Anticancer. Medical search. Frequent questions

Drugs like bevacizumab ($50,000 per treatment episode) and ipilimumab ($120,000 per episode) have fueled the perception that the launch prices of anticancer drugs are increasing over time. (nber.org)
Using an original dataset of 58 anticancer drugs approved between 1995 and 2013, we find that launch prices, adjusted for inflation and drugs' survival benefits, increased by 10%, or about $8,500, per year. (nber.org)
Pricing in the Market for Anticancer Drugs, " Journal of Economic Perspectives, vol 29(1), pages 139-162. (nber.org)
If successfully developed into a treatment, the compound would be the first of a new class of anticancer drugs. (scripps.edu)
Substances causing this re-programming are already being used as anticancer drugs. (scienceblog.com)
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries have been serendipitous. (nature.com)
Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. (news-medical.net)
The results suggest that blunting the activity of Abcc10 might help counter resistance and extend the effectiveness of these anticancer drugs. (news-medical.net)
The researchers isolated cells from the knockout mice and tested the cells' reactions to taxanes and two other anticancer drugs, vincristine and Ara-C. Compared to cells from normal mice that still possessed the gene for Abcc10, the knockout mouse cells were much more sensitive to the drugs. (news-medical.net)
The results provide the first evidence from living organisms that Abcc10 is a cell's built-in protection against the effects of powerful drugs, and raises the possibility of using Abcc10 inhibitors to break down that resistance and sensitize tumor cells to anticancer agents. (news-medical.net)
The introduction of new anticancer drugs into the clinic is often hampered by a lack of qualified biomarkers. (nih.gov)
The conjugation of diazido Pt( IV ) complexes with anticancer drugs or cancer-targeting vectors is an effective strategy to optimise the design of these photoactive prodrugs. (rsc.org)
Investigational trials of anticancer drugs: establishing safeguards for experimentation. (cdc.gov)
According to the pharmacokinetics of anticancer drugs and aspects such as frequency and duration of treatment, several oral side effects may be observed. (bvsalud.org)
Objective: To report the potential oral repercussions derived from the use of anticancer drugs. (bvsalud.org)
The cytotoxic effect of anticancer drugs may promote a direct action that results in flaking, ulceration, xerostomia, and neurotoxicity, and an indirect action that causes the appearance of bleeding and opportunistic infections due to immunosuppression caused by the drug. (bvsalud.org)
Final Considerations: Clinical studies based on scientific evidence are required for the adaptation of protocols directed to the prevention and control of oral lesions arising from the toxicity of anticancer drugs. (bvsalud.org)

Diazido Pt( IV ) complexes with a general formula [Pt(N 3 ) 2 (L)(L′)(OR)(OR′)] are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy. (rsc.org)
Diazido Pt( IV ) complexes represent a series of promising anticancer prodrugs owing to their novel mechanism of action which differs from that of classical cisplatin and its analogues. (rsc.org)
Development of 5-fluorouracil-dichloroacetate mutual prodrugs as anticancer agents. (bvsalud.org)

So, could cannabinoids be used to develop new anticancer therapies? (erowid.org)
Vincent A, Ouelkdite-Oumouchal A, Souidi M, Leclerc J, Neve B, Van Seuningen I. Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies. (wjgnet.com)

Cold atmospheric plasma (CAP) has been reported to have strong anticancer effects in vitro and in vivo . (hindawi.com)

Animal tumor models and apoptin-transgenic mice have shown apoptin to be a safe and effective anticancer agent which causes a significant tumor regression. (wikipedia.org)
The novel anticancer agent FL118 may have additional applications as a personalized therapy for certain tumor types after a recent study showed the drug's efficacy in treating tumors. (pharmacytimes.com)
Gastric gastrointestinal stromal tumor (GIST) en face. (medscape.com)

The methylated flavonoids, compounds 1-3 and 5, were evaluated for their anticancer activities in comparison to the non-methylated parent flavonoids taxifolin (4) and quercetin (6). (mendeley.com)

Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
Anticancer and interferon agents : synthesis and properties / edited by Raphael M. Ottenbrite, George B. Butler. (who.int)

These compounds have been characterized on the basis of elemental analysis, IR, 1 H NMR and MS. Compounds have been evaluated for their anticancer and antioxidant activities. (ijpsonline.com)
Study Design: Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
The anticancer model's overall antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

