Antibody therapeutic development to vaccine vaccines conjugate. Medical search. Frequent questions

This study is aimed at determining whether anti-Tn monoclonal antibody treatment ameliorates hyperoxia-induced kidney injury in neonatal mice. (bvsalud.org)
The mice were divided into four study groups: RA + PBS, RA + anti-Tn monoclonal antibody, O2 + PBS, and O2 + anti-Tn monoclonal antibody. (bvsalud.org)
Anti-Tn monoclonal antibody treatment reduced kidney injury and cytokine levels to normoxic levels. (bvsalud.org)
Therefore, we propose that anti-Tn monoclonal antibody treatment ameliorates hyperoxia-induced kidney injury by suppressing oxidative stress and inflammation in neonatal mice. (bvsalud.org)
ii) To develop combination therapy with monoclonal antibody (mAb) cocktails for disseminated candidiasis. (lsuhsc.edu)
Using ELISA, we demonstrated that the recombinant protein specifically interacts with the anti-benzo[a]pyrene monoclonal antibody (mAB B2). (actanaturae.ru)

The research showed LEAPS COVID-19 conjugates induced faster and much higher than expected antibody responses against a nonmutating region of the SARS-CoV-2 virus after only one injection. (scienceboard.net)

The core of Defence Therapeutics platform is the ACCUM TM technology, which enables precision delivery of vaccine antigens or ADCs in their intact form to target cells. (pharmiweb.com)
This Accum® technology can be exploited to design a multitude of products including: i) antibody-drug conjugates ("ADCs"), ii) protein/cellular vaccines, and iii) the design of anti-cancer small chemotypes. (defencetherapeutics.com)
The treatment regimens used with these ADCs usually require large doses, while the therapeutic response is limited or weak. (defencetherapeutics.com)
By bio-conjugating ADCs with Accum®, Defence has demonstrated improved potency of commercially available ADCs by 20 to 100 folds. (defencetherapeutics.com)
Although Defence is using this approach to optimize commercially available ADCs such as Enhertu®, the company is actively working on developing two in-house ADCs using its own proprietary monoclonal antibodies targeting two tumor-specific cell surface proteins and payloads. (defencetherapeutics.com)

In fact, not all vaccine recipients mount a protective response, even after receiving the recommended immunization schedule. (cdc.gov)
The only currently available intervention that could provide a state of immediate immunity is passive immunization with protective antibody. (cdc.gov)
Maternal immunization with the Tn vaccine increases serum anti-Tn antibody titers and attenuates hyperoxia-induced kidney injury in neonatal rats. (bvsalud.org)
On August 13, 2014, the Advisory Committee on Immunization Practices (ACIP) recommended routine use of 13-valent pneumococcal conjugate vaccine (PCV13 [Prevnar 13, Wyeth Pharmaceuticals, Inc., a subsidiary of Pfizer Inc.]) among adults aged ≥65 years. (cdc.gov)
Immunization with the rS1-Fc protein via intramuscular and intravenous injections induced antibodies against the SARS-CoV-2 protein in all mice within the first week of administration. (globenewswire.com)
As there is no approved antifungal vaccine for use in humans and significant therapeutic challenges remain, our approach is disease prevention through active vaccination and/or passive immunization with protective antibodies. (lsuhsc.edu)
Cel-Sci noted that immunoglobulin G (IgG) antibodies were generated within 10 days of a single immunization. (scienceboard.net)
A stabilized prefusion spike protein licensed by Oragenics has generated neutralizing antibodies in mice during immunization against SARS-CoV-2, according. (scienceboard.net)
In addition, the European Medicines Agency (EMA) has accepted Pfizer's marketing authorization application (MAA) under accelerated assessment for its RSV vaccine candidate for both older adults and maternal immunization to help protect infants. (biospace.com)
These data will be presented on February 23 to the U.S. Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices (ACIP) and, separately, during the ReSViNET Foundation's 2023 Global Conference on Novel RSV Preventive and Therapeutic Interventions. (biospace.com)
The antibody titers were high over four months post-first immunization. (virginkillersweaterbuy.com)
Immunization is a success story for global health and development, saving millions of lives every year. (who.int)
Innovative ways are being found to distribute and administer vaccines and to improve immunization services. (who.int)
Digital tools, new, needle-free techniques for vaccine administration and more robust vaccine storage and supply chains promise to transform immunization programmes1 over the next decade. (who.int)
First, as immunization programmes are only one component of health systems, the term aligns the global vision and strategy with the broader health and development agenda. (who.int)

