Antibody mediated. Medical search. Frequent questions

Risk factors for developing antibody-mediated rejection (AMR) include pregnancy, previous transplantation, blood transfusions, sensitization by OKT3 induction therapy, and use of ventricular assist devices. (medscape.com)

That is, the infected cell is not attacked as in Antibody-dependent cell-mediated cytotoxicity, instead the virions are rapidly destroyed and the cell may be relieved of infection. (wikipedia.org)
The interaction with Fc-receptors can lead to killing of virus-infected cells through a variety of immune effector mechanisms, including antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). (ru.nl)
Antibody-mediated complement activation may lead to complement-dependent cytotoxicity (CDC). (ru.nl)
The anti-tumor activity of KIR3DL3 blockade with NPX267 was also demonstrated in NK-cell mediated cytotoxicity assays. (bmj.com)
Antibody-dependent cell-mediated cytotoxicity (ADCC) was evaluated with FRβ positive CHO cells as target cells and isolated peripheral blood monocytes as effector cells in an in vitro assay. (biomedcentral.com)
Here we show that incorporating a short juxtamembrane sequence into the EGFRt polypeptide enhances its expression on the surface of T cells and their susceptibility to antibody-dependent cellular cytotoxicity (ADCC). (biorxiv.org)

Human immunodeficiency virus (HIV)-1-specific broadly neutralizing monoclonal antibodies are currently under development to treat and prevent HIV-1 infection. (nature.com)
Monoclonal antibodies (mAbs) have revolutionized the treatment of B-cell malignancies. (manchester.ac.uk)
CBA/Ca mice may be made tolerant to minor histoincompatible B10.BR skin grafts by treatment with a short course of non-depleting anti-mouse CD4 and CD8 monoclonal antibodies (mAb), during the transplantation period. (ox.ac.uk)
Blocking of CTL-mediated killing by monoclonal antibodies to LFA-1 and Lyt-2, 3. (aai.org)
We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand. (aai.org)
A new generation of anti-HIV-1 monoclonal antibodies, possessing extraordinary potency and breadth of neutralizing activity, has recently been isolated from infected individuals. (pasteur.fr)

The Food and Drug Administration (FDA) is announcing a public workshop regarding new developments and scientific issues related to antibody mediated rejection (AMR) in kidney transplantation. (myast.org)

Rejection refers to the organ recipient's immune system recognizing a transplanted organ as foreign and mounting a response to it via cellular and/or humoral (antibody-mediated) mechanisms. (medscape.com)
Based on the observation that, in contrast to the inhibition of HIV-1 entry, antibody mediated enhancement was not temperature dependent and could not be mediated by F(ab) fragments, we concluded that the mechanisms underlying these phenomena are different and that antibody mediated enhancement of HIV-1 entry is largely if not exclusively mediated by HIV-1 glycoprotein cross-linking. (microbiologyresearch.org)
The current lack of understanding of the mechanisms by which antibodies can protect against RSV infection and disease or, alternatively, contribute to disease severity, hampers the design of safe and effective vaccines against this virus. (ru.nl)
Importantly, neutralization is only one of many mechanisms by which antibodies can interfere with viral infection. (ru.nl)
The induced IgG and IgM antibodies were able to stimulate various Fc-mediated effector mechanisms associated with protection against malaria, including phagocytosis, release of reactive oxygen species, production of IFN-γ as well as complement activation and fixation. (nature.com)
However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
Although Fc-dependent mechanisms of mAb-mediated tumor clearance have been extensively studied, the ability of mAbs to directly evoke programmed cell death (PCD) in the target cell and the underlying mechanisms involved remain under-investigated. (manchester.ac.uk)
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. (ox.ac.uk)
This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)

Di Cocco P, Fratti A, Kaylan KB, Tzvetanov IG, Benedetti E. Treatment Strategies for Antibody-mediated Rejection in Kidney Transplantation and Its Prevention. (lidsen.com)
This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. (lidsen.com)