The anticancer activity of these compounds was evaluated in colon cancer, HCT-116, and noncancerous, HEK-293, cell lines using the MTT antiproliferative assays. (mendeley.com)
Conclusion: The results support the traditional use of anticancer species as nutritional and dietary supplements, whose bioactive compounds are relevant in managing cancer patients. (who.int)

Anticancer therapy using cold atmospheric plasma (CAP) is a rapidly developing field through collaboration with physics, biology, chemistry, and medicine [ 1 - 6 ]. (hindawi.com)

In comparison to quercetin and ascorbic acid, the scavenging of superoxide radical (SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biologically active) of the anticancer plant was also evaluated. (who.int)

Upon irradiation, diazido Pt( IV ) complexes release anticancer active Pt( II ) species, azidyl radicals and ROS, which interact with biomolecules and therefore affect the cellular components and pathways. (rsc.org)
L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

Scientists have verified the anticancer effects of Kencur, a tropical plant of the ginger family, mainly grown in Southeast Asia, in cell and animal experiments. (sciencedaily.com)

Each of these alterations is possible when a particular cellular anticancer mechanism suffers disruptions. (cdc.gov)

When overexpressed ectopically, anticancer genes preferentially kill cancer cells while sparing the normal healthy cells. (wikipedia.org)
In the late 1990s, research on cancer cells led to the identification of anticancer genes. (wikipedia.org)
Guzman M. "Cannabinoids: potential anticancer agents" Nat Rev Cancer . (erowid.org)
RÉSUMÉ Le cancer du sein est le type de malignité le plus courant en Iraq. (who.int)
Les résultats de cette étude justifient un renforcement des efforts visant à mettre en place des programmes complets de lutte contre le cancer du sein en Iraq. (who.int)

Fig. 6: Anticancer activity of disulfiram and vanadium. (nature.com)

In earlier work, Elizabeth A. Hopper-Borge, Ph.D., an assistant professor at Fox Chase, showed that Abcc10 confers resistance to a number of anticancer agents, particularly taxanes, which include paclitaxel (Taxol) and docetaxel (Taxotere). (news-medical.net)

In addition, another recent study in mice found that the eating pattern may even have anticancer effects. (medicalnewstoday.com)

Ogundare O. C., Adedosu O. T., Afolabi O. K., Adeleke G. E., Akinboro T., Daniel A. A., Akoro S. M., Oludare V. I.. Ethnobotanical Survey, Physiochemical Composition and Preliminary Cytotoxic Evaluation of some Medicinal Plants with Anticancer Potential from Certain Areas in South-West Nigeria. (who.int)

Experiments from the UNC School of Medicine lab of Nobel Prize-winning scientist Aziz Sancar, MD, PhD, show how a common molecular tool for DNA labeling also has anticancer properties worthy of further investigation, especially for brain cancers. (newswise.com)
Sancar and his team hope to pursue follow-up collaborations with other researchers to investigate EdU's properties as an anticancer agent. (newswise.com)
and arthritis and is said to have anticancer properties. (msdmanuals.com)

Below is a non-comprehensive list of common anticancer genes. (wikipedia.org)

Predictors of prescription errors involving anticancer chemotherapy agents. (ahrq.gov)

Genentech negotiated exclusive worldwide rights to acquire one of Forma Therapeutics' preclinical-stage small molecule anticancer programs. (genengnews.com)
Cancer treatment has experienced a rapid increase in oral anticancer medications, including cytotoxic agents, small-molecule inhibitors, and agents targeted at receptors that regulate cellular differentiation, growth, and survival. (ons.org)

Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials. (nih.gov)
The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. (nih.gov)

Paclitaxel is a very potent anticancer drug that has been used since 1967 to treat breast, ovarian, and lung cancer, as well as advanced forms of Kaposi's sarcoma [ 1 ]. (hindawi.com)
B. Basse, B. C. Baguley, E. S. Marshall, W. R. Joseph, B. van Brunt, G. Wake and D. J. N. Wall, Modelling cell death in human tumour cell lines exposed to the anticancer drug paclitaxel , J. Math. (aimsciences.org)

In one study, a team of investigators at Northwestern University has shown that they can combine two powerful but extremely toxic anticancer agents - cisplatin and doxorubicin - in one polymer nanoparticle, producing a substantial boost in their ability of the combination to destroy tumors. (foresight.org)

