• Compared to current anti-cancer chemotherapeutic drugs (or small molecules), anticancer peptides (ACPs) have numerous advantageous properties, such as high specificity, low production cost, high tumor penetration, ease of synthesis and modification. (springer.com)
  • Microtubules as a target for anticancer drugs. (nih.gov)
  • Some of its active components exert chemosensitization of well-known anticancer drugs. (hindawi.com)
  • DESCRIPTION (provided by applicant): This Phase II SBIR project is aimed at developing a novel type of drugs, termed SNX9-class compounds, with a unique combination of two anticancer activities. (sbir.gov)
  • PUBLIC HEALTH RELEVANCE: The goal of thisPhase II SBIR project is to develop a novel type of drug with a unique combination of two anticancer activities: selective killing of tumor cells and increasing the effect of existing anticancer drugs. (sbir.gov)
  • Development of anticancer drugs targeting the MAP kinase pathway. (nih.gov)
  • The rationale for targeting the MAP kinase pathway will be reviewed here along with a discussion of various pharmacological approaches and the promise they hold for a new generation of anticancer drugs. (nih.gov)
  • Organometallic ruthenium(II)-arene complexes are currently attracting increasing interest as anticancer compounds with the potential to overcome drawbacks of traditional drugs like cis platin with respect to resistance, selectivity, and toxicity. (ingentaconnect.com)
  • Hazardous anticancer drugs in healthcare: environmental exposure assessment. (cdc.gov)
  • Exposure of health care workers to anticancer drugs became problematic in the 1970s. (cdc.gov)
  • Other anticancer/hazardous drugs would most likely be used in these areas. (cdc.gov)
  • An exposure assessment of areas where anticancer/hazardous drugs are handled must consider every potential source and route of exposure. (cdc.gov)
  • We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. (plos.org)
  • Given their unique mode of action and potential for unique synergies with established anticancer drugs, our results provide a strong basis to further explore the potential application of these compounds in cancer in pre-clinical or and clinical settings. (plos.org)
  • PharmaMar (MSE:PHM), a world-leading biopharmaceutical company in the discovery and development of innovative marine-derived anticancer drugs, announced today that its novel Antibody-Drug Conjugate (ADC) demonstrates strong anticancer activity in vitro and in vivo against tumors expressing HER2 derived from breast, gastric and ovarian cancers. (eurekalert.org)
  • Headquartered in Madrid, PharmaMar is a world-leading biopharmaceutical company in the discovery and development of innovative marine-derived anticancer drugs. (eurekalert.org)
  • Amgoth C, Dharmapuri G, Kalle AM, Paik P (2016) Nanoporous capsules of block copolymers of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for the controlled release of anticancer drugs for therapeutic applications. (springer.com)
  • Eckschlager T, Plch J, Stiborova M, Hrabeta J. Histone Deacetylase Inhibitors as Anticancer Drugs. (mdpi.com)
  • Anticancer drugs research and development ha ve been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. (scirp.org)
  • This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment. (scirp.org)
  • For over 50 years, the search for anticancer drugs has been governed by the fact that tumor cells replicate more rapidly than normal cells and that DNA is the most important molecule in cell division. (scirp.org)
  • The labs of Paul Dyson and Ursula Röthlisberger at EPFL, together with the lab of Curtis Davey at NTU, explored the synergistic effects of two unrelated drugs: auranofin (Ridaura), a gold-containing drug that is used to alleviate the symptoms of rheumatoid arthritis, and RAPTA-T, a ruthenium-containing anticancer drug that disrupts both tumor growth and metastasis, while also reducing the side effects of chemotherapy due to its low toxicity. (eurekalert.org)
  • After strong public reaction, Norway's health minister, Jonas Gahr Støre, has reversed a decision to exclude the two anticancer drugs ipilimumab and abiraterone from the list of drugs covered by national insurance. (bmj.com)
  • This invention relates broadly to the controlled release of drugs to the bloodstream and tissues of mammals and more particularly to a shaped article formed from a biodegradable polymer which contains one or more anticancer agents so that the article is suitable for implantation in a mammal to controllably release the anticancer agents. (freepatentsonline.com)
  • Ruthenium anti-cancer drugs are coordination complexes of ruthenium complexes that have anticancer properties. (wikipedia.org)
  • They promise to provide alternatives to platinum-based drugs for anticancer therapy. (wikipedia.org)
  • Ruthenium complexes as anticancer drugs are almost always designed to mimic platinum drugs, for targeting DNA. (wikipedia.org)
