Antibody highly immunogenic carrier protein carrier proteins. Medical search. Frequent questions

Peptides can be defined as fragments of larger functional proteins. (proteogenix.science)
Immunogenic versus antigenic peptides, what is the difference? (proteogenix.science)
However, it is important to note that while all immunogenic peptides possess antigenicity, not all antigenic peptides possess immunogenicity. (proteogenix.science)
Antigenic peptides tend to be shorter than immunogenic ones, retaining the ability to interact with a paratope but failing to trigger an immune response. (proteogenix.science)
Although most applications of immunogenic and antigenic peptides overlap, there are some grounds for differentiation. (proteogenix.science)
For instance, immunogenic peptides are, by nature, harder to design and produce because they need not only to possess antigenicity but also to be recognized as foreign by the organism they are administered to. (proteogenix.science)
Making antigenic peptides immunogenic can be achieved by fusion with carrier proteins or virus-like proteins . (proteogenix.science)
Antibodies generated by using immunogenic peptides are often called anti-peptide antibodies. (proteogenix.science)
Non-immunogenic antigenic peptides, due to their ease of production, remain useful for other applications. (proteogenix.science)
In contrast, peptides conjugated to a carrier may even be more antigenic than free peptides due to the conformation changes induced by the carrier. (proteogenix.science)
These peptides often present three-dimensional structures that are better recognized by antibodies. (proteogenix.science)
The OMVs can be rigged with immunogenic peptides and/or proteins that stimulate effective adaptive immunity. (biotechnology.report)
and virions, antigenic peptides selected from intra cellular (IMV) and extracellular virions (EE Vs) structural proteins. (sumobrain.com)
In order to improve expression levels, solubility, folding, purification and detection of recombinant proteins, a very strategy is the conjugation with peptides or proteins. (antibodies-online.com)
Low molecular weight haptens such as peptides, small proteins and drug molecules are generally not immunogenic and require the aid of a carrier protein in order to stimulate an immune response. (antibodies-online.com)
According to Morad, peptides have several advantages over antibodies, including that they are smaller, cheaper, and easier to produce and regulate. (thebrainsyouwerebornwith.com)

These strategies have been successfully employed in the production of peptide vaccines or antibody generation applications ( hybridoma or polyclonal antibody production ). (proteogenix.science)
Th1 response can be attainable through the system, which is of great benefit in SARS CoV-2 infection and the system can be tested for future applications including vaccine development and polyclonal antibody production. (springeropen.com)

Prior to carrying out the pivotal clinical trial, we are profiling epitope-specific antibodies from archived sera to develop an assay that predicts protection. (utsouthwestern.edu)
Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases used knowledge from the crystal structure of an HIV-1 neutralizing antibody, VRC34.01, in complex with its epitope on the HIV-1 Env trimer, to develop novel immunogens. (nih.gov)
The interaction between paratope (antibody) and epitope (antigen) is the fundamental driving force of both immunogenicity and antigenicity. (proteogenix.science)
Epitope is immunologically active regions of an immunogen (or antigen) that binds to antigen-specific membrane receptors on lymphocytes or to secreted antibodies. (microbiologyinfo.com)
Epitope tags are usually engineered onto either the N- or C- terminus in order to minimize tertiary structure disruptions that may alter protein function. (antibodies-online.com)

Vaccines are examples of antigens in an immunogenic form, which are intentionally administered to a recipient to induce the memory function of the adaptive immune system towards antigens of the pathogen invading that recipient. (wikipedia.org)
T-dependent antigen - Antigens that require the assistance of T cells to induce the formation of specific antibodies. (wikipedia.org)
The OMV carrier has been optimized to induce a more effective immune response against these newly introduced antigens. (biotechnology.report)
When administered to a host alone, as polymers or as carrier-bound conjugates, the polypeptides induce the proliferation of thymus-derived cells in hosts primed against hepatitis B virus. (justia.com)
Most importantly, infection and current vaccines do not appear to effectively induce these antibodies in humans. (cdc.gov)
Current influenza virus vaccines attempt to induce strong antibody responses against the viral glycoproteins hemagglutinin (HA) and, with lesser emphasis, neuraminidase (NA) because their protective efficacy is well documented. (cdc.gov)
Unable to induce an immune response by itself, they require carrier molecule to act as a complete antigen. (microbiologyinfo.com)
Interpretation of pet model data is normally further challenging by proof that persistent carrier state governments and recurrent attacks are normal in human beings, and these exposures usually do not induce immune system responses sufficient to safeguard from subsequent attacks20. (californiaehealth.org)
In this study, we are testing the efficacy of the RBD displayed on a baculovirus as a mean to formulate a safe and stable carrier to induce the immune system against SARS-CoV-2. (springeropen.com)
Licensed influenza vaccines that induce high antibody titers to the highly polymorphic viral surface antigen hemagglutinin must be re-formulated and readministered annually. (ox.ac.uk)

