of care treatment, have refused, or are otherwise ineligible for standard of care treatment. (who.int)
Washout period of at least 3-weeks or 5 times the half-life, whichever is shorter, of any cancer therapy (including anticancer therapy, vaccination, or any investigational agent). (who.int)

With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
In 1917, the first case was reported of the development of radiation enteritis following the use of radiotherapy to treat malignancy. (medscape.com)
A combination of radiotherapy and anticancer drugs is used to increase the sensitivity of cancer cells. (emergency.co.jp)

Activity against the former target contributes to its dual-acting oncotoxic and immunomodulatory functions designed to enhance the effectiveness and safety of standard oncology treatments, i.e., chemotherapies, radiation therapies, and immune checkpoint inhibitors. (businesswire.com)
Noxopharm is running comprehensive drug discovery programs in both oncology and inflammation, and is the major shareholder of U.S. biotechnology company, Nyrada Inc (ASX:NYR), active in the areas of drug development for cardiovascular and neurological diseases. (businesswire.com)

Drugs called checkpoint inhibitors may block checkpoints, which are proteins that help turn the immune response off and on. (msdmanuals.com)
Checkpoint inhibitors are sometimes given alone or combined with other anticancer drugs. (msdmanuals.com)

In line with this, the increasing use of nanomedicine to increase the efficient delivery of the anticancer drug to the affected tissues by enhancing the efficacy and reducing the side effects. (imarcgroup.com)
Our therapeutic approach may provide an important alternative or adjunct to surgery, radiation or chemotherapies that is designed to be non-toxic to healthy cells/tissues in the body," said Finston, who co-founded Ahmedabad (India)-based Amrita Therapeutics, with Chakrabarty, in an interview to Hi India newspaper here. (hillpost.in)
Our therapeutic approach may provide an important alternative or adjunct to surgery, radiation or chemotherapies that is designed to be non-toxic to healthy cells/tissues in the body. (hillpost.in)
Because senescent cells are believed to play a role in the late effects of radiation on normal tissues and certain age-related diseases, this study has broad implications for future therapies targeting the common biological mechanism that contributes to late tissue injury caused by radiation and aging. (appliedradiationoncology.com)
The period of no medication gives the body enough time to recuperate from the side-effects on the normal tissues of the body. (fagoniacreticaforcancer.com)
Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
X-rays or other types of ionizing in much higher dosage, are used to and there is excess risk of B-cel radiation, immunosuppression is maintain the functional and anatom- non-Hodgkin lymphoma (NHL) when most pronounced if the entire body, ical integrity of foreign tissues graft- immunosuppression is accompanied rather than a limited area, is irra- ed onto another individual, such as by continuing immune stimulation diated. (who.int)

Because RT is increasingly used to treat pelvic malignancies, the surgical prevention and treatment of the complications of radiation enteritis and proctitis continue to evolve. (medscape.com)

Methods: The development of nanotechnology for anticancer drug delivery has developed several potentials as nanocarriers, which may boost the pharmacokinetic and pharmacodynamic effects of the drug product and substantially reduce the side effects. (benthamscience.com)
Multimodal strategies for tumor diagnosis and treatment based on nanomaterials and nanotechnology represent highly relevant challenges for the future of anticancer treament. (frontiersin.org)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)

Pharmorage will also focus on advancing Hudson's several lead RNA drugs through development as treatments for autoimmune and inflammatory diseases. (businesswire.com)
The differential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer drugs temozolomide (TMZ) and doxorubicin (DOX) were investigated. (nature.com)
Our radiation oncologists are experienced in advanced radiation treatments for GI cancer and will plan your treatment schedule and follow your progress. (dartmouth.edu)
Radiation treatments as a young child or adult to treat other cancers of the chest can increase the risk of developing breast cancer. (tourmyindia.com)
If you have cancer of the larynx, your treatment is more likely to be successful and the side effects of treatments more manageable if you can give up, smoking and drinking alcohol before you start your treatment. (healthlibrary.com)
Two weeks later, at completion of these treatments and the oral antimicrobial drugs, the abdominal lymphadenopathy showed improvement on computed tomography. (cdc.gov)
Surgery combined with radiation is one of the most common treatments for malignant tumors in the head and neck. (bvsalud.org)

