Anticancer activities. Medical search. Frequent questions

Aryl hydrazine and hydrazide analogues were synthesized based on p-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus, and tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. (amrita.edu)
Anolgues 12 and 15 emerged as molecules with significant in vitro anticancer activity. (amrita.edu)
In vitro anticancer activity of some plants used in Moroccan traditional medicine. (academicjournals.org)

Several compounds of this series displayed promising activity compared with a lead sulindac analog. (nih.gov)
These compounds have been characterized on the basis of elemental analysis, IR, 1 H NMR and MS. Compounds have been evaluated for their anticancer and antioxidant activities. (ijpsonline.com)
Compounds 2b, 2c and 6b exhibited significant antitumor activity against human breast cancer MCF 7 cell line. (ijpsonline.com)
2,5-Disubstituted-1,3,4-thiadiazoles represent one of the most active classes of compounds possessing wide spectrum of biological activities. (ijpsonline.com)
Based on the significant antibacterial activity, the sorting of bacterial cells against the compounds (MID6 and MID9) was analyzed by flow cytometry. (degruyter.com)
Compounds 1-3 gave nanomolar IC 50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. (rsc.org)
Optimisation and characterisation of various extraction conditions of phenolic compounds and antioxidant activity in olive seeds. (academicjournals.org)
Supercritical CO2 extraction and purification of compounds with antioxidant activity. (academicjournals.org)
Determination of antioxidant activity was performed using the DPPH assay (1.1-diphenyl-2-picrylhydrazyl), FTC (ferric thiocyanate) and determination of phenolic compounds by Follin method. (blogspot.com)
The antioxidant activity of the FTC method was 80% to 108.3% hydrogen peroxide kidnapping, the DPPH method showed an EC50 3.97 mg/mL, the content of total phenolic compounds was determined by calibration curve gallic acid, resulting from 0.0005 mg/100 g of gallic acid equivalent. (blogspot.com)
In fact, three of the predicted compounds had thesame structure with known anticancer compounds(HSCORE=1). (edu.et)
Predicted compounds were also shown to havering structures and functional groups deemed important foranticancer activity.CONCLUSIONS: Given the findings, there is apromising anticancer activity by thetraditionally used medicinal plants and apotential for the predicted phytochemicals to bepursued as possible hits or me-too drugs. (edu.et)
Several compounds showed low nanomolar or sub-nanomolar cell growth inhibitory activity. (bvsalud.org)
A structure-activity relationship for the estimation of rate constants for the gasphase reactions of OH radicals with organic compounds. (cdc.gov)

Animal tumor models and apoptin-transgenic mice have shown apoptin to be a safe and effective anticancer agent which causes a significant tumor regression. (wikipedia.org)
Accordingly, it was concluded that more effective anticancer agents can be developed by incorporating phenolic -OH group in the coumarin moiety and substituting a fluorine atom at an appropriate place of 3a-3j‎‎. (pharmacophorejournal.com)

The agar well diffusion method was used to assess the antibacterial and antifungal activities of partially pure fungal taxol against human and fungal pathogens. (degruyter.com)
Frankincense is an aromatic resin obtained from trees of the genus Boswellia and has been hypothesized to exhibit a number of health supporting properties, including the treatment of rheumatoid arthritis and anti-inflammatory, antibacterial, antifungal and anticancer activities ( 5 - 8 ). (spandidos-publications.com)

The antiviral, antibacterial, and anticancer properties of its chemo-skeleton have motivated this study to explore its efficacy in pharmaceutics. (nih.gov)
Prevention concluded that further in vitro testing of antiviral drugs exhibit in vitro anti-SARS-CoV activity. (cdc.gov)
The recent epidemic has shown that knowledge is lack- allow rapid screening of commercially available antiviral ing regarding the clinical management and treatment of agents, enabling those with in vitro evidence of activity to infected patients. (cdc.gov)

The aim of the present study was to evaluate the phytochemical composition, antioxidant and anticancer activity ofaqueous and methanol extracts against Human glioblastoma cells U87MG. (greenmedinfo.com)
The study aimed to evaluate the antimicrobial activity, antioxidant, toxicity and phytochemical screening of the Red Propolis Alagoas. (blogspot.com)

The results showed that the obtained complex could induce and stabilize G-quadruplex structure as well as exhibit potent inhibitory activity against telomerase. (telomerescience.com)
Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer. (bvsalud.org)