Here, we describe an alternative glycoconjugate vaccine for S. Typhi, Vi-CRM(197), where Vi was obtained from Citrobacter freundii WR7011 and CRM(197), the mutant diphtheria toxin protein, was used as the carrier. (nih.gov)
Up until now our discussion has focused on L1 virus-like particle vaccines, which maintain a highly safe and efficacious track record in preventing persistent infection and precursor lesions induced by vaccine types HPV-16 and HPV-18. (medscape.com)
This is because vaccine-elicited anti-L1 antibodies bind to surface-exposed viral capsid loops that are highly heterogeneous among the different HPV types. (medscape.com)
Currently, some of the most promising newcomer HPV vaccine candidates aiming to fill the gaps of cross-protection and cost while maintaining long-term protection are not L1 based, but focus on the minor capsid protein L2. (medscape.com)
The fusion peptide can be displayed on scaffold proteins and - when coupled to HIV-1 Env trimer boosts - has the potential to elicit antibodies capable of neutralizing diverse HIV-1 strains in mice, guinea pigs and rhesus macaques, and might therefore serve as the basis for an effective HIV vaccine. (nih.gov)
Although the vaccine was highly effective in trials in Finland among children greater than or equal to 18 months of age (3), postmarketing efficacy studies in the United States demonstrated variable efficacy (4,5). (cdc.gov)
Conjugation of the PRP polysaccharide with protein carriers confers T-cell- dependent characteristics to the vaccine and substantially enhances the immunologic response to the PRP antigen. (cdc.gov)
Because of their potential for broadening vaccine-mediated protection in humans, they have been studied extensively in animals and found to be mediated predominantly by virus-specific memory T cells ( 6 , 7 ), antibodies ( 8 - 10 ), or a combination of both ( 11 - 13 ). (cdc.gov)
The present invention is drawn to a next generation nano vaccine platform by using structure- based design to utilize the conserved or less variable or highly immunogenic domains or epitopes and displaying it in a nano cage and produces it in as nanoparticle protein in prokaryotic expression system. (sumobrain.com)
We postulated which the outcomes from these basic research would partly provide an important part of the set up of a highly effective combinatorial vaccine. (californiaehealth.org)
As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and humoral immunity. (springeropen.com)
They are now used as safe immunogenic vaccine vectors in clinical trials and exhibit outstanding performance (Gurwith et al. (springeropen.com)
A vaccine may contain live-attenuated or killed microorganisms or parts or products from them capable of stimulating a specific immune response comprised of protective antibodies and T cell immunity. (microbenotes.com)
A vaccine should stimulate a sufficient number of memory T and B lymphocytes to yield effector T cells and antibody-producing B cells from memory cells. (microbenotes.com)
A vaccine is an agent that is prepared from an antigen or pathogen by either deactivating its mechanisms of protein synthesis or denaturing or killing them. (microbenotes.com)
A vaccine providing protective immunity to the highly conserved internal antigens could provide longer-lasting protection against multiple influenza subtypes. (ox.ac.uk)
CONCLUSIONS: We conclude that the vaccine was both safe and remarkably immunogenic, leading to frequencies of responding T cells that appear to be much higher than those induced by any other influenza vaccination approach. (ox.ac.uk)

The present invention relates to the production of novel synthetic antigens based upon information derived from DNA and/or protein sequences and to the use of those antigens in the production of vaccines, diagnostic reagents, and the like. (justia.com)
Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table_1 ). (cdc.gov)
Effective vaccines change the immune system by promoting the development of antibodies that can quickly and effectively attack disease-causing microorganisms when it enters the body, preventing disease development. (microbenotes.com)
The viral vaccines should also be able to stimulate high titers of neutralizing antibodies. (microbenotes.com)
Most of the SARS-CoV-2-based vaccines are based on the full spike protein, which is presented as a trimerized protein, and many viral vector vaccines express the spike protein into the host cells and do not display it on virus surfaces. (springeropen.com)
Most of the candidate vaccines are mRNA or DNA vaccines, live vaccines, vector virus vaccines, inactivated vaccines or viral protein subunits vaccines. (springermedizin.at)