  • Those plant chemicals that are selectively more toxic to cancer cells than normal cells have been discovered in screening programs and developed as chemotherapy drugs Some plants that indicate potential as an anticancer agent in laboratory-based in vitro research - for example, Typhonium flagelliforme, and Murraya koenigii are currently being studied. (wikipedia.org)
  • Anticancer Drugs. (wikipedia.org)
  • Herein, we provide a brief overview of the evidence supporting anticancer activity of Indian Gooseberry extracts, suggest possible mechanisms for these actions, and provide future directions that might be taken to translate these findings clinically. (hindawi.com)
  • Nam Dang M.D, Ph.D., researcher from the University of Florida and colleagues from Japan have documented the dramatic anticancer effect of the humble papaya against a wide range of lab-grown tumors including cancers of lung, breast, pancreas and the cervix. (ibtimes.com)
  • Anticancer mechanisms of cannabinoids. (nih.gov)
  • Of late elucidation of the intricate mechanisms involved in the molecular aspect of interaction of cinnamon with development of malignancy has become an important area of exploration where it is felt that probing into the multifarious process, through which cinnamon brings about its anticarcinogenic efficacy, is immensely required for its implementation in the field of anticancer drug development. (hindawi.com)
  • Here, we will provide an overview of the literature supporting these concepts and attempt to lend insight into possible mechanisms whereby the anticancer properties are achieved. (hindawi.com)
  • There is a wealth of information emanating from both in vitro and in vivo studies indicating fruit extract of the Phyllanthus emblica tree, commonly referred to as Indian Gooseberries, has potent anticancer properties. (hindawi.com)
  • HDAC inhibitors have also shown preclinical promise when combined with other therapeutic agents, and innovative drug delivery strategies, including liposome encapsulation, may further enhance their clinical development and anticancer potential. (nih.gov)
  • Guillermo Velasco and colleagues, at Complutense University, Spain, have provided evidence that suggests that cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells. (medicalnewstoday.com)
  • En 2016, Rémi Fromentin, associé de recherche au sein du laboratoire de Nicolas Chomont, a démontré que les cellules abritant les virus persistants ont des caractéristiques immunologiques particulières : trois protéines nommées PD-1, LAG-3 et TIGIT s'exprimant fréquemment à leur surface. (eurekalert.org)
  • Anticancer genes are genes that, when ectopically overexpressed, specifically destroy tumour cells without harming normal cells. (wikipedia.org)
  • The mechanism of the anticancer action of the ethyl acetate extract of the traditional Chinese medicinal plant Euphorbia helioscopia was explored through the use of a hepatocellular carcinoma xenograft model in nude mice. (hindawi.com)
  • We performed in vacuo density functional theory(DFT) calculations, classical MD, and mixed QM/MM Car-Parrinello MD explicit solvent simulations to rationalize the binding mode of two series of anticancer ruthenium(II) arene complexes to double-stranded DNA (dsDNA).Binding energies between the metal centers and the surrounding ligands as well as proton affinities were calculated using DFT. (ingentaconnect.com)
  • The fact that SR/CR mice survived the initial challenge with cancer cells without any prior exposure suggests that the anticancer response is innate immunity. (pnas.org)
  • Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. (nih.gov)
  • Dr. Nam Dang, professor of medicine at the University of Florida and his colleagues in Japan have recently shown that papaya leaf tea (extract) has anticancer effects and at the same time it does not have any harmful or toxic impact on normal cells, which greatly improves its chances of being an effective cancer-fighting agent. (emaxhealth.com)
  • Anticancer genes emerged from studies on cancer cells in the late 1990s. (wikipedia.org)
  • Public warning issued by the Anticancer Fund Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells). (wikipedia.org)
  • Therefore, in silico designing of anticancer peptides is beneficial, prior to their synthesis and characterization. (springer.com)
  • The extract was made of dried papaya leaves and results showed the anticancer effects stronger than when tea was used as a substitute. (ibtimes.com)
  • The results from the study that showed the success of the papaya as an anticancer, without toxicity is also consistent with reports from Indigenous populations in Australia and his native Vietnam, said Dang. (ibtimes.com)
  • For centuries, various cultures have claimed that papaya has anticancer abilities, with stories reporting remission after consuming papaya tea extract. (emaxhealth.com)