AMR refers to allograft injury resulting from activation of the complement system, typically by recipient-generated antibodies directed against the allograft tissue. (medscape.com)
Antibodies consist of two structural regions: a variable fragment (Fab) that mediates antigen binding and a constant fragment (Fc) that mediates downstream effector functions via its interaction with Fc-receptors on (innate) immune cells or with C1q, the recognition molecule of the complement system. (ru.nl)
Scholars@Duke publication: Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. (duke.edu)
Results demonstrated that the classical pathway of complement mediated serum neutralization of influenza virus. (duke.edu)
Staining for AChE and synaptophysin (a synaptic vesicle marker) was also disrupted in ganglia exposed to AChE antibodies in complement-sufficient serum. (elsevierpure.com)
When complement was eliminated by substituting serum that was heat-inactivated or deficient in C3, synaptic input was retained in 60-90% of neurons incubated with AChE antibodies. (elsevierpure.com)
These findings strongly implicate the complement cascade in the destruction of preganglionic sympathetic terminals that follows binding of AChE antibodies. (elsevierpure.com)
Antibodies, the complement system, and the cellular receptors regulating signaling, such as Fc receptors and integrins, are natural components to study. (lu.se)
however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)

Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
Purified anti-human leukocyte antigen class I antibody (W6/32), isotype control antibody, or saline was injected into recipient mice weekly until day 42, at which point the degree of intimal expansion (IE) of vessels was assessed by histologic analysis.Results. (ox.ac.uk)

Methods To explore the therapeutic potential of HHLA2-KIR3DL3 blockade, we generated NPX267, a first-in-class, monoclonal antibody that binds with high affinity to human KIR3DL3. (bmj.com)
In this study we aimed to develop an FRβ-specific human monoclonal antibody (mAb) that could be used as a therapeutic agent to treat rheumatoid arthritis and other autoimmune diseases, as well as FRβ positive cancers. (biomedcentral.com)
These data suggest that further investigation of the potential of antibody-based therapeutic strategies for long-term suppression of HIV is warranted, including in individuals off ART and with low viral load. (nature.com)
Thus, our studies define a critical role of the immunoproteasome in chronic kidney allograft rejection and suggest immunoproteasome inhibition as a promising therapeutic approach to suppress chronic antibody-mediated rejection. (uni-konstanz.de)
This was investigated by a series of adoptive transfer experiments in which mAb-treated cells were removed from therapeutic antibody at defined times after skin grafting, and exposed to fresh antigen in the absence of further mAb treatment. (ox.ac.uk)
Complex steps involved in the antibody response allows for several potential targets for therapeutic intervention, including suppression of T and B cells, elimination of circulating antibodies, and inhibition of residual antibodies. (psu.edu)
In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a mouse model of type II collagen-induced arthritis (CIA). (nih.gov)

abstract = "Background: In the treatment of refractory antibody-mediated rejection (AMR), splenectomy has been associated with surprisingly rapid recovery of renal function. (elsevierpure.com)
abstract = "Background: The importance of antibody-mediated rejection (AMR) following lung transplantation remains contentious. (elsevierpure.com)
abstract = "Antibody-mediated rejection (AMR) continues to present a challenge for the survival of the cardiac allograft. (psu.edu)
abstract = "When administered to rats, antibodies against acetylcholinesterase (AChE) selectively destroy presynaptic inputs to sympathetic ganglia. (elsevierpure.com)
Orandi B, Chow E, Arendonk KVan, Montgomery J, Gupta N, Montgomery R, Segev D. Early Antibody-Mediated Rejection Portends Worse Long-Term Renal Graft and Patient Survival [abstract]. (atcmeetingabstracts.com)

Chronic antibody-mediated rejection is the major cause of fading allograft function and loss after renal transplantation. (uni-konstanz.de)
Currently, pharmacological agents for the suppression of chronic antibody-mediated rejection are lacking. (uni-konstanz.de)

The secondary endpoints were changes in anti-PGT121 antibody titers and CD4 + T-cell count, and development of HIV-1 sequence variations associated with PGT121 resistance. (nature.com)
While females had greater neutralizing antibody titers against the vaccine virus , both sexes showed a lower neutralization capacity against mutant viruses . (bvsalud.org)
Immunogenicity outcomes of interest were seroconversion, geometric mean titers (GMTs), or antibody avidity. (cdc.gov)

