AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Vaccinia virusVacciniaAntibodiesAntibodies, ViralAntibody SpecificityViral ProteinsVirus ReplicationAntibodies, MonoclonalPoxviridaeAntibodies, BacterialGenes, ViralMolecular Sequence DataVariola virusAntibody FormationAntibodies, NeutralizingCell LineCowpox virusSmallpoxRNA VirusesNeutralization TestsAmino Acid SequenceSmallpox VaccineVaccines, SyntheticPoxviridae InfectionsAntigens, ViralFluorescent Antibody TechniqueVirus CultivationVirus AssemblyHeLa CellsDNA, ViralCercopithecus aethiopsReceptors, VirusViral Plaque AssayGenetic VectorsFowlpox virusEpitopesViral VaccinesVirionVirus DiseasesViral Envelope ProteinsVirus SheddingMice, Inbred BALB COrthopoxvirusRNA, ViralDefective VirusesAntibody AffinityMeasles virusHIV AntibodiesViral Structural ProteinsRecombinant ProteinsCross ReactionsSimian virus 40Gene Expression Regulation, ViralBase SequenceSindbis VirusDNA VirusesVero CellsRespiratory Syncytial VirusesRabies virusRecombination, GeneticRabbitsImmunizationMonkeypox virusPlant VirusesAntibodies, Anti-IdiotypicBinding Sites, AntibodyVaccinationViral Core ProteinsInfluenza A Virus, H1N1 SubtypeOncolytic VirusesAntiviral AgentsInfluenza A Virus, H5N1 SubtypeVesicular stomatitis Indiana virusCells, CulturedHemagglutinins, ViralTranscription, GeneticAntibodies, NeoplasmAntibodies, ProtozoanImmunization, SecondaryMyxoma virusHemagglutinin Glycoproteins, Influenza VirusHepatitis B virusSimian immunodeficiency virusInfluenza A Virus, H3N2 SubtypeOpen Reading FramesMolecular WeightHaplorhiniWest Nile virusT-Lymphocytes, CytotoxicCytopathogenic Effect, ViralEnzyme-Linked Immunosorbent AssayCowpoxImmunoglobulin MImmunoglobulin GAIDS VaccinesImmune SeraAntibodies, AntinuclearL Cells (Cell Line)CD8-Positive T-LymphocytesPlasmids
VaccineAnkaraAnti-VacciniaMonoclonal AntibodyVaccinationVariola virusOrthopoxvirusInfectionStrainSpecificityResponsesViralSpeciesProteinImmunogenPoxvirusTherapeuticProteinsRecombinant antibodyCowpoxOncolytic virusesImmune globulinAntigensInoculationImmunizationVaccinesPolyclonalInfluenza virusAntiviralTiterHerpesCloneStrainsHumanMpoxTargetsAntigenFlow cytometric analysisParticlesHemagglutininReplicationProgressiveCell-to-cell spreadInfectionsELISADisseminateVector2019CoronavirusPeptidesVectorsVirionsImmunogenic
Vaccine34
  • The MVA-based vaccine was well tolerated and induced antibodies to both the homologous (A/Vietnam/1194/2004, clade 1) and a heterologous (A/Indonesia/5/2005, clade 2.1) H5N1 virus ( 8 ). (cdc.gov)
  • Results of hemagglutination-inhibition (HI) testing of modified vaccinia virus Ankara influenza vaccine cross-reactivity. (cdc.gov)
  • Certain military recruits continue to receive vaccinia vaccine owing to the concern for bioterrorism. (medscape.com)
  • In the United States, Dryvax became the first approved vaccinia virus vaccine in 1931. (medscape.com)
  • Vaccinia virus is the species now characterized as the constituent of smallpox vaccine. (medscape.com)
  • Report possible human cases of vaccinia virus (smallpox vaccine) to your local hospital epidemiologist and/or infection control personnel, who will contact your local, state, or territorial health department. (cdc.gov)
  • ACAM2000, a replicating vaccinia virus-based second generation smallpox vaccine, can provide effective protection even after exposure to MPXV. (nature.com)
  • a) Vaccine: A suspension of live (usually attenuated) or inactivated microorganisms (e.g., bacteria, viruses, or rickettsiae) or fractions thereof administered to induce immunity and prevent infectious disease or its sequelae. (cdc.gov)
  • Vaccination and vaccine derive from vaccinia, the virus once used as smallpox vaccine. (cdc.gov)
  • Active immunization is the production of antibody or other immune responses through the administration of a vaccine or toxoid. (cdc.gov)
  • They started with a strain of vaccinia virus - that's the poxvirus which was used as a vaccine to immunize against, and ultimately eradicate, smallpox. (thenakedscientists.com)
  • Vaccinia is a live virus vaccine that was last routinely used in the United States in 1972. (netce.com)
  • Virologists at the University of Missouri (US) analysing 200 strains of the Monkeypox virus circulating since 1965 found mutations that allow it to avoid natural and vaccine-induced antibodies. (cosmosmagazine.com)
  • But while the vaccine can safeguard against infection, the monkeypox virus - like all viruses - has its own arsenal of weapons. (cosmosmagazine.com)
  • The mutations were occurring at critical points impacting DNA genome binding, as well as where drugs and vaccine-induced antibodies are supposed to bind," Singh says. (cosmosmagazine.com)
  • With three vaccine shots, one every four weeks, the vaccine induces neutralizing antibodies and T-cell responses. (arttic.eu)