Moreover, strategic collaborations between pharmaceutical companies, research institutions, and healthcare providers to develop innovative therapies and drugs are propelling market growth. (imarcgroup.com)
Other drug-based treatment approaches are targeted therapies, immunotherapies, and hormonal therapies. (bosch.com)

The lifetime when appropriate levels of its application in anticancer chemo- Group 1 agents that act by immuno- immunosuppression are maintained. (who.int)

we propose that these inhibitors could be used in conjunction with therapeutic RNAs to limit their side effects in patients and maximize their therapeutic potential. (businesswire.com)
The effects produced by some of these components are found to be comparable to those of well-known P-gp inhibitors verapamil and cyclosporine. (nih.gov)

We are investigating next-generation small-molecule drugs that are optimized to clear senescent cells without drug-induced toxicity," Zhou said. (appliedradiationoncology.com)
Consequently, there is an increasing trend to optimize pharmacokinetics, enhance antitumour activity and reduce systemic toxicity of existing anti-cancer drugs by inhibiting P-gp mediated transport. (nih.gov)
Bialk-Bielinska A., Mulkiewicz E., Stokowski, M., Stolte S. , Stepnowski P. (2017) Acute aquatic toxicity assessment of six anti-cancer drugs and one metabolite using bio test battery - Biological effects and stability under test conditions. (uni-bremen.de)

Ionizing radiation can cause biological effects which are passed on to offspring through the epigenome. (wikipedia.org)
On the other hand, it is now widely recognized that P-gp also influences drug transport across various biological membranes. (nih.gov)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

We assessed the antiphotoaging effects of Ce6-curcumin derivatives on cell viability, antioxidant activity, the mechanism of matrix metalloproteinase-1 and 2 (MMP-2) expression, and collagen synthesis in UVB-irradiated in vitro models. (bvsalud.org)
The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

Pt NPs anticancer activity was tested performing cell viability experiments with TNBC and comparing with a common chemotherapeutic drug (cisplatin). (aiche.org)

It is particularly suitable for pediatric cancer patients because it minimizes the effects of radiation on the growing tissue. (emergency.co.jp)

Advances in medical imaging have resulted in increased exposure of humans to low doses of ionizing radiation. (wikipedia.org)
Survivors who had head and neck tumors treated with higher doses of radiation and/or older radiation techniques (from the 1950s and 1960s) often develop hearing loss. (alexslemonade.org)

The effects of radiation on cells has been found to be dependent on the dosage of the radiation, the location of the cell in regards to tissue, and whether the cell is a somatic or germ line cell. (wikipedia.org)
Although the benefits of treatment with radiation are well established, damage to the healthy, nonneoplastic tissue may be severe. (medscape.com)
A treatment in which a radiation source is inserted near or inside cancerous tissue. (emergency.co.jp)
Proton beams can reach depths where radiation has the greatest effect when focused on cancerous tissue. (emergency.co.jp)
It is more precise than regular X-ray irradiation and delivers a higher dose of radiation to cancer tissue. (emergency.co.jp)
This is a special cancer treatment in which a boron drug is administered to the cancer patient, followed by neutron irradiation of the cancer tissue. (emergency.co.jp)
This treatment delivers a high dose of radiation to cancerous tissue with minimal damage to surrounding normal tissue. (emergency.co.jp)
Since chronic inflammation and oxidative stress are thought to be the root cause of some late effects of radiation and many age-related diseases, including radiation-induced long-term bone marrow injury and age-related osteoarthritis and atherosclerosis, eliminating senescent cells has the potential to mitigate radiation-induced late tissue injury and treat many age-related diseases. (appliedradiationoncology.com)
Nanomaterials can combine multiple treatment methods according to the characteristics of tumor tissue microenvironment to greatly improve the effect of cancer treatment. (frontiersin.org)
Identification of effective P-gp modulator among herbal compounds have an added advantage of being safe, thereby making them ideal candidates for bioavailability enhancement, tissue-penetration (e.g. blood brain barrier (BBB)), decreasing biliary excretion and multi-drug resistance modulating agents. (nih.gov)

Phytochemicals are viewed as appropriate possibility for anticancer medication advancements due to their pleiotropic activities on track occasions with numerous habits. (researchsquare.com)
Along with this, ongoing research and technological advancements in novel treatment modalities, drug delivery systems, and diagnostic tools for lung cancer are expected to stimulate market growth. (imarcgroup.com)