Researchers designed fusion peptide immunogens that were comprised of the exposed residues of the fusion peptide coupled to highly immunogenic carrier proteins to focus the immune response to this conserved site of vulnerability. (nih.gov)
On a fundamental level, peptide antibodies can also be used to characterize epitopes in proteins in their native conformation. (proteogenix.science)
In combination with a protein or peptide they are used for separation but also for the detection of the protein used or to distinguish between native and enhanced expression. (antibodies-online.com)

High virus neutralizing antibody titers were detected against all the variant viruses. (biotechnology.report)

For instance, they can serve as ligands to screen highly-diverse antibody libraries using display techniques (e.g., phage display). (proteogenix.science)
We successfully constructed a single domain antibody phage display library with a capacity of 1.8 × 10 9 by immunizing and cloning the VHH gene from Bactrian camel. (springeropen.com)
In 2018, a team of scientists won the Nobel Prize for their work on phage display in the directed evolution of new proteins - in particular, for the production of antibody therapeutics. (thebrainsyouwerebornwith.com)

The mouse monoclonal antibody has been a dominant tool in research and diagnostic and therapeutic areas. (mddionline.com)
therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C121217 Cifurtilimab A proprietary, non-fucosylated monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. (nih.gov)

Because these tags are entities with known sequences and well characterized physicochemical properties, they are an essential tool in molecular biology for purification of recombinant proteins. (antibodies-online.com)
Reactivity of serum IgG was examined with a range of recombinant protein, representing over 2,652 USA300 stress. (californiaehealth.org)
The recombinant single-domain antibody was solublely expressed in E. coli and specifically bound to adenoviruses rAd26, ChAd63 and HAd5 in ELISA and live cell immunofluorescence assays. (springeropen.com)

But, by 1903, he understood that an antigen induces the production of immune bodies (antibodies) and wrote that the word antigen is a contraction of antisomatogen (Immunkörperbildner). (wikipedia.org)
Antigen is a substances usually protein in nature and sometimes polysaccharide, that generates a specific immune response and induces the formation of a specific antibody or specially sensitized T cells or both. (microbiologyinfo.com)
In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC), and eventually inhibits the proliferation of CD40-expressing tumor cells. (nih.gov)

Most antigens have the potential to be bound by multiple antibodies, each of which is specific to one of the antigen's epitopes. (wikipedia.org)
Using the "lock and key" metaphor, the antigen can be seen as a string of keys (epitopes) each of which matches a different lock (antibody). (wikipedia.org)
In fact, most natural epitopes are discontinuous consisting of residues that are not adjacent in the sequence but instead brought into proximity due to the conformation of the cognate, intact protein. (proteogenix.science)

For the separation of proteins a variety of conjugates can be used with a high specificity for a certain matrix. (antibodies-online.com)
Antibody performance related to sensitivity, specificity, linear dynamic range, matrix effect, and immunoassay standardization sets the primary determinant for the quality of IVD medical devices. (mddionline.com)
therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C128288 Luvixasertib An orally bioavailable, selective inhibitor of the dual specificity protein kinase TTK (monopolar spindle 1 kinase, Mps1), with potential antineoplastic activity. (nih.gov)
Dot blot and Western blot were used to screen and validate the polyclonal antibodies' specificity to the SARS-CoV-2 RBD. (springeropen.com)

P24 is the capsid protein of HIV virus which can stimulate immune response. (omicsonline.org)

We investigate how the immune system can recognize pathogen-associated activities, such as the enzymatic activity of pathogen secreted proteins or changes in homeostasis induced by pathogens using a combination of immunology, cellular biology, and biochemistry. (utsouthwestern.edu)
To HhAntag greatly help guide the introduction of effective immune system protective and healing agents, we searched for to perform impartial research of individual immune system responsiveness to all or any potential proteins antigens encoded with the genome of epidemic community-acquired MRSA (CA-MRSA) stress USA300. (californiaehealth.org)
Development of antibodies by the immune system to neutralize the antigens. (microbenotes.com)
The outcome of our investigation showed that the monomeric RBD proteins were properly displayed on baculovirus and efficiently triggered the mouse immune system. (springeropen.com)