  • GeoVax has demonstrated that a single intramuscular (IM) dose of its vaccine candidate, GEO-EM01, provided 100% protection in rhesus macaques challenged with a lethal dose of Ebola virus (EBOV). (gabio.org)
  • In addition to its vaccine for EBOV, GeoVax is also developing preventive vaccines for other hemorrhagic fever viruses highly lethal to humans. (gabio.org)
  • Separately, GeoVax is leading a multi-party collaboration for the development of its SUDV and Marburg virus (MARV) vaccine candidates. (gabio.org)
  • Additionally, GeoVax's vaccine against Lassa Fever virus (LASV) is progressing in preclinical studies with funding support from the U.S. Department of Defense. (gabio.org)
  • David Dodd, GeoVax President and CEO, commented, "While our corporate focus and development priorities continue to be our COVID-19 vaccine and cancer immunotherapy programs, developing vaccines against lethal hemorrhagic fever viruses is also of interest and under consideration as part of our longer-term focus. (gabio.org)
  • Our Modified Vaccinia Ankara-Virus Like Particle (MVA-VLP) based vaccine platform utilizes MVA, a large virus capable of carrying several vaccine antigens, that expresses proteins that assemble into VLP immunogens in the person receiving the vaccine. (gabio.org)
  • TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. (virology.ws)
  • In this context, and in the broader context of a need for data comparability, as discussed in the overview paper in this volume, establishing criteria for assessing adverse events following smallpox (vaccinia) vacciniation is important for clinicians administering the smallpox vaccine and appropriately treating patients with adverse events following immunization (AEFI), and also for scientists collecting, analyzing, and communicating data on AEFI. (brightoncollaboration.org)
  • Vaccine-induced anti-RH5 serum antibodies exhibited cross-strain functional growth inhibition activity (GIA) in vitro, targeted linear and conformational epitopes within RH5, and inhibited key interactions within the RH5 invasion complex. (jci.org)
  • Several strategies for the development of a vaccine against this virus are currently pursued. (asm.org)
  • Using a subviral particle vaccine candidate, we show here that one protein complex of HCMV, termed the pentameric complex (PC), enhances the neutralizing antibody response against viral infection of different cell types. (asm.org)
  • This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
  • With this target, we have created book vaccine applicants predicated on the poxvirus customized vaccinia pathogen Ankara (MVA) stress expressing the full-length SARS-CoV-2 spike (S) protein, and we've evaluated their immunogenicity Levofloxacin hydrate in mice using MVA/MVA or DNA/MVA perfect/increase immunization protocols. (spierarchitecturalarts.com)
  • A lot of vaccine applicants are under advancement, based either overall pathogen (inactivated or attenuated infections), nonreplicating viral vectors expressing SARS-CoV-2 antigens, nucleic acidity (mRNA or DNA), and subunits (proteins or virus-like contaminants) (7, 8). (spierarchitecturalarts.com)
  • Perhaps one of the most set up and guaranteeing applicant vector to get a vaccine is certainly vaccinia pathogen (VACV), which offered to eliminate smallpox (27). (spierarchitecturalarts.com)
  • The Orthopoxvirus genus also includes variola virus (which causes smallpox), vaccinia virus (used in the smallpox vaccine), and cowpox virus. (cdc.gov)
  • The apparent changing epidemiology of the disease, the current reliance on the public health system for testing and access to vaccine, and the need for prompt public health response to identified cases for the purposes of reducing spread all support the need for a standardized case definition and national notifiability for mpox virus infection. (cdc.gov)
  • Like other arenaviruses, Lassa virus lacks a ogy and clinical presentation, treatment, prevention conventional negative-strand coding arrangement and control as well as the current theories of its patho- and the isolates of the virus differ in their genetic, genesis and efforts in vaccine development. (folkhalsomyndigheten.se)
Ankara9
  • Modified vaccinia virus Ankara (MVA) is a promising viral vector platform for the development of influenza vaccines ( 5 ). (cdc.gov)
  • The so-called 'Modified Vaccinia virus Ankara', or MVA, was then manipulated genetically to express a protein found on Mycobacterium tubercolosis , called 85A. (thenakedscientists.com)
  • At first, two protein antigens are injected, followed by an MVA ("modified vaccinia virus Ankara") vector. (arttic.eu)
  • ATLANTA, GA, October 14, 2021 - GeoVax Labs, Inc . (Nasdaq: GOVX), a biotechnology company developing human immunotherapies and vaccines against infectious diseases and cancer, today announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for Patent Application No. 15/543,139 entitled "Replication-Deficient Modified Vaccinia Ankara (MVA) Expressing Ebola Virus Glycoprotein (GP) and Matrix Protein (VP40) . (gabio.org)
