• Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
  • The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
  • Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
  • This antibody is reactive against recombinant protein in ELISA. (novusbio.com)
  • All refer to the same protein glutamate carboxypeptidase II. (wikipedia.org)
  • The FOLH1 gene has multiple potential start sites and splice forms, giving rise to differences in membrane protein structure, localization, and carboxypeptidase activity based on the parent tissue. (wikipedia.org)
  • ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein. (avivasysbio.com)
  • This antibody was purified via Protein A. (gentaur.com)
  • Specificity: Alternative Names: P06621 Immunogen: Recombinant Pseudomonas sp.Carboxypeptidase G2 protein (23-415AA) Technical Notes: For Research Use Only. (telospub.com)
  • Analysis of Protein Array containing more than 19,000 full-length human proteins using Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (neobiotechnologies.com)
  • This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant protein of Carboxypeptidase A2 (CPA2). (angioproteomie.com)
  • However, in the 1980s, insulin autoantibodies (IAAs), GAD antibodies (GADAs), islet antigen-2 antibodies (IA-2As), 64-kDa autoantibodies (64KAs), insulin receptor autoantibodies, carboxypeptidase-H autoantibodies, and heat shock protein (HSP) autoantibodies [7] - [11] were recognized. (scirp.org)
  • Prostate specific membrane antigen (PSMA) otherwise known as glutamate carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in prostate cancer and in the neovasculature of a wide variety of tumours including glioblastomas, breast and bladder cancers. (omicsdi.org)
  • Elabscience Category Type: Monoclonal Synonyms: E1, Anti 2019-nCoV S-NTD antibody, Anti 2019-nCoV Spike protein NTD antibody Applications: ELISA. (proteomecommons.org)
  • Antibody is suitable for use in Western blot and ELISA and does not cross-react in ELISA with HCoV-229E full-length spike protein (REC31880). (thenativeantigencompany.com)
  • Antibody detected SARS-CoV-2 spike S2 subunit (lanes 3 and 5), and full-length spike protein (lane 9). (thenativeantigencompany.com)
  • Antibody does not cross-react in ELISA with HCoV-229E full-length spike protein (REC31880). (thenativeantigencompany.com)
  • SARS-CoV-2 Spike (S2) polyclonal antibody binds the S2 domain of the SARS-CoV-2 Spike protein. (thenativeantigencompany.com)
  • The exact immunogen sequence used to generate this antibody is proprietary information. (abcam.com)
  • If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (abcam.com)
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. (avivasysbio.com)
  • Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. (wikipedia.org)
  • We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. (uni-regensburg.de)
  • Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
  • The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease. (omicsdi.org)
  • In this article, we review the relevant research in PSMA on the 20th anniversary of its cloning.A PubMed search using the keywords "prostate-specific membrane antigen" or "glutamate carboxypeptidase II" provided 1019 results. (omicsdi.org)
  • This antibody was made by immunising rabbits with a recombinant SARS-CoV-2 Spike subunit 2 antigen ( REC31830 ). (thenativeantigencompany.com)
  • Some antibodies require special fixation methods or antigen retrieval steps. (sysy.com)
  • I mmuno h isto c hemistry (IHC-P) of f ormalin f ixed, p araffin e mbedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the "Remarks" section). (sysy.com)
  • On prostate cancer (PC) cells, the cell surface enzyme prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II or N -acetyl- l -aspartyl- l -glutamate peptidase, is highly upregulated, whereas it shows low or no expression in the normal prostate ( 3 ). (snmjournals.org)
  • PSMA dimers but not monomers displayed a native conformation and possessed high-level carboxypeptidase activity. (omicsdi.org)
  • When used to immunize animals, dimer but not monomer elicited antibodies that efficiently recognized PSMA-expressing tumor cells. (omicsdi.org)
  • PSMA antibody-auristatin conjugates have been considered 1 option ( 4 ), but they face the inherent resistance of mCRPC against most (excepting taxanes) conventional chemotherapies. (snmjournals.org)
  • If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (polyclon.com)
  • MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. (polyclon.com)
  • MyBioSource supplies antibodies that are for research of human proteins. (polyclon.com)
  • The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by MyBioSource. (polyclon.com)
  • Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. (gentaur.com)
  • But in at least 50% of cases, the patients produce neutralizing antibodies, rendering therapy with these proteins ineffective. (genengnews.com)
  • Carboxypeptidase A1 (CPA1) is secreted as a pancreatic peptidase that comes from the precursor form of inactive procarboxypeptidase. (abeomics.com)
  • Formalin-fixed, paraffin-embedded human Pancreas stained with Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • SDS-PAGE Analysis Purified Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • Western Blot Analysis of pancreatic tissue lysate using Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). (neobiotechnologies.com)
  • Carboxypeptidase A1/ CPA1 is a 419 amino acid zinc metalloenzymes belongs to the peptidase M14 family. (biogenex.com)
  • The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. (uni-regensburg.de)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • This antibody was selected for its ability to detect human Carboxypeptidase A2 (CPA2). (angioproteomie.com)
  • Rat carboxypeptidase z (cpz) elisa kit - mybiosource. (cggi.ru)
  • Ultra-LEAF™ purified anti-CXCL12 (SDF-1β) antibody (clone W15149B) (purple squares) neutralizes the chemotaxis of recombinant mouse CXCL12 (SDF-1β) at 0.25 ng/mL on mouse Baf3-hCXCR4 cells in a dose-dependent manner. (biolegend.com)