In community pharmacies, multiple barriers exist that prevent these pharmacies from preparing extemporaneous oral anticancer drug formulations for a patient's use at home. (medscape.com)
[ 9-14 ] According to the United States Food and Drug Administration, no pediatric-specific formulation of any anticancer drug has been approved for the U.S. market. (medscape.com)
In 2D drug testing systems, cells lie flat on a surface, completely exposed and vulnerable to an anticancer drug on one side and protected by the dish on the other. (nih.gov)
An experimental anticancer drug called saracatinib shows promise as a treatment for Idiopathic Pulmonary Fibrosis (IPF), a chronic and often fatal condition that causes scarring or fibrosis of the lungs and makes breathing difficult. (nih.gov)
A. Altinok, F. Lévi and A. Goldbeter, A cell cycle automaton model for probing circadian patterns of anticancer drug delivery , Adv. Drug Deliv. (aimsciences.org)
A. Altinok, F. Lévi and A. Goldbeter, Optimizing temporal patterns of anticancer drug delivery by simulations of a cell cycle automaton , In M. Bertau, E. Mosekilde and H. Westerhoff, editors, Biosimulation in Drug Development, 275-297, Wiley, 2008. (aimsciences.org)
In the market update, PharmAust said the acquired library of AADs would assist with the company's main anticancer drug, Monepantel, which PharmAust is developing for clinical trials in humans and dogs diagnosed with cancer. (businessnews.com.au)

Pharmacists must have an understanding of the basic scientific principles that are an essential foundation for the proper preparation of extemporaneous oral anticancer liquid formulations. (medscape.com)

Figure 2: Potential immune mechanisms that explain the anticancer effects of probiotics. (nature.com)

This technology includes mutant isocitrate dehydrogenase (IDH1) inhibitors to be utilized as anticancer therapy. (nih.gov)

Anticancer agent that targets IDH1 mutations. (nih.gov)

The increase in oral anticancer medications calls on treatment centers to establish a workflow that ensures education, symptom management, and adherence monitoring are in the forefront. (ons.org)

Rznomics will leverage Charles River's viral vector CDMO experience to initiate clinical development of its RNA-based anticancer gene therapy in liver cancer patients. (biospace.com)

It will be indispensable to identify individual strains and clones (rather than phyla and genera) that have optimal anticancer effects. (nature.com)
Figure 3: Anticancer effects of bacterial products. (nature.com)
The active form of vitamin D3 seems to have anticancer effects. (massagemag.com)

Our study suggests that any possible anticancer benefits of methionine restriction require careful consideration of both the microbiota and the immune system. (nih.gov)

Apoptin was the first anticancer gene to be isolated. (wikipedia.org)

Nevertheless, studies on the potential anticancer activity of A. californica are rare, ambiguous ( 4 ) and largely performed with essential oils, but provide some preliminary data supporting its anticancer properties ( 5 ). (spandidos-publications.com)

In the late 1990s, research on cancer cells led to the identification of anticancer genes. (wikipedia.org)

[ 3-7 ] One survey found that some of the pills that were crushed in a nursing home included anticancer therapy such as tamoxifen. (medscape.com)

AntiCancer.News is a fact-based public education website published by AntiCancer News Features, LLC. (anticancer.news)

Below is a non-comprehensive list of common anticancer genes. (wikipedia.org)

When overexpressed ectopically, anticancer genes preferentially kill cancer cells while sparing the normal healthy cells. (wikipedia.org)

Anatomy12

Organisms12

Diseases16

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes41

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture6

Information Science2

Health Care2

Drugs17

Prodrugs3

Therapies2

Vitro1

Tumor3

Flavonoids1

Synthesis2

Antioxidant3

Compounds2

Therapy1

Quercetin1

Species2

Scientists1

Mechanism1

Cancer5

Activity1

Agents1

Mice1

Potential1

Properties3

Common1

Chemotherapy1

Small molecule2

Oncology2

Paclitaxel2

Doxorubicin1

Drug7

Formulations1

Mechanisms1

Inhibitors1

Targets1

Oral1

Clinical1

Effects3

Suggests1

Gene1

Preliminary1

Research1

Found1

News1

List1

Cancer cells1