Can be caused by HLA and non-HLA donor specific antibodies (e.g. (pathologyoutlines.com)
In particular, the diagnostic criteria suggested to define AMR, namely the presence of donor-specific antibodies (DSA), C4d immunoreactivity, histological features and allograft dysfunction are not always readily applicable or confirmatory in lung transplantation. (elsevierpure.com)
Natera on Tuesday announced results from a study showing that donor-derived cell-free DNA (dd-cfDNA) testing with its Prospera Kidney test was superior to the current standard of care, donor-specific antibody testing, in predicting antibody-mediated rejection. (labpulse.com)
The investigators in the Trifecta study in Transplantation assessed dd-cfDNA donor fraction, estimated amount of dd-cfDNA, and donor-specific antibody-status for 280 samples from recipients of kidney transplants matched to kidney biopsies evaluated by both RNA-based molecular pathology and histology, Natera said. (labpulse.com)
Pancreatic AMR is best identified by a combination of serological and immunohistopathological findings consisting of (i) identification of circulating donor-specific antibodies, and histopathological data including (ii) morphological evidence of microvascular tissue injury and (iii) C4d staining in interacinar capillaries. (houstonmethodist.org)

Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded. (wikipedia.org)
Finally, NPX267 blockade of HHLA2 mediated KIR3DL3 signaling enhanced anti-tumor immunity in humanized mouse models bearing HHLA2 + human tumors. (bmj.com)
NPX267, a first-in-class KIR3DL3 blocking antibody, potentiates anti-tumor immunity against HHLA2 + tumors and may represent a promising approach to treat certain cancers. (bmj.com)
A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. (cdc.gov)
We review the literature on the role of CD4+ and CD8+ T cell-mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. (cdc.gov)
Mouse models of influenza A virus pneumonia provide a well-developed experimental system to analyze T cell-mediated immunity. (cdc.gov)
Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells. (bvsalud.org)
Neutralizing antibodies can confer immunity to primate lentiviruses by blocking infection in macaque models of AIDS. (pasteur.fr)

Recently, we and others have shown that the interaction between envelope specific antibodies and primary human immunodeficiency virus type 1 (HIV-1) isolates may result in either inhibition or enhancement of virus entry. (microbiologyresearch.org)
To study the mechanism underlying this phenomenon, a series of HIV-1 envelope glycoproteins from closely related primary virus isolates of different syncytium inducing phenotypes, together with chimeras of these proteins, were tested in an envelope transcomplementation assay for their sensitivity to either antibody mediated inhibition or enhancement of HIV-1 entry. (microbiologyresearch.org)

m909 was not only able to select FRβ positive, activated macrophages from synovial fluid cells of arthritis patients as efficiently as folate, but also able to mediate ADCC in FRβ positive cells. (biomedcentral.com)

El Hag M. Acute antibody mediated rejection including hyperacute rejection. (pathologyoutlines.com)
Cardiac transplant rejection manifests in one or more of the following three ways: acute cell-mediated rejection, antibody-mediated rejection (AMR), and allograft vasculopathy. (medscape.com)
Acute cell-mediated rejection is primarily a host T-lymphocyte-mediated response mounted against the allograft tissue. (medscape.com)
Contrast these with the third image which demonstrates severe acute cell-mediated rejection. (medscape.com)
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy. (scilifelab.se)
8: 237) dealt primarily with the diagnosis of acute T-cell-mediated rejection (ACMR), while only tentatively addressing issues pertaining to antibody-mediated rejection (AMR). (houstonmethodist.org)

However, one antibody could effectively promote vital immune functions, including phagocytosis and in vivo protection. (lu.se)
The antibody causes phagocytosis (see above) to occur. (scienceaid.net)

Here we demonstrate that, although mice lacking all receptors for the Fc part of IgG (FcγRs) develop normal IgG responses after MCMV-TRP2 vaccination, the protection against B16 melanoma was completely abrogated, indicating that FcγRs are indispensable in the downstream effector pathway of the polyclonal anti-TRP2 antibody response. (oncotarget.com)
In addition to RFC and PCFT, a limited number of cells express folate receptors (FRs) that can mediate unidirectional transportation of folates into cells. (biomedcentral.com)
Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)

Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy. (ox.ac.uk)
Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. (cdc.gov)
Antibody-mediated protection is therefore effective against homologous viral strains but inadequate against heterologous strains with serologically distinct coat proteins. (cdc.gov)
In contrast, T cells, which mediate cellular immune responses, can target internal proteins common to heterologous viral strains. (cdc.gov)
The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
Antibodies (or immunoglobulins) are made of chains of proteins joined by disulfide bridges: a very strong bond. (scienceaid.net)
CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)