The Company has been informed by Pfizer that the majority of the write-offs relate to raw materials, mainly formulation-related lipids, purchased during the pandemic, as well as COVID-19 vaccine doses adapted to other, non-XBB.1.5 variants produced at risk. (pingintau.id)
According to Pfizer, the write-offs do not address Pfizer-BioNTech COVID-19 Vaccine doses adapted to the XBB.1.5 variant, which has been approved and is being marketed in key geographies. (pingintau.id)
NEW YORK & MAINZ, Germany-(BUSINESS WIRE) September 11, 2023 - Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced that the U.S. Food and Drug Administration (FDA) approved the supplemental Biologics License Application ( COMIRNATY 2023-2024 Formulation) for individuals 12 years and older and granted emergency use authorization for individuals 6 months through 11 years of age for the companies' Omicron XBB.1.5-adapted monovalent COVID-19 vaccine. (medicaladvise.org)
Children under the age of 5 may be eligible to receive additional doses of this season's vaccine if they have not already completed a three-dose series with previous formulations of a COVID-19 vaccine. (medicaladvise.org)
This decision follows guidance from the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC), which recommended an Omicron XBB.1.5-adapted monovalent COVID-19 vaccine for the 2023-2024 fall and winter season. (medicaladvise.org)
4 Pfizer and BioNTech have been manufacturing the 2023-2024 COVID-19 vaccine at risk to ensure supply readiness ahead of the fall and winter season, when demand for COVID-19 vaccination is expected to increase in line with the seasonality period also seen with other respiratory viruses. (medicaladvise.org)
Now, most people 6 months or older in the U.S. are eligible to receive this season's COVID-19 vaccine, even if they have never been vaccinated against COVID-19 before," said Albert Bourla, Chairman and Chief Executive Officer at Pfizer. (medicaladvise.org)
We expect this season's vaccine to be available in the coming days, pending recommendation from public health authorities, so people can ask their doctor about receiving their COVID-19 vaccine during the same appointment as their annual flu shot, saving time now and helping to prevent severe disease later when respiratory viruses are at their peak. (medicaladvise.org)
The approval of this season's COVID-19 vaccine is based on the full body of previous clinical, non-clinical, and real-world evidence supporting the safety and efficacy of the COVID-19 vaccines by Pfizer and BioNTech. (medicaladvise.org)
Additionally, pre-clinical data demonstrate that serum antibodies induced by Omicron XBB.1.5-adapted monovalent COVID-19 vaccine, when compared to the Omicron BA.4/BA.5-adapted bivalent vaccine, effectively neutralize the recently emerged Omicron BA.2.86 (Pirola) and the globally dominant Omicron-related EG.5.1 (Eris) subvariant. (medicaladvise.org)
This season's COVID-19 vaccine will be available in pharmacies, hospitals, and clinics across the U.S. following a recommendation by the Centers for Disease Control and Prevention (CDC). (medicaladvise.org)
In the European Union, the Omicron XBB.1.5-adapted monovalent COVID-19 vaccine (COMIRNATY ® Omicron XBB.1.5) has also received marketing authorization by the European Commission for individuals 6 months of age and older on August 31, 2023. (medicaladvise.org)
Valneva COVID-19 vaccine (VLA2001) consists of inactivated whole virus particles of SARS-CoV-2. (precisionvaccinations.com)
Vaxzevria AstraZeneca COVID-19 Vaccine (AZD1222) consists of the replication-deficient simian adenovirus vector ChAdOx1. (precisionvaccinations.com)
Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler. (ncsu.edu)
Each received an mRNA COVID-19 vaccine before or after treatment with a type of immunotherapy drug known as an immune checkpoint inhibitor. (cdc.gov)
Overall, 26% of respondents had already received their COVID-19 vaccine, while 76% of respondents responded they did not want to be vaccinated. (bvsalud.org)