  • GEO-EM01 is based on the Company's novel Modified Vaccinia Ankara (MVA) Virus-Like Particle (VLP) platform, which generates noninfectious VLPs in the individual being vaccinated. (gabio.org)
  • Safe and effective third-generation smallpox vaccines, namely, LC16m8 and modified vaccinia virus Ankara (MVA), are effective in protecting vaccinees from hMPX. (go.jp)
  • Third-generation smallpox vaccines, such as modified vaccinia virus-Ankara (MVA) and LC16m8, are effective. (go.jp)
  • We utilized established viral vectors, the replication-deficient chimpanzee adenovirus serotype 63 (ChAd63), and the attenuated orthopoxvirus modified vaccinia virus Ankara (MVA), encoding RH5 from the 3D7 clone of P. falciparum. (jci.org)
  • Since that time, attenuated VACV strains highly, like customized vaccinia pathogen Ankara (MVA), have already been produced and proven in a number of preclinical and scientific trials to become a fantastic vector to create efficacious vaccines against a number of pathogens (28,C32). (spierarchitecturalarts.com)
Anti-Vaccinia1
  • Monkeypox virus antigen was readily demonstrated by immunohistochemistry using anti-vaccinia mouse polyclonal antibodies as well as anti-monkeypox rabbit polyclonal antibodies. (blogspot.com)
Monoclonal Antibody2
  • The following product was used in this experiment: CD279 (PD-1) Monoclonal Antibody (J43), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-9985-82, RRID AB_467023. (thermofisher.com)
  • Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. (thermofisher.com)
Vaccination11
Variola virus8
Orthopoxvirus4
Infection29
  • Several poultry farms in the Netherlands, Germany, United Kingdom, and Italy were recently affected by infection with H5N8 virus closely related to the strains circulating in Asia ( 4 ), leading to implementation of preventive measures to restrict viral spread. (cdc.gov)
  • Inoculation with vaccina virus produces a localized skin infection. (medscape.com)
  • although the cause remains unknown (immune-mediated response versus direct viral infection), a cardiac tissue biopsy may be used to evaluate for the presence of virus or histological evidence of inflammation. (cdc.gov)
  • Immunosuppressed individuals tend to have a larger fatality rate and tendency to get the virus due to HIV infection, iatrogenic immunosuppression, etc. (wikipedia.org)
  • The Committee noted progress in the development of a solid-membrane assay suitable for use in the field which could detect the presence of orthopoxviruses or varicella virus in individuals presenting with symptoms consistent with smallpox infection. (who.int)
  • The immune system could play a crucial role in virus infection. (medsci.org)
  • The successful development and implementation to intervene prevention and treatment of virus infection over the past hundred years have had great advances on human and animal health. (medsci.org)
  • However, to this day, in the fight against virus infection, there is no real winner. (medsci.org)
  • It is primarily used for replacement therapy in primary antibody-deficiency disorders, for the treatment of Kawasaki disease, immune thrombocytopenic purpura, hypogammaglobulinemia in chronic lymphocytic leukemia, and some cases of HIV infection. (cdc.gov)
  • These data suggest that despite successful use of ART, HIV infection is associated with a significant loss in virus-specific CD4+ T cell memory and antiviral antibody responses that may leave a sizeable proportion of HIV+ people at increased risk for virus-associated disease manifestations. (natap.org)
  • After the introduction of HAART, the incidence of certain virus-associated cancers such KS and NHL decreased whereas cervical cancer incidence remained largely unaltered[38], indicating that prolonged immune suppression plays a role in susceptibility to some pathogens but may not completely explain the increased risks associated with HIV infection. (natap.org)
  • 350 cells/mm3 after ART), antigen-specific CD4+ T cell memory to vaccinations/infections that occurred before HIV infection did not recover after immune reconstitution and a previously unrealized decline in pre-existing antibody responses was observed. (natap.org)
  • Since Africa suffers from a high infection rate and particular HBV viruses can be found there, part of the clinical trial will be conducted in Tanzania. (arttic.eu)
  • VLPs mimic a natural infection, triggering the body to produce a robust and durable immune response with both antibodies and T cells. (gabio.org)
  • The production of VLPs in the person being vaccinated can mimic virus production in a natural infection, stimulating both the humoral and cellular arms of the immune system to recognize, prevent, and control the target infection. (gabio.org)
