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  • therapeutic
  • Custom antibody development and commercial partnerships to advance your diagnostic and therapeutic discovery. (abcam.com)
  • PrPSc did not reappear in cells being cultured for 14 additional days without therapeutic antibody treatment. (uni-muenchen.de)
  • Get access to the best antibodies, discovery platforms, and know-how to advance your diagnostic and therapeutic programs. (abcam.com)
  • extracellular
  • 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. (abcam.com)
  • Here, we use a combination of two- and three-dimensional culture systems to dissect the extracellular signals that control endogenous estrogen receptor α. (biologists.org)
  • detection
  • Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. (ac.be)
  • specific
  • Three strategies resulted in downregulation or blocking of LRP and prevented PrPSc accumulation in different scrapie infected neuronal cell lines (i) transfection with an antisense LRP RNA expression plasmid (ii) transfection with small interfering (siRNAs) specific for the LRP mRNA and (iii) incubation with the polyclonal anti-LRP antibody, W3. (uni-muenchen.de)
  • Treatment of established tubular structures with 100 µg-ml anti-LRP-LR specific antibody completely blocked angiogenesis. (duhnnae.com)
  • Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells. (wits.ac.za)
  • membrane
  • We find that RGDS, antibody to fibronectin, and the Fab' fragment cause a decrease in the number of mesoderm cells spread on the basement membrane, and a perturbation of cell shape suggesting locomotory impairment. (biologists.org)
  • Moreover, estrogen receptor-dependent reporter gene expression, as well as estrogen receptor α levels, were increased threefold in a functionally normal mammary epithelial cell line when reconstituted basement membrane was added to the medium. (biologists.org)
  • role
  • We conclude that the in vivo dependence of mesoderm cells on fibronectin is confirmed, but that although these cells have the ability to recognise sites in laminin as mediators of attachment and spreading, the in vivo role of this molecule in mesoderm morphogenesis is not yet certain. (biologists.org)
  • expression
  • In this context, an approach based on the expression of single chain antibodies as secretory molecules in the brain via an adeno-associated virus (AAV) vector was initiated. (uni-muenchen.de)
  • we found previously that two distinct signals control β-casein expression in response to laminin-1. (biologists.org)