Research and development highlights from the research period include the company's work with Mirati Therapeutics in developing methods to determine torsion rotational energy barriers of the clinical compound, MRTX1719, which is being developed for use as an inhibiter to MTAP-deleted cancers. (pharmaceutical-technology.com)
Recent studies support the development of cancer therapeutics to target Globo H-ceramide, the most prevalent tumor-associated carbohydrate antigen in epithelial cancers. (bvsalud.org)
Biotechnology Company Defence Therapeutics focuses on therapeutic methods to fight cancer and the development of vaccines against infectious diseases. (news.financial)
Vancouver, BC, Canada, July 5 th , 2022 - Defence Therapeutics Inc. (" Defence " or the " Company "), a Canadian biopharmaceutical company specialized in the development of immune-oncology vaccines and drug delivery technologies, is pleased to provide an update on its ADC programs in development using Defence's Accum TM , including key in vivo studies with worldwide collaborators. (pharmiweb.com)
Defence Therapeutics is a publicly-traded biotechnology company working on engineering the next generation vaccines and ADC products using its proprietary platform. (pharmiweb.com)
Ying Tam, chief scientific officer, Acuitas Therapeutics-a biotechnology company specializing in LNP delivery technology from R&D to commercial development-also points to LNP delivery as a significant advancement in drug delivery. (biopharminternational.com)
SAN DIEGO, July 01, 2020 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc. (Nasdaq: SRNE, "Sorrento") announced today that it has published a pre-print publication ( https://www.biorxiv.org/content/10.1101/2020.06.29.178616v1.full.pdf ) describing initial pre-clinical results from its COVID-19 vaccination program, which introduced a novel targeted protein vaccine against COVID-19, referred to as T-VIVA-19. (globenewswire.com)
Dr. Henry Ji, Chairman and CEO of Sorrento Therapeutics, said, "If successful and approved, we plan to produce the T-VIVA-19 vaccine in our therapeutic antibody cGMP production facility in San Diego. (globenewswire.com)
Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor (CAR) T cells, several protein-based therapeutics, including bispecific immune checkpoint modulators, targeted cancer antibodies and antibody-drug conjugate (ADC) therapeutics, as well as small molecules. (pingintau.id)
Whether using an antibody, cell-based vaccine or small molecule therapeutics, the common denominator in all of Defence's development products is the Accum® technology, a platform specifically designed to strategically enhance and increase the efficacy of any existing bio-drug against cancer. (defencetherapeutics.com)
Nanobody-peptide-conjugate (NPC) for passive immunotherapy against SARS-CoV-2 variants of concern (VoC): a prospective pan-coronavirus therapeutics. (cdc.gov)

The world-renowned Curie Institute, one of Defence's collaborator, is currently performing therapeutic efficacy study of Accum TM -T-DM1 Antibody Drug Conjugate ("ADC") in patient-derived xenograft ("PDX") model of breast cancer, including in 3 HER2+ and in 1 triple-negative PDX. (pharmiweb.com)
The results of the CAPiTA trial demonstrated 45.6% (95% confidence interval [CI] = 21.8%-62.5%) efficacy of PCV13 against vaccine-type pneumococcal pneumonia, 45.0% (CI = 14.2%-65.3%) efficacy against vaccine-type nonbacteremic pneumococcal pneumonia, and 75.0% (CI = 41.4%-90.8%) efficacy against vaccine-type IPD among adults aged ≥65 years ( 1 ). (cdc.gov)
Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer while avoiding side effects. (mdpi.com)
iii) To determine the protective efficacy of vaccines and therapeutic mAb cocktails in neutropenic mouse model of disseminated candidiasis. (lsuhsc.edu)
In the present study, researchers assessed the efficacy of VLP-based vaccines displaying linear peptides from PCSK9 in reducing cholesterol levels in animal models. (virginkillersweaterbuy.com)
First, taking the vaccine via intramuscular shot is less efficient at getting it into the pulmonary system, and so can limit its efficacy. (ncsu.edu)

Another aspect of the deal involves Bicocon selling 15% of its biologics subsidiary to Serum Institute of India, in return for Biocon gaining access to 100 million annual doses of vaccines for a 15-year period. (wikipedia.org)
Moreover, many vaccines require multiple doses to achieve a protective immune response, which would limit their usefulness in an emergency vaccination program to provide rapid prophylaxis after an attack. (cdc.gov)
However, after two doses of the bivalent vaccine, LDL-C levels were significantly lower and unaffected by statin treatment. (virginkillersweaterbuy.com)
In rodent models, the RBD-decorated LSC-Exo vaccine (RBD-Exo) elicited production of antibodies specific to the RBD, and protected the rodents, after two vaccine doses, from infection with live SARS-CoV-2. (ncsu.edu)

Vaccination can reduce the susceptibility of a population against specific threats provided that a safe vaccine exists that can induce a protective response. (cdc.gov)
Persons with impaired immunity are often unable to generate effective response to vaccination, and certain vaccines may be contraindicated for them ( 1 ). (cdc.gov)
Furthermore, vaccination critics who reject the Corona vaccine due to a lack of long-term experience could perhaps be swayed to change their minds in this way. (news.financial)
If approved and recommended, MenABCWY could help simplify the meningococcal vaccination schedule and provide the broadest serogroup coverage of any meningococcal vaccine. (biospace.com)
Therapeutic vaccination has the major advantage that the induced immune response selectively attacks tumors while leaving the healthy cells untouched. (universiteitleiden.nl)
Longitudinal data on humoral response and neutralizing antibodies against SARS-CoV-2 Omicron BA.1 and subvariants BA.4/5 and BQ.1.1 after COVID-19 vaccination in cancer patients. (cdc.gov)
COVID-19 infection after SARS-CoV-2 mRNA vaccination in Multiple Sclerosis, AQP4-antibody NMOSD and MOGAD patients during the Omicron subvariant BA.1/2 wave in Singapore. (cdc.gov)