  • Human monkeypox (hMPX), a smallpox-like disease caused by infection with the monkeypox virus (MPXV), is endemic to Central and Western Africa. (go.jp)
  • Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. (microbiologyresearch.org)
  • In addition, this Health Update provides an update to a HAN Health Advisory that the Centers for Disease Control and Prevention (CDC) issued May 20, 2022 titled Monkeypox Virus Infection in the United States and Other Non-endemic Countries-2022 . (cdc.gov)
  • Using a recombinant γHV68 that is cleared following acute infection, we show that ABCs persist in the absence of latent virus, though their expression of IFNγ and TNF is decreased. (nature.com)
  • We predict that ABCs could be playing a role throughout γHV68 infection due to their long-term persistence, activation of T cells, and continuous cytokine and antibody production. (nature.com)
  • Of particular interest was the finding that PC-positive DBs induced an antibody response that blocked the infection of fibroblasts by a PC-positive viral strain more efficiently than sera following immunizations with PC-negative particles. (asm.org)
  • the presence of the PC in the particles also enhanced the neutralizing antibody response against the infection of fibroblasts by HCMV. (asm.org)
  • A connection between cancer regression and viruses has long been theorised, and case reports of regression noted in cervical cancer , Burkitt lymphoma , and Hodgkin lymphoma , after immunisation or infection with an unrelated virus appeared at the beginning of the 20th century. (privacytools.io)
  • [15] Efforts to treat cancer through immunisation or virotherapy (deliberate infection with a virus), began in the mid-20th century. (privacytools.io)
  • Severe acute respiratory syndrome (SARS) is a serious, potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family, the SARS-associated coronavirus (SARS-CoV). (medscape.com)
  • Mpox (previously named monkeypox) is a zoonotic disease that is caused by infection with mpox virus. (cdc.gov)
  • Serum samples from those afflicted demonstrated evidence of Hantavirus infection and within 10 weeks of the original outbreak, researchers had successfully developed a diagnostic test for the virus. (medscape.com)
  • The virus exhibits persistent, asymptomatic infection with profuse urinary virus excretion in the ubiquitous rodent vector, Mastomys natalensi s. (folkhalsomyndigheten.se)
  • tent, asymptomatic infection, with profuse urinary virus excretion in Mastomys natalensi s, the ubiqui- The emergence of this highly virulent and contagious tous and highly commensal rodent host2,3. (folkhalsomyndigheten.se)
Strain8
  • Therefore, shortly after the H5N8 outbreak in poultry in the Netherlands, we determined whether MVA-H5-sfMR-induced antibodies cross-react with the new H5N8 strain. (cdc.gov)
  • A/Vietnam/1194/2004-specific serum (homologous titer 80) displayed low cross-reactivity with the clade 0, 2.2, and 2.3 viruses and completely failed to react with H5N8 strain A/chicken/Netherlands/EMC-3/2014. (cdc.gov)
  • Immunogen: Vaccinia virus antibody (FITC) was raised in rabbit using new york city board of health (NYCBOH) strain, Vaccinia (whole virus) as the immunogen. (gentaur.be)
  • Although some vaccinia viruses commonly disseminate through the bloodstream, the NYCBOH strain reportedly causes only limited viremia in a small percentage of recipients during the period of pustule formation. (wikipedia.org)
  • The vaccinia virus Tiantan strain (VTT) was used to vaccinate against smallpox in China 42 years ago. (nature.com)
  • Nucleotide sequence of 21·8 kbp of variola major virus strain Harvey and comparison with vaccinia virus. (microbiologyresearch.org)
  • Cynomolgus monkeys (Macaca fascicularis) were exposed by fine-particle aerosol to lethal doses of monkeypox virus, Zaire strain. (blogspot.com)
  • To be able to directly compare the impact of the PC on the levels of neutralizing antibody (NT-abs) responses, a PC-positive variant of the HCMV laboratory strain Towne was established by bacterial artificial chromosome (BAC) mutagenesis (Towne-UL130rep). (asm.org)
Specificity7
  • Find Dual Specificity Phosphatase 3 Antibodies for a variety of species such as anti-Human Dual Specificity Phosphatase 3, anti-Mouse Dual Specificity Phosphatase 3, anti-Rat Dual Specificity Phosphatase 3. (antibodies-online.com)
  • Find Dual Specificity Phosphatase 3 Antibodies validated for a specific application such as WB, ELISA, IHC, IF (cc). (antibodies-online.com)
  • Find Dual Specificity Phosphatase 3 Antibodies with a specific Host. (antibodies-online.com)
  • Find available monoclonal or polyclonal Dual Specificity Phosphatase 3 Antibodies. (antibodies-online.com)
