• CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mouse, is member C of the class 1 (receptor-like) protein tyrosine phosphatase family (PTPRC) (1, 2). (rndsystems.com)
  • CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds (3, 6‑8). (rndsystems.com)
  • CD45RB is a splice isoform of CD45 (also called protein tyrosine phosphatase, receptor type, C), a glycoprotein receptor that is required for T-cell activation. (lsbio.com)
  • The antibody MEM-143 reacts with a protein determinant of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). (lsbio.com)
  • The mouse monoclonal antibody HI30 recognizes an extracellular epitope on all isoforms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. (exbio.cz)
  • CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (exbio.cz)
  • Left Plot) or BD Horizon BV480 Mouse Anti-Human CD45 antibody (Cat. (bdbiosciences.com)
  • CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. (thermofisher.com)
  • IHC testing of FFPE human tonsil with anti-CD45 antibody (clone SPM570). (nsjbio.com)
  • This anti-CD45 antibody is available for research use only. (nsjbio.com)
  • CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. (nsjbio.com)
  • This antibody will bind to all CD45 isoforms. (nsjbio.com)
  • Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. (nsjbio.com)
  • Due to variation in protocol and secondary antibody used, the anti-CD45 antibody may need to be titered for optimal performance. (nsjbio.com)
  • Neoplastic cells from a T cell lymphoma were used as the immunogen for the anti-CD45 antibody. (nsjbio.com)
  • Anti-CD45 antibody (with azide) can be stored at 2-8oC. (nsjbio.com)
  • CD45, also known as leukocyte common antigen (LCA), protein tyrosine phosphatase, receptor type I (PTPR) is a type I transmembrane protein encoded by PTPR gene specifically expresses in hematopoietic cells. (biomabinc.com)
  • Conventional monoclonal antibodies(mAbs) raised against CD45 have reactivity against all isoforms, while restricted mAB only reacts to specific isotypes (CD45RA, CD45RB, CD45RO). (biomabinc.com)
  • The effect of two anti-CD45 (T200, LCA, Ly5) antibodies on the activation of the murine T-cell hybridoma 13.13 has been evaluated. (mssm.edu)
  • Pretreatment of the cells with the anti-CD45 mAb M1/89.18.7.HK markedly inhibited all three biological responses, while an alternate anti-CD45 antibody, M1/9.3.4.HL.2, had little effect. (mssm.edu)
  • The two antibodies bound to CD45 with similar affinities, and no differences in the lateral mobility of antibody-CD45 complexes in the cell membrane were observed. (mssm.edu)
  • If M1/89.18.7.HK was added to the 13.13 cells after they had already been activated with anti-CD3, it very effectively stimulated dephosphorylation of substrates that had been phosphorylated on tyrosines prior to adding the anti-CD45 antibody. (mssm.edu)
  • These results indicate that the phosphotyrosine protein phosphatase activity of CD45 is critical to its biological function and that bivalent (i.e. uncross-linked) anti-CD45 antibodies can give rise to markedly different responses. (mssm.edu)
  • One of the antibodies, M1/89.18.7.HK, appears to behave much like a receptor ligand and is able to activate the enzymatic activity associated with the CD45 transmembrane protein. (mssm.edu)
  • PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. (ximbio.com)
  • The following product was used in this experiment: ZO-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 71-1400, RRID AB_2533976. (thermofisher.com)
  • COX11 Polyclonal Antibody detects endogenous levels of COX11 protein. (abbkine.com)
  • The reactivity of the antibody MEM-143 can be blocked by a peptide including amino acids 79-88. (lsbio.com)
  • 1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. (abbkine.com)
  • The combination of the 1858T variant and anti-CCP antibodies gave 100% specificity for the disease. (nih.gov)
  • Manufactured using AbAb's Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 064-044. (absoluteantibody.com)
  • Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
  • Full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell. (origene.com)
  • PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. (ximbio.com)
  • inactivating the protein kinase activity of EIF2AK3/PERK. (cusabio.com)
  • Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. (affbiotech.com)
  • However, they exhibited a marginal reduction in α(IIb)β(3)-mediated Src family kinase activation and tyrosine phosphorylation. (ox.ac.uk)
  • These defects were associated with reduced activation of Src family kinase and spleen tyrosine kinase, suggesting a causal relationship. (ox.ac.uk)
  • The cytoplasmic region contains a juxtamembrane motif with two tyrosine residues which are the major autophosphorylation sites, a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxy tail which contains one conserved tyrosine residue. (rndsystems.com)