Beyond our expertise in small molecules, we have built a solid reputation with biopharmaceutical companies for the characterisation and analysis of monoclonal antibodies, therapeutic proteins and biosimilars. (pharmaceutical-technology.com)
Glycans, chains of sugar molecules found conjugated to cell proteins and lipids, contribute to their growth, movement and differentiation. (bvsalud.org)
The current barrier to this transition is the fact that most therapeutic peptides and proteins must be delivered via injection, but the tide is slowly starting to turn. (biopharminternational.com)
We defined six T-cell peptides found in Candida albicans cell wall proteins and conjugated each peptide, originally intended to act as a carrier to the fungal cell wall β-1,2- trisaccharide [β-(Man) 3 ] to create glycopeptide conjugate vaccines. (lsuhsc.edu)
In 1937, Creech and Franks first synthesized conjugates of carcinogens with high-molecular carriers - blood serum proteins. (actanaturae.ru)
This protein-based vaccine is based on the use of a single protein (in contrast to a mix of 9 viral-derived capsid proteins). (defencetherapeutics.com)

AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens, and patients with the BCS2 and BCS1A subtypes were identified as candidate populations for mRNA vaccines. (frontiersin.org)
Antibodies targeting two tumor antigens and CD3 are being tested. (msdmanuals.com)

Our results demonstrated that the Y-5A15 remarkably enhanced the Aβ epitope immunogenicity and elicited high antibody titers against Aβ in AD mice. (mdpi.com)
Antibody titers against target peptides of PCSK9 and full-length PCSK9 were measured. (virginkillersweaterbuy.com)
Individual VLPs and the bivalent vaccine elicited high titers against target peptides and the full-length protein, but the bivalent vaccine induced lower titers than individual VLPs against target epitopes. (virginkillersweaterbuy.com)
Nevertheless, the bivalent vaccine elicited robust anti-mPCSK9 immunoglobulin G (IgG) titers. (virginkillersweaterbuy.com)
After one year, the antibody titers were 10-fold lower than the peak but were still high. (virginkillersweaterbuy.com)

During 2021 Biocon Biologics and Serum Institute of India formed a joint agreement to commercialise vaccines, biological drugs, and antibody therapies together. (wikipedia.org)
Sorrento is a clinical stage, antibody-centric, biopharmaceutical company developing new therapies to treat cancers. (globenewswire.com)
Conformational changes of the SARS-CoV-2 spike protein -- the target of many vaccines and therapies -- may have features that help the virus hide from. (scienceboard.net)
These limitations have led to the development of non-statin therapies targeting other pathways involved in LDL-C metabolism. (virginkillersweaterbuy.com)
Discussion topics will cover Immune Biomarkers & Translational Research, Preclinical Research, Clinical Development, Cell Therapies and Next-Generation Therapies. (hub-xchange.com)

The Institut de Recherche en Cancérologie de Montpellier (IRCM), an internationally recognized institute for its translational research and expertise's in immunotherapy and radiotherapy, is currently performing in vivo studies using Accum TM with radio-immuno-therapeutic conjugates. (pharmiweb.com)
In 2016 the Leiden University Translational Drug Discovery & Development "Molecule to Man" Award was received with the aim to develop Personalized Cancer Immunotherapy. (universiteitleiden.nl)
INOVIO VGX-3100 is an investigational immunotherapy vaccine. (precisionvaccinations.com)
Monoclonal antibodies in immunodiagnosis and immunotherapy 2023 0 0. (cdc.gov)
People with cancer undergoing immunotherapy can safely receive messenger RNA COVID-19 vaccines. (cdc.gov)
People with cancer who are treated with certain immunotherapy drugs can receive mRNA COVID-19 vaccines without an increased risk of immune-related side effects, new research suggests. (cdc.gov)
Administration of exogenous antibodies constitutes passive humoral immunotherapy. (msdmanuals.com)

If approved, 20vPnC would have the potential to cover more of the clinically significant remaining burden of infant pneumococcal disease than any other available pneumococcal conjugate vaccine. (biospace.com)
Vaxcyte Inc. VAX-24 Pneumococcal Conjugate Vaccine candidate addresses infection from 24 serotypes of pneumococcal disease. (precisionvaccinations.com)