  • Find Dual Specificity Phosphatase 3 Antibodies with a specific conjugate such as Biotin, FITC, HRP. (antibodies-online.com)
  • In order to study the specificity of cellular immune responses against SARS CoV-2 and potential immunity caused by other human Corona Viruses, Abcepta provides Spike peptide individually, as pools and in plate. (abcepta.com)
  • Antibody modification increased specificity, sensitivity, and yield of PCR. (biolmedonline.com)
Responses7
  • A successful "take" is required for the development of antivaccinia antibody and cell-mediated responses. (wikipedia.org)
  • This may be because the other vaccines induce antibody responses in the immune system, rather than the killer cell-mediated immunity, and the two immunological strategies are known to inhibit one-another. (thenakedscientists.com)
  • The loss of CD4+ T cell memory and antibody responses to infections encountered prior to HIV acquisition could have implications with regard to protective immunity to common acute or chronic viral infections. (natap.org)
  • The MVA-VLP derived vaccines can elicit durable immune responses in the host similar to a live-attenuated virus, while providing the safety characteristics of a replication-defective vector. (gabio.org)
  • This is the first time to our knowledge that substantial RH5-specific responses have been induced by immunization in humans, with levels greatly exceeding the serum antibody responses observed in African adults following years of natural malaria exposure. (jci.org)
  • Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
  • [1] [2] Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. (privacytools.io)
Viral10
  • Dissociation of progeny vaccinia virus from the cell membrane is regulated by a viral envelope glycoprotein: effect of a point mutation in the lectin homology domain of the A34R gene. (microbiologyresearch.org)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • Research by Singh's team shows that monkeypox's mutation help change parts of the viral structure targeted by antibodies and antiviral drugs. (cosmosmagazine.com)
  • Instead of the classical types of vaccines such as live and inactivated viruses, several novel immunogens including protein subunit and DNA vaccines as well as viral and bacterial vectors are currently being examined. (aerzteblatt.de)
  • Unexpectedly, large-scale outbreaks of emerging viral infections caused by viruses spilled over from nonhuman mammals to humans have occurred in the last 20 years. (go.jp)
  • Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir. (virology.ws)
  • We find that mice without ABCs display defects in anti-viral IgG2a/c antibodies and are more susceptible to reactivation of γHV68 following virus challenges that typically do not break latency. (nature.com)
  • Overview of Viral Infections A virus is composed of nucleic acid, either DNA or RNA, surrounded by a protein coat. (msdmanuals.com)
  • They are not related to chickenpox, which is caused by varicella-zoster virus and is part of another viral group. (msdmanuals.com)
  • Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting and, chest and abdominal pain. (folkhalsomyndigheten.se)
Species4
  • All human viruses have their origin in a virus that crossed from a different animal species. (virology.ws)
  • The neutralizing antibody response to PC-positive DBs was superior to that of PC-negative DBs, as tested on fibroblasts, epithelial cells, and endothelial cells and for both animal species used. (asm.org)
  • Differences between CRS and controls were compared across individual antimicrobial antibodies and the species. (elsevierpure.com)
  • The Centers for Disease Control and Prevention (CDC) can confirm the presence of mpox virus and determine the clade (West African (Clade II) or Congo Basin clade (Clade I)) by mpox virus species-specific RT-PCR. (cdc.gov)
Protein10
  • Lipase activities of p37, the major envelope protein of vaccinia virus. (microbiologyresearch.org)
  • Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein. (microbiologyresearch.org)
  • Sequence analysis, expression, and deletion of a vaccinia virus gene encoding a homolog of profilin, a eukaryotic actin-binding protein. (microbiologyresearch.org)
  • TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
  • In this study, the role of the His residue at position 39 in the M protein (M39) of dengue virus type 2 (DENV-2) in the virus life cycle was investigated. (microbiologyresearch.org)
  • Expression of cloned envelope protein genes from the flavivirus tick-borne encephalitis virus in mammalian cells and random mutagenesis by PCR. (microbiologyresearch.org)
  • Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form. (microbiologyresearch.org)
  • Methods: We profiled IgG and IgA antibodies to individual microbial proteins in serum samples of CRS patients and controls using a novel high-throughput microarray protein technology, Nucleic Acid Programmable Protein Array (NAPPA). (elsevierpure.com)