  • Rabbit antibodies are very stable and can be stored for several days at room temperature. (polyclon.com)
  • Western blot was carried out using rabbit anti SARS-CoV-2 Spike (S2) polyclonal antibody (1mg/ml, 1:1000) and STAR124P secondary antibody (1mg/ml, 1:1000). (thenativeantigencompany.com)
  • Ace2 Antibody is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • Biochemical characterization revealed that both antibodies detect the same 58-64-kDa glycoprotein anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. (uni-regensburg.de)
  • SARS-CoV-2 Spike (S2) polyclonal antibody is an antibody that recognizes the SARS-CoV-2 Spike glycoprotein subunit 2. (thenativeantigencompany.com)
  • Regular acidCSchiff (PAS), alcian blue, immunohistochemistry (trypsin, carboxypeptidase A, DNA damage-inducible transcript 3 [DDIT3], and activating transcription aspect 4 [ATF4]), immunofluorescence (calreticulin), and electron microscopy assays had been performed in mice with acinar cell vacuolation. (bioskinrevive.com)
  • Cambridge, UK), and tagged streptavidin-biotin (LSAB) staining technique had been employed for anti-trypsin and anti-carboxypeptidase A antibodies, anti-calreticulin antibody, anti-DDIT3 antibody, and anti-ATF4 antibody, respectively. (bioskinrevive.com)
  • Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. (gentaur.com)
  • Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. (neobiotechnologies.com)
  • CusabioAce2 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
  • Indeed delivery of drug-Tf conjugates and TfR antibody conjugates have had some success (Dufès AMG-925 et al. (biotech-angels.com)
  • Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500ug/ml. (angioproteomie.com)
  • The following product was used in this experiment: CCP2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-113003, RRID AB_2867737. (thermofisher.com)
  • A mutation of carboxypeptidase E (CPE), an enzyme active in the processing and sorting of prohormones, causes obesity in the fat/fat mouse. (nih.gov)
  • Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long. (polyclon.com)
  • Recombinant Human Carboxypeptidase A1 is produced by our Mammalian expression system and the target gene encoding Lys17-Tyr419 is expressed with a 6His tag at the C-terminus. (abeomics.com)
  • It has been shown that within the variable regions of even fully human antibodies, somatic mutations and other alterations in sequence information can stimulate a powerful reaction on the part of the host. (genengnews.com)
  • Many antibodies, including humanized and fully human antibodies, did not present serious immune dysfunction issues until they had been approved and a large body of documentation concerning their performance had accumulated," Dr. Baker continues. (genengnews.com)
  • 1990. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter. (neobiotechnologies.com)
  • Human donor specific background has been observed in relation to the presence of anti-polyethylene glycol (PEG) antibodies, developed as a result of certain vaccines containing PEG, including some COVID-19 vaccines. (bdbiosciences.com)
  • 2013 Right here we hypothesized that TfR antibody affinity determines TfR trafficking destiny and sought to review the cellular systems root the robust distinctions between high and low anti-TfR affinity variations and TfR trafficking aswell as the influence of the strategies on human brain uptake of biotherapeutics. (biotech-angels.com)
  • Outcomes High-affinity binding to TfR drives cortical TfR degradation in vivo To comprehend how anti-TfR affinity inversely AMG-925 influences human brain contact with antibody we initial determined whether degrees of TfR are influenced by dosing of high- versus low-affinity TfR bispecific antibodies. (biotech-angels.com)
  • 2013 Yu and Watts 2013 though many limitations have also surfaced including evidence that high-affinity TfR antibodies remain trapped within mind vasculature (Moos and Morgan 2001 Gosk et al. (biotech-angels.com)
  • 2011 We also lately reported that affinity and effector function determine the basic safety profile of TfR healing antibodies in vivo hence further helping low-affinity strategies and the necessity to better understand the root cell biology (Sofa et al. (biotech-angels.com)
  • When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
  • Cells may be prepared, stained with antibodies and washed twice with wash buffer per established protocols for immunofluorescent staining prior to acquisition on a flow cytometer. (bdbiosciences.com)
  • Cytotoxic To Cells Expressing Glutamate Carboxypeptidase 2 was the leading MoA in the pipeline market. (globaldata.com)
  • We feel the ability of EpiScreen to recognize these problematic antibodies early in their development is an important tool for insuring highly successful biologics. (genengnews.com)
  • Even molecules not usually recognized as foreign (such as humanized antibodies), when pumped into the circulation in quantities large enough to perform their therapeutic function, can activate an autoimmune response. (genengnews.com)
  • Detection of target molecules is carried out with antibodies. (sysy.com)
  • These bacteria liberate intercellular mediators, humoral antibodies and effector molecules for periapical tissues 3 . (bvsalud.org)
  • If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
  • Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. (avivasysbio.com)
  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703). (neobiotechnologies.com)
  • ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. (prosci-inc.com)
  • The Renin-angiotensin system study combines topics in areas such as Molecular biology, Radioimmunoassay, Antibody and Pharmacology. (research.com)
  • In addition, carboxypeptidase M expression could be detected in HL-60, U937, and THP-1 myeloid cell lines. (uni-regensburg.de)
  • Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. (uni-regensburg.de)