The developed vaccine, AccuVAC-PT001, showed serum cross-reactivity with the spike protein of several SARS-CoV2 variants in laboratory tests in isolated vaccinated animals. (news.financial)
Mice, heterozygous for Ldlr tm1Her mutation, that express high serum cholesterol but low function LDL-R were used to study vaccine effects. (virginkillersweaterbuy.com)
Further, serum levels of PCSK9 were unchanged in mPCSK9 153-163 recipients but increased in mPCSK9 207-223 recipients relative to controls, whereas recipients of the bivalent vaccine had 40% lower PCSK9 in serum. (virginkillersweaterbuy.com)

Recently the research findings from the laboratory and in experimental animals are translated to an early clinical study in which cancer patients are injected with and experimental tumor-specific peptide-conjugate vaccine. (universiteitleiden.nl)

We look forward to progressing the review of Pfizer's RSV maternal vaccine candidate with the FDA and other regulatory authorities, given its significant potential to positively contribute to global health in the prevention of RSV in infants. (biospace.com)

T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)

However, few studies exist that are focused on the application and development of mRNA vaccines in bladder cancer (BLCA). (frontiersin.org)
Weighted gene co-expression network analysis (WGCNA) was used to identify key genes for mRNA vaccines. (frontiersin.org)
Owing to the worldwide spread of COVID-19, mRNA vaccines have received increasing interest ( 5 , 6 ). (frontiersin.org)
As an emerging vaccine technology, mRNA vaccines represent a promising alternative to conventional vaccine approaches due to their high potency, capacity for rapid development, and potential for low-cost manufacturing and safe administration ( 11 ). (frontiersin.org)
Recent years, the shortages of mRNA vaccines have been improved by new delivery strategies and materials ( 12 ). (frontiersin.org)
Second, mRNA vaccines in their current formulation require cold storage and trained medical personnel to deliver them. (ncsu.edu)
The researchers compared the distribution and retention of LSC-Exo to nanoparticles similar to lipid nanoparticles currently used with mRNA vaccines. (ncsu.edu)
For example, mRNA vaccines deliver a script to your cell that instructs it to produce antibodies to the spike protein. (ncsu.edu)

The company is recognized in the M&A, Product Launches and Research and Development categories in the 2022 Pharmaceutical Technology Excellence Awards. (pharmaceutical-technology.com)
Toxicity results of variants are expected for Q3 of 2022 and antibody conjugation shall begin in Q4 of 2022. (pharmiweb.com)
Top-line results from a randomized, active-controlled, and observer-blinded Phase 3 trial of Pfizer's pentavalent meningococcal vaccine candidate (NCT04440163) were previously announced in September 2022. (biospace.com)

Furthermore, a combination cocktail of monoclonal antibodies (mAbs) specific for the synthetic peptides of the double chimeric vaccine provided the most effective protection against disseminated candidiasis. (lsuhsc.edu)
These peptides were conjugated onto Qβ bacteriophage VLPs by a crosslinker. (virginkillersweaterbuy.com)

T-VIVA-19 is a recombinant fusion protein of the spike protein S1-domain and the Fc portion of the human IgG1 antibody (rS1-Fc). (globenewswire.com)
Next, the researchers created and tested an inhalable, protein-based, virus-like particle (VLP) vaccine by decorating the exterior of LSC-Exo with a portion of the spike protein - known as the receptor binding domain, or RBD - from the SARS-CoV-2 virus. (ncsu.edu)
This VLP vaccine, on the other hand, introduces a portion of the spike protein to the body, triggering the immune system to produce antibodies to the spike protein. (ncsu.edu)
Establishment of Neutralizing Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 by the Screening with Exosomes Expressing the Viral Spike Protein. (cdc.gov)

The only available countermeasure that can provide immediate immunity against a biological agent is passive antibody. (cdc.gov)
Unlike vaccines, which require time to induce protective immunity and depend on the host's ability to mount an immune response, passive antibody can theoretically confer protection regardless of the immune status of the host. (cdc.gov)
Passive antibody therapy has substantial advantages over antimicrobial agents and other measures for postexposure prophylaxis, including low toxicity and high specific activity. (cdc.gov)
Passive antibody therapy was widely used in the pre-antibiotic era but was largely abandoned with the advent of antimicrobial chemotherapy ( 2 , 3 ). (cdc.gov)

Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary antibody deficiencies. (medscape.com)
IgA-deficient patients with immunoglobulin E (IgE)-class anti-IgA antibodies are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin, but this situation is extremely rare. (medscape.com)

In recent years, there has been a renaissance in the use of antibodies for therapy: 10 monoclonal antibodies (MAbs) are currently licensed and dozens are in the developmental pipeline ( 4 ). (cdc.gov)

Then, another breakthrough is that the addition of tetanus toxoid to glycopeptide conjugate resulted in a glycopeptide-TT vaccine induced dual (double) antibody-dependent protective immunity without the need for adjuvant, which is feasible for human use. (lsuhsc.edu)