Then, global structure-activity relationships are discussed for ruthenium and osmium metallodrugs with respect to in vitro antiproliferative/cytotoxic activity and in vivo tumor-inhibiting properties, as well as pharmacokinetics. (rsc.org)
Cytotoxic activity of a-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. (academicjournals.org)
Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. (academicjournals.org)
Our investigation revealed that the cytotoxic activity was significantly affected by N3-alkyl substituents. (irost.org)

Future studies should focus on characterizing active red ginseng derivatives as potential anticancer drugs. (novapublishers.com)
The anticancer activity of betulinic acid and its 3- O -acylated derivatives were then evaluated in vitro against human lung carcinoma (A549) and human ovarian (CAOV3) cancer cell lines. (go.jp)
Accordingly, it was decided to prepare and perform the anticancer activity of novel coumarin derivatives. (pharmacophorejournal.com)

The results illustrated that certain cells (MCF-7 and HS-1 cells) demonstrate increased sensitivity to the two essential oils, and the anticancer effects of myrrh is superior to frankincense. (spandidos-publications.com)
The propolis extract showed high activity with a higher percentage than 75% inhibition of tumor cells OVCAR-8, SF-295 and HCT116. (blogspot.com)
Nevertheless, its activity in normal T cells underlines the need for extensive toxicological investigation. (iiarjournals.org)
To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)
Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)
SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
When overexpressed ectopically, anticancer genes preferentially kill cancer cells while sparing the normal healthy cells. (wikipedia.org)
In the late 1990s, research on cancer cells led to the identification of anticancer genes. (wikipedia.org)
Importantly, treatment with RTX-CD47 synergistically enhanced the phagocytic elimination of primary malignant B cells by autologous phagocytic effector cells as induced by therapeutic anticancer antibodies daratumumab (anti-CD38), alemtuzumab (anti-CD52) and obinutuzumab (anti-CD20). (rug.nl)
In conclusion, RTX-CD47 blocks CD47 "don't eat me" signaling by cancer cells in a CD20-directed manner with essentially no activity towards CD20(neg)/CD47(pos) cells and enhances the activity of therapeutic anticancer antibodies directed to B-cell malignancies. (rug.nl)
It enhances the activity of NK cells and has been found to initiate T cell responses against microbial pathogens and tumors. (depkewellness.com)
In conclusion, cytotoxicity against tumor cells, cytokine-mediated immunomodulatory properties, and broad-spectrum antimicrobial activity suggest that the Ps-1Pb and Ps-2Pa represent templates for design of non-hemolytic analogs for tumor therapy and for treatment of infections in cancer patients produced by multidrug-resistant pathogens. (ulster.ac.uk)
We found that FK866 shows anti-proliferative activity in three PDAC cell lines , as well as in Jurkat T-cell leukemia cells . (bvsalud.org)
Anticancer activity against human lung A549 cells and HL-60 leukemia cells was also evaluated. (cdc.gov)

Anthocyanins, flavanols, flavanols and resveratrol are the most important grape polyphenols because they possess many biological activities such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties. (oatext.com)

The synthesized analogues were tested for anticancer activity using NCI protocol. (amrita.edu)
More than 50 FK866 analogues were synthesized that introduce substituents on the phenyl ring of the piperidine benzamide group of FK866 and exchange its buta-1,4-diyl tether for 1-oxyprop-3-yl, (E)-but-2-en-1,4-diyl and 2- and 3- carbon tethers. (bvsalud.org)

The nutritional agent capsaicin displayed robust growth-inhibitory activity in a diverse array of human cancers. (worldhealth.net)
The ethanol extract of propolis of Alagoas showed significant results for antimicrobial activity, and inhibitory activity for Staphylococcus aureus and Candida krusei. (blogspot.com)
MATERIALS AND METHODS: DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. (nutrimedical.com)
The bioassay studies illustrated that compound 1 had antibacterial activity against gram-positive bacteria, with its minimum inhibitory concentration and minimum bactericidal concentration of 16-32 and 64-128 μg mL 1 , respectively. (scialert.net)

BACKGROUND: The merits of ethnomedicine-led approachto identify and prioritize anticancer medicinal plants havebeen challenged as cancer is more likely to be poorlyunderstood in traditional medicine practices. (edu.et)
Thus, this study combined an ethnobtanical studywith ligand based in silico screening to identify relevantmedical plants and predict their anticancer potential based ontheir phytoconstiutents reported in scientific literatures.METHODS: First, relevant medicinal plants were identifiedthrough an ethnobotanical survey. (edu.et)
Then, theirphytochemicals were subjected to in silico evaluation, whichincluded a hybrid score similarity measure, rule of five, Ghose-Viswanadhan-Wendoloski (GVW)-indices and structural featurescriteria, to predict their anticancer activity and drugability.RESULTS: A total of 18 medicinal plants and 265phytoconstituents were identified. (edu.et)