All of these exist as low frequency radiation which can come from wireless cellular devices or through electrical appliances which induce extremely low frequency radiation (ELF). (wikipedia.org)
Irradiated cells can also induce genomic instability in neighboring un-radiated cells via the bystander effect. (wikipedia.org)
In addition, nanomaterials combined with chemotherapeutic drugs can can induce deleterious oxidative stress in tumor sites, consume GSH and other antioxidant substances to alter cell REDOX homeostasis and achieve anti-tumor effect. (frontiersin.org)

For the last century, breast cancer patients have had to rely on disfiguring surgery, radiation and/or chemotherapies - carrying substantial health risks and possible side-effects as debilitating as the cancer itself. (hillpost.in)
It may be used as an adjunct to surgery, radiation and chemotherapies. (hillpost.in)
Palliative surgery is used to relieve side-effects caused by the growing cancer in cases that are otherwise inoperable due to the stage and extent of local spread. (fagoniacreticaforcancer.com)

A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in a spheroid. (nature.com)
There is a high need for personalization of the drug-based cancer treatment of tumors in order to administer the adequate and successful individual medication for each cancer patient. (bosch.com)

In particular, platinum nanoparticles (Pt NPs) have been reported with promising anticancer results. (aiche.org)

Further, saffron may even reduce the toxic effects of some radiation drugs. (naturalnews.com)
however, senescent cells become "toxic" as they accumulate after exposure to radiation and with age. (appliedradiationoncology.com)
It has toxic side effects that make it inappropriate for development as an agent for diseases of aging. (appliedradiationoncology.com)
Using a combination of drugs reduces the dose of each drug, which is better tolerated by the patient owing to the decreases in their toxic effects. (fagoniacreticaforcancer.com)

golimumab decreases effects of anthrax vaccine by pharmacodynamic antagonism. (medscape.com)
TRO increases radiation sensitivity through G0-G1 arrest or decreases radiation sensitivity through catalase-mediated ROS scavenging according to TRO dose or cell types. (e-roj.org)

Presently, research is in progress for search of novel phytochemicals having anti cancerous properties with minimum or zero side effects. (researchsquare.com)
Though mRNA vaccine technology has had a strong debut, unwanted side effects remain common, including fatigue, severe headache, chills, and injection-site pain. (businesswire.com)
You and your doctor will discuss the best course of treatment for your condition, what you can expect for results, and what you may experience as side effects. (dartmouth.edu)
Our medical oncologists will meet with you to discuss your treatment options and potential side effects and will follow you and your progress throughout treatment. (dartmouth.edu)
This phase I/II trial studies the side effects and the best dose of ruxolitinib phosphate when given together with paclitaxel and carboplatin and to see how well they work in treating patients with stage III-IV epithelial ovarian, fallopian tube, or primary peritoneal cancer. (uchicagomedicine.org)
We are engaging early on with FDA regulators on both the device and drug side of the house to ensure that we understand the evolving regulatory roadmap and have the smoothest possible transition from pre-clinical to clinical research. (hillpost.in)
Harm to healthy cells is what causes side effects. (ostatic.com)
In addition, undesired serious side effects can occur because of the administered drug (see Figure 1A). (bosch.com)
Side effects. (cigna.com)
The schedule for each drug is such that it maximizes the anti-cancer action and minimizes the side-effects. (fagoniacreticaforcancer.com)
the different treatment options what is involved the side effects you might have. (healthlibrary.com)
any significant risks or side effects of the treatment. (healthlibrary.com)
Some other side effects might include cough, dry mouth, and headache. (medlineplus.gov)
An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
There are, however, severe side effects, causing morbidities and reducing patients' quality of life. (bvsalud.org)
Although this therapeutic modality has obtained high levels of cure and greater survival, its side effects are quite severe. (bvsalud.org)

The direct effects of radiation on the bowel mucosa lead to acute radiation enteritis. (medscape.com)
virtually every patient has some manifestation of acute radiation-induced injury of the GI tract in the form of abdominal cramping, tenesmus, urgency, bleeding, diarrhea, and incontinence. (medscape.com)
Gemtuzumab ozogamicin , a combined antibody and drug, is effective in some people with acute myeloid leukemia. (msdmanuals.com)