Beacon Cancer Vaccine provides the solution you need to master the prophylactic and therapeutic cancer vaccines field. (azurewebsites.net)

For example, the vaccine against hepatitis B does not elicit an antibody response in approximately 10% of vaccines, and the percentage of nonresponders is substantially higher in immunocompromised persons ( 1 ). (cdc.gov)
Vaqta is an inactivated whole virus vaccine derived from hepatitis A virus grown in cell culture in human MRC-5 diploid fibroblasts. (precisionvaccinations.com)
VBI-2601 (BRII-179) is a hepatitis therapeutic vaccine candidate that targets B- and T-cell immunity. (precisionvaccinations.com)
A population-based, postlicensure evaluation of the safety of a combination diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine in a large managed care organization. (cdc.gov)

In a recent study published in npj Vaccines, researchers evaluated the effectiveness of virus-like particle (VLP)-based vaccines targeting epitopes in the low-density lipoprotein (LDL) receptor (LDL-R) domain of proprotein convertase subtilisin/kexin type 9 (PCSK9). (virginkillersweaterbuy.com)

There are now vaccines to protect against malaria, dengue and Ebola virus disease, and promising vaccines against respiratory syncytial virus, tuberculosis and all influenza virus strains are in the pipeline. (who.int)

Finally, Warne explains that vaccine adjuvants have enhanced the immunogenicity of a number of critical vaccines, enabling billions of children and adults to avoid life-threatening diseases. (biopharminternational.com)
immunogenicity evidence was assessed using two phase III RCTs of PCV13 compared to PPSV23, which measured antibody responses by opsonophagocytic assay (OPA) and four RCTs of PCV7 compared to PPSV23, which measured antibody responses by enzyme-linked immunosorbent assay (ELISA). (bvsalud.org)

In those studies, the LEAPS H1N1 conjugate reduced morbidity and mortality after virus challenge as a therapeutic intervention. (scienceboard.net)

PCV13 should be administered in series with the 23-valent pneumococcal polysaccharide vaccine (PPSV23 [Pneumovax23, Merck & Co., Inc.]), the vaccine currently recommended for adults aged ≥65 years. (cdc.gov)
The intervention evaluated was a single dose of PCV13 compared to a dose of 23-valent polysaccharide vaccine (PPSV23). (bvsalud.org)

On December 30, 2011, PCV13 was approved for use among adults aged ≥50 years to prevent pneumonia and invasive disease caused by S. pneumoniae serotypes contained in the vaccine. (cdc.gov)

July 24, 2020 -- Cel-Sci completed animal testing using its Ligand Epitope Antigen Presentation System (LEAPS) COVID-19 conjugate, which means the firm can now move into animal challenge studies with the live SARS-CoV-2 virus. (scienceboard.net)

Thus, PCSK9 can elevate LDL-C by preventing LDL-R recycling and is a significant therapeutic target to decrease LDL-C and prevent ASCVD. (virginkillersweaterbuy.com)

Glycosphingolipids (GSLs), consisting of glycans conjugated to a lipid (ceramide) core, are found in the lipid bilayer of eukaryotic cell membranes. (bvsalud.org)
According to Warne, there are multiple examples of enabling technologies, such as antibody-drug conjugates for the treatment of cancer cells and lipid nanoparticle (LNP) delivery of RNA to treat diseases, including infective diseases. (biopharminternational.com)
A replicating RNA vaccine delivered with a lipid-based nanoparticle emulsion has been shown to produce potent antibodies against SARS-CoV-2 in mice and. (scienceboard.net)
The researchers also found that the delivery mechanism for this vaccine - a lung-derived exosome called LSC-Exo - is more effective at evading the lung's mucosal lining than the lipid-based nanoparticles currently in use, and can be used effectively with protein-based vaccines. (ncsu.edu)

Combining the Accum TM technology to the radio-immuno-conjugate is expected to amplify the therapeutic index of the drug while minimizing side effects observed in patients undergoing the therapy. (pharmiweb.com)
Defence's Accum TM platform has been primarily developed and tested in vitro and in vivo to enhance the intranuclear drug delivery on multiple FDA approved antibody-conjugates or new conjugates under development. (pharmiweb.com)
Another successful Defence's vaccine example demonstrating yet again the versatility of the Accum® technology is the design of the ARM vaccine, relying on the use of a type of stem cell pharmacologically re-programmed to behave as antigen presenting cells. (defencetherapeutics.com)

Use of a 7-valent pneumococcal conjugate vaccine (PCV7) since 2000 and PCV13 since 2010 among children in the United States has reduced pneumococcal infections directly and indirectly among children, and indirectly among adults. (cdc.gov)