Considering the above facts, the goal of the present study was to combine disubstituted pyrimidines with 1,3,4-thiadiazole residues in order to develop hybrid molecules with potential of enhanced activity and to test their antioxidant and antitumor activities. (ijpsonline.com)
The present study aimed to investigate the composition and potential anticancer activities of essential oils obtained from two species, myrrh and frankincense, by hydrodistillation. (spandidos-publications.com)
This investigation might be further evaluated for its anticancer potential in a significant level. (florajournal.com)
The sulforhodamine B (SRB) colorimetric method was adopted to assess the anticancer potential of 3a-3j with respect to HCT-116 and MCF-7 cell lines. (pharmacophorejournal.com)
These findings indicate that the Ru-Se complex may be a potential telomerase inhibitor and a viable drug candidate in antiangiogenesis for anticancer therapies. (telomerescience.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)

We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin (Cis) with C60 fullerene (C60+Cis complex) and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. (hereon.de)

Alexidine dihydrochloride did not interfere with the activities of cisplatin, 5-fluorouracil, or radiation, and interacted in a less-than-additive manner. (aacrjournals.org)
Pt NPs anticancer activity was tested performing cell viability experiments with TNBC and comparing with a common chemotherapeutic drug (cisplatin). (aiche.org)

Flavonoids are the main groups of soluble phenolics in grapes as well as major contributors of the biological activities in products derived from grapes [10,11]. (oatext.com)
Therefore, it is paramount to understand the principles of biological activity, bioavailability and metabolism of grape flavonoids in relation to human health. (oatext.com)

In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. (frontiersin.org)
L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

The anticancer activity of red ginseng is higher than that of white ginseng due to the production of active anticancer ginsenosides during the steaming process, resulting in apoptosis/paraptosisinduction and angiogenesis inhibition. (novapublishers.com)
RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
Grape-related anti-tumoral activity encompasses a wide array of biological mechanisms and cellular targets, eventually leading to inhibition of cell growth and to enhanced apoptosis in several cancer cell lines, including lung, colon, breast, bladder, leukemia and prostate tumors. (oatext.com)
Complete inhibition of cytopathic anti-SARS-CoV activity. (cdc.gov)
Combination BRAFV600E inhibition with the multitargeting tyrosine kinase inhibitor axitinib shows additive anticancer activity in BRAFV600E-mutant anaplastic thyroid cancer. (cdc.gov)

The DPPH, ABTS+, OH radical, Iron (II) chelation and FRAP assays exhibited that methanol extract show a modulate antioxidant activity. (greenmedinfo.com)
In vitro antioxidant activity such as DPPH radical scavenging activity, hydroxyl radical scavenging activity, total antioxidant activity, reducing power of the methanolic extract of flowers were analyzed. (florajournal.com)
Radical scavenging activity was found to be higher in the methanolic extract of flowers. (florajournal.com)

Recently published in Pharmacology & Therapeutics , a leading medical review journal in the field of pharmacology, the article chronicles the growth-suppressive activity of sustained-release capsaicin drugs, including solid dispersion systems, liposomes, phospholipid complexes, and nanoparticles. (worldhealth.net)

Might particular monoamine oxidase inhibitors, currently used primarily to treat depression, have anti-cancer activity too? (sciencedaily.com)

Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)
GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated down- and up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases. (oatext.com)

Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)

FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl) acrylamide ) is a well-known NAMPT ( nicotinamide phosphoribosyltransferase ) inhibitor with anti- cancer activities, but it failed in phase II clinical trials. (bvsalud.org)

Below is a non-comprehensive list of common anticancer genes. (wikipedia.org)
In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the ones studied by the Wistar team until made accessible by the activity of other enzymes responsible for gene expression. (sciencedaily.com)
Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. (scienceblog.com)

SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

On the basis of fresh weight of fruit, Hull Thornless also had significantly higher anthocyanin, total phenolic content, antioxidant and antiproliferation activity than other two cultivars. (cdc.gov)

A study by a team of researchers at the Marshall University Joan C. Edwards School of Medicine provides the first published in-depth description of the anti-cancer activity of capsaicin sustained-release formulations. (worldhealth.net)
Sustained-release formulations of capsaicin are being explored for extended anti-cancer activity. (worldhealth.net)
This is the first publication to provide an in-depth description of the anti-cancer activity of capsaicin sustained-release formulations. (worldhealth.net)