By investigating compound FcγR-deficient mouse strains and by using immune cell type-specific cell ablation we show that the IgG antibody-mediated tumor protection elicited by MCMV-TRP2 mainly depends on FcγRI expression on macrophages, whereas FcγRIV plays only a modest role. (oncotarget.com)
Thus, tumor-specific antibody therapy might benefit from combination therapy that recruits FcγRI-expressing pro-inflammatory macrophages to the tumor micro-environment. (oncotarget.com)

Recent studies have emphasized the importance of Fc-mediated antibody effector functions in both protection and pathogenesis for various infectious agents. (ru.nl)
In this review article, we aim to provide a comprehensive overview of the current knowledge on Fc-mediated antibody effector functions in the context of RSV infection, discuss their potential role in establishing the balance between protection and pathogenesis, and point out important gaps in our understanding of these processes. (ru.nl)
5. Occurrence of immune-mediated enhancement of SARS-CoV infection raises safety concerns regarding the use of SARS-CoV vaccine in humans and enables new ways to investigate SARS pathogenesis (tropism and immune response deregulation). (hku.hk)

Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)

B lymphocytes generate antibodies to neutralize numerous antigens via RAG endonuclease-initiated V(D)J recombination which joins diverse V and D segments into several J segments. (aacrjournals.org)
Generally speaking, solid organ rejection is mediated via host T lymphocytes that recognize donor major histocompatibility complexes (MHC) I and II. (medscape.com)
If antibody therapy is continued for the full 5 weeks, T cell tolerance can still be established, suggesting that antibody therapy does not prevent lymphocytes from registering the presence of antigen. (ox.ac.uk)

Antibodies generated by these antigenic differences between donor and recipient as well as direct cytotoxic effects of the donor's immune system are responsible for the pathology seen in transplant rejection. (medscape.com)
Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy. (ox.ac.uk)

In these studies, bNAb resistance emerged in nearly all treated participants who received monotherapy, but in two notable cases 4 the repeated administration of a combination of two bNAbs in the setting of viremia maintained viral suppression for 3 months without development of resistance to either antibody. (nature.com)
Either antibody alone can potently block virus acquisition. (pasteur.fr)

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. (lu.se)
Modulation of primary human immunodeficiency virus type 1 envelope glycoprotein-mediated entry by human antibodies. (microbiologyresearch.org)

Remarkably, this antibody primarily interacts through a bivalent dual-Fab cis mode, where the Fabs bind to two distinct epitopes in the M protein. (lu.se)
Following maA/Cal/09 vaccination , females produced greater virus -specific, class-switched total IgG and IgG2c antibodies against the vaccine and all mutant viruses , and antibodies from females recognized a greater number of unique, linear HA epitopes than did antibodies from males . (bvsalud.org)
Vaccinated females benefited from the greater production of class-switched, somatically hypermutated antibodies generated in germinal center B cells , which increased recognition of more diverse maA/Cal/09 hemagglutinin antigen epitopes . (bvsalud.org)

Non-selective proteasome inhibitors suppress antibody-mediated allograft rejection. (uni-konstanz.de)

Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-depend- ent antibodies, including IgE. (cdc.gov)

Current vaccine strategies against influenza focus on generating robust antibody responses. (cdc.gov)
We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure. (cdc.gov)
Vaccine approaches against respiratory virus infections such as influenza have relied on inducing antibodies that protect against viral infection by neutralizing virions or blocking the virus's entry into cells. (cdc.gov)
HKU Scholars Hub: SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. (hku.hk)

For protection against infection, young children mainly depend on their innate immune system and maternal antibodies. (ru.nl)
The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)

In autoimmune limbic encephalitis, it is assumed that these auto-antibodies diffusely interfere with basal synaptic transmission or neural excitability and weaken overall functions of the temporal lobe [ 18 ]. (springer.com)
As a group, autoimmune blistering skin diseases are recognized as autoantibody-mediated diseases. (medscape.com)

2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immune-serum was observed in vitro. (hku.hk)

