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  • allele
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • The first childhood leukaemia studies examined HLA class-II antigen frequencies found an increased allele frequency of DR7 in Switzerland where DR7 is the most common DR53 group antigen 8;9 . (dorak.info)
  • The increased HLA-DR53 allele frequency in adult ALL (66.7% vs 52.3%) could have been significant if homozygosity had been considered 11 . (dorak.info)
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • Finally, case control analyses using imputed HLA types indicated that the DR10 allele of HLA-DRB1 was more frequent in individuals with SLI than population controls ( P = 0.004, relative risk = 2.575), as has been reported for individuals with attention deficit hyperactivity disorder (ADHD). (biomedcentral.com)
  • Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family. (healthmatics.info)
  • human
  • Jean Dausset described the first human MHC antigen MAC (HLA-A2) as part of the Hu-1 system 5 followed by the discovery of the FOUR series 4a and 4b (HLA-Bw4 and -Bw6) by the Leiden group led by Jon van Rood in 1963 6;7 . (dorak.info)
  • DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated with insulin-dependent diabetes mellitus (IDDM) and Pemphigus vulgaris (PV) have been identified. (google.com.au)
  • Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV). (healthmatics.info)
  • Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. (healthmatics.info)
  • Haplotype
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • serum
  • Known exposure to offending antigen A.History of appropriate exposure B. Environmental tests confirm Ag presence C. Positive serum IgG to Ag 2. (blogspot.com)
  • Another study found antibodies that bound to rodent Purkinje cells in the serum of a mother with a child with specific language disorder, a child with autism, and a child with typical development. (biomedcentral.com)
  • The presence in a given individual is determined by the finding of HIV antibodies in the serum (HIV SEROPOSITIVITY). (healthmatics.info)
  • DR53
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • responses
  • An effective tumor vaccine may be required to induce both CTLs and T-helper (Th) responses against tumor-associated antigens. (aacrjournals.org)
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • In CRS patients E2 was the dominant antigen to which both cellular and humoral immune responses were elicited. (ubc.ca)
  • Given the identification of possible abnormal immune responses observed in participants with autism (for example, antibodies which react to proteins found in the central nervous system [ 5 ]) and similarities between schizophrenia and diseases with established HLA associations [ 6 ], several studies have examined the possible involvement of HLA loci in neurodevelopmental disorders. (biomedcentral.com)
  • These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. (smokershistory.com)
  • proteins
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • loci
  • However, to date, no studies have investigated the possible involvement of HLA loci in specific language impairment (SLI), a disorder that is defined primarily upon unexpected language impairment. (biomedcentral.com)
  • These preliminary data provide an intriguing link to those described by previous studies of other neurodevelopmental disorders and suggest a possible role for HLA loci in language disorders. (biomedcentral.com)
  • locus
  • The HLA-DRB4 promoter polymorphism is associated with differential expression of this locus 4 and this occurs at the level of mRNA production 3 . (dorak.info)
  • Dausset
  • The workshop was convened for the purpose of comparing the different in vitro assay systems used at the time to define antigens which were described as Hu-1 (Dausset and Ivanyi), LA (Payne and Bodmer), and Four (van Rood). (ihiws.org)
  • transplantation
  • Crossmatching is essential prior to kidney transplantation to confirm compatibility between the donor and the recipient, particularly to prevent acute antibody-mediated rejection. (hindawi.com)
  • frequencies
  • The very first paper which studied HLA-A, and -B frequencies in childhood leukaemia found a significant increase in HLA-A2B12 (Ref.3). (dorak.info)
  • crossmatch
  • An unexpected positive crossmatch may be obtained in recipients with an autoimmune disease or preexisting antibodies not detected by single-antigen bead array due to complement interference or who have been previously treated by desensitization protocols such as rituximab, antithymocyte globulin, or intravenous immunoglobulins. (hindawi.com)
  • positivity
  • These include recurrent fetal miscarriage, intrauterine fetal growth retardation, and preeclampsia, in connection with positivity for antiphospholipid antibodies. (healthdocbox.com)
  • frequency
  • In this study, the frequency of s of HLA-DR, HLA-DQ, and HLA-DP antigens was evaluated by means of the PCR- RFLP method. (healthdocbox.com)
  • Intensity (concentration) and duration of exposure to the antigen, frequency of exposure, particle size, and antigen solubility may influence disease latency, prevalence, severity and course [6, (worldallergy.org)
  • The MHC was first associated with disease in 1967 when HLA-B antigens were found at increased frequency in patients with Hodgkin's lymphoma . (plos.org)
  • assay
  • Clinicians should use an HIV antibody test with confirmation by Western blot or indirect immunofluorescence assay to establish diagnosis of chronic HIV infection. (thebodypro.com)
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • recipients
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • Several
  • The first HLA workshop involved scientists from several countries and proved to be a seminal event, an impetus for more extensive collaborations in the following years. (ihiws.org)
  • 6 - 8 A non-HLA B-cell antigen known as D8/17 has been investigated in several population groups. (mja.com.au)
  • Several of these antigens (e.g. (healthmatics.info)
  • Reactions
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • exposure
  • In general, there appears to be a direct relationship between the intensity of antigen exposure and the development of HP. (worldallergy.org)
  • It is believed that acute HP usually results from intense intermittent exposure to inhaled antigens and that subacute HP results from a less intense but more persistent exposure. (worldallergy.org)
  • adjuvant
  • Antigens that cause HP also have adjuvant properties that enable them to activate complement and release cytokines directly which also may be relevant [6, (worldallergy.org)