Nucleic acids are usually poorly immunogenic. (microbiologyinfo.com)

In general lipids are non-immunogenic, although they may be haptens. (microbiologyinfo.com)
Depending on the cell of origin, EVs carry effector functions from one cell to the other by horizontal transfer of their bioactive cargoes, including DNA, RNA, proteins, lipids, and metabolites. (bmbreports.org)

Antigenic molecules, normally "large" biological polymers, usually present surface features that can act as points of interaction for specific antibodies. (wikipedia.org)
Moreover, they can be used in protein-protein interaction studies or multiple immunoassays as reagents or standards. (proteogenix.science)
The PhD student will then demonstrate the applicability of the developed system and methodology for separation of magnetic nanorods provided by PHENIX and monitoring their interaction with human plasma proteins to evaluate their behavior under biological conditions. (afsep.com)
Thyroid hormone [3,5,3'-triiodothyronine (T.sub.3)] exerts diverse metabolic effects on mammalian cells, primarily through its interaction with nuclear receptor proteins of the cells. (everypatent.com)

Adjuvants are substances that are non-immunogenic alone but enhance the immunogenicity of any added immunogen. (microbiologyinfo.com)

in some instances, however, antibodies may cross-react to bind more than one antigen. (wikipedia.org)
These can cross-react with the original intact protein, making them invaluable for isolating, monitoring, and localizing protein expression. (proteogenix.science)

While antibodies to the immunodominant, but highly variable, regions of HA and NA can provide potent virus strain-specific protection, the existence of weaker and more broadly protective immune activities directed to less variable regions of viral proteins has long been known ( 5 ). (cdc.gov)

In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. (wikipedia.org)
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells. (lookformedical.com)

Together gp120 and gp41 make up the HIV-1 Env spike, which is a target for neutralizing antibodies. (nih.gov)
The first set of pre-clinical studies of Avacc 10®, published in Frontiers of Immunology in December 2021, demonstrated high levels of spike-binding immunoglobulin G (IgG) and A (IgA) antibodies in serum, and the nose and lungs after two intranasal vaccinations 3 weeks apart. (biotechnology.report)
For the dosing study, mice were vaccinated intranasally with two doses of various concentrations of OMV and Spike protein. (biotechnology.report)
All Avacc 10® vaccinated animals showed high IgG antibodies levels against Spike as well as virus neutralizing antibodies. (biotechnology.report)

Antibodies usually do not react with self-antigens due to negative selection of T cells in the thymus and B cells in the bone marrow. (wikipedia.org)
The diseases in which antibodies react with self antigens and damage the body's own cells are called autoimmune diseases. (wikipedia.org)
They are often designed to mimic a specific biological role, such as the ability to react with a functional binding site of a complementary antibody. (proteogenix.science)
Haptens can react specifically with its corresponding antibody. (microbiologyinfo.com)

[ 123 ] Regardless of whether HPV detaches or remains bound to HSPGs, in vitro and more importantly in vivo data have demonstrated that L1 and L2 antibodies elicited by vaccination can prevent infection by different mechanisms. (medscape.com)
Three weeks after the last vaccination neutralizing antibodies against the SARS-CoV-2 Wuhan strain and variants of concern Delta, Gamma and Omicron were determined in the sera. (biotechnology.report)
Direct comparison of studies is complicated by differing vaccination and blood collection regimens and interlaboratory variation in assays for measurement of PRP antibody. (cdc.gov)
The reason for these differences in the relative strength of T-cell and antibody-mediated protection is not clear but could be attributable to differences in vaccination procedures, virus challenge, and read out (how protection was measured) between the various studies. (cdc.gov)

To truly appreciate why L2-directed antibodies can cross-neutralize many HPV types, we must take a closer look at basic L2 biology during initial steps of viral entry. (medscape.com)
Thus, typical HA-specific antibodies neutralize viral infectivity and fully protect against infection when they are present at sufficient concentration in the lining fluid of the respiratory tract, and typical NA-specific antibodies inhibit the release of newly formed virus from infected host cells and thus limit the spread and shedding of virus during infection. (cdc.gov)