30th Annual meeting of Canadian Association of Radiation Oncologist. (usherbrooke.ca)
24th Canadian Association of Radiation Oncologist Scientific meeting. (usherbrooke.ca)

Our approach uses a tumor sample to test different drugs and determine a recommendation for the individual medication. (bosch.com)
We are investigating and developing innovative technological solutions for the personalization of cancer treatment by using a patient tumor sample to perform drug screening and determine the appropriate medication for the cancer patient. (bosch.com)

Cell cycle, and SOD and catalase may affect on radiation sensitivity. (e-roj.org)
We investigated the effect of TRO on radiation sensitivity in cancer cells in vitro . (e-roj.org)
By pretreatment with 5 µM TRO radiation sensitivity was increased in HeLa and Me180, but it was decreased in SiHa. (e-roj.org)
The change of radiation sensitivity by combined with TRO is not dependent on the PPARγ expression level. (e-roj.org)
Both SOD and catalase may decrease radiation sensitivity via reactive oxygen species (ROS) scavenging. (e-roj.org)

Microbubbles are commonly used as intravascular ultrasound imaging probes and are becoming increasingly popular tools for targeted drug delivery. (hindawi.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)

This paper presents an overview of the investigations on the feasibility and application of flavonoids as P-gp modulators for improved efficacy of anti-cancer drugs like taxanes, anthracyclines, epipodophyllotoxins, camptothecins and vinca alkaloids. (nih.gov)
The review also focuses on flavonoid-drug interactions as well as the reversal activity of flavonoids useful against MDR. (nih.gov)
Grape contains flavonoids, which can have antioxidant effects. (medlineplus.gov)

Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
However, cancer treatment by drugs is seriously limited by P-glycoprotein (P-gp) associated multi-drug resistance (MDR) in various tumor cells. (nih.gov)

The ionizing radiation from these techniques can cause many other detrimental effects in cells including changes in gene expression and halting the cell cycle. (wikipedia.org)
Oxygen free radicals are naturally produced by mitochondrial and sperm plasma membrane and have beneficial and detrimental effects that cannot be overlooked. (scialert.net)

In the absence of evidence to the contrary, ATSDR assumes that humans are more sensitive to the effects of hazardous substance than animals and that certain persons may be particularly sensitive. (cdc.gov)

Radiation Research Radiation Research, 186(5): 520-530 (2016). (usherbrooke.ca)
Radiation Physics and Chemistry 128, 36-43 (2016). (usherbrooke.ca)
Invest New Drugs 34, 269-276 (2016). (usherbrooke.ca)

Drug companies aim to produce drugs to treat chronic and complex diseases with a high safety margin. (nature.com)

Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
The mechanisms of interaction between ultrasound and nanocarriers are not clearly understood, which may be related to cavitation, mechanical effects, thermal effects, and so forth. (hindawi.com)
In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)
Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)

which help to control the immune system, and in so doing stimulate the body's natural anticancer immunity. (msdmanuals.com)

However, in some cases, complementary medicines that are recommended for some patients can actually have adverse effects on certain other patients. (issels.com)
One of the major and debilitating adverse effects of RT is the development of radiation enteritis and proctitis. (medscape.com)
As the use of RT and x-rays in medicine increased, the harmful adverse effects were better recognized. (medscape.com)
An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure. (cdc.gov)
MRLs are derived for hazardous substances using the no-observed-adverse-effect level/uncertainty factor approach. (cdc.gov)
They are below levels that might cause adverse health effects in the people most sensitive to such effects. (cdc.gov)
Exposure to a level above the MRL does not mean that adverse health effects will occur. (cdc.gov)
They may also be viewed as a mechanism to identify those hazardous waste sites that are not expected to cause adverse health effects. (cdc.gov)

The anti-tumor effects of TMZ and DOX were mediated in part by selective induction of apoptosis. (nature.com)

Outer ear infections, which are common after high-dose radiation, can impair hearing by drying out and thickening the external ear canal and eardrum. (alexslemonade.org)

During the development of toxicological profiles, Minimal Risk Levels (MRLs) are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure. (cdc.gov)