  • Recombinant HIV protein including HIV envelopes, envelope derivatives, Virus Like Particles, as well as formulations of HIV proteins with immune enhancers such as adjuvants and immune modulators. (nih.gov)
  • The envelope S protein mediates pathogen cell admittance through binding to its web host receptor, angiotensin-converting enzyme 2 (ACE2) (9), and may be the primary focus on for neutralizing antibodies (nAbs) (10,C12). (spierarchitecturalarts.com)
Immunogen1
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abcepta.com)
Poxvirus1
  • This uses an attenuated (weakened) version of the vaccinia virus - a poxvirus - which after two doses administered a month apart allows the recipient's body to produce lifelong antibody resistance to monkeypox and smallpox. (cosmosmagazine.com)
Therapeutic2
  • Symphogen is a private biopharmaceutical company leading the field of recombinant antibody mixtures for therapeutic use in oncology. (symphogen.com)
  • These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. (waccobb.net)
Proteins5
  • Seven virus-encoded proteins have been identified that are components of IEV, and five of them are present in CEV or EEV. (microbiologyresearch.org)
  • The roles of these proteins in virus morphogenesis and dissemination, and as targets for neutralizing antibody are reviewed. (microbiologyresearch.org)
  • Senior author of the paper published in Journal of Autoimmunity Kamlendra Singh says the research team was able to identify monkeypox's mutations by using three-dimensional modelling of the virus proteins. (cosmosmagazine.com)
  • Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. (microbiologyresearch.org)
  • With its history as an original manufacturer, Abcepta has a deep and practical understanding of the production process for antibodies, peptides, and recombinant proteins. (abcepta.com)
Recombinant antibody2
  • See more details about Hi-Affi™ recombinant antibody benefits . (creativebiolabs.net)
  • Download resources about recombinant antibody development and antibody engineering to boost your research. (creativebiolabs.net)
Cowpox1
Oncolytic viruses4
  • This review integrates most experimental studies and clinical trials of various oncolytic viruses (OVs) in the diagnosis and treatment of GC. (frontiersin.org)
  • [3] [4] Oncolytic viruses also have the ability to affect the tumor micro-environment in multiple ways. (privacytools.io)
  • [8] Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the senecavirus , [9] resulting in clinical trials . (privacytools.io)
  • [15] [16] As the technology to create a custom virus did not exist, all early efforts focused on finding natural oncolytic viruses. (privacytools.io)
Immune globulin6
  • vaccinia immune globulin intravenous, axicabtagene ciloleucel. (medscape.com)
  • vaccinia immune globulin intravenous, brexucabtagene autoleucel. (medscape.com)
  • vaccinia immune globulin intravenous, idecabtagene vicleucel. (medscape.com)
  • vaccinia immune globulin intravenous, lisocabtagene maraleucel. (medscape.com)
  • c) Immune globulin (IG): A sterile solution containing antibodies from human blood. (cdc.gov)
  • e) Specific immune globulin: Special preparations obtained from blood plasma from donor pools preselected for a high antibody content against a specific antigen (e.g., hepatitis B immune globulin, varicella-zoster immune globulin, rabies immune globulin, tetanus immune globulin, vaccinia immune globulin, and cytomegalovirus immune globulin). (cdc.gov)
Antigens3
  • The majority of the population pre-1981 who should be immunized with VTT still maintains certain levels of MPXV-specific antibodies, in particular, targeting A35R and B6R antigens. (nature.com)
  • others have antigens that are complex or incompletely defined (e.g., killed Bordetella pertussis or live attenuated viruses). (cdc.gov)
  • f) Antitoxin: A solution of antibodies (e.g., diphtheria antitoxin and botulinum antitoxin) derived from the serum of animals immunized with specific antigens. (cdc.gov)
Inoculation3
  • citation needed] The virus may gain access to the blood at an early stage, and secondary skin lesions, which follow the same evolution as the inoculation site, may appear across the body. (wikipedia.org)
  • in layman's terms, inoculation means the introduction of a pathogen or antigen into a living organism to stimulate the production of antibodies. (wikipedia.org)
  • All piglets 3-5 days of age (DOA) born to mass-exposed sows through live virus inoculation with the recently introduced wild-type virus two weeks prior were sampled and followed up at 17-19 DOA. (bvsalud.org)
Immunization2