In 1899, Ladislas Deutsch (László Detre) named the hypothetical substances halfway between bacterial constituents and antibodies "antigenic or immunogenic substances" (French: substances immunogènes ou antigènes). (wikipedia.org)

The site-specific conjugation of the cytotoxic agent to the antibody improves the biophysical properties of anvatabart opadotin, increases payload stability and optimizes its efficacy. (nih.gov)

This is caused, to a certain extent, by a lack of high-quality antibodies in immunoassays and by increased demand for better or novel antibodies along with the emergence of genomics, proteomics, and epitomics. (mddionline.com)
Here we describe a GWAS using a highly multiplexed aptamer-based affinity proteomics platform. (nature.com)
However, proteomics-based genetic association studies have been limited by small protein panels or cohort sizes, and thus, have not systematically addressed associations across multiple chromosome locations. (nature.com)
Here we use a highly multiplexed, aptamer-based, affinity proteomics platform (SOMAscan) 10 in a GWAS to quantify levels of 1,124 proteins in blood plasma samples. (nature.com)

He originally believed those substances to be precursors of antibodies, just as a zymogen is a precursor of an enzyme. (wikipedia.org)

it is safe and immunogenic in humans. (utsouthwestern.edu)
As a result, variable expression levels of these proteins in humans, due to inherited factors (pharmacogenetics) and/or environmental factors (e.g. drug-drug interactions), can have important consequences for an individual's susceptibility to certain drug-induced side effects and treatment efficacy (2). (aacrjournals.org)

Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. (wikipedia.org)

The immunogenic part of HIV capsid consists of viral protein p24 . (omicsonline.org)
The multiple copies of coat proteins that form the virus outer shell of viruses are collectively known as the capsid [ 7 ] . (encyclopedia.pub)

The most promising approaches are based on antibodies specific for the relatively conserved ectodomain of matrix protein 2 and the intersubunit region of hemagglutinin. (cdc.gov)

Group members use a broad mix of experimental approaches, ranging from studies in animal models to the use of structural methods to understand protein function. (utsouthwestern.edu)
Three genes (gag, pol and env) contain information needed to make the structural proteins for new virus particles. (omicsonline.org)
6. The method as claimed in claim 1, wherein the nano-cage is selected from non- structural protein 10 (nsplO), Ferritin and Lumazine. (sumobrain.com)
The diameter of the adenovirus shell is 70-90 nm, and it is composed of three main structural proteins: fiber, the penton base and the hexon. (springeropen.com)

Most protein and cell analysis techniques involving antibodies rely on conjugates to enhance or simplify the procedure. (antibodies-online.com)
Antibody conjugates mainly help in detection of the antibody and its binding partners but can als be used for separation. (antibodies-online.com)
In immunization experiments conjugates (espcially KHL) are used extensively as a carrier protein in the production of antibodies. (antibodies-online.com)

Example: Serum Protein such as Albumin or Globulin. (microbiologyinfo.com)
Examples: tetanus toxoid, egg albumin, thyroglobulin are highly antigenic. (microbiologyinfo.com)

These may be pure proteins or they may be glycoproteins or lipoproteins. (microbiologyinfo.com)

Vi conjugated to a carrier protein (i.e., an exoprotein A mutant from Pseudomonas aeruginosa [rEPA]) is highly immunogenic, provides long-term protection, and shows more than 90% protective efficacy in children 2 to 5 years old. (nih.gov)
The non-fucosylated antibody shows increased efficacy as compared to its fucosylated counterpart. (nih.gov)

The importance and detectability of genetic variants for a given protein depends on the contribution of the variant gene product to pharmacological response, the availability of alternative pathways of elimination for a given drug, and the frequency of occurrence of the least common variant allele. (aacrjournals.org)
We quantify 539 associations between protein levels and gene variants (pQTLs) in a German cohort and replicate over half of them in an Arab and Asian cohort. (nature.com)
We find that up to 60% of the naturally occurring variance in the blood plasma levels of essential proteins can be explained by two or more independent variants of a single gene located on another chromosome, and identify strong genetic associations with intermediate traits in pathways involved in complex disorders. (nature.com)