Additionally, a large subset of mice received the bivalent vaccine comprising 5 μg each of mPCSK9 153-163 and mPCSK9 207-223 VLPs. (virginkillersweaterbuy.com)
Recipients of mPCSK9 207-223 VLPs or bivalent vaccine showed significantly lower total cholesterol levels than controls. (virginkillersweaterbuy.com)
Livers were harvested from bivalent vaccine recipients and controls to measure LDL-R. LDL-R expression increased by about 50% in bivalent vaccine recipients compared to controls. (virginkillersweaterbuy.com)
A subset of bivalent vaccine recipients was followed for more than a year post-first dose, and sera were collected regularly. (virginkillersweaterbuy.com)
Twenty-four healthy macaques aged 7-12 were screened for triglyceride and total cholesterol levels and assigned to receive the 1) bivalent vaccine comprising rhesus macaque PCSK9 153-163 (rhPCSK9 153-163 ) and rhPCSK9 207-223 VLPs, 2) rhPCSK9 207-223 VLPs alone, or 3) wild-type Qβ VLPs (controls) at days 0, 28, and 56. (virginkillersweaterbuy.com)
Although Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccines provide some protection against a range of outcomes from XBB-related COVID-19, 2,3 evidence suggests that vaccines better matched to currently circulating strains can offer improved protection against symptomatic and severe disease. (medicaladvise.org)
Further, the application included pre-clinical data showing this season's vaccine substantially improved responses against multiple Omicron XBB-related sublineages, including XBB.1.5, XBB.1.16, and XBB.2.3, compared to the Omicron BA.4/BA.5-adapted bivalent vaccine. (medicaladvise.org)

During the ACIP meeting on February 22-23, the company also will present positive Phase 3 results supporting the regulatory filings of Pfizer's pentavalent meningococcal vaccine (MenABCWY) candidate, as well as Pfizer's 20-valent pneumococcal conjugate vaccine (20vPnC) candidate for pediatric use. (biospace.com)

This article reviews the activity of humoral immunity against several biological agents, discusses the advantages and disadvantages of an antibody-based defense strategy ( Table ), and proposes stockpiling specific antibodies for use in the event of biological attacks. (cdc.gov)

Vidprevtyn is a protein-based adjuvanted vaccine produced by Sanofi-GSK. (precisionvaccinations.com)

Our comprehensive analytical testing portfolio integrates a broad range of capabilities spanning all stages of drug discovery, development and manufacturing. (pharmaceutical-technology.com)
Brad Nelson has twenty five years of experience in leading rapid growth life science organizations, delivering new technology and applications for drug discovery, development and clinical markets. (hub-xchange.com)

Methods: The development of nanotechnology for anticancer drug delivery has developed several potentials as nanocarriers, which may boost the pharmacokinetic and pharmacodynamic effects of the drug product and substantially reduce the side effects. (benthamscience.com)
Antibody decay was substantially slower after an initial decline. (virginkillersweaterbuy.com)

A vaccine that is stable at room temperature and that could be self-administered would greatly reduce wait times for patients as well as stress on the medical profession during a pandemic. (ncsu.edu)
Objective.In the context of the global COVID-19 pandemic, COVID-19 vaccines were made available to different countries. (bvsalud.org)

HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients. (cdc.gov)

3. Jackson LA, Carste BA, Malais D, Froeschle J. Retrospective population-based assessment of medically attended injection site reactions, seizures, allergic responses and febrile episodes after acellular pertussis vaccine combined with diphtheria and tetanus toxoids. (cdc.gov)

This forms the basis of Defence's vaccine program. (defencetherapeutics.com)

Additionally, the RBD-Exo vaccine remained stable at room temperature for three months. (ncsu.edu)

Our research goal is to further develop the first "universal" multi-epitope vaccine protects against all the medically significant Candida species in addition to C. albicans, as well as address the fundamental question concerning vaccine induced immunity in high-risk immunocompromised populations. (lsuhsc.edu)
An inhalable vaccine will confer both mucosal and systemic immunity, it's more convenient to store and distribute, and could be self-administered on a large scale," Cheng says. (ncsu.edu)

7. Andrews N, Stowe J, Wise L, Miller E. Post-licensure comparison of the safety profile of diphtheria/tetanus/whole cell pertussis/ Haemophilus influenza type b vaccine and a 5-in-1 diphtheria/tetanus/acellular pertussis/ Haemophilus influenza type b/polio vaccine in the United Kingdom. (cdc.gov)
Safety of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV) vaccine. (cdc.gov)

Our goal is to provide people worldwide with COVID-19 vaccines that are adapted to circulating virus variants or sublineages. (medicaladvise.org)