  • Intended for intramuscular administration, IG is primarily indicated for routine maintenance of immunity of certain immunodeficient persons and for passive immunization against measles and hepatitis A. IG does not transmit hepatitis B virus, human immunodeficiency virus (HIV), or other infectious diseases. (cdc.gov)
  • Passive immunization means the provision of temporary immunity by the administration of preformed antibodies. (cdc.gov)
Vaccines3
  • Immunobiologic: Immunobiologics include antigenic substances, such as vaccines and toxoids, or antibody-containing preparations, such as globulins and antitoxins, from human or animal donors. (cdc.gov)
  • Some of those mutations have occurred in regions of the virus that medications and vaccines are designed to target. (cosmosmagazine.com)
  • Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. (mdpi.com)
Polyclonal1
Influenza virus3
  • Thirty-nine study participants received MVA-H5-serumfree Munich-Rotterdam (sfMR), which encoded hemagglutinin of influenza virus A/Vietnam/1194/2004 (H5N1), and 40 received vector control. (cdc.gov)
  • Influenza-virus-mediated disease can be associated with high levels of morbidity and mortality, particularly in younger children and older adults. (mdpi.com)
  • Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. (mdpi.com)
Antiviral2
  • Nonetheless, the initial spread of the virus is slowed by innate antiviral mechanisms, and, by the second week, the cell-mediated immune response begins to eliminate infected cells. (wikipedia.org)
  • there was a significant loss in vaccinia-specific CD4+ T cell memory among HIV+ subjects (P=0.039) whereas antiviral CD8+ T cell memory remained intact (P=1.0). (natap.org)
Titer1
  • Here, we recruited 294 volunteers and detected the level of residual humoral immunity, including the vaccinia-specific IgG level and neutralizing antibody titer, and the cross-antibodies of MPXV A29L, B6R, A35R, and M1R. (nature.com)
Herpes3
  • [7] A number of viruses including adenovirus , reovirus , measles , herpes simplex , Newcastle disease virus , and vaccinia have been clinically tested as oncolytic agents. (privacytools.io)
  • [12] In 2015, talimogene laherparepvec (OncoVex, T-VEC), an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in the United States and the European Union , for the treatment of advanced inoperable melanoma . (privacytools.io)
  • Herpes simplex virus (HSV) was one of the first viruses to be adapted to attack cancer cells selectively, because it was well understood, easy to manipulate and relatively harmless in its natural state (merely causing cold sores ) so likely to pose fewer risks. (privacytools.io)
Clone1
  • Mutations encoding basic (Arg), non-polar (Leu and Pro) and uncharged polar (Asn, Gln and Tyr) amino acids at M39 were introduced into a DENV-2 genomic-length cDNA clone and their effects on virus replication were examined. (microbiologyresearch.org)
Strains2
  • Virus strains in the two repositories. (who.int)
  • West African sub-region with consideration of the mented RNA virus belonging to the Arenaviridae origin of the virus, its properties/strains, epidemiol- family. (folkhalsomyndigheten.se)
Human12
  • Aquatic birds form a natural reservoir of avian influenza viruses from which new human and animal influenza viruses originate. (cdc.gov)
  • Capturing the natural diversity of the human antibody response against vaccinia virus. (symphogen.com)
  • Recombinant Vaccinia virus containing the human CD105 cDNA. (exbio.cz)
  • Incidence of human mpox has been increasing in West and Central Africa, including in the Democratic Republic of Congo (DRC), where monkeypox virus (MPXV) is endemic. (researchgate.net)
  • We review the evidence for respiratory transmission of monkeypox virus (MPXV), examining key works from animal models, human outbreaks and case reports, and environmental studies. (researchgate.net)
  • The Monkeypox virus circulating around the world is mutating in a way that allows it to evade human immunity. (cosmosmagazine.com)
  • Close contact, sustained skin-to-skin contact including sexual contact, with a person with monkeypox or contact with contaminated fomites (e.g., shared linens) are the most significant risk factors associated with human-to-human transmission of Monkeypox virus . (cdc.gov)
  • This product is a recombinant Human antibody that recognizes A33. (creativebiolabs.net)
  • CRS patients without polyps showed more antibodies against human herpesvirus 1 and vaccinia virus WR. (elsevierpure.com)
  • Significantly higher antibodies against S. aureus, human metapneumovirus, human herpesvirus 5, and human herpesvirus 4 in CRS need further study. (elsevierpure.com)
  • About 20 viruses have been identified within the genus Hantavirus, family Bunyaviridae, but only 11 have been shown to cause human disease. (medscape.com)
  • Background: Ebola Virus causes disease both in human and non-human primatesespecially in developing countries. (bvsalud.org)