[ 120 ] The L2 N-terminus is then cleaved by a furin convertase, releasing the 12 most N-terminal amino acids and exposing highly conserved L2 regions against which cross-neutralizing antibodies are directed. (medscape.com)

Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)

The six remaining genes like tat, rev, nef, vif, vpr, and vpu (or vpx in the case of HIV-2), are regulatory genes for proteins that control the ability of HIV to infect cells, produce new copies of virus [ 11 , 12 ]. (omicsonline.org)
1. The proteins encoded by these genes are classified as alpha or beta forms on the basis of the predicted amino acid sequences and have homologs in man. (everypatent.com)

During infection, the major envelope protein of HIV-1 is cleaved by host cell proteases into two smaller versions (gp120 and gp41). (nih.gov)
The primary envelope glycoprotein gp64 is the most abundant envelope protein and is essential for both insect cell infection and mammalian cell transduction [ 9 ]. (springeropen.com)

Chemically synthesized polypeptides include amino acid residue sequences that substantially correspond to the amino acid residue sequences of T Cell and B cell determinant portions of a natural, pathogen-related protein, in particular, a hepatitis B virus surface antigen (HBsAG). (justia.com)
More specifically, this invention relates to synthetic antigenic polypeptides, which when used alone, as a polymer or upon coupling to a carrier, immunologically correspond to a T cell and B cell determinant portion of hepatitis B virus surface antigen (HBsAg). (justia.com)
PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES. (lookformedical.com)

Although all antigens are recognized by specific lymphocytes or by antibodies, only some antigens are capable of activating lymphocytes. (microbiologyinfo.com)

4] The emm gene encodes the M protein. (medscape.com)

Storage of these immune effector antibodies as memory antibodies for future response in case an individual is exposed to the live pathogen or disease. (microbenotes.com)

However, additional conserved determinants for protective antibodies are likely to exist, and their identification should be encouraged. (cdc.gov)
On average, the prevalent influenza A virus strain acquires 3-4 amino acid changes per year in HA, with most being located in the regions recognized by protective antibodies. (cdc.gov)
Jointly, our studies have got uncovered a hierarchy inside the different protein from the immunome, which can only help to progress efforts to build up protective immunotherapeutic realtors. (californiaehealth.org)

They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. (lookformedical.com)

Can the highly site specific colonization of certain bacteria for a tumor be clinically useful in the diagnosis of cancer or delivery of a therapeutic agent? (biomedcentral.com)
tumor_purity tumor purity C C177536 GDC Property Terminology C13202 Chromosome A structure found in cells that is comprised of a strand of linearized double-stranded DNA plus proteins that package the DNA in a condensed coil form and regulate chromosomal function. (nih.gov)
Upon administration of anvatabart opadotin, the antibody moiety targets and binds to HER2 on tumor cells. (nih.gov)
Upon antibody/antigen binding and internalization, opadotin binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. (nih.gov)

however S. typhi is a promising carrier of therapeutic agents for melanoma, colon and bladder cancers. (biomedcentral.com)
The development of monoclonal therapeutic antibodies and specific immunomodulatory drugs represent new treatment options in the fight against infectious diseases. (springermedizin.at)

High concentrations of L1 antibodies prevent initial engagement with HSPGs on the basement membrane. (medscape.com)
High-level reactivity was showed for 104 protein with serum IgG in every patient samples. (californiaehealth.org)
General, high-level HhAntag IgG-reactivity was most directed against a subset of secreted protein typically. (californiaehealth.org)
Methods: A total of 190 Spanish overweight and obese participants were randomly assigned to two hypocaloric diets for 4 months: 61 women and 29 men followed a moderately high protein (MHP) diet, and 72 women and 28 men followed a low fat (LF) diet. (unav.edu)

From this urgent need, the first 2D-ME prototype to be developed in microfluidic format will be used for resolute charge, size and shape characterization of spheric MNPs and nanorods serving as innovative drug carriers. (afsep.com)
Research endeavors over the past several decades have identified various types of cells as suitable living drugs and versatile drug carriers. (biomedcentral.com)

antibodies-online offers conjugated antibodies linked to a variety of colorimetric and fluorescent labels for use in detection, purification, sorting, and microscopy applications. (antibodies-online.com)
The conjugate choice depends upon the experimental application and therefore the and allows colorimetric, fluorescent or chemiluminescent detection of primary antibodies in cell imaging, immunohistochemistry, flow cytometry and western blotting. (antibodies-online.com)
To achieve low limits of detection (LODs), both immobilised antibody-based (direct) and immobilised antigen-based (competitive) assay setups were applied. (mdpi.com)