RT is considered insensitive to GIST,However, recently, the effective clinical practice of RT in GIST has been reported,The purpose of this study was to clarify the synergistic effect of RT combined with IM on GIST and the potential molecular mechanism. (researchsquare.com)
This work provides valuable resources for bioengineering and in vitro synthesis of the natural compounds for medical research and for potential drug development. (biomedcentral.com)
In addition, PPARγ agonist is of particular interest as a potential anticancer agent because of its effect on cellular differentiation, proliferation, and tumorigenesis [ 3 , 4 ]. (e-roj.org)
These substance-specific estimates, which are intended to serve as screening levels, are used by ATSDR health assessors to identify contaminants and potential health effects that may be of concern at hazardous waste sites. (cdc.gov)
Potential y neoplastic cel s that of the effect increases with increasing tem to respond effectively to foreign arise natural y, or that have been dose or continuing exposure - and is antigens, including surface antigens transformed by carcinogens acting usually transient: immune function on tumour cells. (who.int)

Rituximab linked to a radioactive isotope can be used to deliver radiation directly to lymphoma cells. (msdmanuals.com)

Exposure to radiation from atomic bombs, nuclear accidents, and prior cancer treatment may affect risk. (medicalnewstoday.com)

2012) Directeur, axe de recherche en imagerie médicale et radiothérapie. (usherbrooke.ca)
2e Congrès International - Radiations Médicales: Recherche et Applications. (usherbrooke.ca)

In 1930, researchers reported the development of factitial proctitis in a group of patients who received pelvic radiation to treat malignant disease. (medscape.com)
A single drug, or more frequently, combinations of several drugs that act differently are used to destroy the malignant tumour. (fagoniacreticaforcancer.com)
Treatment with radiation is based on the principle of cytotoxicity against malignant cells and is more effective during cell mitosis and nonspecific to all cells exposed to radiation. (bvsalud.org)

The drug was given to women primarily between the 1940s and 1960s. (tourmyindia.com)
Some anticancer drugs, primarily cisplatin, can cause substantial hearing loss in the high- to ultra-high-frequency range-6,000 to 12,000 Hertz (Hz). (alexslemonade.org)

Clinical significance of above mentioned carrier is appreciated from the fact that more than fifty percent of existing anti-cancer drugs undergo inhibitable and saturable P-gp mediated efflux. (nih.gov)
Proposed MRLs undergo a rigorous review process: Health Effects/MRL Workgroup reviews within the Division of Toxicology, expert panel peer reviews, and agencywide MRL Workgroup reviews, with participation from other federal agencies and comments from the public. (cdc.gov)

Cell survival by radiation was measured with clonogenic assay. (e-roj.org)
Researchers from the University of Arkansas for Medical Sciences (UAMS) and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells. (appliedradiationoncology.com)

Laboratory and animal studies have tested the effects of PSK on the immune system, including immune cells called natural killer cells and T-cells. (cigna.com)

A lower dosage is also used in order to fully rid the possibility of a harmful effect from the medical imaging tools. (wikipedia.org)

The extent of how radiation effects cells depends on the type of cell and the dosage of the radiation. (wikipedia.org)
The younger you started with such radiations and the higher dosage of radiation received, the more likely you are to get breast cancer in the future. (tourmyindia.com)

A: ABCD is the first therapeutic cancer device to utilise drug-eluting technology and requires pre-clinical testing and evaluation as both an anti-cancer drug and a therapeutic device. (hillpost.in)

Anatomy12

Organisms7

Diseases33

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes49

Disciplines and Occupations7

Technology, Industry, Agriculture8

Information Science3

Health Care14

Chemotherapy33

Therapy37

Radiotherapy3

Oncology2

Checkpoint inhibitors2

Tissues10

Malignancies1

Nanotechnology3

Treatments7

Therapies2

Chemo1

Inhibitors2

Toxicity3

Biological3

Antioxidant activity2

Cell viability1

Minimizes the effects1

Doses2

Tissue10

Advancements2

Induce3

Surgery3

Tumors2

Nanoparticles1

Toxic4

Decreases2

Side16

Acute3

Oncologist2

Medication2

Sensitivity5

Commonly2

Flavonoids3

Resistance3

Detrimental effects2

Humans1

20163

Diseases1

Nanocarriers5

Stimulate1

Adverse8

Anti-tumor1

High-dose radiation1

Organ1

Potential5

Lymphoma1

Exposure to radiation1

Recherche2

Malignant3

Primarily2

Undergo2

Survival2

Immune system1

Possibility1

Dosage2

Evaluation1