Therefore, we aimed to study whether decreased levels of intracellular HMGB1 or antibody-mediated neutralization of secreted HMGB1 would rescue mitochondrial dysfunction. (cdc.gov)

Several bNAbs have been tested to date in HIV-1-infected individuals, including the CD4-binding, site-specific antibodies VRC01, 3BNC117, VRC07-523LS and N6-LS, the V3-glycan-specific antibody 10-1074 and the V2-apex-specific antibodies PGDM1400 and CAP256-VRC26.25 (refs. (nature.com)

3. Antibody-mediated infection of SARS-CoV triggers entry into human haematopoietic cells via an FcγR-dependent and ACE2-, pH-, cysteine-protease-independent pathways. (hku.hk)

Recently it has been shown that vaccination with a mouse CMV (MCMV) vector expressing the melanoma-specific antigen TRP2 (MCMV-TRP2) protects mice against outgrowth of TRP2-positive B16 melanoma tumors, and this protection was dependent on the induction of IgG antibodies. (oncotarget.com)
Because each antibody has two binding sites, it can bind to two different pathogens, this causes large, lattice-like, structures called antibody-antigen complexes to form. (scienceaid.net)

The ability of NPX267 to block KIR3DL3-mediated suppression of T cell activation was assessed with a T cell reporter system and primary CD8 + T cell functional assays. (bmj.com)
KIR3DL3 blockade with NPX267 inhibited HHLA2-mediated suppression of T cell activation in a dose dependent manner. (bmj.com)
Two individuals with low baseline viral loads experienced ART-free viral suppression for ≥168 days following antibody infusion, and rebound viruses in these individuals demonstrated full or partial PGT121 sensitivity. (nature.com)

A broadly binding, protective monoclonal antibody could be a candidate for anti-streptococcal therapy. (lu.se)
This antibody is a broadly neutralizing antibody to HIV. (hptn.org)

Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice . (bvsalud.org)
IMPORTANCE Adult females develop greater antibody responses to influenza vaccines than males . (bvsalud.org)
However, when anti-AChE antibodies were present (0.16 mg/ml), none of 61 neurons from six incubated ganglia showed synaptic responses although membrane potential and input resistance remained normal. (elsevierpure.com)
We show, in macaques immunized with Wu-Hu-1 spike, that a single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs. (scilifelab.se)
The IgE antibodies and associated cellular responses are responsible for the allergic airway diseases, allergic rhinitis and allergic asthma, which are increasing in societies with Western life style. (cdc.gov)

In mice that received antibody where vessels were transplanted within 6 hr of procurement, no IE was observed. (ox.ac.uk)
However, earlier studies of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies administered to infected individuals or humanized mice reported poor control of virus replication and the rapid emergence of resistant variants. (pasteur.fr)
Chicken type II collagen was used to induce CIA in mice, which were then treated with an anti-human DR5 antibody, TRA-8. (nih.gov)

The susceptibility of the envelope glycoprotein chimeric viruses to neutralization or enhancement of infectivity proved to be primarily determined by the configuration of the V3 loop, and the affinity of the antibodies to monomeric HIV-1 gp160 molecules, proved to be of quantitative importance only. (microbiologyresearch.org)

Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. (lu.se)
Here we have examined two of the new antibodies, directed to the CD4-binding site and the V3 region (3BNC117 and 10-1074, respectively), for their ability to block infection and suppress viraemia in macaques infected with the R5 tropic simian-human immunodeficiency virus (SHIV)-AD8, which emulates many of the pathogenic and immunogenic properties of HIV-1 during infections of rhesus macaques. (pasteur.fr)
RÉSUMÉ Les objectifs de la présente étude étaient de documenter la prévalence et l'incidence de fond de l'infection par le virus de l'hépatite C chez les agents de santé de l'hôpital universitaire Ain Shams du Caire et d'analyser les facteurs de risque de contracter une infection par le virus de l'hépatite C. Une enquête transversale a été menée en 2008 auprès de 1770 agents de santé. (who.int)

Receptor-mediated activation of immunodeficiency viruses in viral fusion. (microbiologyresearch.org)
KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1. (bmj.com)
The functionally inert, non-immunogenic cell surface marker derived from human epidermal growth factor receptor (EGFRt) is a promising safety switch that has been used in multiple clinical constructs and can be targeted by cetuximab, a clinically available monoclonal antibody. (biorxiv.org)
Antibody, regardless of its specificity, may promote IE in human vessels that are injured through cold ischemia via interaction with Fc-receptor-positive cells. (ox.ac.uk)