Furthermore, a specific form of ibuprofen, dexibuprofen or the S-(+) form, shows interesting neurological activities and has been proposed for the treatment of Alzheimer's disease. (nih.gov)
To date, the global marine pharmaceutical pipeline consists of seven approved pharmaceuticals in clinical use, four of which are anticancer drugs, and about 26 natural products in Phase I to Phase III clinical trials, 23 as anticancer agents, two for schizophrenia and Alzheimer's, and one for chronic pain ( http://marinepharmacology.midwestern.edu/clinPipeline.htm ). (frontiersin.org)
Clinical trials of ginseng as a treatment for Alzheimer's patients support its beneficial activity without side effects, demonstrating that ginseng might be a promising medicine for Alzheimer's disease. (novapublishers.com)

Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area. (academicjournals.org)
Antimicrobial activity was evaluated by disk diffusion method. (blogspot.com)

Several scientific researches have been focalized on anti-inflammatory, anti-proliferative, antioxidant and other pharmacological activities of parsley. (greenmedinfo.com)

Investigational trials of anticancer drugs: establishing safeguards for experimentation. (cdc.gov)

Such data chal enge the "ca- and in experimental animals, with The four anticancer agents dis- nonical" site-specificity of carcino- reference to the possible underlying cussed here were first used in clin- ical practice in the 1960s, but since genesis. (who.int)

Antibacterial and Anticancer Properties of Microbispora sp. (scialert.net)
and arthritis and is said to have anticancer properties. (msdmanuals.com)
Some preclinical data have shown some anticancer calculated using the statistical formula n = Z2 P(1-P)/ properties of camel urine but it has not been investigated d2, where Z was the statistic corresponding to level of clinically ( 5 - 7 ). (who.int)

Anticancer Effect in Human Glioblastoma and Antioxidant Activity ofL. (greenmedinfo.com)

Methyl jasmonate enhances antioxidant activity and flavonoid content in blackberries (Rubus sp. (cdc.gov)
The effects of preharvest methyl jasmonate (MJ) application on fruit quality, antioxidant activity and flavonoid content in blackberries (Rubus sp. (cdc.gov)

Anticancer metallodrugs based on ruthenium and osmium are among the most investigated and advanced non-platinum metallodrugs. (rsc.org)

Substances causing this re-programming are already being used as anticancer drugs. (scienceblog.com)

Four different paclitaxel mimetics have successfully been synthesized and tested for their biological activity in five breast-derived cell lines. (lu.se)

In addition, the anticancer effects of myrrh were markedly increased compared with those of frankincense, however, no significant synergistic effects were identified. (spandidos-publications.com)

In particular, platinum nanoparticles (Pt NPs) have been reported with promising anticancer results. (aiche.org)
Additionally, the results of the Ames test show that the formation of such a complex diminishes the Cis mutagenic activity and may reduce the probability of secondary neoplasm formation. (hereon.de)
This activity eventually results in the formation of a tumourous mass. (scientificamerican.com)
They can change their methods rapidly, so that the results of a study about such activities may be outdated even at the moment of release. (who.int)

However, the presence of the ligand Phen-Se did not appear to have a significant effect either on G-quadruplex binding or on biological activity. (telomerescience.com)

Background: Little is known regarding the potentially chemopreventive activity of cyanidin-3-O-β-glucopyranoside (Cy-g), the main anthocyanin present in the juice of pigmented oranges, apart from its antioxidant activity. (iiarjournals.org)

Anatomy14

Organisms22

Diseases20

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes31

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture7

Information Science1

Vitro anticancer3

Compounds14

Effective anticancer2

Antifungal2

Antiviral3

Phytochemical2

Potent2

Cytotoxic activity4

Derivatives3

Cells15

Cardioprotective1

Analogues2

Inhibitory4

Medicinal3

Potential6

Tumor1

Cisplatin2

Flavonoids2

Extracts2

Inhibition5

Extract3

Complexes1

Inhibitors1

Species2

Apoptosis3

Inhibitor1

Genes3

DPPH1

Phenolic1

Anti-cancer activity3

Alzheimer's3

Antimicrobial activity2

Pharmacological activities1

Trials1

Agents1

Properties3

Human1

Content2

Ruthenium1

Drugs1

Cell1

Effects1

Results4

Biological activity1

Chemopreventive1