Valneva chikungunya vaccine VLA1553 is a monovalent, single dose, live-attenuated chikungunya vaccine candidate. (precisionvaccinations.com)
Vaxart's oral norovirus vaccine candidate GI.1/GII.4 VXA-G1.1-NN consists of both Monovalent GII.4 VXA-G2.4-NS and Monovalent GI.1 VXA-G1.1-NN. (precisionvaccinations.com)

The Tn antigen, an N-acetylgalactosamine structure linked to serine or threonine, has been shown to induce high-specificity, high-affinity anti-Tn antibodies in mice. (bvsalud.org)
On postnatal days 2, 4, and 6, the mice were injected intraperitoneally with PBS alone or with anti-Tn monoclonal antibodies at 25 µg/g body weight in 50 µL phosphate-buffered saline (PBS). (bvsalud.org)
Here, we designed a yeast-based vaccine Y-5A15 comprising five copies of Aβ1-15 displayed on the surface of yeast cell wall, and we subcutaneously immunized APP/PS1 mice three times. (mdpi.com)

GRADE was used to evaluate 13-valent Pneumococcal Conjugate Vaccine (PCV13) for routine use among adults aged ≥65 years. (bvsalud.org)

If approved, RSVpreF would help protect infants at their first breath from the devastating effects of this infectious disease, which though well-known, has been particularly evident throughout this RSV season," said Annaliesa Anderson, Ph.D., Senior Vice President and Chief Scientific Officer, Vaccine Research & Development, Pfizer. (biospace.com)
Prior to Flagship Biosciences, he served in senior scientific roles in oncology drug development for OSI Pharmaceuticals and Pfizer. (hub-xchange.com)

Approximately 80% of the mice's sera possessed neutralizing antibodies and completely prevented virus infection in in vitro cell cultures using 100 TCID50 viruses and VERO cells. (globenewswire.com)
Vitagerpavac is a multivalent vaccine for the treatment of chronic herpesvirus infection (HCV) of types I and II currently available in Russia. (precisionvaccinations.com)

Based on its deep expertise in mRNA vaccine development and in-house manufacturing capabilities, BioNTech and its collaborators are developing multiple mRNA vaccine candidates for a range of infectious diseases alongside its diverse oncology pipeline. (pingintau.id)
The next phase of Cel-Sci's research will take place at the University of Georgia Vaccine Center, where the company will try to replicate the success of the animal challenge studies that were conducted at the U.S. National Institutes of Health's National Institute of Allergy and Infectious Diseases emerging diseases laboratory during the H1N1 flu outbreak. (scienceboard.net)

This article proposes a biological defense initiative based on developing, producing, and stockpiling specific antibody reagents that can be used to protect the population against biological warfare threats. (cdc.gov)
Our integrated analytical services include method development and release testing of traditional and highly innovative products, elemental and trace analysis, solid-state development, microbiology and biological analysis, ligands and catalyst technology, custom synthesis, and manufacturing. (pharmaceutical-technology.com)

Between 2010 and 2018, 23 million deaths were averted with measles vaccine alone (1) . (who.int)

A history devoid of previous blood product administration does not exclude the possibility of anti-IgA antibodies or adverse reactions. (medscape.com)
assessment of the first two years' data from the Vaccine Adverse Event Reporting System (VAERS). (cdc.gov)
This study aimed to assess travelers' attitudes and practices toward the COVID vaccine and adverse events. (bvsalud.org)

The final studies are currently underway, and Valneva expects to receive emergency approval for the vaccine this year. (news.financial)

Anatomy13

Organisms24

Diseases18

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes30

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Named Groups1

Health Care8

Geographicals1

Monoclonal antibody6

Expected antibody responses1

ADCs5

Immunization15

COVID-19 Vaccine17

Therapeutics11

Efficacy6

Doses4

Vaccination7

Proteins6

Antigens2

Titers5

Therapies5

Immunotherapy7

Pneumococcal disease2

Serum3

Tumor-specific1

Maternal1

Bispecific1

MRNA vaccines8

20223

Peptides2

Spike protein4

Passive4

Immunoglobulin2

MAbs1

Protective immunity1

Prophylactic1

Hepatitis4

Virus-like par1

Respiratory syncy1

Immunogenicity2

Morbidity1

Polysaccharide2

Serotypes1

20201

Significant therapeutic1

Lipid4

Accum3

20001

Bivalent7

Pediatric1

Humoral1

Protein-based1

Drug discovery2

Substantially2

Pandemic2

Recipients1

Responses1

Defence's1

Additionally1

Immunity2

Tetanus2

Variants1

Monovalent2

Mice3

Among adults aged1

Pfizer2

Infection2

Infectious diseases2

Biological2

Measles1

Adverse3

Valneva1