  • Following B-cell receptor activation, 2 waves of tyrosine kinase phosphorylation occur. (medscape.com)
  • the second activates Bruton tyrosine kinase and Syk. (medscape.com)
  • The BTK gene is present on Xq21.3-q22, and its defect results in deficiency of Bruton tyrosine kinase. (medscape.com)
  • X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK) [Väliaho et al. (lu.se)
  • ZAP-70 deficiency is a rare autosomal recessive form of severe combined immunodeficiency (SCID) caused by mutations in the gene coding for T cell receptor z-chain associated protein kinase [ Chan et al. (lu.se)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. (antibodiesinc.com)
  • It is a variably glycosylated 180‑220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin (1‑3). (rndsystems.com)
  • CD304, also known as neuropilin-1, BDCA-4 and VEGF165R, is a 140 kD type I transmembrane protein. (biolegend.com)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.co.jp)
  • This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. (origene.com)
  • It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. (origene.com)
  • Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation. (nsjbio.com)
  • Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. (antibodiesinc.com)
  • Purified by protein-A affinity chromatography. (lsbio.com)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. (abcam.com)
  • The antibody was purified by affinity chromatography. (biolegend.com)
  • We have generated a high affinity and selective humanized monoclonal IgG4 antibody, TSR-033, which binds human LAG-3 and serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. (aacrjournals.org)
  • The antibody works well on Westerns, but not well for immunoprecipitations or affinity purifications. (uiowa.edu)
  • The optimal Ig concentration for an application varies by species and antibody affinity. (uiowa.edu)
  • In general, rabbit antibodies demonstrate greater affinity and are used at a magnitude lower Ig concentration for initial testing. (uiowa.edu)
  • The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions. (biolegend.com)
  • Centroblasts progress to centrocytes with high-affinity antibody production, and then they differentiate further to long-term memory cells and plasmablasts. (medscape.com)
  • We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis (RA) in individuals who subsequently developed RA. (nih.gov)
  • Antibodies targeting CD markers or other extracellular proteins may be added prior to fixation if the epitope is disrupted by formaldehyde and/or methanol. (cellsignal.com)
  • These peptide usually contains the epitope recognized by the antibody. (affbiotech.com)
  • Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
  • This antibody reacts with an epitope unique for CD45R0. (ximbio.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)
  • Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. (affbiotech.com)
  • Noonan syndrome (NS) is caused by mutations in PTPN11 , a gene encoding the nonreceptor protein tyrosine phosphatase SHP2. (lu.se)
  • The mouse CD45RABC cDNA encodes 1291 amino acids (aa), including a 23 aa signal sequence, a 541 aa extracellular domain containing the splicing region, a cysteine-rich region and two fibronectin type III domains, a 22 aa transmembrane sequence, and a 705 aa cytoplasmic domain that contains two phosphatase domains, D1 and D2. (rndsystems.com)
  • This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. (origene.com)
  • There are two classes of receptors, designated A and B. Both the A and B class receptors have an extracellular region consisting of a globular domain, a cysteine-rich domain, and two fibronectin type III domains. (rndsystems.com)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • Some patients also have deficient humoral immunity (sometimes called antibody deficiency), characterized by abnormal antibody responses to polysaccharide antigens despite normal immunoglobulin levels. (msdmanuals.com)
  • Patients (dominant and recessive) have cutaneous anergy to Candida , absent proliferative responses to Candida antigen (but normal proliferative responses to mitogens), and intact antibody response to Candida and other antigens. (msdmanuals.com)
  • 20. There are currently several known genes associated with Hashimoto's thyroiditis: cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), human leukocyte antigens (HLA), protein tyrosine phosphatase 22 (PTPN22), and thyroglobulin receptor gene. (healthmedin.com)
  • The human immune system is capable of producing up to 10 9 different antibody species to interact with a wide range of antigens. (medscape.com)
  • SHPS1 Antibody detects endogenous levels of total SHPS1. (affbiotech.com)
  • To refine the effect of age in relation to islet antibody type on progression from single to multiple autoantibodies in relatives of people with type 1 diabetes. (nih.gov)
  • Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. (wikipedia.org)
  • Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I". Chromosoma. (wikipedia.org)
  • In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • Secreted autoantibodies specific to receptors or receptor ligands can activate or inhibit receptor functions. (hindawi.com)
  • Bulk Order Inquiry for Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL550 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
  • Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. (antibodiesinc.com)
  • Five-year risk was inversely related to age, but the pattern differed by antibody type: Relatives with GADA showed a gradual decrease in risk over the four age groups, whereas relatives with IAA showed a sharp decrease above age 8 years. (nih.gov)
  • They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target) is a type of antinuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. (wikipedia.org)
  • In addition to HLA-DR, the protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype showed significant association with anti-topo I. The TAP1 gene (6p21.3, HLA complex) has also been found in association with ATA+ sclerosis. (wikipedia.org)
  • Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
  • Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
  • The autoantigens include glutamic acid decarboxylase 65 (GAD65), voltage-gated Ca 2+ channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluRdelta). (springer.com)
  • In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2). (ox.ac.uk)
  • We fulfill our mission with an extensive catalog of validated neuroscience antibodies and a suite of services governed by a stringent and long-established Quality Management System -- and we do it all in Davis, California, USA. (antibodiesinc.com)
  • The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. (abcam.com)
  • They recognize microorganisma through their Fc, complement and toll-like receptors (TLR), as well as non-TLR. (medscape.com)
  • Toll-like receptors in the pathogenesis of human disease. (antibodies-online.com)
  • See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. (lsbio.com)
  • Here, we describe a method to detect microcystins in human plasma by using immunocapture followed by a protein phosphatase inhibition assay. (cdc.gov)
  • Norman Relkin , at Weill Medical College of Cornell University in New York, presented the latest data on his efforts to test intravenous immunoglobulin (IVIg), a somewhat mysterious mixture of purified human polyclonal antibodies originating from the plasma of blood donors. (alzforum.org)
  • This antibody gave a positive result in IHC in the following FFPE tissue: Human normal testis. (abcam.co.jp)
  • Recombinant protein encoding aa 2290-2491 of human FAP-1. (antibodies-online.cn)
  • Synthetic peptide corresponding to Human VEGF Receptor 2 (phospho Y951). (abcam.com)
  • This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. (abbkine.com)
  • Lymphocyte activation gene-3 (LAG-3) is a coinhibitory receptor associated with impaired T-cell function and is frequently coexpressed with programmed cell death protein-1 (PD-1) in the context of human cancers. (aacrjournals.org)
  • Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. (ximbio.com)
  • To develop thyroid hormones, the human body needs iodine and tyrosine that can be obtained from its diet. (healthmedin.com)
  • We targeted this Adda side chain using a commercial antibody and extracted microcystins from human samples for screening and analysis. (cdc.gov)
  • METHODS AND RESULTS: PTP-1B-deficient mouse platelets responded normally to the glycoprotein VI-specific agonist collagen-related peptide and antibody-mediated CLEC-2 activation. (ox.ac.uk)
  • Secondary B lymphopoiesis is an antigen-dependent process and occurs in the germinal center of peripheral lymphoid organs with specific antibody production. (medscape.com)
  • An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
  • Only membrane-bound or Fc‑clustered ligands are capable of activating the receptor in vitro . (rndsystems.com)
  • Soluble monomeric ligands bind the receptor but do not induce receptor autophosphorylation and activation (2). (rndsystems.com)
  • In vivo , the ligands and receptors display reciprocal expression (3). (rndsystems.com)
  • It has been found that nearly all the receptors and ligands are expressed in developing and adult neural tissue (3). (rndsystems.com)
  • Anti-GAD65 antibody (Ab) acts on the terminals of inhibitory neurons that suppress GABA release, whereas anti-VGCC, anti-mGluR1, and anti-GluR Abs impair LTD induction. (springer.com)
  • These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins (1, 2). (novusbio.com)
  • [ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
  • Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
  • Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
  • Rheumatoid arthritis (RA), a complex chronic inflammatory disease with a worldwide prevalence of 0.5-1.0 % [ 1 ], is characterized by production of anti-citrullinated protein/peptide antibodies (ACPA) in the majority of patients and persistent inflammation in the synovial tissue of the joints leading to destruction of cartilage and bone [ 2 - 4 ]. (biomedcentral.com)
  • Anti-topoisomerase antibodies can be classified according to their immunoglobulin class (IgM, IgG or IgA). (wikipedia.org)
  • SHPS1 Immunoglobulin-like cell surface receptor for CD47. (affbiotech.com)
  • The B-cell receptor is formed from the noncovalent association between surface IgM or IgD and 2 transmembrane proteins, IgA and immunoglobulin B. The presence of CD22 and CD19/CD21 on the cell surface, playing the role of coreceptorlike molecules, is necessary for the activation of the receptor. (medscape.com)
  • The loss of ZAP-70 function leads to selective inability to produce CD8+ T lymphocytes and abolishes T cell receptor stimulation in mature CD4+ T lymphocytes [Arpaia, et al. (lu.se)
  • [ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
  • The antibodies will remain bound to the target of interest during the fixation and permeabilization process. (cellsignal.com)
  • The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)
  • Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
  • IVIg contains so-called natural antibodies that always course through people's bodies rather than being made specifically in response to a given infection. (alzforum.org)
  • The numbers of natural antibodies appear to decline in people with AD. (alzforum.org)
  • These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
  • This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (origene.com)
  • This Cell Signaling Technology antibody is conjugated to FITC and tested in-house for direct flow cytometric analysis in mouse cells. (cellsignal.com)
  • May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. (cusabio.com)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • As part of the innate immune system the Toll-like receptor (TLR) signaling pathway contributes to the first line of defense against microbial pathogens. (antibodies-online.com)
  • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. (antibodies-online.com)
  • Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. (antibodies-online.com)
  • The PTPN22 1858T variant and anti-CCP antibodies were clearly associated (OR = 3.80, 95% CI 1.51-9.57). (nih.gov)
  • This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. (antikoerper-online.de)
  • The insulin receptor (IR) and JAK1 tyrosine kinases and STAT3 can serve as direct substrates for the T-cell protein tyrosine phosphatase (TCPTP). (diabetesjournals.org)
  • Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B. (ox.ac.uk)
  • Activation of 13.13 cells with the anti-CD3 monoclonal antibody, 145.2C11, gave rise to rapid increases in intracellular calcium and interleukin-2 production. (mssm.edu)
  • The inhibition of activation of the cells by M1/89.18.7.HK was abrogated significantly both by the phosphotyrosine protein phosphatase inhibitor orthovanadate and by excess M1/9.3.4.HL.2. (mssm.edu)
  • Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band. (antibodiesinc.com)
  • WB: For western blot detection of denatured protein samples. (affbiotech.com)
  • Do not aliquot the antibody. (cellsignal.com)
  • 2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year. (abbkine.com)
  • Somatic mutations at the phosphotyrosine-binding pocket of the C-terminal SH2 domain of GTPase-activating protein RASA1 have been found in a subset of Basal-cell carcinoma (BCC) [Friedman, 1995]. (lu.se)
  • PTPmu is an Ig superfamily receptor protein-tyrosine phosphatase, which promotes cell-cell adhesion and interacts with the cadherin-catenin complex. (ximbio.com)
  • Scleroderma results from the overproduction of collagen in affected tissues, one study claims that there is an increased density of Topoisomerase I sites in the collagen genes, and that the antibodies may be altering transcription at these loci. (wikipedia.org)
  • In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
  • Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
  • Antibodies against P. gingivalis virulence factor arginine gingipainB (RgpB), and a citrullinated peptide (CPP3) derived from the P. gingivalis peptidylarginine deiminase enzyme, were analysed by ELISA. (biomedcentral.com)
  • This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Following dimerization, TLR signals are transduced via a cytoplasmic C-terminal Toll IL-1 receptor (TIR) domain to a set of adapter proteins. (antibodies-online.com)
  • Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance. (cusabio.com)