Mpox9
  • The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. (nature.com)
  • Mpox is a zoonotic disease caused by the mpox virus (MPXV) characterized by smallpox-like symptoms, including fever and rash, but the signs of mpox are milder and the mortality rate is lower than those of smallpox. (nature.com)
  • Amid the global 2022 mpox outbreak, new estimates are needed to characterize the virus' epide. (researchgate.net)
  • In this article we consider what was known about mpox prior to the 2022 outbreak, what we have learned about mpox and Clade IIb virus during the outbreak, and what outbreak response actions and continued research are needed to ensure the global public health community is equipped to detect and halt the further spread of this disease threat. (cdc.gov)
  • Testing for mpox virus is available through commercial laboratories and through public health laboratories that are part of the Laboratory Response Network (LRN). (cdc.gov)
  • Detection of mpox virus by genomic sequencing in a clinical specimen. (cdc.gov)
  • Mpox is caused by the monkeypox virus, which is related to the smallpox virus and causes a similar, but usually milder, illness. (msdmanuals.com)
  • Mpox is caused by the monkeypox virus, which is related to the smallpox virus. (msdmanuals.com)
  • The disease caused by the monkeypox virus was also originally called "monkeypox," but in November 2022 the World Health Organization introduced the name "mpox" for the disease caused by the virus (see WHO recommends new name for monkeypox disease ). (msdmanuals.com)
Targets4
  • Symphogen is dedicated to bringing truly innovative oncology products to the market, creating optimally selected antibody mixtures that address multiple oncology targets in a single drug product. (symphogen.com)
  • We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. (abcepta.com)
  • For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abcepta.com)
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abcepta.com)
Antigen1
  • The presence of poxviral antigen, as determined by immunohistochemistry, correlated with ultrastructural identification of replicating virus. (blogspot.com)
Flow cytometric analysis3
  • Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis and the oligomer sequence is confirmed by sequencing. (biolegend.com)
  • Applications Reported: The J43 antibody has been reported for use in flow cytometric analysis. (thermofisher.com)
  • Applications Tested: The J43 antibody has been tested by flow cytometric analysis of Con A-simulated mouse splenocytes and mouse PD-1 transfected cells. (thermofisher.com)
Particles3
  • The production of several different virus particles in the VV replication cycle represents a coordinated strategy to exploit cell biology to promote virus spread and to aid virus evasion of antibody and complement. (microbiologyresearch.org)
  • The formation of intracellular prM/E heterodimers occurs rapidly after translation and is believed to be important for the assembly and secretion of immature virus particles. (microbiologyresearch.org)
  • As the infected cancer cells are destroyed by oncolysis , they release new infectious virus particles or virions to help destroy the remaining tumour. (privacytools.io)
Hemagglutinin2
Replication1
Progressive1
Cell-to-cell spread1
Infections2
  • Opportunistic fungal, protozoal, or bacterial infections and the vaccinia virus itself may lead to septic shock and disseminated intravascular coagulation, in addition to necrosis and ulcerated skin tissue. (wikipedia.org)
  • The attempts to treat virus infections occur even earlier than there was an understanding of the concept of a virus as an independent entity. (medsci.org)
ELISA1
Disseminate1
Vector2
  • This vector is designed to express hepatitis B viruses found worldwide. (arttic.eu)
  • Over the next month, a highly effective collaboration ensued between the Indian Health Service, the University of New Mexico School of Medicine, and the Centers for Disease Control and Prevention, leading not only to the successful isolation of the virus, but also to the identification of the reservoir and vector for the disease, Peromyscus maniculatus (deer mouse) (see image below). (medscape.com)
20191
Coronavirus1
  • RÉSUMÉ Une analyse documentaire des informations publiques disponibles a été entreprise afin de passer en revue les connaissances et les lacunes actuelles sur le coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV), notamment sur son origine, la transmission, les mesures de lutte efficaces et la prise en charge. (who.int)
Peptides1
Vectors1
  • Adeno-associated virus ( AAV) vectors for the delivery of broadly neutralizing antibodies. (nih.gov)
Virions1
  • These virions have different abundance, structure, location and roles in the virus life-cycle. (microbiologyresearch.org)
Immunogenic1