Neutralizing anti-drug antibodies were not elicited. (nature.com)
These neutralizing antibodies target different regions of the HIV-1 envelope glycoprotein including the CD4-binding site, glycans located in the V1/V2, V3 and V4 regions, and the membrane proximal external region of gp41 (refs 9-14). (pasteur.fr)

Antibody-mediated rejection (AMR) incidence will increase as incompatible renal transplantation becomes more common. (atcmeetingabstracts.com)

The VRC01 antibody is able to bind onto HIV at the CD4 binding site on the gp120 protein. (hptn.org)

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. (microbiologyresearch.org)
Traditionally, antibody-mediated protection against viral infections is thought to be mediated by direct binding of antibodies to viral particles, resulting in virus neutralization. (ru.nl)
PGT121 is a monoclonal antibody isolated in 2011 from an African donor infected with HIV-1 subtype A, whose sera had demonstrated superior neutralization breadth and potency in an observational cohort, and so was considered an 'elite neutralizer' 9 . (nature.com)
When administered individually to recently infected macaques, the 10-1074 antibody caused a rapid decline in virus load to undetectable levels for 4-7 days, followed by virus rebound during which neutralization-resistant variants became detectable. (pasteur.fr)
This was reversed by the antibody-mediated neutralization of HMGB1. (cdc.gov)

Bispecific antibodies (BsAbs) bind to two different targets, and create two binary and one ternary complex (TC). (nih.gov)
Here, we have presented a general target-mediated drug disposition (TMDD) model for these BsAbs, which bind to two different targets on different cell membranes. (nih.gov)
The antibodies bind with high affinity in the central region of the surface-bound M protein. (lu.se)

Among 48 participants enrolled, no treatment-related serious adverse events, potential immune-mediated diseases or Grade 3 or higher adverse events were reported. (nature.com)
Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
Whereas the pemphigus subset of diseases is mediated by autoantibodies that target the extracellular skin components that link one epidermal cell to another, the pemphigoid subset is mediated by autoantibodies that target the extracellular skin components that link the skin basement membrane components either to the lowermost layer of epidermal cells or to the dermal components. (medscape.com)

Finally, we discuss the implications of Fc-mediated antibody effector functions for the rational design of safe and effective vaccines and monoclonal antibody therapies against RSV. (ru.nl)

The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)

The multifunctional activity of the humoral immune response remained for at least 6 months after vaccination and was comparable to that of naturally acquired anti-MSP1 antibodies from semi-immune adults from Kenya. (nature.com)
4. The antibody-mediated enhancement phenomenon is not a mandatory component of the humoral immune response elicited by SARS vaccines, as pure neutralising antibody only could be obtained. (hku.hk)

However, this approach requires high and persistent cell surface expression of EGFRt to ensure that antibody mediated depletion of engineered cells is rapid and complete. (biorxiv.org)
The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthritis via targeted depletion of macrophages and immunomodulation. (nih.gov)

Anatomy21

Organisms20

Diseases6

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Health Care5

Developing antibody-mediated rejection1

Cytotoxicity6

Monoclonal antibodies6

Related to antibody mediated rejection1

Mechanisms9

Rejection in Kidney Transplantation2

Complement9

Anti-human leukocy2

Therapeutic8

Abstract5

Chronic2

Titers3

Donor specific5

Immunity8

Inhibition2

ADCC1

Acute6

Phagocytosis2

Receptors3

Proteins7

Tumor2

Pathogenesis3

Humoral rejection1

Lymphocytes3

Transplant2

Either antibody2

Human antibodies2

Epitopes3

Allograft rejection1

Antigens1

Vaccine4

Innate3

Autoimmune2

Vitro1

Intracellular1

Specific antibodies1

Pathways1

Antigen2

Suppression3

Broadly2

Responses5

Mice3

Susceptibility1

Infection3

Receptor4

Neutralizing2

Renal transplantation1

VRC011

Neutralization5

Bind3

Diseases3

Effective vaccines1

Etiology1

Immune response2

Depletion2