Cowpea mosaic virus structure, Protein subunits in red and blue. (encyclopedia.pub)

It involves the introduction of DNA coding for a protein, such as an antibody, into a bacteriophage - a virus that infects bacteria. (thebrainsyouwerebornwith.com)

Antibody against PRP was shown to be the primary component of serum bactericidal activity against the organism. (cdc.gov)
Although predicated on limited research, we discovered subsets of protein with differential reactivity with serum examples from sufferers with different scientific syndromes. (californiaehealth.org)

The double-stranded DNA Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the prototype of baculoviruses that has been used extensively to produce eukaryotic complex proteins [ 5 ]. (springeropen.com)

METHODS: We prepared a Modified Vaccinia virus Ankara (MVA) vector encoding nucleoprotein and matrix protein 1 (MVA-NP+M1) and conducted a phase I clinical trial in healthy adults. (ox.ac.uk)

Furthermore, security from particular types of clinical an infection syndromes may need antibody replies to different pieces of staphylococcal antigens. (californiaehealth.org)

Non-specific lipid transfer proteins (LTPs) are important allergens in fruits, pollen, vegetables, nuts and latex. (nih.gov)
This study prepared an adenoviral vector-specific single-domain antibody for use in adenovirus identification and purification. (springeropen.com)
The preparation of the adenovirus-specific single-domain antibody lays a foundation for the one-step immunoaffinity purification and identification of adenoviruses. (springeropen.com)
Many species, however, share an important characteristic: highly site-specific colonization. (biomedcentral.com)

Researchers can use these protein-displaying phages to screen for interactions with other proteins, DNA sequences and small molecules. (thebrainsyouwerebornwith.com)

While the immunoassay is the most popular analytical technique applied in clinical and nonclinical diagnoses, there is still a gap between the antibody developer and IVD manufacturer. (mddionline.com)
This paradigm shift was instigated by the discovery of a significant number of highly innovative and distinct classes of molecules in terms of both mechanism of action and chemical structure, along with the deployment of an array of new approaches to clinical trial design. (aacrjournals.org)
Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease associations and translate them into clinical applications. (nature.com)

A large Stokes shift is indicative of less overlap between the two wavelengths, and is highly desirable since it means that the emitted light can be clearly distinguished from the light source which was used for excitation. (antibodies-online.com)

We established an effective method for immunoaffinity purification of adenovirus by immobilizing the single domain antibody to Sepharose beads, and it may be used to selectively capture adenoviruses from cell culture medium. (springeropen.com)

We used linear additive genetic regression models, adjusted for relevant covariates, to analyse 509,946 common autosomal SNPs for genome-wide associations with 1,124 protein levels measured in 1,000 blood samples from the KORA study (see Methods). (nature.com)

The optimal saccharide/protein ratio of the glycoconjugates was identified for the best antibody production. (nih.gov)

Anatomy9

Organisms17

Diseases1

Chemicals and Drugs140

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science4

Health Care4

Peptides16

Polyclonal antibody production2

Epitope5

Induce10

Vaccine17

Vaccines6

Peptide3

Titers1

Phage display3

Monoclonal antibody2

Recombinant3

Induces3

Epitopes3

Specificity4

Stimulate1

Immune system4

Nucleic Acids1

Lipids2

Interaction4

Immunogen1

Cross-react2

Viral proteins1

Bind2

Spike4

React4

Vaccination4

Neutralize2

Constituents1

Conjugation1

Proteomics4

Precursors1

Humans2

Receptors1

Capsid2

Hemagglutinin1

Structural4

Conjugates3

Albumin2

Glycoproteins1

Efficacy2

Variants3

Amino acids1

Sera1

Genes2

Envelope protein2

Polypeptides3

Lymphocytes1

Gene1

Pathogen1

Protective3

Cytotoxic1

Tumor4

Therapeutic2

High4

Drug carriers2

Detection3

Subunits1

Bacteria1

Serum2

Extensively1

Nucleoprotein1

Staphylococcal1

Specific4

Sequences1

Clinical3

Overlap1

Purification1

Genome1

Production1