• Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
  • Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the cell cycle. (wikipedia.org)
  • Examples of anthracyclines include: Daunorubicin Doxorubicin (Adriamycin®) Epirubicin Idarubicin Anti-tumor antibiotics that are not anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone Phototrexate Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy, a surgical procedure to treat glaucoma. (wikipedia.org)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • This class of carcinogens includes various hormones (e.g., estrogen and diethylstilbestrol), immunosuppressive drugs (e.g., azathioprine), solid-state carcinogens (e.g., asbestos), and promoting agents (agents that increase tumor development when given after a genotoxic chemical). (doctorlib.info)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • Drug treatment regimens for cancer usually involve combinations of agents given intermittently. (doctorlib.info)
  • Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. (wikipedia.org)
  • They can also cause base mispairing between strands, which interferes with the progression of the replication fork [3]. (savedelicious.com)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
  • thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer. (wikipedia.org)
  • Besides the toxic effects of chemotherapy, another major problem is chemoresistance [5]. (savedelicious.com)
  • Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)
  • Most cancer chemotherapeutic drugs affect only one characteristic aspect, which is uncontrolled proliferation [3]. (savedelicious.com)
  • There are a number of strategies in the administration of chemotherapeutic drugs used today. (worldsbest.rehab)
  • Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
  • Due to their efficiency, these drugs are the most widely used cytostatics. (wikipedia.org)
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
  • However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
  • PABA is needed in enzymatic reactions that produce folic acid, which acts as a coenzyme in the synthesis of purines and pyrimidines, the building-blocks of DNA. (wikipedia.org)
  • Combining drugs with different mechanisms of action can produce larger therapeutic effects with fewer side effects. (doctorlib.info)
  • Several neoplastic diseases can be cured with drugs alone or with a combination of drugs and other treatment modalities. (doctorlib.info)
  • Drugs used in the treatment of cancer are summarised in table 2. (savedelicious.com)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
  • Main categories of these drugs include: base analogues (altered nucleobases) - structures that can substitute for a normal nucleobases in nucleic acids. (wikipedia.org)
  • When patients develop resistance, multiple drugs with different pathways of entry and different cellular targets are used. (savedelicious.com)
  • however, the most prevalent forms of human cancer respond poorly or not at all to chemotherapy. (doctorlib.info)
  • An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. (wikipedia.org)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (worldsbest.rehab)
  • These can also be used for signal pathway research, drug discovery and drug repurposing, etc. (chemscene.com)
  • This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc. (chemscene.com)
  • and miscellaneous agents, which include a number of recently developed drugs such as monoclonal antibodies. (savedelicious.com)